MX351818B - Compuestos antivirales. - Google Patents
Compuestos antivirales.Info
- Publication number
- MX351818B MX351818B MX2014003887A MX2014003887A MX351818B MX 351818 B MX351818 B MX 351818B MX 2014003887 A MX2014003887 A MX 2014003887A MX 2014003887 A MX2014003887 A MX 2014003887A MX 351818 B MX351818 B MX 351818B
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- viral compounds
- rig
- pathway
- viral infection
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000000840 anti-viral effect Effects 0.000 title 1
- 102100037435 Antiviral innate immune response receptor RIG-I Human genes 0.000 abstract 2
- 101710127675 Antiviral innate immune response receptor RIG-I Proteins 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 2
- 230000037361 pathway Effects 0.000 abstract 2
- 230000009385 viral infection Effects 0.000 abstract 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
En la presente se describen los compuestos y las composiciones relacionadas para el tratamiento de una infección viral, que incluye la infección viral de ARN, y los compuestos que pueden modular la ruta de RIG-l en las células de vertebrados, que incluyen los compuestos que pueden activar la ruta de RIG-l.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161542049P | 2011-09-30 | 2011-09-30 | |
PCT/US2012/057646 WO2013049407A2 (en) | 2011-09-30 | 2012-09-27 | Anti-viral compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014003887A MX2014003887A (es) | 2014-11-21 |
MX351818B true MX351818B (es) | 2017-10-30 |
Family
ID=47996748
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014003887A MX351818B (es) | 2011-09-30 | 2012-09-27 | Compuestos antivirales. |
Country Status (16)
Country | Link |
---|---|
US (2) | US9555106B2 (es) |
EP (1) | EP2748172B1 (es) |
JP (2) | JP2014528412A (es) |
KR (1) | KR20140070631A (es) |
CN (1) | CN103857683B (es) |
AP (1) | AP2014007595A0 (es) |
AU (3) | AU2012315953A1 (es) |
BR (1) | BR112014007599A2 (es) |
CA (1) | CA2859946C (es) |
HK (1) | HK1199029A1 (es) |
IL (1) | IL231780A (es) |
MX (1) | MX351818B (es) |
SG (1) | SG11201401084TA (es) |
TW (1) | TW201326163A (es) |
WO (1) | WO2013049407A2 (es) |
ZA (1) | ZA201401825B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013049407A2 (en) | 2011-09-30 | 2013-04-04 | Kineta, Inc | Anti-viral compounds |
US9073946B2 (en) | 2013-01-15 | 2015-07-07 | Kineta, Inc. | Anti-viral compounds |
MX2016014642A (es) * | 2014-05-09 | 2017-05-25 | Kineta Inc | Compuestos y composiciones farmaceuticas antivirales, asi como metodos de uso de los mismos. |
KR20200006972A (ko) | 2017-04-14 | 2020-01-21 | 톨나인, 인크. | 면역조절 폴리뉴클레오티드, 이의 항체 접합체, 및 이의 사용 방법 |
EP3810613B1 (en) | 2018-06-19 | 2023-01-11 | Novartis AG | N-substituted tetrahydrothienopyridine derivatives and uses thereof |
WO2020036574A1 (en) * | 2018-08-17 | 2020-02-20 | Kineta, Inc. | Activators of the retinoic acid inducible gene "rig-i' pathway and methods of use thereof |
EP4110830A1 (en) | 2020-02-28 | 2023-01-04 | Tallac Therapeutics, Inc. | Transglutaminase-mediated conjugation |
WO2022180003A1 (en) * | 2021-02-24 | 2022-09-01 | F. Hoffmann-La Roche Ag | Benzothiazolyl bicyclo[1.1.1]pentane derivatives for the treatment and prophylaxis of hepatitis b virus infection |
Family Cites Families (40)
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US3489558A (en) * | 1967-09-18 | 1970-01-13 | Ibm | Photoconductive benzobisthiazoles and their use in electrophotographic processes |
JPS60205454A (ja) * | 1984-03-29 | 1985-10-17 | Mitsubishi Paper Mills Ltd | 電子写真感光体 |
JPS63190880A (ja) * | 1986-09-09 | 1988-08-08 | Nippon Tokushu Noyaku Seizo Kk | 新規n−ベンゾチアゾリル−アミド類及び殺虫剤 |
JPS63270608A (ja) * | 1986-12-10 | 1988-11-08 | Sumitomo Chem Co Ltd | 種子消毒剤 |
US4940722A (en) * | 1986-12-10 | 1990-07-10 | Sumitomo Chemical Companmy, Limited | Seed disinfectant composition |
IL90337A0 (en) * | 1988-05-24 | 1989-12-15 | Pfizer | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents |
DE69414708T2 (de) * | 1993-08-24 | 1999-04-15 | Medivir Ab, Huddinge | Verbindungen und methoden zur inhibition von hiv und verwandten viren |
EP0927164A1 (en) * | 1996-09-10 | 1999-07-07 | PHARMACIA & UPJOHN COMPANY | 8-hydroxy-7-substituted quinolines as anti-viral agents |
CN1167680C (zh) * | 1999-12-27 | 2004-09-22 | 日本烟草产业株式会社 | 稠环化合物及其药物用途 |
JP3972167B2 (ja) * | 2000-01-26 | 2007-09-05 | 株式会社大塚製薬工場 | ホスホン酸ジエステル誘導体 |
KR20020084116A (ko) * | 2000-02-07 | 2002-11-04 | 애보트 게엠베하 운트 콤파니 카게 | 2-벤조티아졸릴 우레아 유도체 및 이의 단백질 키나제억제제로서의 용도 |
WO2001070705A1 (en) * | 2000-03-17 | 2001-09-27 | Alcon, Inc. | 2-acylaminobenzimidazole derivatives for treating glaucoma |
US7122544B2 (en) * | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
JP4038665B2 (ja) * | 2002-06-19 | 2008-01-30 | 株式会社大塚製薬工場 | ホスホン酸ジエステル誘導体 |
WO2004078115A2 (en) * | 2003-02-28 | 2004-09-16 | Viropharma, Incorporated | Benzothiazole compounds, compositions and methods for treatment and prophylaxis of rotavirus infections and associated diseases |
EP1608369B1 (en) * | 2003-03-28 | 2013-06-26 | Novartis Vaccines and Diagnostics, Inc. | Use of organic compounds for immunopotentiation |
US20050130974A1 (en) * | 2003-10-17 | 2005-06-16 | Rigel Pharmaceuticals, Inc. | Benzothiazole compositions and their use as ubiquitin ligase inhibitors |
WO2006032322A1 (en) * | 2004-09-20 | 2006-03-30 | 4Sc Ag | NOVEL HETEROCYCLIC NF-κB INHIBITORS |
US20100267717A1 (en) | 2005-07-29 | 2010-10-21 | 4Sc Ag | Novel Heterocyclic NF-kB Inhibitors |
GB0421908D0 (en) * | 2004-10-01 | 2004-11-03 | Angeletti P Ist Richerche Bio | New uses |
EA200702445A1 (ru) * | 2005-05-09 | 2008-04-28 | Ачиллион Фармасьютикалз, Инк. | Соединения тиазола и способы их применения |
AP2008004459A0 (en) * | 2005-10-06 | 2008-06-30 | Univ Massachusetts | Composition and sythesis of new reagents for inhibition of HIV replication |
RU2008128452A (ru) * | 2005-12-12 | 2010-01-20 | Дженелабс Текнолоджис, Инк. (Us) | Соединения n-(6-членных арил)-амидов, фармацевтическая композиция с противовирусной активностью на их основе, способ лечения или профилактики вирусной инфекции с их помощью и способ их получения |
EA200801838A1 (ru) * | 2006-03-15 | 2009-02-27 | 4ЭсЦэ АГ | НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-kB |
BRPI0718162A2 (pt) * | 2006-10-20 | 2013-11-26 | Irm Llc | Composição e métodos para modulara os receptores c-kit e pdgfr |
WO2008141385A1 (en) * | 2007-05-21 | 2008-11-27 | Biota Scientific Management Pty Ltd | Viral polymerase inhibitors |
JP2010535708A (ja) * | 2007-08-03 | 2010-11-25 | ビオマリン アイジーエー リミテッド | デュシェンヌ型筋ジストロフィーの治療のための薬物併用 |
UA100527C2 (en) * | 2007-10-10 | 2013-01-10 | Астразенека Аб | Benzothiazoles as ghrelin receptor modulators |
EP2303886A2 (en) * | 2008-06-24 | 2011-04-06 | Takeda Pharmaceutical Company Limited | Pi3k/m tor inhibitors |
WO2010024903A1 (en) | 2008-08-29 | 2010-03-04 | Yangbo Feng | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS |
GB0820856D0 (en) * | 2008-11-14 | 2008-12-24 | Univ Leuven Kath | Novel inhibitors of flavivirus replication |
PA8854001A1 (es) * | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
BRPI1005828A2 (pt) * | 2009-02-27 | 2017-07-18 | Siga Tech Inc | composição farmacêutica; método para o tratamento ou a profilaxia de uma infecção viral ou doença associada com a mesma; composto; método para a preparação de uma mistura de terc-butil(4e)-4-(hidroximetileno)-5-oxoazepano-1-carboxilato e terc-butil (3e)-3-(hidroximetileno)-4-oxoazepano-1-carboxilato; método para a preparação de uma mistura de terc-butil 3-ciano-2-tioxo-1,2,5,6,8,9-hexaidro-1h-pirido [2,3-d] azepina-7-carboxilato e terc-butil 3-ciano-2-tioxo-1,2,5,7,8,9-hexaidro-6h-pirido [3,2-c] azepina-6-carboxilato; método para a preparação de ácido 3-amino-7-terc-butiloxicarbonil-6,7,8,9-tetraidro-5h-1-tia-7,10-diaza-ciclohepta [f] indeno-2-carboxílico (5-fenil-[1,3,4]tiazol-2-il)-amida; método para a preparação de ácido 3-amino-6,7,8,9-tetraidro-5h-1-tia-7,10-diaza-ciclohepta [f] indeno-2-carboxílico (5-fenil-[1,3,4] tiadiazol-2-il)-amida; método para a preparação de ácido 3-amino-6-tercbutiloxicarbonil-6,7,8,9-tetraidro-5h-1-tia-6,10-diaza-ciclohepta [f] indeno-2-carboxílico (5-fenil-[1,3,4] tiadiazol-2-il)-amida e método para a preparação de ácido 3-amino-6,7,8,9-tetraidro-5h-1-tia-6,10-diaza-ciclohepta [f] indeno-2-carboxílico (5-fenil-[1,3,4] tiadiazol-2-il)-amida |
WO2010100144A1 (en) * | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Fused bicyclic compounds as inhibitors for pi3 kinase |
US8338441B2 (en) * | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
WO2010144909A1 (en) * | 2009-06-12 | 2010-12-16 | Novartis Ag | Fused heterocyclic compounds and their uses |
AP2012006094A0 (en) | 2009-06-30 | 2012-02-29 | Siga Technologies Inc | Treatment and prevention of dengue virus infections. |
WO2011006158A2 (en) * | 2009-07-10 | 2011-01-13 | University Of Maryland, Baltimore | Targeting nad biosynthesis in bacterial pathogens |
WO2011022721A1 (en) * | 2009-08-21 | 2011-02-24 | Microbiotix, Inc | Inhibitors of botulinum neurotoxins |
WO2013049407A2 (en) | 2011-09-30 | 2013-04-04 | Kineta, Inc | Anti-viral compounds |
-
2012
- 2012-09-27 WO PCT/US2012/057646 patent/WO2013049407A2/en active Application Filing
- 2012-09-27 EP EP12836843.8A patent/EP2748172B1/en not_active Not-in-force
- 2012-09-27 KR KR1020147011230A patent/KR20140070631A/ko not_active Application Discontinuation
- 2012-09-27 US US14/348,516 patent/US9555106B2/en active Active
- 2012-09-27 SG SG11201401084TA patent/SG11201401084TA/en unknown
- 2012-09-27 AP AP2014007595A patent/AP2014007595A0/xx unknown
- 2012-09-27 MX MX2014003887A patent/MX351818B/es active IP Right Grant
- 2012-09-27 CA CA2859946A patent/CA2859946C/en not_active Expired - Fee Related
- 2012-09-27 CN CN201280047516.0A patent/CN103857683B/zh not_active Expired - Fee Related
- 2012-09-27 BR BR112014007599A patent/BR112014007599A2/pt active Search and Examination
- 2012-09-27 JP JP2014533336A patent/JP2014528412A/ja active Pending
- 2012-09-27 AU AU2012315953A patent/AU2012315953A1/en not_active Abandoned
- 2012-09-28 TW TW101136064A patent/TW201326163A/zh unknown
-
2014
- 2014-03-13 ZA ZA2014/01825A patent/ZA201401825B/en unknown
- 2014-03-27 IL IL231780A patent/IL231780A/en active IP Right Grant
- 2014-12-12 HK HK14112536.0A patent/HK1199029A1/xx not_active IP Right Cessation
-
2017
- 2017-01-30 US US15/419,784 patent/US9956285B2/en not_active Expired - Fee Related
- 2017-06-13 JP JP2017116041A patent/JP2017222656A/ja active Pending
- 2017-07-31 AU AU2017210483A patent/AU2017210483A1/en not_active Abandoned
- 2017-10-30 AU AU2017254812A patent/AU2017254812B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
NZ622636A (en) | 2016-07-29 |
WO2013049407A2 (en) | 2013-04-04 |
MX2014003887A (es) | 2014-11-21 |
US9555106B2 (en) | 2017-01-31 |
AU2017254812B2 (en) | 2018-07-19 |
CA2859946A1 (en) | 2013-04-04 |
US20170258897A1 (en) | 2017-09-14 |
CN103857683A (zh) | 2014-06-11 |
AP2014007595A0 (en) | 2014-04-30 |
IL231780A0 (en) | 2014-05-28 |
AU2012315953A1 (en) | 2014-04-03 |
AU2017210483A1 (en) | 2017-08-17 |
CN103857683B (zh) | 2016-10-12 |
TW201326163A (zh) | 2013-07-01 |
JP2017222656A (ja) | 2017-12-21 |
KR20140070631A (ko) | 2014-06-10 |
EP2748172A2 (en) | 2014-07-02 |
AU2017254812A1 (en) | 2017-11-16 |
SG11201401084TA (en) | 2014-04-28 |
EP2748172A4 (en) | 2015-10-14 |
IL231780A (en) | 2017-08-31 |
US9956285B2 (en) | 2018-05-01 |
EP2748172B1 (en) | 2017-12-06 |
US20140227320A1 (en) | 2014-08-14 |
BR112014007599A2 (pt) | 2017-04-11 |
ZA201401825B (en) | 2017-08-30 |
CA2859946C (en) | 2019-11-05 |
WO2013049407A3 (en) | 2013-05-30 |
JP2014528412A (ja) | 2014-10-27 |
HK1199029A1 (en) | 2015-06-19 |
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