BR112012008518A2 - derivado heterocíclico, e, composição farmacêutica - Google Patents
derivado heterocíclico, e, composição farmacêuticaInfo
- Publication number
- BR112012008518A2 BR112012008518A2 BR112012008518A BR112012008518A BR112012008518A2 BR 112012008518 A2 BR112012008518 A2 BR 112012008518A2 BR 112012008518 A BR112012008518 A BR 112012008518A BR 112012008518 A BR112012008518 A BR 112012008518A BR 112012008518 A2 BR112012008518 A2 BR 112012008518A2
- Authority
- BR
- Brazil
- Prior art keywords
- heterocyclic derivative
- pharmaceutical composition
- heterocyclic
- present
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
derivado heterocíclico, e, composição farmacêutica. a presente invenção se refere a um derivado heterocíclico da fórmula (i) em que as variáveis são como definido na especificação ou um sal farmaceuticamente aceitável ou solvado do mesmo. a presente invenção ainda se refere ás composições farmacêuticas que compreendem os ditos derivados heterocíclicos e em uso em terapia, por exemplo, no tratamento ou prevenção das doenças mediadas pelos receptores acetilcolina nicotínicos, tal como esquizofrenia e mal de alzheimer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25110109P | 2009-10-13 | 2009-10-13 | |
EP09172872 | 2009-10-13 | ||
PCT/EP2010/065160 WO2011045258A1 (en) | 2009-10-13 | 2010-10-11 | Condensed azine - derivatives for the treatment of diseases related to the acetylcholine receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012008518A2 true BR112012008518A2 (pt) | 2016-04-05 |
Family
ID=42040651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012008518A BR112012008518A2 (pt) | 2009-10-13 | 2010-10-11 | derivado heterocíclico, e, composição farmacêutica |
Country Status (12)
Country | Link |
---|---|
US (1) | US8841289B2 (pt) |
EP (1) | EP2488520B1 (pt) |
JP (1) | JP2013507417A (pt) |
KR (1) | KR20120100913A (pt) |
CN (1) | CN102666540A (pt) |
AU (1) | AU2010305825A1 (pt) |
BR (1) | BR112012008518A2 (pt) |
CA (1) | CA2776835A1 (pt) |
IN (1) | IN2012DN02968A (pt) |
MX (1) | MX2012004289A (pt) |
RU (1) | RU2012119488A (pt) |
WO (1) | WO2011045258A1 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013018735A1 (ja) | 2011-07-29 | 2013-02-07 | 大正製薬株式会社 | アミジン化合物又はその塩 |
AU2013229229B2 (en) | 2012-03-07 | 2017-10-19 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
US20150164858A1 (en) * | 2012-05-22 | 2015-06-18 | King Abdullah University Of Science And Technology | Combination comprising parthenolide for use in the treatment of alzheimer's disease and other neurodegenerative disorders |
NO3044221T3 (pt) | 2013-09-11 | 2018-07-21 | ||
US9617226B2 (en) | 2014-09-05 | 2017-04-11 | AbbVie Deutschland GmbH & Co. KG | Fused heterocyclic or carbocyclic compounds carrying a substituted cycloaliphatic radical and use thereof for treating vasopressin-related diseases |
EP3623371A1 (en) | 2014-12-16 | 2020-03-18 | Axovant Sciences GmbH | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
TWI698436B (zh) | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶7抑制劑之吡咯并及吡唑并嘧啶 |
MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
US9932351B2 (en) | 2015-02-05 | 2018-04-03 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
US9840491B2 (en) | 2015-02-05 | 2017-12-12 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
WO2016126935A1 (en) | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
CN106146410B (zh) * | 2015-04-03 | 2018-10-12 | 中南大学 | 6-氨基-4(3h)-喹唑啉酮衍生物及其合成方法和用途 |
CN106279211B (zh) | 2015-06-03 | 2020-09-15 | 北京大学 | 一种噻唑并嘧啶酮化合物及其制备方法和应用 |
WO2016201096A1 (en) | 2015-06-10 | 2016-12-15 | Forum Pharmaceuticals, Inc. | Aminobenzisoxazole compounds as agonists of a7-nicotinic acetylcholine receptors |
US10428062B2 (en) | 2015-08-12 | 2019-10-01 | Axovant Sciences Gmbh | Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors |
LT3386591T (lt) | 2015-12-09 | 2020-10-12 | Cadent Therapeutics, Inc. | Heteroaromatiniai nmda receptoriaus moduliatoriai ir jų panaudojimas |
ES2950348T3 (es) | 2015-12-09 | 2023-10-09 | Novartis Ag | Moduladores de receptores NMDA de tienopirimidinona y usos de los mismos |
WO2018119374A1 (en) | 2016-12-22 | 2018-06-28 | Cadent Therapeutics | Nmda receptor modulators and uses thereof |
WO2020004594A1 (ja) * | 2018-06-27 | 2020-01-02 | 株式会社リボルナバイオサイエンス | 脊髄性筋萎縮症の予防または治療剤 |
HU231414B1 (hu) * | 2018-07-13 | 2023-08-28 | Richter Gedeon Nyrt. | Tiadiazin származékok |
KR20210039368A (ko) | 2018-07-26 | 2021-04-09 | 도메인 테라퓨틱스 | 치환된 퀴나졸리논 유도체 및 mGluR4의 양성 알로스테릭 조절인자로서의 이의 용도 |
LT3830092T (lt) | 2018-08-03 | 2023-09-11 | Novartis Ag | Heteroaromatiniai nmda receptorių moduliatoriai ir jų panaudojimai |
WO2021198188A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
WO2021198191A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
CN112898290B (zh) * | 2021-01-29 | 2022-08-05 | 中南大学 | 异噁唑甲酰胺基-4(3h)-喹唑啉酮衍生物及其合成方法和用途 |
WO2024054591A1 (en) | 2022-09-07 | 2024-03-14 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
MXPA03009650A (es) * | 2001-04-20 | 2005-03-07 | Vertex Pharma | Derivados de 9-deazoguanidina como inhibidores de gsk-3. |
US7148236B2 (en) | 2002-01-17 | 2006-12-12 | Merck & Co., Inc. | Modulators of acetylcholine receptors |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
TW200536830A (en) * | 2004-02-06 | 2005-11-16 | Chugai Pharmaceutical Co Ltd | 1-(2H)-isoquinolone derivative |
AU2006274245B2 (en) * | 2005-07-26 | 2011-11-24 | Sanofi-Aventis | Piperidinyl-substituted isoquinolone derivatives as Rho-kinase inhibitors |
CA2663161C (en) * | 2006-09-11 | 2014-10-28 | N.V. Organon | Quinazolinone and isoquinolinone acetamide derivatives |
BRPI0720909A2 (pt) | 2006-12-27 | 2016-11-01 | Sanofi Aventis | derivados de isoquinolina e isoquinolinona substituídos |
JP2010229035A (ja) * | 2007-08-01 | 2010-10-14 | Taisho Pharmaceutical Co Ltd | ピリドピリミジン−4−オン誘導体 |
MX2010005040A (es) * | 2007-11-14 | 2010-05-21 | Neurosearch As | Nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil-pirimidina y su uso medico. |
KR20100114123A (ko) | 2008-02-29 | 2010-10-22 | 테크노 코어 인터내셔널 가부시키가이샤 | 팩 전지의 충전 장치 및 팩 전지의 품질 판정 장치 |
-
2010
- 2010-10-11 CA CA2776835A patent/CA2776835A1/en not_active Abandoned
- 2010-10-11 BR BR112012008518A patent/BR112012008518A2/pt not_active Application Discontinuation
- 2010-10-11 RU RU2012119488/04A patent/RU2012119488A/ru unknown
- 2010-10-11 US US13/501,587 patent/US8841289B2/en active Active
- 2010-10-11 CN CN2010800465507A patent/CN102666540A/zh active Pending
- 2010-10-11 JP JP2012533593A patent/JP2013507417A/ja active Pending
- 2010-10-11 MX MX2012004289A patent/MX2012004289A/es not_active Application Discontinuation
- 2010-10-11 KR KR1020127009340A patent/KR20120100913A/ko not_active Application Discontinuation
- 2010-10-11 IN IN2968DEN2012 patent/IN2012DN02968A/en unknown
- 2010-10-11 AU AU2010305825A patent/AU2010305825A1/en not_active Abandoned
- 2010-10-11 EP EP10771062.6A patent/EP2488520B1/en active Active
- 2010-10-11 WO PCT/EP2010/065160 patent/WO2011045258A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
KR20120100913A (ko) | 2012-09-12 |
US20120208796A1 (en) | 2012-08-16 |
IN2012DN02968A (pt) | 2015-07-31 |
RU2012119488A (ru) | 2013-11-20 |
US8841289B2 (en) | 2014-09-23 |
EP2488520A1 (en) | 2012-08-22 |
AU2010305825A1 (en) | 2012-04-19 |
WO2011045258A1 (en) | 2011-04-21 |
MX2012004289A (es) | 2012-06-12 |
CA2776835A1 (en) | 2011-04-21 |
CN102666540A (zh) | 2012-09-12 |
EP2488520B1 (en) | 2015-09-02 |
JP2013507417A (ja) | 2013-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |