BR112012004719A2 - emulsões múltiplas criadas por uso de jateamento e outras técnicas - Google Patents

emulsões múltiplas criadas por uso de jateamento e outras técnicas

Info

Publication number
BR112012004719A2
BR112012004719A2 BR112012004719A BR112012004719A BR112012004719A2 BR 112012004719 A2 BR112012004719 A2 BR 112012004719A2 BR 112012004719 A BR112012004719 A BR 112012004719A BR 112012004719 A BR112012004719 A BR 112012004719A BR 112012004719 A2 BR112012004719 A2 BR 112012004719A2
Authority
BR
Brazil
Prior art keywords
blasting
techniques
multiple emulsions
emulsions created
created
Prior art date
Application number
BR112012004719A
Other languages
English (en)
Inventor
Adam R Abate
David A Weitz
Julian W P Thiele
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of BR112012004719A2 publication Critical patent/BR112012004719A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/80—Falling particle mixers, e.g. with repeated agitation along a vertical axis
    • B01F25/90—Falling particle mixers, e.g. with repeated agitation along a vertical axis with moving or vibrating means, e.g. stirrers, for enhancing the mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3035—Micromixers using surface tension to mix, move or hold the fluids
    • B01F33/30351—Micromixers using surface tension to mix, move or hold the fluids using hydrophilic/hydrophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17D—PIPE-LINE SYSTEMS; PIPE-LINES
    • F17D1/00—Pipe-line systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/045—Numerical flow-rate values
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0459—Numerical values of dimensionless numbers, i.e. Re, Pr, Nu, transfer coefficients
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4144—Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/85938—Non-valved flow dividers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Colloid Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
BR112012004719A 2009-09-02 2010-09-01 emulsões múltiplas criadas por uso de jateamento e outras técnicas BR112012004719A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23940509P 2009-09-02 2009-09-02
US35309310P 2010-06-09 2010-06-09
PCT/US2010/047467 WO2011028764A2 (en) 2009-09-02 2010-09-01 Multiple emulsions created using jetting and other techniques

Publications (1)

Publication Number Publication Date
BR112012004719A2 true BR112012004719A2 (pt) 2016-04-05

Family

ID=43649934

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012004719A BR112012004719A2 (pt) 2009-09-02 2010-09-01 emulsões múltiplas criadas por uso de jateamento e outras técnicas

Country Status (8)

Country Link
US (3) US20120211084A1 (pt)
EP (1) EP2473263B1 (pt)
JP (1) JP5869482B2 (pt)
KR (1) KR20120089661A (pt)
CN (1) CN102574078B (pt)
BR (1) BR112012004719A2 (pt)
IN (1) IN2012DN01874A (pt)
WO (1) WO2011028764A2 (pt)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9039273B2 (en) 2005-03-04 2015-05-26 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
US20110218123A1 (en) 2008-09-19 2011-09-08 President And Fellows Of Harvard College Creation of libraries of droplets and related species
GB2471522B (en) * 2009-07-03 2014-01-08 Cambridge Entpr Ltd Microfluidic devices
CN102574078B (zh) 2009-09-02 2016-05-18 哈佛学院院长等 使用喷射和其它技术产生的多重乳液
EP2714254B1 (en) 2011-05-23 2017-09-06 President and Fellows of Harvard College Control of emulsions, including multiple emulsions
EP2729238A2 (en) * 2011-07-06 2014-05-14 President and Fellows of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
CN103764272A (zh) 2011-08-30 2014-04-30 哈佛学院院长等 壳包囊的体系和方法
WO2013095737A2 (en) * 2011-09-28 2013-06-27 President And Fellows Of Harvard College Systems and methods for droplet production and/or fluidic manipulation
CN104203382A (zh) 2012-02-08 2014-12-10 哈佛学院院长及董事 使用流体破裂的液滴生成
EP3305918B1 (en) 2012-03-05 2020-06-03 President and Fellows of Harvard College Methods for epigenetic sequencing
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR102090851B1 (ko) 2012-08-14 2020-03-19 10엑스 제노믹스, 인크. 마이크로캡슐 조성물 및 방법
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9644204B2 (en) 2013-02-08 2017-05-09 10X Genomics, Inc. Partitioning and processing of analytes and other species
CN103131665A (zh) * 2013-02-25 2013-06-05 东南大学 一种复合结构编码微载体及其制备方法和应用
CN103240042B (zh) * 2013-05-09 2014-08-13 四川大学 一种液体浸润引发液滴融合的方法
WO2014210353A2 (en) 2013-06-27 2014-12-31 10X Technologies, Inc. Compositions and methods for sample processing
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
WO2015069634A1 (en) 2013-11-08 2015-05-14 President And Fellows Of Harvard College Microparticles, methods for their preparation and use
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
KR102596508B1 (ko) 2014-04-10 2023-10-30 10엑스 제노믹스, 인크. 시약을 캡슐화 및 구획화하기 위한 유체 디바이스, 시스템, 및 방법, 및 이의 응용
WO2015160919A1 (en) 2014-04-16 2015-10-22 President And Fellows Of Harvard College Systems and methods for producing droplet emulsions with relatively thin shells
US20150298091A1 (en) * 2014-04-21 2015-10-22 President And Fellows Of Harvard College Systems and methods for barcoding nucleic acids
CA2952503A1 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Processes and systems for nucleic acid sequence assembly
KR20230070325A (ko) 2014-06-26 2023-05-22 10엑스 제노믹스, 인크. 개별 세포 또는 세포 개체군으로부터 핵산을 분석하는 방법
CN107002128A (zh) 2014-10-29 2017-08-01 10X 基因组学有限公司 用于靶核酸测序的方法和组合物
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
US10258986B2 (en) * 2014-11-12 2019-04-16 University Of New Hampshire Viscoelastic fluid drop production
US9878299B2 (en) 2014-11-24 2018-01-30 The Procter & Gamble Company Methods for encapsulation of actives within droplets and other compartments
CA2972113C (en) 2014-12-24 2023-03-14 National Research Council Of Canada Microparticles and apparatus for smart ink production
US10221436B2 (en) 2015-01-12 2019-03-05 10X Genomics, Inc. Processes and systems for preparation of nucleic acid sequencing libraries and libraries prepared using same
MX2017008916A (es) 2015-01-13 2017-10-19 10X Genomics Inc Sistemas y metodos para visualizar informacion de fases y variaciones estructurales.
CN107208156B (zh) 2015-02-09 2021-10-08 10X基因组学有限公司 用于使用变异识别数据来确定结构变异和定相的***和方法
US10697000B2 (en) 2015-02-24 2020-06-30 10X Genomics, Inc. Partition processing methods and systems
US11274343B2 (en) 2015-02-24 2022-03-15 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequence coverage
US11746367B2 (en) 2015-04-17 2023-09-05 President And Fellows Of Harvard College Barcoding systems and methods for gene sequencing and other applications
CN107405633A (zh) * 2015-05-22 2017-11-28 香港科技大学 基于高深宽比诱导生成液滴的液滴发生器
WO2017060876A1 (en) * 2015-10-09 2017-04-13 King Abdullah University Of Science And Technology Microfluidic droplet generator with controlled break-up mechanism
US11123297B2 (en) 2015-10-13 2021-09-21 President And Fellows Of Harvard College Systems and methods for making and using gel microspheres
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
EP3882357B1 (en) 2015-12-04 2022-08-10 10X Genomics, Inc. Methods and compositions for nucleic acid analysis
WO2017138984A1 (en) 2016-02-11 2017-08-17 10X Genomics, Inc. Systems, methods, and media for de novo assembly of whole genome sequence data
EP3736572A1 (en) 2016-04-05 2020-11-11 Université de Strasbourg Intra-droplet surface engineering to capture a molecular target
CN105771825A (zh) * 2016-05-11 2016-07-20 中国工程物理研究院激光聚变研究中心 一种可连续生产的乳粒发生器
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
WO2017199123A1 (en) * 2016-05-17 2017-11-23 Ecole Polytechnique Federale De Lausanne (Epfl) Device and methods for shell phase removal of core-shell capsules
US11534778B2 (en) 2016-09-30 2022-12-27 Amorepacific Corporation Device for preparing cosmetic composition containing emulsion material instantly emulsified based on microfluidic channel
CN106492716B (zh) * 2016-12-20 2024-01-30 中国工程物理研究院激光聚变研究中心 一体式双重乳粒发生装置及其加工方法
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4029939B1 (en) 2017-01-30 2023-06-28 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US10995333B2 (en) 2017-02-06 2021-05-04 10X Genomics, Inc. Systems and methods for nucleic acid preparation
EP4215616A1 (en) 2017-05-18 2023-07-26 10X Genomics, Inc. Methods and systems for sorting droplets and beads
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
WO2018213774A1 (en) 2017-05-19 2018-11-22 10X Genomics, Inc. Systems and methods for analyzing datasets
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN109526228B (zh) 2017-05-26 2022-11-25 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
US10821442B2 (en) 2017-08-22 2020-11-03 10X Genomics, Inc. Devices, systems, and kits for forming droplets
CN111132765B (zh) * 2017-09-19 2022-05-13 高保真生物技术有限公司 微流体***中的颗粒分选
US10837047B2 (en) 2017-10-04 2020-11-17 10X Genomics, Inc. Compositions, methods, and systems for bead formation using improved polymers
US10590244B2 (en) 2017-10-04 2020-03-17 10X Genomics, Inc. Compositions, methods, and systems for bead formation using improved polymers
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING
WO2019084043A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS
CN114525273A (zh) 2017-10-27 2022-05-24 10X基因组学有限公司 用于样品制备和分析的方法和***
EP3625361A1 (en) 2017-11-15 2020-03-25 10X Genomics, Inc. Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019108851A1 (en) 2017-11-30 2019-06-06 10X Genomics, Inc. Systems and methods for nucleic acid preparation and analysis
EP3720602A1 (en) 2017-12-06 2020-10-14 Samplix ApS A microfluidic device and a method for provision of double emulsion droplets
WO2019110591A1 (en) 2017-12-06 2019-06-13 Samplix Aps A microfluidic device and a method for provision of emulsion droplets
KR102023745B1 (ko) * 2017-12-06 2019-09-20 (주)아모레퍼시픽 순간 유화 화장품 제조 장치
US11666874B2 (en) * 2017-12-14 2023-06-06 Glaxosmithkline Intellectual Property Deveelopment Limited Methods and apparatus for variable emulsification
EP3752832A1 (en) 2018-02-12 2020-12-23 10X Genomics, Inc. Methods characterizing multiple analytes from individual cells or cell populations
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
CN112262218A (zh) 2018-04-06 2021-01-22 10X基因组学有限公司 用于单细胞处理中的质量控制的***和方法
US20190321791A1 (en) * 2018-04-19 2019-10-24 President And Fellows Of Harvard College Apparatus and method for forming emulsions
US11932899B2 (en) 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
US11703427B2 (en) 2018-06-25 2023-07-18 10X Genomics, Inc. Methods and systems for cell and bead processing
US11964294B2 (en) 2018-07-10 2024-04-23 Panasonic Intellectual Property Management Co., Ltd. Mist-generating device
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
CN109289950A (zh) * 2018-10-19 2019-02-01 扬州大学 一种多孔微球的制备装置及方法
US20200171445A1 (en) * 2018-12-03 2020-06-04 President And Fellows Of Harvard College Method for optimization of droplet formation rate using dripping/jetting to co-flow transition of vacuum-driven microfluidic flow-focusing device with rectangular microchannels
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
US11845983B1 (en) 2019-01-09 2023-12-19 10X Genomics, Inc. Methods and systems for multiplexing of droplet based assays
EP3917655A1 (en) 2019-01-31 2021-12-08 Samplix ApS A microfluidic device and a method for provision of emulsion droplets
CN113710352B (zh) * 2019-01-31 2024-03-26 赛普公司 微流体装置和用于提供双乳液液滴的方法
US11851683B1 (en) 2019-02-12 2023-12-26 10X Genomics, Inc. Methods and systems for selective analysis of cellular samples
WO2020168013A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Methods for processing nucleic acid molecules
US11467153B2 (en) 2019-02-12 2022-10-11 10X Genomics, Inc. Methods for processing nucleic acid molecules
US11655499B1 (en) 2019-02-25 2023-05-23 10X Genomics, Inc. Detection of sequence elements in nucleic acid molecules
EP3938537A1 (en) 2019-03-11 2022-01-19 10X Genomics, Inc. Systems and methods for processing optically tagged beads
CN110170343A (zh) * 2019-05-27 2019-08-27 天津大学 一种油包水微液滴制造***及制造方法
US11793753B2 (en) 2019-09-12 2023-10-24 Nulixir Inc. Methods and systems for forming layered solid particles
CA3157359A1 (en) 2019-10-10 2021-04-15 1859, Inc. Methods and systems for microfluidic screening
CN110804531B (zh) * 2019-11-15 2023-09-26 深圳市第二人民医院 一种基于微液滴的肠道微生物检测***
CN110819507B (zh) * 2019-11-15 2023-09-26 深圳市第二人民医院 用于肠道微生物检测的微液滴制备芯片
US11851700B1 (en) 2020-05-13 2023-12-26 10X Genomics, Inc. Methods, kits, and compositions for processing extracellular molecules
CN111606299B (zh) * 2020-05-21 2021-01-26 深圳技术大学 一种用于控制液滴形状的薄膜及其制备方法与应用
WO2022182682A1 (en) 2021-02-23 2022-09-01 10X Genomics, Inc. Probe-based analysis of nucleic acids and proteins
US20230070896A1 (en) 2021-09-09 2023-03-09 Nautilus Biotechnology, Inc. Characterization and localization of protein modifications
WO2023099661A1 (en) 2021-12-01 2023-06-08 Vilnius University Microcapsules comprising biological samples, and methods for use of same
WO2023117364A1 (en) 2021-12-01 2023-06-29 Vilnius University A microcapsule and methods of making and using same
WO2023168423A1 (en) * 2022-03-04 2023-09-07 10X Genomics, Inc. Droplet forming devices and methods having fluoropolymer silane coating agents
GB2616677A (en) * 2022-03-18 2023-09-20 Sphere Fluidics Ltd Droplet formation system and method
ES2966288A1 (es) * 2022-09-22 2024-04-19 Univ Rovira I Virgili Reometro y procedimientos asociados

Family Cites Families (239)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2379816A (en) 1939-07-17 1945-07-03 Gelatin Products Corp Capsulating process and apparatus
US2918263A (en) 1957-08-09 1959-12-22 Dow Chemical Co Mixing liquids and solids
NL6605917A (pt) 1965-04-30 1966-10-31
US3980541A (en) 1967-06-05 1976-09-14 Aine Harry E Electrode structures for electric treatment of fluids and filters using same
US3675901A (en) 1970-12-09 1972-07-11 Phillips Petroleum Co Method and apparatus for mixing materials
FR2180722B1 (pt) 1972-04-20 1975-12-26 Centre Rech Metallurgique
US3816331A (en) 1972-07-05 1974-06-11 Ncr Continuous encapsulation and device therefor
CH563807A5 (en) 1973-02-14 1975-07-15 Battelle Memorial Institute Fine granules and microcapsules mfrd. from liquid droplets - partic. of high viscosity requiring forced sepn. of droplets
CH564966A5 (pt) 1974-02-25 1975-08-15 Sauter Fr Ag Fabrik Elektrisch
NL180807C (nl) 1975-12-26 1987-05-04 Morishita Jintan Co Inrichting voor het vervaardigen van naadloze, met materiaal gevulde capsules.
JPS5857973B2 (ja) 1978-02-13 1983-12-22 ぺんてる株式会社 無機質壁マイクロカプセルの製造方法
US4279345A (en) 1979-08-03 1981-07-21 Allred John C High speed particle sorter using a field emission electrode
JPS5933018B2 (ja) 1980-03-17 1984-08-13 森下仁丹株式会社 高融点物質のマイクロカプセル製造方法とその製造装置
JPS6057907B2 (ja) 1981-06-18 1985-12-17 工業技術院長 液体の混合噴霧化方法
US4422985A (en) 1982-09-24 1983-12-27 Morishita Jintan Co., Ltd. Method and apparatus for encapsulation of a liquid or meltable solid material
JPS59131355A (ja) 1983-01-17 1984-07-28 森下仁丹株式会社 多重軟カプセルの製法
US5100933A (en) 1986-03-31 1992-03-31 Massachusetts Institute Of Technology Collapsible gel compositions
JPS6046980B2 (ja) 1983-08-11 1985-10-18 森下仁丹株式会社 変形シ−ムレス軟カプセルの製法およびその製造装置
US4865444A (en) 1984-04-05 1989-09-12 Mobil Oil Corporation Apparatus and method for determining luminosity of hydrocarbon fuels
US4732930A (en) 1985-05-20 1988-03-22 Massachusetts Institute Of Technology Reversible, discontinuous volume changes of ionized isopropylacrylamide cells
US5209978A (en) 1985-12-26 1993-05-11 Taisho Pharmaceutical Co., Ltd. Seamless soft capsule and production thereof
US4916070A (en) 1986-04-14 1990-04-10 The General Hospital Corporation Fibrin-specific antibodies and method of screening for the antibodies
US5204112A (en) 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
US4743507A (en) 1986-09-12 1988-05-10 Franses Elias I Nonspherical microparticles and method therefor
AT393633B (de) 1986-11-26 1991-11-25 Waagner Biro Ag Verfahren zum mischen von medien unterschiedlicher zaehigkeit
JPH075743B2 (ja) 1986-12-22 1995-01-25 ダイキン工業株式会社 テトラフルオロエチレン系共重合体粉末およびその製造法
US4888140A (en) 1987-02-11 1989-12-19 Chesebrough-Pond's Inc. Method of forming fluid filled microcapsules
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
US4978483A (en) 1987-09-28 1990-12-18 Redding Bruce K Apparatus and method for making microcapsules
US5418154A (en) 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US4931225A (en) 1987-12-30 1990-06-05 Union Carbide Industrial Gases Technology Corporation Method and apparatus for dispersing a gas into a liquid
JPH0694483B2 (ja) 1988-01-29 1994-11-24 三田工業株式会社 粒径の増大した単分散重合体粒子の製造方法
US5093602A (en) 1989-11-17 1992-03-03 Charged Injection Corporation Methods and apparatus for dispersing a fluent material utilizing an electron beam
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
GB9021061D0 (en) 1990-09-27 1990-11-07 Unilever Plc Encapsulating method and products containing encapsulated material
US6149789A (en) 1990-10-31 2000-11-21 Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Process for manipulating microscopic, dielectric particles and a device therefor
US5232712A (en) 1991-06-28 1993-08-03 Brown University Research Foundation Extrusion apparatus and systems
DE4127405C2 (de) 1991-08-19 1996-02-29 Fraunhofer Ges Forschung Verfahren zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter dielektrischer Teilchen und Vorrichtung zur Durchführung des Verfahrens
US5216096A (en) 1991-09-24 1993-06-01 Japan Synthetic Rubber Co., Ltd. Process for the preparation of cross-linked polymer particles
SE500071C2 (sv) 1992-06-25 1994-04-11 Vattenfall Utveckling Ab Anordning för blandning av två fluider, i synnerhet vätskor med olika temperatur
FR2696658B1 (fr) 1992-10-14 1994-11-18 Hospal Ind Procédé et dispositif d'encapsulation d'une substance, ainsi que capsule obtenue.
DE4308839C2 (de) 1993-03-19 1997-04-30 Jordanow & Co Gmbh Vorrichtung zum Mischen von Strömungsmedien
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
EP0687858B1 (en) 1994-06-13 2000-10-25 Praxair Technology, Inc. Narrow spray angle liquid fuel atomizers for combustion
US5935331A (en) 1994-09-09 1999-08-10 Matsushita Electric Industrial Co., Ltd. Apparatus and method for forming films
US5762775A (en) 1994-09-21 1998-06-09 Lockheed Martin Energy Systems, Inc. Method for electrically producing dispersions of a nonconductive fluid in a conductive medium
EP0812434B1 (en) 1995-03-01 2013-09-18 President and Fellows of Harvard College Microcontact printing on surfaces and derivative articles
US5595757A (en) 1995-03-29 1997-01-21 Warner-Lambert Company Seamless capsules
US5888538A (en) 1995-03-29 1999-03-30 Warner-Lambert Company Methods and apparatus for making seamless capsules
US6238690B1 (en) 1995-03-29 2001-05-29 Warner-Lambert Company Food products containing seamless capsules and methods of making the same
CA2332731A1 (en) 1995-06-07 1996-12-19 Sydney Brenner Oligonucleotide tags for sorting and identification
US5851769A (en) 1995-09-27 1998-12-22 The Regents Of The University Of California Quantitative DNA fiber mapping
JP3759986B2 (ja) 1995-12-07 2006-03-29 フロイント産業株式会社 シームレスカプセルおよびその製造方法
US5681600A (en) 1995-12-18 1997-10-28 Abbott Laboratories Stabilization of liquid nutritional products and method of making
US6355198B1 (en) 1996-03-15 2002-03-12 President And Fellows Of Harvard College Method of forming articles including waveguides via capillary micromolding and microtransfer molding
JP3633091B2 (ja) 1996-04-09 2005-03-30 旭硝子株式会社 微小無機質球状中実体の製造方法
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6196525B1 (en) 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
US6405936B1 (en) 1996-05-13 2002-06-18 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
US6197835B1 (en) 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for creating spherical particles of uniform size
US6299145B1 (en) 1996-05-13 2001-10-09 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
US6248378B1 (en) 1998-12-16 2001-06-19 Universidad De Sevilla Enhanced food products
US6187214B1 (en) 1996-05-13 2001-02-13 Universidad De Seville Method and device for production of components for microfabrication
ES2140998B1 (es) 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US6386463B1 (en) 1996-05-13 2002-05-14 Universidad De Sevilla Fuel injection nozzle and method of use
US6189803B1 (en) 1996-05-13 2001-02-20 University Of Seville Fuel injection nozzle and method of use
US6429025B1 (en) 1996-06-28 2002-08-06 Caliper Technologies Corp. High-throughput screening assay systems in microscale fluidic devices
AU4113297A (en) 1996-09-04 1998-03-26 Technical University Of Denmark A micro flow system for particle separation and analysis
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6120666A (en) 1996-09-26 2000-09-19 Ut-Battelle, Llc Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same
JPH10219222A (ja) 1997-02-07 1998-08-18 Nissei Tekunika:Kk 液晶表示パネル基板の接着用のマイクロカプセル型接着性粒子
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
WO1998048783A1 (en) 1997-04-30 1998-11-05 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents and for delivery of drugs into the bloodstream
JP4102459B2 (ja) 1997-05-14 2008-06-18 森下仁丹株式会社 生体高分子を合成するシームレスカプセルおよびその製造方法
DK1801214T3 (da) 1997-07-07 2011-01-24 Medical Res Council In vitro sorteringsfremgangsmåde
US5980936A (en) 1997-08-07 1999-11-09 Alliance Pharmaceutical Corp. Multiple emulsions comprising a hydrophobic continuous phase
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US6004525A (en) 1997-10-06 1999-12-21 Kabushiki Kaisha Toyota Chuo Kenkyusho Hollow oxide particle and process for producing the same
US6614598B1 (en) 1998-11-12 2003-09-02 Institute Of Technology, California Microlensing particles and applications
US6450189B1 (en) 1998-11-13 2002-09-17 Universidad De Sevilla Method and device for production of components for microfabrication
GB9900298D0 (en) 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US6506609B1 (en) 1999-05-17 2003-01-14 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US20030124509A1 (en) 1999-06-03 2003-07-03 Kenis Paul J.A. Laminar flow patterning and articles made thereby
CA2374232C (en) 1999-06-11 2013-08-20 Aradigm Corporation Method for producing an aerosol
AU779988B2 (en) 1999-06-28 2005-02-24 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
US6380297B1 (en) 1999-08-12 2002-04-30 Nexpress Solutions Llc Polymer particles of controlled shape
US6890487B1 (en) 1999-09-30 2005-05-10 Science & Technology Corporation ©UNM Flow cytometry for high throughput screening
DE19961257C2 (de) 1999-12-18 2002-12-19 Inst Mikrotechnik Mainz Gmbh Mikrovermischer
US6790328B2 (en) 2000-01-12 2004-09-14 Ut-Battelle, Llc Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
BR0109088A (pt) 2000-03-10 2003-05-20 Flow Focusing Inc Métodos para a produção de fibra ótica por meio de focalização de lìquido de alta viscosidade
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
DE10015109A1 (de) 2000-03-28 2001-10-04 Peter Walzel Verfahren und Vorrichtungen zur Herstellung gleich großer Tropfen
US6413548B1 (en) 2000-05-10 2002-07-02 Aveka, Inc. Particulate encapsulation of liquid beads
US6645432B1 (en) 2000-05-25 2003-11-11 President & Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
US6686184B1 (en) 2000-05-25 2004-02-03 President And Fellows Of Harvard College Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
US6777450B1 (en) 2000-05-26 2004-08-17 Color Access, Inc. Water-thin emulsions with low emulsifier levels
US20060263888A1 (en) 2000-06-02 2006-11-23 Honeywell International Inc. Differential white blood count on a disposable card
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
DE10035302C2 (de) 2000-07-18 2002-12-19 Deotexis Inc Mikrokapsel, Verfahren zu ihrer Herstellung und Verwendung derselben
US6623788B1 (en) 2000-07-25 2003-09-23 Seagate Technology Llc Defect-free patterning of sol-gel-coated substrates for magnetic recording media
US6301055B1 (en) 2000-08-16 2001-10-09 California Institute Of Technology Solid immersion lens structures and methods for producing solid immersion lens structures
JP4778639B2 (ja) 2000-08-17 2011-09-21 中外製薬株式会社 シームレスカプセルの製造方法
DE10041823C2 (de) 2000-08-25 2002-12-19 Inst Mikrotechnik Mainz Gmbh Verfahren und statischer Mikrovermischer zum Mischen mindestens zweier Fluide
US6610499B1 (en) 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
US7294503B2 (en) 2000-09-15 2007-11-13 California Institute Of Technology Microfabricated crossflow devices and methods
US6508988B1 (en) 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
WO2002047665A2 (en) 2000-12-07 2002-06-20 President And Fellows Of Harvard College Methods and compositions for encapsulating active agents
US20040096515A1 (en) 2001-12-07 2004-05-20 Bausch Andreas R. Methods and compositions for encapsulating active agents
EP1741482B1 (en) 2001-02-23 2008-10-15 Japan Science and Technology Agency Process and apparatus for producing microcapsules
EP1510251B1 (en) 2001-02-23 2006-09-06 Japan Science and Technology Agency Process and apparatus for producing microcapsules
JP3860186B2 (ja) 2001-02-23 2006-12-20 独立行政法人科学技術振興機構 エマルションの製造装置
US6752922B2 (en) 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
US6806058B2 (en) 2001-05-26 2004-10-19 One Cell Systems, Inc. Secretions of proteins by encapsulated cells
GB0114854D0 (en) 2001-06-18 2001-08-08 Medical Res Council Selective gene amplification
US20030015425A1 (en) 2001-06-20 2003-01-23 Coventor Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
EP1412065A2 (en) 2001-07-27 2004-04-28 President And Fellows Of Harvard College Laminar mixing apparatus and methods
EP1304167B1 (en) 2001-10-18 2004-07-28 Aida Engineering Ltd. Micro-globule metering and sampling structure and microchips having the structure
DE10206083B4 (de) 2002-02-13 2009-11-26 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Verfahren zum Erzeugen monodisperser Nanotropfen sowie mikrofluidischer Reaktor zum Durchführen des Verfahrens
US6976590B2 (en) 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US7718099B2 (en) * 2002-04-25 2010-05-18 Tosoh Corporation Fine channel device, fine particle producing method and solvent extraction method
EP1508044B1 (en) 2002-05-09 2010-09-01 The University of Chicago Device and method for pressure-driven plug transport and reaction
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
US20030227820A1 (en) 2002-06-05 2003-12-11 Parrent Kenneth Gaylord Apparatus for mixing, combining or dissolving fluids or fluidized components in each other
JP2006507921A (ja) * 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
JP4186637B2 (ja) 2002-11-06 2008-11-26 東ソー株式会社 粒子製造方法及びそのための微小流路構造体
GB2395196B (en) 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
JP4527384B2 (ja) 2002-12-06 2010-08-18 綜研化学株式会社 マイクロチャンネルを用いた着色球状粒子の製造方法、およびその製造方法に用いるマイクロチャンネル式製造装置
CA2513541A1 (en) 2003-01-29 2004-08-19 454 Corporation Method for preparing single-stranded dna libraries
WO2004071638A2 (en) 2003-02-11 2004-08-26 Regents Of The University Of California, The Microfluidic devices and method for controlled viscous shearing and formation of amphiphilic vesicles
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US7045040B2 (en) 2003-03-20 2006-05-16 Asm Nutool, Inc. Process and system for eliminating gas bubbles during electrochemical processing
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
JP2006522303A (ja) 2003-03-31 2006-09-28 ベール ゲーエムベーハー ウント コー カーゲー 熱交換機およびその表面処理方法
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
JP2006523142A (ja) 2003-04-10 2006-10-12 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体種の形成および制御
US7115230B2 (en) 2003-06-26 2006-10-03 Intel Corporation Hydrodynamic focusing devices
GB0315438D0 (en) 2003-07-02 2003-08-06 Univ Manchester Analysis of mixed cell populations
WO2005010145A2 (en) 2003-07-05 2005-02-03 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
US20050032238A1 (en) 2003-08-07 2005-02-10 Nanostream, Inc. Vented microfluidic separation devices and methods
WO2005021151A1 (en) 2003-08-27 2005-03-10 President And Fellows Of Harvard College Electronic control of fluidic species
EP1668355A4 (en) 2003-08-28 2011-11-09 Celula Inc METHODS AND APPARATUS FOR SORTING CELLS USING AN OPTICAL SWITCH IN A MICROFLUIDIC CHANNEL NETWORK
JP4341372B2 (ja) 2003-10-30 2009-10-07 コニカミノルタホールディングス株式会社 液体の混合方法および混合装置ならびに混合システム
JP4042683B2 (ja) 2003-11-17 2008-02-06 東ソー株式会社 微小流路構造体及びこれを用いた微小粒子製造方法
EP1691792A4 (en) 2003-11-24 2008-05-28 Yeda Res & Dev COMPOSITIONS AND METHODS FOR IN VITRO / I SORTING OF MOLECULAR AND CELLULAR BANKS
JP4305145B2 (ja) 2003-11-25 2009-07-29 東ソー株式会社 微小流路による粒子製造方法
JP3777427B2 (ja) 2003-11-25 2006-05-24 独立行政法人食品総合研究所 エマルションの製造方法および製造装置
US7595155B2 (en) 2004-02-27 2009-09-29 Hitachi Chemical Research Center Multiplex detection probes
WO2005089921A1 (ja) 2004-03-23 2005-09-29 Japan Science And Technology Agency 微小液滴の生成方法及び装置
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
JP4339163B2 (ja) 2004-03-31 2009-10-07 宇部興産株式会社 マイクロデバイスおよび流体の合流方法
US8696952B2 (en) 2004-04-23 2014-04-15 Eugenia Kumacheva Method of producing polymeric particles with selected size, shape, morphology and composition
JP4461900B2 (ja) 2004-05-10 2010-05-12 富士ゼロックス株式会社 微粒子分散液の送液方法、及び微粒子分散液の送液装置
WO2006002641A1 (en) 2004-07-02 2006-01-12 Versamatrix A/S Spherical radiofrequency-encoded beads
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US7759111B2 (en) 2004-08-27 2010-07-20 The Regents Of The University Of California Cell encapsulation microfluidic device
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
CN100464833C (zh) 2004-11-11 2009-03-04 中国科学院化学研究所 用模板法制备中空球和复合结构的中空球的方法
US20080004436A1 (en) 2004-11-15 2008-01-03 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Directed Evolution and Selection Using in Vitro Compartmentalization
US20070009668A1 (en) 2004-11-18 2007-01-11 Wyman Jason L Microencapsulation of particles in a polymer solution by selective withdrawal through a high viscosity low density fluid and subsequent crosslinking
US20080213593A1 (en) 2005-01-21 2008-09-04 President And Fellows Of Harvard College Systems And Methods For Forming Fluidic Droplets Encapsulated In Particles Such As Colloidal Particles
US20070054119A1 (en) 2005-03-04 2007-03-08 Piotr Garstecki Systems and methods of forming particles
US9039273B2 (en) * 2005-03-04 2015-05-26 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
JP2006349060A (ja) 2005-06-16 2006-12-28 Ntn Corp ボールねじ
US20070047388A1 (en) 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
US8734003B2 (en) 2005-09-15 2014-05-27 Alcatel Lucent Micro-chemical mixing
DE102005048259B4 (de) 2005-10-07 2007-09-13 Landesstiftung Baden-Württemberg Vorrichtung und Verfahren zur Erzeugung eines Gemenges von zwei ineinander unlösbaren Phasen
BRPI0619938A2 (pt) 2005-12-16 2011-10-25 Univ Kansas nano agrupamentos para envio de terapêuticos
GB2433448B (en) 2005-12-20 2011-03-02 Q Chip Ltd Method for the control of chemical processes
US7932037B2 (en) 2007-12-05 2011-04-26 Perkinelmer Health Sciences, Inc. DNA assays using amplicon probes on encoded particles
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
AU2007210152A1 (en) 2006-01-27 2007-08-09 President And Fellows Of Harvard College Fluidic droplet coalescence
EP2530168B1 (en) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Microfluidic Devices
JP5630998B2 (ja) 2006-05-15 2014-11-26 マサチューセッツ インスティテュート オブ テクノロジー 機能的粒子のためのポリマー
CN100510742C (zh) * 2006-08-25 2009-07-08 浙江大学 负压进样微流控化学合成反应***
JP2008073581A (ja) 2006-09-20 2008-04-03 Univ Waseda マイクロカプセル、マイクロカプセル製造装置及びマイクロカプセル製造方法
WO2008058297A2 (en) 2006-11-10 2008-05-15 Harvard University Non-spherical particles
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US9029085B2 (en) 2007-03-07 2015-05-12 President And Fellows Of Harvard College Assays and other reactions involving droplets
EP2136786B8 (en) 2007-03-28 2012-11-14 President and Fellows of Harvard College Apparatus for forming droplets
TW200845197A (en) 2007-03-28 2008-11-16 Matsushita Electric Ind Co Ltd Plasma etching apparatus
JP4226634B2 (ja) 2007-03-29 2009-02-18 財団法人 岡山県産業振興財団 マイクロリアクター
WO2008134153A1 (en) 2007-04-23 2008-11-06 Advanced Liquid Logic, Inc. Bead-based multiplexed analytical methods and instrumentation
JP2010530912A (ja) 2007-06-22 2010-09-16 フィオ コーポレイション 量子ドットをドープしたポリマーマイクロビーズの製造システム及び方法
GB0712860D0 (en) 2007-07-03 2007-08-08 Eastman Kodak Co continuous inkjet drop generation device
GB0712861D0 (en) 2007-07-03 2007-08-08 Eastman Kodak Co Continuous ink jet printing of encapsulated droplets
GB0712863D0 (en) 2007-07-03 2007-08-08 Eastman Kodak Co Monodisperse droplet generation
WO2009011808A1 (en) 2007-07-13 2009-01-22 President And Fellows Of Harvard College Droplet-based selection
US8883291B2 (en) 2007-08-07 2014-11-11 President And Fellows Of Harvard College Metal oxide coating on surfaces
WO2009039458A2 (en) 2007-09-19 2009-03-26 Massachusetts Institute Of Technology Virus/nanowire encapsulation within polymer microgels for 2d and 3d devices for energy and electronics
WO2009048532A2 (en) 2007-10-05 2009-04-16 President And Fellows Of Harvard College Formation of particles for ultrasound application, drug release, and other uses, and microfluidic methods of preparation
WO2009061372A1 (en) 2007-11-02 2009-05-14 President And Fellows Of Harvard College Systems and methods for creating multi-phase entities, including particles and/or fluids
US20110027376A1 (en) 2007-12-11 2011-02-03 Nanyang Technological University Hollow Multi-Layered Microspheres for Delivery of Hydrophilic Active Compounds
US20090191276A1 (en) 2008-01-24 2009-07-30 Fellows And President Of Harvard University Colloidosomes having tunable properties and methods for making colloidosomes having tunable properties
US9011777B2 (en) 2008-03-21 2015-04-21 Lawrence Livermore National Security, Llc Monodisperse microdroplet generation and stopping without coalescence
US8802027B2 (en) 2008-03-28 2014-08-12 President And Fellows Of Harvard College Surfaces, including microfluidic channels, with controlled wetting properties
US20110305761A1 (en) 2008-06-05 2011-12-15 President And Fellows Of Harvard College Polymersomes, colloidosomes, liposomes, and other species associated with fluidic droplets
JP2010000428A (ja) 2008-06-19 2010-01-07 Hitachi Plant Technologies Ltd マイクロリアクタ
JP5341188B2 (ja) 2008-07-15 2013-11-13 エル３ テクノロジー リミテッド アッセイ装置および方法
US20140024023A1 (en) 2012-07-23 2014-01-23 Bio- Rad Laboratories, Inc Droplet generation system with features for sample positioning
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
KR101132732B1 (ko) 2008-11-26 2012-04-06 한국과학기술연구원 인 시튜 조직재생용 지능형 다공성 생분해 고분자 지지체 및 이의 제조방법
CA2750815C (en) 2009-02-09 2018-03-13 Swetree Technologies Ab Polymer shells
WO2010104597A2 (en) 2009-03-13 2010-09-16 President And Fellows Of Harvard College Scale-up of microfluidic devices
WO2010104604A1 (en) 2009-03-13 2010-09-16 President And Fellows Of Harvard College Method for the controlled creation of emulsions, including multiple emulsions
WO2010110842A1 (en) 2009-03-25 2010-09-30 Eastman Kodak Company Droplet generator
CN101856603A (zh) 2009-04-09 2010-10-13 美国吉姆迪生物科技有限公司 透明质酸的纳米/微封装和释放
WO2010121307A1 (en) 2009-04-21 2010-10-28 The University Of Queensland Complex emulsions
WO2010128157A1 (en) 2009-05-07 2010-11-11 Universite De Strasbourg Microfluidic system and methods for highly selective droplet fusion
FR2946895A1 (fr) 2009-06-19 2010-12-24 Commissariat Energie Atomique Systeme microfluidique et procede correspondant pour le transfert d'elements entre phases liquides et utilisation de ce systeme pour extraire ces elements
GB2471522B (en) 2009-07-03 2014-01-08 Cambridge Entpr Ltd Microfluidic devices
JP5212313B2 (ja) 2009-08-24 2013-06-19 株式会社日立プラントテクノロジー 乳化装置
US9789451B2 (en) 2009-08-28 2017-10-17 Georgia Tech Research Corporation Method and electro-fluidic device to produce emulsions and particle suspensions
EP2940153B1 (en) 2009-09-02 2020-05-13 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
CN102574078B (zh) 2009-09-02 2016-05-18 哈佛学院院长等 使用喷射和其它技术产生的多重乳液
KR20120089662A (ko) 2009-09-02 2012-08-13 바스프 에스이 연접을 이용하여 생성된 다중 에멀젼
WO2011056872A2 (en) 2009-11-03 2011-05-12 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
CN101721964A (zh) 2009-11-12 2010-06-09 同济大学 一种防功能性物质泄露的核壳微/纳米球的制备方法
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
WO2011079176A2 (en) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
BR112012023441A2 (pt) 2010-03-17 2016-05-24 Basf Se emulsificação por fusão
EP2550528B1 (en) 2010-03-25 2019-09-11 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
GB2512213B (en) 2010-10-08 2015-02-11 Harvard College High-throughput single cell barcoding
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
EP2714254B1 (en) 2011-05-23 2017-09-06 President and Fellows of Harvard College Control of emulsions, including multiple emulsions
EP2729238A2 (en) * 2011-07-06 2014-05-14 President and Fellows of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
CN103764272A (zh) * 2011-08-30 2014-04-30 哈佛学院院长等 壳包囊的体系和方法
US9249460B2 (en) 2011-09-09 2016-02-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for obtaining a sequence
EP4148142A1 (en) 2012-05-21 2023-03-15 The Scripps Research Institute Methods of sample preparation
US20140378349A1 (en) 2012-08-14 2014-12-25 10X Technologies, Inc. Compositions and methods for sample processing
US20150005200A1 (en) 2012-08-14 2015-01-01 10X Technologies, Inc. Compositions and methods for sample processing
KR102090851B1 (ko) 2012-08-14 2020-03-19 10엑스 제노믹스, 인크. 마이크로캡슐 조성물 및 방법
DE102012110868A1 (de) 2012-11-13 2014-05-15 Fischerwerke Gmbh & Co. Kg Kombination mit einem Anker für plattenförmige Bauteile sowie Befestigungsanordnung
US9644204B2 (en) 2013-02-08 2017-05-09 10X Genomics, Inc. Partitioning and processing of analytes and other species

Also Published As

Publication number Publication date
JP2013503743A (ja) 2013-02-04
EP2473263B1 (en) 2022-11-02
US20180071695A1 (en) 2018-03-15
WO2011028764A3 (en) 2011-09-29
CN102574078B (zh) 2016-05-18
JP5869482B2 (ja) 2016-02-24
US10874997B2 (en) 2020-12-29
EP2473263A2 (en) 2012-07-11
IN2012DN01874A (pt) 2015-08-21
US20120211084A1 (en) 2012-08-23
EP2473263A4 (en) 2015-12-02
KR20120089661A (ko) 2012-08-13
CN102574078A (zh) 2012-07-11
WO2011028764A2 (en) 2011-03-10
US20210268454A1 (en) 2021-09-02

Similar Documents

Publication Publication Date Title
BR112012004719A2 (pt) emulsões múltiplas criadas por uso de jateamento e outras técnicas
BR112012004715A2 (pt) emulsões múltiplas criadas por uso de junções
BRPI1012533A2 (pt) composto de piradazinona e uso do mesmo
BRPI1006572A2 (pt) bombas
BRPI0905850A2 (pt) Unidade de aeronave
BRPI1010774A2 (pt) método de uso de particulados.
BRPI0911695A2 (pt) conjunto de barbear
DK2216140T3 (da) Hammer
BR112012011629A2 (pt) nanopapel forte
BRPI0911269A2 (pt) análogos de halicondrina b
ES1065656Y (es) Helicoptero
BR112013011304A2 (pt) combustor de detonação pulsada
BRPI0817379A2 (pt) aeronave
BRPI0812818A2 (pt) Turbo-reator para aeronave
BRPI1007494A2 (pt) composto e uso do mesmo
BR112012014167A2 (pt) aparelho de barbear
BRPI1011310A2 (pt) aeronave
BRPI1012728A2 (pt) uso de tripeptídeos
BR112013021221A2 (pt) cutelo com revestimento de endurecimento
BRPI0912302A2 (pt) emulsões autopreservados
BRPI1011036A2 (pt) uso
BRPI1006996A2 (pt) composição, método e uso
BRPI0907543A2 (pt) Aparelho de barbear
BRPI1013597A2 (pt) seringa para uso único
BRPI0909840A2 (pt) Uso de 4-tio-2-deoxinucleosídios

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]

Free format text: O DEPOSITANTE DEVE RESPONDER A EXIGENCIA FORMULADA NESTE PARECER POR MEIO DO SERVICO DE CODIGO 206 EM ATE 60 (SESSENTA) DIAS, A PARTIR DA DATA DE PUBLICACAO NA RPI, SOB PENA DO ARQUIVAMENTO DO PEDIDO, DE ACORDO COM O ART. 34 DA LPI.PUBLIQUE-SE A EXIGENCIA (6.20).

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL