IN2012DN02968A - - Google Patents

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Publication number
IN2012DN02968A
IN2012DN02968A IN2968DEN2012A IN2012DN02968A IN 2012DN02968 A IN2012DN02968 A IN 2012DN02968A IN 2968DEN2012 A IN2968DEN2012 A IN 2968DEN2012A IN 2012DN02968 A IN2012DN02968 A IN 2012DN02968A
Authority
IN
India
Prior art keywords
present
relates
heterocyclic
schizophrenia
solvate
Prior art date
Application number
Inventor
Paul David Ratcliffe
Thomas Russell Clarkson
Fiona Jeremiah
John Kinnaird Ferguson Maclean
Original Assignee
Msd Oss Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msd Oss Bv filed Critical Msd Oss Bv
Publication of IN2012DN02968A publication Critical patent/IN2012DN02968A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to a heterocyclic derivative of formula (I) wherein the variables are as defined in the specification or to a pharmaceutically acceptable salt or solvate thereof. The present invention further relates to pharmaceutical compositions comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of disorders mediated by nicotinic acetylcholine receptors, such as schizophrenia and Alzheimer's disease.
IN2968DEN2012 2009-10-13 2010-10-11 IN2012DN02968A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25110109P 2009-10-13 2009-10-13
EP09172872 2009-10-13
PCT/EP2010/065160 WO2011045258A1 (en) 2009-10-13 2010-10-11 Condensed azine - derivatives for the treatment of diseases related to the acetylcholine receptor

Publications (1)

Publication Number Publication Date
IN2012DN02968A true IN2012DN02968A (en) 2015-07-31

Family

ID=42040651

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2968DEN2012 IN2012DN02968A (en) 2009-10-13 2010-10-11

Country Status (12)

Country Link
US (1) US8841289B2 (en)
EP (1) EP2488520B1 (en)
JP (1) JP2013507417A (en)
KR (1) KR20120100913A (en)
CN (1) CN102666540A (en)
AU (1) AU2010305825A1 (en)
BR (1) BR112012008518A2 (en)
CA (1) CA2776835A1 (en)
IN (1) IN2012DN02968A (en)
MX (1) MX2012004289A (en)
RU (1) RU2012119488A (en)
WO (1) WO2011045258A1 (en)

