BR112012020693A8 - Derivados de ciclobutano e metilciclobutano como inibidores de janus quinase e composição que os compreende - Google Patents

Derivados de ciclobutano e metilciclobutano como inibidores de janus quinase e composição que os compreende

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Publication number
BR112012020693A8
BR112012020693A8 BR112012020693A BR112012020693A BR112012020693A8 BR 112012020693 A8 BR112012020693 A8 BR 112012020693A8 BR 112012020693 A BR112012020693 A BR 112012020693A BR 112012020693 A BR112012020693 A BR 112012020693A BR 112012020693 A8 BR112012020693 A8 BR 112012020693A8
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BR
Brazil
Prior art keywords
cyclobutane
janus kinase
kinase inhibitors
composition
methylcyclobutane
Prior art date
Application number
BR112012020693A
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English (en)
Other versions
BR112012020693B1 (pt
BR112012020693A2 (pt
Inventor
Li Yun-Long
D Rodgers James
Original Assignee
Incyte Corp
Incyte Holdings Corp
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Publication date
Application filed by Incyte Corp, Incyte Holdings Corp filed Critical Incyte Corp
Publication of BR112012020693A2 publication Critical patent/BR112012020693A2/pt
Publication of BR112012020693A8 publication Critical patent/BR112012020693A8/pt
Publication of BR112012020693B1 publication Critical patent/BR112012020693B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

DERIVADOS DE CICLOBUTANO E METILCICLOBUTANO COMO INIBIDORES DE JANUS QUINASE. A presente invenção refere-se aos derivados de ciclobutano e metilciclobutano, assim como os seus sais, composições, e métodos de uso, que são inibidores da Janus quinase (JAK) úteis no tratamento de doenças associadas com a JAK incluindo, por exemplo, os distúrbios inflamatórios e autoimunes, assim como câncer e distúrbios mieloproliferativos.
BR112012020693-1A 2010-02-18 2011-02-18 Derivados de ciclobutano e metilciclobutano como inibidores de janus quinase e composição que os compreende BR112012020693B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30563010P 2010-02-18 2010-02-18
US61/305,630 2010-02-18
PCT/US2011/025433 WO2011103423A1 (en) 2010-02-18 2011-02-18 Cyclobutane and methylcyclobutane derivatives as janus kinase inhibitors

Publications (3)

Publication Number Publication Date
BR112012020693A2 BR112012020693A2 (pt) 2016-07-26
BR112012020693A8 true BR112012020693A8 (pt) 2017-07-11
BR112012020693B1 BR112012020693B1 (pt) 2020-05-12

Family

ID=44227587

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012020693-1A BR112012020693B1 (pt) 2010-02-18 2011-02-18 Derivados de ciclobutano e metilciclobutano como inibidores de janus quinase e composição que os compreende

Country Status (11)

Country Link
US (2) US20110207754A1 (pt)
EP (1) EP2536729A1 (pt)
JP (1) JP5858434B2 (pt)
KR (1) KR101836538B1 (pt)
CN (1) CN102844317B (pt)
AU (1) AU2011217961B2 (pt)
BR (1) BR112012020693B1 (pt)
CA (1) CA2790070C (pt)
EA (1) EA023444B1 (pt)
MX (1) MX2012009541A (pt)
WO (1) WO2011103423A1 (pt)

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US20150087662A1 (en) 2015-03-26
EA201290807A1 (ru) 2013-03-29
AU2011217961B2 (en) 2016-05-05
EA023444B1 (ru) 2016-06-30
US20110207754A1 (en) 2011-08-25
KR20130009763A (ko) 2013-01-23
BR112012020693B1 (pt) 2020-05-12
BR112012020693A2 (pt) 2016-07-26
KR101836538B1 (ko) 2018-03-08
CN102844317B (zh) 2015-06-03
CA2790070C (en) 2018-03-06
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CA2790070A1 (en) 2011-08-25
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