BR112012026644A2 - compostos antivirais - Google Patents
compostos antiviraisInfo
- Publication number
- BR112012026644A2 BR112012026644A2 BR112012026644A BR112012026644A BR112012026644A2 BR 112012026644 A2 BR112012026644 A2 BR 112012026644A2 BR 112012026644 A BR112012026644 A BR 112012026644A BR 112012026644 A BR112012026644 A BR 112012026644A BR 112012026644 A2 BR112012026644 A2 BR 112012026644A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- antiviral compounds
- rig
- viral infection
- reaction series
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
- C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32211—Cardiovirus, e.g. encephalomyocarditis virus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
compostos antivirais. descritos aqui são compostos e composições relacionadas para o tratamento de infecção viral, incluindo infecção de rna vira, e os compostos podem modular a série de reação rig-i em células de vertebrados, incluindo os compostos que podem ativar a série de reação rig-i.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32757910P | 2010-04-23 | 2010-04-23 | |
PCT/US2011/033336 WO2011133728A2 (en) | 2010-04-23 | 2011-04-20 | Anti-viral compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012026644A2 true BR112012026644A2 (pt) | 2017-12-19 |
Family
ID=44815983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012026644A BR112012026644A2 (pt) | 2010-04-23 | 2011-04-20 | compostos antivirais |
Country Status (12)
Country | Link |
---|---|
US (1) | US9408826B2 (pt) |
EP (1) | EP2560652A4 (pt) |
JP (1) | JP2013527159A (pt) |
KR (1) | KR20130055612A (pt) |
CN (1) | CN102946881A (pt) |
AU (1) | AU2011242689B2 (pt) |
BR (1) | BR112012026644A2 (pt) |
CA (1) | CA2798209A1 (pt) |
IL (1) | IL222633A0 (pt) |
MX (1) | MX2012012354A (pt) |
TW (1) | TW201139419A (pt) |
WO (1) | WO2011133728A2 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011133728A2 (en) | 2010-04-23 | 2011-10-27 | Kineta, Inc. | Anti-viral compounds |
EP2918273B1 (en) | 2011-02-25 | 2016-12-21 | Kineta, Inc. | Methods and cells for identifying rig-i pathway regulators |
WO2013049352A2 (en) * | 2011-09-30 | 2013-04-04 | Kineta, Inc. | Anti-viral compounds |
US9073946B2 (en) * | 2013-01-15 | 2015-07-07 | Kineta, Inc. | Anti-viral compounds |
WO2014142645A1 (en) * | 2013-03-15 | 2014-09-18 | University Of Malaya | Antiviral activity of quercetin against japanese encephalitis virus |
MY188046A (en) * | 2013-03-15 | 2021-11-12 | Univ Malaya | Antiviral activity of baicalein against japanese encephalitis virus |
CA2915874A1 (en) * | 2013-07-16 | 2015-01-22 | Kineta, Inc. | Anti-viral compounds, pharmaceutical compositions, and methods of use thereof |
CN104628717B (zh) * | 2015-03-16 | 2017-02-15 | 湖南大学 | 3‑[5‑(1,2,4‑***‑1‑基)噻唑‑2‑基]苯并噁嗪及其应用 |
CN104829607B (zh) * | 2015-05-11 | 2017-04-12 | 邵阳学院 | N‑噻唑苯并噁嗪酮衍生物作为神经氨酸酶抑制剂的应用 |
US10376504B2 (en) | 2015-07-29 | 2019-08-13 | Merck, Sharp & Dohme Corp. | Substituted quinolinones as PDE9 inhibitors |
US10370336B2 (en) | 2015-07-29 | 2019-08-06 | Merck Sharp & Dohme Corp. | Phenyl-cyanoquinolinone PDE9 inhibitors |
WO2017019726A1 (en) | 2015-07-29 | 2017-02-02 | Merck Sharp & Dohme Corp. | Oxy-cyanoquinolinone pde9 inhibitors |
JP2018052878A (ja) | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
WO2021026672A1 (en) | 2019-08-09 | 2021-02-18 | Novartis Ag | Heterocyclic wdr5 inhibitors as anti-cancer compounds |
KR20220064369A (ko) | 2019-08-14 | 2022-05-18 | 인사이트 코포레이션 | Cdk2 저해제로서의 이미다졸릴 피리디미딘일아민 화합물 |
BR112022006977A2 (pt) | 2019-10-11 | 2022-09-20 | Incyte Corp | Aminas bicíclicas como inibidores de cdk2 |
US11975106B2 (en) * | 2020-03-26 | 2024-05-07 | Provectus Pharmatech, Inc. | Uses of halogenated xanthenes in oncology and virology |
US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0267218A (ja) * | 1988-08-31 | 1990-03-07 | Nagakura Seiyaku Kk | ウイルス・ゲノム不活化剤 |
AU3456499A (en) * | 1998-03-30 | 1999-10-18 | University Of Mississippi, The | Isoflavones for treating giardiasis and malaria |
GB9920912D0 (en) * | 1999-09-03 | 1999-11-10 | Indena Spa | Novel derivatives of flavones,xanthones and coumarins |
US20080221029A1 (en) * | 2002-10-31 | 2008-09-11 | Regents Of The University Of Colorado | Methods for treatment of thiol-containing compound deficient conditions |
US7902253B2 (en) | 2003-05-15 | 2011-03-08 | Chengdu Dikang Pharmaceutical Institute | Isoflavone derivatives of tectorigenin, the preparation thereof and the antiviral medicine containing the same as an effective constituent |
WO2005103039A1 (en) | 2004-04-15 | 2005-11-03 | Neurocrine Biosciences, Inc. | 2- (3-aminopyrrolidin-1-yl) pyridines as melanin-concentrating hormone receptor an tagonists |
GB0412768D0 (en) * | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
WO2006002422A2 (en) * | 2004-06-24 | 2006-01-05 | Novartis Vaccines And Diagnostics Inc. | Compounds for immunopotentiation |
WO2006034219A2 (en) * | 2004-09-17 | 2006-03-30 | The General Hospital Corporation | Inactivation of microorganisms with multidrug resistance inhibitors and phenothiaziniums |
AU2007294752A1 (en) * | 2006-09-14 | 2008-03-20 | Synta Pharmaceuticals Corp. | Compounds for the treatment of angiogenesis |
CA2667972A1 (en) | 2006-10-30 | 2008-05-08 | Michael Tovey | Gene reporter assay, kit and cells with improved sensitivity and/or specificity for determining the level of an extracellular signal |
WO2008080091A2 (en) | 2006-12-21 | 2008-07-03 | Vical Incorporated | Activation of rig-i pathway |
WO2008134372A2 (en) | 2007-04-26 | 2008-11-06 | The Samuel Roberts Noble Foundation, Inc. | Production of proanthocyanidins to improve forage quality |
CN101969959A (zh) * | 2007-07-31 | 2011-02-09 | 利默里克生物制药公司 | 磷酸化吡喃酮类似物和方法 |
TWI324514B (en) | 2008-02-26 | 2010-05-11 | Univ Kaohsiung Medical | Isoflavone derivatives and pharmaceutical compositions comprising the same |
US20100009970A1 (en) | 2008-03-19 | 2010-01-14 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
CN101301287A (zh) * | 2008-06-12 | 2008-11-12 | 上海双科医药科技有限公司 | 射干异黄酮类化合物在制备抗肝炎药物中的应用 |
WO2010032248A2 (en) * | 2008-09-17 | 2010-03-25 | Yeda Research And Development Co. Ltd. | Multifunctional albumin conjugates |
WO2012003030A2 (en) | 2010-04-23 | 2012-01-05 | Kineta, Inc. | Methods of identifying & using anti-viral compounds |
WO2011133728A2 (en) | 2010-04-23 | 2011-10-27 | Kineta, Inc. | Anti-viral compounds |
EP2918273B1 (en) | 2011-02-25 | 2016-12-21 | Kineta, Inc. | Methods and cells for identifying rig-i pathway regulators |
-
2011
- 2011-04-20 WO PCT/US2011/033336 patent/WO2011133728A2/en active Application Filing
- 2011-04-20 EP EP11772680.2A patent/EP2560652A4/en not_active Withdrawn
- 2011-04-20 AU AU2011242689A patent/AU2011242689B2/en not_active Ceased
- 2011-04-20 BR BR112012026644A patent/BR112012026644A2/pt not_active IP Right Cessation
- 2011-04-20 MX MX2012012354A patent/MX2012012354A/es not_active Application Discontinuation
- 2011-04-20 JP JP2013506289A patent/JP2013527159A/ja active Pending
- 2011-04-20 KR KR1020127030544A patent/KR20130055612A/ko not_active Application Discontinuation
- 2011-04-20 CA CA2798209A patent/CA2798209A1/en not_active Abandoned
- 2011-04-20 CN CN2011800293577A patent/CN102946881A/zh active Pending
- 2011-04-21 US US13/091,983 patent/US9408826B2/en not_active Expired - Fee Related
- 2011-04-22 TW TW100114195A patent/TW201139419A/zh unknown
-
2012
- 2012-10-23 IL IL222633A patent/IL222633A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN102946881A (zh) | 2013-02-27 |
US20110262482A1 (en) | 2011-10-27 |
EP2560652A4 (en) | 2013-08-14 |
EP2560652A2 (en) | 2013-02-27 |
WO2011133728A3 (en) | 2012-05-24 |
CA2798209A1 (en) | 2011-10-27 |
IL222633A0 (en) | 2012-12-31 |
KR20130055612A (ko) | 2013-05-28 |
AU2011242689B2 (en) | 2015-09-17 |
TW201139419A (en) | 2011-11-16 |
US9408826B2 (en) | 2016-08-09 |
AU2011242689A1 (en) | 2012-12-13 |
MX2012012354A (es) | 2013-03-07 |
JP2013527159A (ja) | 2013-06-27 |
WO2011133728A2 (en) | 2011-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B15I | Others concerning applications: loss of priority |
Free format text: PERDA DA PRIORIDADE E US 61/327,579 DE 23/04/2010 REIVINDICADA NO PCT/US2011/033336 POR NAO CUMPRIMENTO DA EXIGENCIA PUBLICADA NA RPI 2440 DE 10/10/2017 PARA APRESENTACAO DE DOCUMENTO DE CESSAO CORRETO. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |