BR112013019011A2 - inibição de il17 e ifn-gama para o tratamento de inflamação autoimune - Google Patents

inibição de il17 e ifn-gama para o tratamento de inflamação autoimune

Info

Publication number
BR112013019011A2
BR112013019011A2 BR112013019011A BR112013019011A BR112013019011A2 BR 112013019011 A2 BR112013019011 A2 BR 112013019011A2 BR 112013019011 A BR112013019011 A BR 112013019011A BR 112013019011 A BR112013019011 A BR 112013019011A BR 112013019011 A2 BR112013019011 A2 BR 112013019011A2
Authority
BR
Brazil
Prior art keywords
ifn
treatment
autoimmune inflammation
gamma inhibition
gamma
Prior art date
Application number
BR112013019011A
Other languages
English (en)
Other versions
BR112013019011B1 (pt
Inventor
Chevrier Carine
Leban Johann
Baumgartner Roland
Tasler Stefan
Saeb Wael
Original Assignee
4Sc Discovery Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Discovery Gmbh filed Critical 4Sc Discovery Gmbh
Publication of BR112013019011A2 publication Critical patent/BR112013019011A2/pt
Publication of BR112013019011B1 publication Critical patent/BR112013019011B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones

Abstract

inibição de il17 e ifn-gama para o tratamento de inflamação autoimune a presente invenção refere-se a compostos da fórmula geral (i) e ao sal ou solvato farmaceuticamente aceitável do mesmo como agentes anti-inflamatórios e imunomodulatórios.
BR112013019011-6A 2011-01-28 2012-01-27 Inibidores de il17 e ifn-gama, e seu uso BR112013019011B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161437061P 2011-01-28 2011-01-28
US61/437,061 2011-01-28
EP11152515.0 2011-01-28
EP11152515 2011-01-28
PCT/EP2012/051357 WO2012101261A1 (en) 2011-01-28 2012-01-27 Il17 and ifn-gamma inhibition for the treatment of autoimmune inflammation

Publications (2)

Publication Number Publication Date
BR112013019011A2 true BR112013019011A2 (pt) 2017-07-11
BR112013019011B1 BR112013019011B1 (pt) 2021-10-13

Family

ID=46577835

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013019011-6A BR112013019011B1 (pt) 2011-01-28 2012-01-27 Inibidores de il17 e ifn-gama, e seu uso

Country Status (23)

Country Link
US (1) US8592456B2 (pt)
EP (1) EP2668182B1 (pt)
JP (1) JP5969505B2 (pt)
KR (1) KR101875248B1 (pt)
CN (1) CN103476771B (pt)
AR (1) AR085040A1 (pt)
AU (1) AU2012210489B2 (pt)
BR (1) BR112013019011B1 (pt)
CA (1) CA2825684C (pt)
DK (1) DK2668182T3 (pt)
EA (1) EA027351B1 (pt)
ES (1) ES2664507T3 (pt)
IL (1) IL227626A0 (pt)
MX (1) MX353762B (pt)
MY (1) MY162397A (pt)
PL (1) PL2668182T3 (pt)
PT (1) PT2668182T (pt)
RU (1) RU2013139663A (pt)
SG (1) SG192176A1 (pt)
TW (1) TWI520955B (pt)
UA (1) UA113160C2 (pt)
UY (1) UY33884A (pt)
WO (1) WO2012101261A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2668183B1 (en) * 2011-01-28 2017-11-01 4SC Discovery GmbH Il17 and ifn-gamma inhibition for the treatment of autoimmune inflammation
US9156837B2 (en) 2011-07-29 2015-10-13 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2013116682A1 (en) 2012-02-02 2013-08-08 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating il-17
EA201791271A1 (ru) 2012-05-31 2018-01-31 Фенекс Фармасьютикалз Аг ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ
JO3215B1 (ar) 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy
CN104978732A (zh) * 2014-04-11 2015-10-14 中国船舶工业***工程研究院 一种摄像机参数标定板
JP2017521479A (ja) * 2014-05-15 2017-08-03 ラニ セラピューティクス， エルエルシー ポリペプチドおよび／またはタンパク質を含む固体塊の薬学的組成物およびそれを製造するための方法
RU2580301C1 (ru) * 2015-04-21 2016-04-10 Людмила Николаевна Хон Способ лечения системной красной волчанки человека
LT3679034T (lt) * 2017-09-06 2022-09-12 Immunic Ag 1-(4-(izoksazol-5-il)-1h-pirazol-1-il)-2-metilpropan-2-olio dariniai ir susiję junginiai, kaip il-7 ir ifn- gama inhibitoriai, skirti autoimuninių ligų ir lėtinių uždegimų gydymui
WO2019223718A1 (zh) * 2018-05-22 2019-11-28 成都先导药物开发股份有限公司 一种免疫调节剂
CN112341519A (zh) * 2019-08-09 2021-02-09 成都先导药物开发股份有限公司 一种免疫调节剂
CN112341442B (zh) * 2019-08-09 2021-10-22 成都先导药物开发股份有限公司 一种免疫调节剂
WO2021027729A1 (zh) * 2019-08-09 2021-02-18 成都先导药物开发股份有限公司 一种免疫调节剂
CN112341435B (zh) * 2019-08-09 2021-10-22 成都先导药物开发股份有限公司 一种免疫调节剂
WO2023281097A1 (en) 2021-07-09 2023-01-12 Immunic Ag Methods for treating cancer
WO2023198873A1 (en) 2022-04-14 2023-10-19 Immunic Ag Deuterated rorgamma/rorgammat inverse agonists
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0610744B1 (en) * 1993-02-09 1998-11-04 Bayer Corporation Sulfonamide aminomethylene derivatives as immunosuppressants
ATE309228T1 (de) * 1997-04-21 2005-11-15 Sumitomo Pharma Isoxazolderivate
US6100260A (en) * 1997-04-21 2000-08-08 Sumitomo Pharmaceutical Company, Limited Isoxazole derivatives
JP3237608B2 (ja) * 1997-04-21 2001-12-10 住友製薬株式会社 イソキサゾール誘導体
US20060089398A1 (en) * 2003-03-19 2006-04-27 Gang Liu Isoxazole carboxamide derivatives as ghrelin receptor modulators
PL1725544T3 (pl) * 2004-03-09 2009-10-30 Boehringer Ingelheim Pharmaceuticals Inc 3-[4-Heterocyklilo-1,2,3-triazol-1-ilo]-N-arylobenzamidy jako inhibitory wytwarzania cytokin, do leczenia przewlekłych chorób zapalnych
TW200826936A (en) * 2006-12-01 2008-07-01 Merck Frosst Canada Ltd Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
EP2350064A1 (en) * 2008-10-01 2011-08-03 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
AR076984A1 (es) * 2009-06-08 2011-07-20 Merck Serono Sa Derivados de pirazol oxadiazol
EP2668183B1 (en) * 2011-01-28 2017-11-01 4SC Discovery GmbH Il17 and ifn-gamma inhibition for the treatment of autoimmune inflammation

Also Published As

Publication number Publication date
RU2013139663A (ru) 2015-03-10
TWI520955B (zh) 2016-02-11
KR101875248B1 (ko) 2018-08-02
BR112013019011B1 (pt) 2021-10-13
CN103476771A (zh) 2013-12-25
EP2668182B1 (en) 2017-11-01
PT2668182T (pt) 2018-01-31
JP2014504608A (ja) 2014-02-24
TW201309682A (zh) 2013-03-01
JP5969505B2 (ja) 2016-08-17
EA201300862A1 (ru) 2014-04-30
DK2668182T3 (da) 2018-01-29
EP2668182A1 (en) 2013-12-04
MX353762B (es) 2018-01-26
US8592456B2 (en) 2013-11-26
WO2012101261A1 (en) 2012-08-02
US20120196861A1 (en) 2012-08-02
MX2013008718A (es) 2014-02-17
SG192176A1 (en) 2013-08-30
NZ613592A (en) 2015-03-27
CA2825684C (en) 2021-11-23
ES2664507T3 (es) 2018-04-19
IL227626A0 (en) 2013-09-30
UA113160C2 (xx) 2016-12-26
AU2012210489B2 (en) 2017-01-12
KR20140041440A (ko) 2014-04-04
PL2668182T3 (pl) 2018-11-30
EA027351B1 (ru) 2017-07-31
MY162397A (en) 2017-06-15
CN103476771B (zh) 2015-12-23
UY33884A (es) 2012-08-31
AR085040A1 (es) 2013-08-07
CA2825684A1 (en) 2012-08-02
AU2012210489A1 (en) 2013-08-15

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/01/2012, OBSERVADAS AS CONDICOES LEGAIS.