BR112012033197A2 - métodos e composições para liberação de cns de n-sulfatase de heparano. - Google Patents

métodos e composições para liberação de cns de n-sulfatase de heparano.

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Publication number
BR112012033197A2
BR112012033197A2 BR112012033197A BR112012033197A BR112012033197A2 BR 112012033197 A2 BR112012033197 A2 BR 112012033197A2 BR 112012033197 A BR112012033197 A BR 112012033197A BR 112012033197 A BR112012033197 A BR 112012033197A BR 112012033197 A2 BR112012033197 A2 BR 112012033197A2
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BR
Brazil
Prior art keywords
heparan
compositions
releasing
methods
cns
Prior art date
Application number
BR112012033197A
Other languages
English (en)
Inventor
Vernaglia Brian
Natoli Farah
Zhu Gaozhong
Tsung Jamie
Terew Jennifer
Pan Jing
Calias Pericles
Pfeifer Richard
Jiang Yuan
Shahrokh Zahra
Original Assignee
Shire Human Genetic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies
Publication of BR112012033197A2 publication Critical patent/BR112012033197A2/pt

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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
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    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0105—Alpha-N-acetylglucosaminidase (3.2.1.50)
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    • C12Y310/00—Hydrolases acting on sulfur-nitrogen bonds (3.10)
    • C12Y310/01—Hydrolases acting on sulfur-nitrogen bonds (3.10) acting on sulfur-nitrogen bonds (3.10.1)
    • C12Y310/01001—N-Sulfoglucosamine sulfohydrolase (3.10.1.1)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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Abstract

métodos e composições para liberação de cns de n-sulfatase de heparano. a presente invenção refere-se a, entre outras coisas, composições e métodos para a liberação de cns de enzimas lisossomais para tratamento eficaz de doenças por armazenamento dos lisossomos. em alguns modalidades, a presente invenção inclui uma formulação estável para a administração por via intratecal de cns direta compreendendo uma proteína de n-sulfatase de heparano (hns0, sal e um tensoativo de polissorbato para o tratamento de síndrome de sanfilippo, tipo a.
BR112012033197A 2010-06-25 2011-06-25 métodos e composições para liberação de cns de n-sulfatase de heparano. BR112012033197A2 (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US35885710P 2010-06-25 2010-06-25
US36078610P 2010-07-01 2010-07-01
US38786210P 2010-09-29 2010-09-29
US201161435710P 2011-01-24 2011-01-24
US201161442115P 2011-02-11 2011-02-11
US201161476210P 2011-04-15 2011-04-15
US201161495268P 2011-06-09 2011-06-09
PCT/US2011/041922 WO2011163647A2 (en) 2010-06-25 2011-06-25 Methods and compositions for cns delivery of heparan n-sulfatase

Publications (1)

Publication Number Publication Date
BR112012033197A2 true BR112012033197A2 (pt) 2017-06-06

Family

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BR112012033197A BR112012033197A2 (pt) 2010-06-25 2011-06-25 métodos e composições para liberação de cns de n-sulfatase de heparano.

Country Status (13)

Country Link
US (1) US9320711B2 (pt)
EP (1) EP2588131B1 (pt)
JP (1) JP6073783B2 (pt)
KR (1) KR20140005842A (pt)
CN (1) CN103260637B (pt)
AU (2) AU2011270667B2 (pt)
BR (1) BR112012033197A2 (pt)
CA (1) CA2805413A1 (pt)
MX (1) MX2013000320A (pt)
NZ (1) NZ605874A (pt)
RU (1) RU2012154576A (pt)
TW (1) TWI546078B (pt)
WO (1) WO2011163647A2 (pt)

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RU2012154576A (ru) 2014-07-27
AU2017202216A1 (en) 2017-04-27
WO2011163647A3 (en) 2012-05-10
JP6073783B2 (ja) 2017-02-01
EP2588131A2 (en) 2013-05-08
EP2588131B1 (en) 2019-08-14
JP2013530988A (ja) 2013-08-01
AU2011270667A1 (en) 2013-02-14
AU2011270667B2 (en) 2017-01-05
MX2013000320A (es) 2013-06-05
CN103260637A (zh) 2013-08-21
TW201204385A (en) 2012-02-01
US9320711B2 (en) 2016-04-26
CA2805413A1 (en) 2011-12-29
EP2588131A4 (en) 2014-04-09
CN103260637B (zh) 2016-04-06
NZ605874A (en) 2015-02-27
US20120014936A1 (en) 2012-01-19
WO2011163647A2 (en) 2011-12-29
KR20140005842A (ko) 2014-01-15

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