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Publication number Priority date Publication date Assignee Title
CA2843383A1 (en) 2011-07-29 2013-02-07 Taisho Pharmaceutical Co., Ltd. Amidine compound or salt thereof
ES2611504T3 (en) 2012-03-07 2017-05-09 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted isoquinolin-1-one compounds and their therapeutic uses
AU2013264943B2 (en) * 2012-05-22 2018-02-01 King Abdullah University Of Science And Technology Combination comprising parthenolide for use in the treatment of Alzheimer's Disease and other neurodegenerative disorders
NO3044221T3 (en) 2013-09-11 2018-07-21
US9617226B2 (en) 2014-09-05 2017-04-11 AbbVie Deutschland GmbH & Co. KG Fused heterocyclic or carbocyclic compounds carrying a substituted cycloaliphatic radical and use thereof for treating vasopressin-related diseases
CA2971413A1 (en) 2014-12-16 2016-06-23 Axovant Sciences Gmbh Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
AR103297A1 (en) 2014-12-30 2017-05-03 Forma Therapeutics Inc PIRROLO AND PIRAZOLOPIRIMIDINAS AS INHIBITORS OF THE SPECIFIC PROTEASE 7 OF UBIQUITINA
MA41291A (en) 2014-12-30 2017-11-07 Forma Therapeutics Inc PYRROLOTRIAZINONE AND IMIDAZOTRIAZINONE DERIVATIVES AS UBIQUE-SPECIFIC PROTEASE INHIBITORS No. 7 (USP7) FOR THE TREATMENT OF CANCER
WO2016126926A1 (en) 2015-02-05 2016-08-11 Forma Therapeutics, Inc. Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
EP3253765A1 (en) 2015-02-05 2017-12-13 Forma Therapeutics, Inc. Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors
WO2016126935A1 (en) 2015-02-05 2016-08-11 Forma Therapeutics, Inc. Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors
CN106146410B (en) * 2015-04-03 2018-10-12 中南大学 6- amino -4 (3H)-Quinazol derivative and its preparation method and use
CN106279211B (en) * 2015-06-03 2020-09-15 北京大学 Thiazolopyrimidinone compound and preparation method and application thereof
US10370370B2 (en) 2015-06-10 2019-08-06 Axovant Sciences Gmbh Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors
EP3334740A4 (en) 2015-08-12 2019-02-06 Axovant Sciences GmbH Geminal substituted aminobenzisoxazole compounds as agonists of 7-nicotinic acetylcholine receptors
WO2017100593A1 (en) 2015-12-09 2017-06-15 Luc Therapeutics Thienopyrimidinone nmda receptor modulators and uses thereof
LT3386591T (en) * 2015-12-09 2020-10-12 Cadent Therapeutics, Inc. Heteroaromatic nmda receptor modulators and uses thereof
EP3558318B1 (en) 2016-12-22 2023-12-20 Novartis AG Nmda receptor modulators and uses thereof
JOP20200338A1 (en) * 2018-06-27 2020-12-24 Reborna Biosciences Inc Prophylactic or therapeutic agent for spinal muscular atrophy
HU231414B1 (en) * 2018-07-13 2023-08-28 Richter Gedeon Nyrt. Thiadiazine derivatives
CA3102326A1 (en) 2018-07-26 2020-01-30 Domain Therapeutics Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4
CA3108519A1 (en) 2018-08-03 2020-04-30 Cadent Therapeutics, Inc. Heteroaromatic nmda receptor modulators and uses thereof
WO2021198191A1 (en) 2020-03-30 2021-10-07 Enyo Pharma Quinazolinone derivatives and uses thereof for treating a cancer
EP4126847A1 (en) 2020-03-30 2023-02-08 ENYO Pharma Quinazolinone derivatives and uses thereof for treating a cancer
CN112898290B (en) * 2021-01-29 2022-08-05 中南大学 Isoxazole formamido-4 (3H) -quinazolinone derivative and synthesis method and application thereof
WO2024054591A1 (en) 2022-09-07 2024-03-14 Arvinas Operations, Inc. Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0000540D0 (en) 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
JP2005504730A (en) * 2001-04-20 2005-02-17 バーテックス　ファーマシューティカルズ　インコーポレイテッド Compositions useful as GSK-3 inhibitors
EP1472248A1 (en) * 2002-01-17 2004-11-03 Eli Lilly And Company Modulators of acetylcholine receptors
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
TW200536830A (en) * 2004-02-06 2005-11-16 Chugai Pharmaceutical Co Ltd 1-(2H)-isoquinolone derivative
RU2414467C2 (en) * 2005-07-26 2011-03-20 Санофи-Авентис PIPERADINYL-SUBSTITUTED ISOQUINOLONE DERIVATIVES AS Rho-KINASE INHIBITORS
ATE523500T1 (en) * 2006-09-11 2011-09-15 Organon Nv QUINAZOLINONE AND ISOQUINOLINONE ACETAMIDE DERIVATIVES
BRPI0720909A2 (en) * 2006-12-27 2016-11-01 Sanofi Aventis substituted isoquinoline and isoquinolinone derivatives
JP2010229035A (en) * 2007-08-01 2010-10-14 Taisho Pharmaceutical Co Ltd Pyridopyrimidin-4-one derivative
BRPI0820259A2 (en) * 2007-11-14 2015-06-16 Neurosearch As 1,4-diaza-bicyclo [3.2.2] nonyl pyrimidine derivative, pharmaceutical composition, use of 1,4-diaza-bicyclo [3.2.2] nonyl pyrimidine derivative, and method of treating, preventing or alleviating a disease or disorder or condition of body of living animal
CN101960691B (en) 2008-02-29 2013-04-24 核心技术国际有限公司 Charging device and quality judging device of pack cell

Also Published As

Publication number Publication date
KR20120100913A (en) 2012-09-12
EP2488520B1 (en) 2015-09-02
US20120208796A1 (en) 2012-08-16
CA2776835A1 (en) 2011-04-21
JP2013507417A (en) 2013-03-04
RU2012119488A (en) 2013-11-20
WO2011045258A1 (en) 2011-04-21
CN102666540A (en) 2012-09-12
US8841289B2 (en) 2014-09-23
EP2488520A1 (en) 2012-08-22
MX2012004289A (en) 2012-06-12
BR112012008518A2 (en) 2016-04-05
AU2010305825A1 (en) 2012-04-19

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