BR112014011900A2 - um método de purificação de anticorpo - Google Patents

um método de purificação de anticorpo

Info

Publication number: BR112014011900A2
Authority: BR; Brazil
Prior art keywords: purification method; antibody purification; antibody; purification
Prior art date: 2011-12-15

Application number

BR112014011900A

Other languages

English (en)

Inventor

Eun Lee Dong

Won Youn Jeong

Yong Yoon Ji

Eun Baek Jung

Kyum Kim Won

Original Assignee

Hanwha Chemical Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-12-15

Filing date

2012-12-14

Publication date

2017-05-16

2012-12-14 Application filed by Hanwha Chemical Corp filed Critical Hanwha Chemical Corp

2017-05-16 Publication of BR112014011900A2 publication Critical patent/BR112014011900A2/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Water Supply & Treatment (AREA)
Peptides Or Proteins (AREA)

BR112014011900A 2011-12-15 2012-12-14 um método de purificação de anticorpo BR112014011900A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR20110135652		2011-12-15
PCT/KR2012/010899 WO2013089477A1 (en)	2011-12-15	2012-12-14	A method of antibody purification

Publications (1)

Publication Number	Publication Date
BR112014011900A2 true BR112014011900A2 (pt)	2017-05-16

Family

ID=48612840

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR112014011900A BR112014011900A2 (pt)	2011-12-15	2012-12-14	um método de purificação de anticorpo

Country Status (10)

Country	Link
US (1)	US9683012B2 (pt)
EP (1)	EP2791176B1 (pt)
JP (1)	JP6092892B2 (pt)
KR (1)	KR101498771B1 (pt)
CN (1)	CN103998469B (pt)
BR (1)	BR112014011900A2 (pt)
DK (1)	DK2791176T3 (pt)
ES (1)	ES2690213T3 (pt)
PT (1)	PT2791176T (pt)
WO (1)	WO2013089477A1 (pt)

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* Cited by examiner, † Cited by third party
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KR102196230B1 (ko)	2012-09-17	2020-12-29	더블유.알. 그레이스 앤드 캄파니-콘.	크로마토그래피 매질 및 장치
CA2921999C (en)	2013-09-13	2023-03-21	Genentech, Inc.	Methods and compositions comprising an anti-il13 antibody and residual hamster phospholipase b-like 2
WO2015064971A1 (ko) *	2013-10-30	2015-05-07	(주)셀트리온	양이온 교환 크로마토그래피를 이용한 항체의 아형 분리 방법
CN104628846B (zh) *	2013-11-06	2019-12-06	三生国健药业（上海）股份有限公司	重组蛋白质的纯化方法
WO2015083853A1 (ko) *	2013-12-05	2015-06-11	한화케미칼 주식회사	이성질 항체의 함량 조절을 통한 항체 제조 방법
EP2986307A4 (en)	2014-01-03	2017-04-12	Bio-rad Laboratories, Inc.	Removal of impurities from protein a eluates
SG11201605712SA (en)	2014-01-16	2016-08-30	Grace W R & Co	Affinity chromatography media and chromatography devices
WO2015137530A1 (ko) *	2014-03-11	2015-09-17	주식회사 녹십자홀딩스	면역글로불린의 정제방법
US11389783B2 (en)	2014-05-02	2022-07-19	W.R. Grace & Co.-Conn.	Functionalized support material and methods of making and using functionalized support material
CN105777903B (zh) *	2015-03-23	2018-04-27	广东东阳光药业有限公司	一种阿达木单抗的阳离子交换色谱纯化方法
SG10201911134QA (en)	2015-06-05	2020-01-30	Grace W R & Co	Adsorbent bioprocessing clarification agents and methods of making and using the same
TW201718623A (zh) *	2015-08-20	2017-06-01	建南德克公司	ＦkpＡ之純化及其用於製備重組多肽之用途
CN106496302B (zh) *	2015-09-08	2021-12-10	三生国健药业（上海）股份有限公司	一种用离子交换层析纯化蛋白质的方法
IL264631B2 (en)	2016-08-16	2024-05-01	Regeneron Pharma	A method for quantifying individual antibodies from a mixture
AU2017350807B2 (en)	2016-10-25	2022-07-07	Regeneron Pharmaceuticals, Inc.	Methods and systems for chromatography data analysis
EP3603663A4 (en) *	2017-03-30	2020-04-08	Jiangsu Hengrui Medicine Co., Ltd.	METHOD FOR PRODUCING ANTIBODY-ACTIVE SUBSTANCE CONJUGATES
KR101999818B1 (ko) *	2017-07-26	2019-07-12	㈜로제타엑소좀	소수성 상호작용을 이용한 세포밖 소포체의 분리방법
CN108101987A (zh) *	2017-11-17	2018-06-01	安徽未名生物医药有限公司	一种重组抗TNF-α全人源单克隆抗体的纯化方法
CN110272491B (zh) *	2018-03-13	2023-01-24	江苏恒瑞医药股份有限公司	一种抗pd-1抗体的纯化工艺
SG11202009629YA (en) *	2018-04-02	2020-10-29	Amgen Inc	Erenumab compositions and uses thereof
TW202005694A (zh)	2018-07-02	2020-02-01	美商里珍納龍藥品有限公司	自混合物製備多肽之系統及方法
CN109336970A (zh) *	2018-11-09	2019-02-15	杭州奕安济世生物药业有限公司	阳离子交换层析法纯化抗体的方法
KR102154952B1 (ko) *	2020-02-21	2020-09-10	프레스티지바이오로직스 주식회사	아달리무맙의 Non-Protein A 정제방법
KR102153258B1 (ko) *	2020-02-21	2020-09-07	프레스티지바이오로직스 주식회사	베바시주맙 정제의 최적화된 방법
AU2021281152A1 (en) *	2020-05-28	2022-12-22	Kashiv Biosciences, Llc	An improved process of storing and preparing the protein

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1401870A4 (en) *	2001-05-24	2006-04-19	Human Genome Sciences	ANTIBODIES AGAINST TUMOR NECROSIS FACTOR DELTA (APRIL)
CA2478925C (en) *	2002-04-26	2016-06-07	Robert Lee Fahrner	Non-affinity purification of proteins
GB0304576D0 (en) *	2003-02-28	2003-04-02	Lonza Biologics Plc	Protein a chromatography
DE10323075A1 (de)	2003-05-22	2004-12-23	Hydac Process Technology Gmbh	Filterelement
WO2005082483A1 (en) *	2004-02-27	2005-09-09	Ge Healthcare Bio-Sciences Ab	A process for the purification of antibodies
BRPI0709726A2 (pt) *	2006-04-05	2011-07-26	Abbott Biotechnology Ltd.	purificaÇço de anticorpo
WO2008079280A1 (en) *	2006-12-21	2008-07-03	Millipore Corporation	Purification of proteins
EP2114984A2 (en) *	2007-01-17	2009-11-11	Merck Serono S.A.	Process for the purification of fc-containing proteins
WO2009058769A1 (en) *	2007-10-30	2009-05-07	Schering Corporation	Purification of antibodies containing hydrophobic variants
BRPI1010119A2 (pt) *	2009-07-24	2016-03-15	Hoffmann La Roche	"método de produção de composição de anticorpo e uso de cromatografia de troca de íons analítica"
CA2787897A1 (en)	2010-02-12	2011-08-18	Dsm Ip Assets B.V.	Single unit antibody purification
EP2773439A4 (en) *	2011-10-31	2015-07-01	Merck Sharp & Dohme	CHROMATOGRAPHY METHOD FOR DECOMPOSING HETEROGENEOUS ANTIBODY AGGREGATES

2012
- 2012-12-14 WO PCT/KR2012/010899 patent/WO2013089477A1/en active Application Filing
- 2012-12-14 BR BR112014011900A patent/BR112014011900A2/pt not_active Application Discontinuation
- 2012-12-14 EP EP12857495.1A patent/EP2791176B1/en active Active
- 2012-12-14 JP JP2014547103A patent/JP6092892B2/ja active Active
- 2012-12-14 US US14/365,027 patent/US9683012B2/en active Active
- 2012-12-14 PT PT12857495T patent/PT2791176T/pt unknown
- 2012-12-14 ES ES12857495.1T patent/ES2690213T3/es active Active
- 2012-12-14 KR KR1020120146672A patent/KR101498771B1/ko active IP Right Grant
- 2012-12-14 CN CN201280060939.6A patent/CN103998469B/zh active Active
- 2012-12-14 DK DK12857495.1T patent/DK2791176T3/en active

Also Published As

Publication number	Publication date
JP6092892B2 (ja)	2017-03-08
KR101498771B1 (ko)	2015-03-09
JP2015501836A (ja)	2015-01-19
ES2690213T3 (es)	2018-11-19
EP2791176A4 (en)	2015-08-19
WO2013089477A1 (en)	2013-06-20
CN103998469A (zh)	2014-08-20
DK2791176T3 (en)	2018-10-15
EP2791176A1 (en)	2014-10-22
PT2791176T (pt)	2018-11-05
US20140316115A1 (en)	2014-10-23
CN103998469B (zh)	2018-01-02
US9683012B2 (en)	2017-06-20
KR20130069515A (ko)	2013-06-26
EP2791176B1 (en)	2018-07-11

Legal Events

Date	Code	Title	Description
2018-03-20	B25A	Requested transfer of rights approved	Owner name: PRESTIGE BIOPHARMA PTE. LTD. (SG)
2018-03-27	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-07-09	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]	Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.
2021-07-13	B350	Update of information on the portal [chapter 15.35 patent gazette]
2021-09-08	B07G	Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]	Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021
2021-09-21	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2022-06-07	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2022-09-13	B11B	Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements

Publication	Publication Date	Title
BR112014011900A2 (pt)	2017-05-16	um método de purificação de anticorpo
CO7020871A2 (es)	2014-08-11	Anticuerpos anti-il-36r
IL232558B (en)	2018-08-30	A method for antibody purification
CO6811812A2 (es)	2013-12-16	Anticuerpo anti-b7-h3
CO6930312A2 (es)	2014-04-28	Método de notificación de aplicación
DK2768857T3 (da)	2020-02-03	Fremgangsmåder til oprensning af antistoffer
BR112014007958A2 (pt)	2017-04-11	método
DK2766392T3 (da)	2019-10-07	Fremgangsmåde til oprensning af antistoffer
DK2776833T3 (da)	2019-01-02	Cobinder-understøttet testfremgangsmåde
CR20140127A (es)	2014-08-20	Anticuerpo anti-abtcr
DK2732131T3 (da)	2019-09-23	Positioneringsfremgangsmåde
BR112013022797A2 (pt)	2016-12-06	anticorpos anti-ctla4 humanizados
BR112014001237A2 (pt)	2017-02-21	método
CO7061068A2 (es)	2014-09-19	Derivados de polimixina
BR112014001765A2 (pt)	2017-02-21	método
BR112013024521A2 (pt)	2019-09-24	métodos de purificação de proteínas
BR112015013188A2 (pt)	2017-07-11	método de fermentação otimizado
DK2723947T3 (da)	2021-01-25	Centreringssystem
BR112014013034A2 (pt)	2017-12-19	método para produzir um anticorpo
BR112014011913A2 (pt)	2017-05-16	método de perfuração
BR112014009795A2 (pt)	2017-04-25	método
CO6801637A2 (es)	2013-11-29	Formulaciones de anticuerpos
HRP20190030T1 (hr)	2019-02-22	Postupak pročišćavanja protutijela
FI20115703A (fi)	2013-01-02	Näytteenotin
BR112013022820A2 (pt)	2016-12-06	método de tratamento