BR112013031021A2 - composições e métodos para a inibição da expressão de gene do vírus da hepatite b' - Google Patents

composições e métodos para a inibição da expressão de gene do vírus da hepatite b'

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Publication number
BR112013031021A2
BR112013031021A2 BR112013031021-9A BR112013031021A BR112013031021A2 BR 112013031021 A2 BR112013031021 A2 BR 112013031021A2 BR 112013031021 A BR112013031021 A BR 112013031021A BR 112013031021 A2 BR112013031021 A2 BR 112013031021A2
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Brazil
Prior art keywords
methods
virus gene
hepatitis
compositions
inhibiting
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BR112013031021-9A
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English (en)
Inventor
Chin Daniel
Deckert Jochen
Rossbach Markus
John Matthias
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Arrowhead Res Corp
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Publication date
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Publication of BR112013031021A2 publication Critical patent/BR112013031021A2/pt

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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl

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Abstract

composições e métodos para a inibição da expressão de gene do vírus da hepatite b. a presente invenção se refere a um ácido ribonucleico de dupla fita (dsrna) para a inibição da expressão de um gene do vírus da hepatite b. a presente invenção também se refere a uma composição farmacêutica compreendendo o dsrna ou moléculas de ácido nucleico ou vetores que codificam as mesmas juntas com um veículo farmaceuticamente aceitável; métodos para tratar as doenças ocasionadas por infecção pelo vírus da hepatite b usando a referida composição farmacêutica; e métodos para a inibição da expressão de um gene do vírus da hepatite b em uma célula.
BR112013031021-9A 2011-06-30 2012-06-28 composições e métodos para a inibição da expressão de gene do vírus da hepatite b' BR112013031021A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11172235 2011-06-30
EP11172235.1 2011-06-30
PCT/US2012/044505 WO2013003520A1 (en) 2011-06-30 2012-06-28 Compositions and methods for inhibiting gene expression of hepatitis b virus
US13/535.454 2012-06-28
US13/535,454 US8809293B2 (en) 2011-06-30 2012-06-28 Compositions and methods for inhibiting gene expression of hepatitis B virus

Publications (1)

Publication Number Publication Date
BR112013031021A2 true BR112013031021A2 (pt) 2018-10-09

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BR112013031021-9A BR112013031021A2 (pt) 2011-06-30 2012-06-28 composições e métodos para a inibição da expressão de gene do vírus da hepatite b'

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Country Link
US (2) US8809293B2 (pt)
EP (3) EP3418386B1 (pt)
JP (5) JP6165723B2 (pt)
KR (5) KR102025295B1 (pt)
CN (3) CN106434665B (pt)
AU (5) AU2012275355B2 (pt)
BR (1) BR112013031021A2 (pt)
CA (2) CA2833778C (pt)
DK (1) DK2726613T3 (pt)
EA (4) EA024762B9 (pt)
ES (1) ES2690538T3 (pt)
HK (1) HK1193633A1 (pt)
HR (1) HRP20181564T1 (pt)
IL (3) IL230226B (pt)
MX (2) MX342731B (pt)
PL (1) PL2726613T3 (pt)
PT (1) PT2726613T (pt)
SG (1) SG194751A1 (pt)
SI (1) SI2726613T1 (pt)
TW (4) TWI695066B (pt)
WO (1) WO2013003520A1 (pt)
ZA (1) ZA201307914B (pt)

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