BR0314182A - Formulações compreendendo um composto de indolinona - Google Patents
Formulações compreendendo um composto de indolinonaInfo
- Publication number
- BR0314182A BR0314182A BR0314182-9A BR0314182A BR0314182A BR 0314182 A BR0314182 A BR 0314182A BR 0314182 A BR0314182 A BR 0314182A BR 0314182 A BR0314182 A BR 0314182A
- Authority
- BR
- Brazil
- Prior art keywords
- formulations
- indolinone
- indolinone compound
- compound
- formulation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
"FORMULAçõES SóLIDAS COMPREENDENDO UM COMPOSTO DE INDOLINONA". A presente invenção descreve formulações de indolinonas. A formulação é adequada para administração parenteral ou oral, onde a formulação compreende uma indolinona, e um veículo farmaceuticamente aceitável por conseguinte. As formulações e os compostos dos mesmos são úteis para o tratamento de distúrbios relacionados com cinase de proteína.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42113302P | 2002-09-10 | 2002-09-10 | |
PCT/IB2003/005293 WO2004024127A2 (en) | 2002-09-10 | 2003-09-10 | Solid formulations comprising an indolinone compound |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0314182A true BR0314182A (pt) | 2005-08-09 |
Family
ID=31994326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0314182-9A BR0314182A (pt) | 2002-09-10 | 2003-09-10 | Formulações compreendendo um composto de indolinona |
Country Status (31)
Country | Link |
---|---|
US (1) | US20040229930A1 (pt) |
EP (1) | EP1536783B2 (pt) |
JP (1) | JP2006503032A (pt) |
KR (1) | KR20050059170A (pt) |
CN (1) | CN1688304A (pt) |
AR (1) | AR041193A1 (pt) |
AT (1) | ATE403425T1 (pt) |
AU (1) | AU2003280108B2 (pt) |
BR (1) | BR0314182A (pt) |
CA (1) | CA2498415C (pt) |
DE (1) | DE60322720D1 (pt) |
DK (1) | DK1536783T3 (pt) |
DO (1) | DOP2003000708A (pt) |
ES (1) | ES2309363T5 (pt) |
GT (1) | GT200300193A (pt) |
HN (1) | HN2003000272A (pt) |
MX (1) | MXPA05002690A (pt) |
MY (1) | MY136767A (pt) |
NL (1) | NL1024261C (pt) |
NO (1) | NO20051670L (pt) |
NZ (1) | NZ538636A (pt) |
PA (1) | PA8581801A1 (pt) |
PE (1) | PE20040989A1 (pt) |
PL (1) | PL375978A1 (pt) |
PT (1) | PT1536783E (pt) |
RU (1) | RU2005110663A (pt) |
SI (1) | SI1536783T1 (pt) |
TW (1) | TW200418836A (pt) |
UY (1) | UY27969A1 (pt) |
WO (1) | WO2004024127A2 (pt) |
ZA (1) | ZA200501897B (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005033098A1 (en) | 2003-10-02 | 2005-04-14 | Pharmacia & Upjohn Company Llc | Salts and polymorphs of a pyrrole-substituted indolinone compound |
CA2622870A1 (en) * | 2005-09-20 | 2007-03-29 | Pfizer Products Inc. | Dosage forms and methods of treatment using a tyrosine kinase inhibitor |
CN101007801A (zh) * | 2006-01-27 | 2007-08-01 | 上海恒瑞医药有限公司 | 吡咯取代的2-二氢吲哚酮衍生物、其制法与医药上的用途 |
TWI482772B (zh) * | 2006-08-21 | 2015-05-01 | Astrazeneca Ab | 適合口服且包含***并[4,5-d]嘧啶衍生物之組合物 |
WO2008024044A1 (en) * | 2006-08-21 | 2008-02-28 | Astrazeneca Ab | Compositions, suitable for oral administration, comprising a triazolo [4, 5] pyrimidin derivate |
US20090004213A1 (en) | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
EP2220071A2 (en) * | 2007-11-21 | 2010-08-25 | Teva Pharmaceutical Industries Ltd. | Sunitinib hemi-l-malate, polymorphs and preparation thereof, polymorphs of racemic sunitinib malate, compositins containing sunitinib base and malic acid and preparation thereof |
EP2113248A1 (en) | 2008-04-29 | 2009-11-04 | Ratiopharm GmbH | Pharmaceutical composition comprising N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2-,4-dimethyl-1H-pyrrole-3-carboxamide |
EP2090306A1 (en) | 2008-02-13 | 2009-08-19 | Ratiopharm GmbH | Pharmaceutical compositions comprising N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide |
US20100310668A1 (en) * | 2008-02-13 | 2010-12-09 | Ratiopharm Gmbh | Pharmaceutical compositions comprising n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide |
EP2138167A1 (en) * | 2008-06-24 | 2009-12-30 | ratiopharm GmbH | Pharmaceutical composition comprising N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene) methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide |
WO2010011834A2 (en) | 2008-07-24 | 2010-01-28 | Teva Pharmaceutical Industries Ltd. | Sunitinib and salts thereof and their polymorphs |
WO2010039798A2 (en) * | 2008-09-30 | 2010-04-08 | Teva Pharmaceutical Industries Ltd. | Amorphous compositions of sunitinib base and l-malic acid |
WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
CN103301116A (zh) * | 2012-03-16 | 2013-09-18 | 大鹏药品工业株式会社 | 口服医药组合物 |
PE20142406A1 (es) | 2012-05-04 | 2015-01-23 | Pfizer | Antigenos asociados a prostata y regimenes de inmunoterapia basados en vacuna |
CN104069076A (zh) * | 2013-03-29 | 2014-10-01 | 浙江九洲药业股份有限公司 | 一种无定型的舒尼替尼与pvp的组合物 |
PL3062815T3 (pl) | 2013-11-01 | 2019-07-31 | Pfizer Inc. | Wektory do ekspresji antygenów związanych z gruczołem krokowym |
WO2015110952A1 (en) | 2014-01-21 | 2015-07-30 | Wockhardt Limited | Solid oral pharmaceutical compositions comprising ticagrelor or salt thereof |
CN104829596B (zh) * | 2014-02-10 | 2017-02-01 | 石家庄以岭药业股份有限公司 | 吡咯取代吲哚酮类衍生物、其制备方法、包含该衍生物的组合物、及其用途 |
EP3539536A1 (en) | 2018-03-15 | 2019-09-18 | MH10 Spolka z ograniczona odpowiedzialnoscia | A pharmaceutical composition of sunitinib or its salt thereof in its polymorphic form i |
BR112021013383A2 (pt) * | 2019-01-09 | 2021-09-14 | Celgene Corporation | Composições farmacêuticas compreendendo (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-4-il)oxi)metil)benzil)piperazin-1-il)-3-fluorobenzonitrila e métodos para usar as mesmas |
US20230355581A1 (en) * | 2020-07-02 | 2023-11-09 | The Board of Regents of the Unversity of Texas System | Methods of treatment for melanoma |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4609675A (en) * | 1984-08-17 | 1986-09-02 | The Upjohn Company | Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing |
US6077533A (en) * | 1994-05-25 | 2000-06-20 | Purdue Pharma L.P. | Powder-layered oral dosage forms |
ES2367007T3 (es) * | 1999-11-24 | 2011-10-27 | Sugen, Inc. | Derivados de indolinona ionizables y su uso como ligandos de ptk. |
DE19956598A1 (de) * | 1999-11-25 | 2001-06-13 | Bosch Gmbh Robert | Ventil zum Steuern von Flüssigkeiten |
WO2001060814A2 (en) * | 2000-02-15 | 2001-08-23 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
CA2455050C (en) * | 2001-08-15 | 2007-02-20 | Pharmacia & Upjohn Company | Crystals including a malic acid salt of n-[2-(diethylamino) ethyl]-5-[(5-fluoro-2-oxo-3h-indole-3-ylidene) methyl]-2, 4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof |
TWI259081B (en) * | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
-
2003
- 2003-09-09 TW TW092124905A patent/TW200418836A/zh unknown
- 2003-09-09 HN HN2003000272A patent/HN2003000272A/es unknown
- 2003-09-10 DO DO2003000708A patent/DOP2003000708A/es unknown
- 2003-09-10 UY UY27969A patent/UY27969A1/es not_active IP Right Cessation
- 2003-09-10 PE PE2003000913A patent/PE20040989A1/es not_active Application Discontinuation
- 2003-09-10 NL NL1024261A patent/NL1024261C/nl not_active IP Right Cessation
- 2003-09-10 DK DK03772489T patent/DK1536783T3/da active
- 2003-09-10 MY MYPI20033418A patent/MY136767A/en unknown
- 2003-09-10 DE DE60322720T patent/DE60322720D1/de not_active Expired - Lifetime
- 2003-09-10 US US10/658,801 patent/US20040229930A1/en not_active Abandoned
- 2003-09-10 CA CA002498415A patent/CA2498415C/en not_active Expired - Lifetime
- 2003-09-10 NZ NZ538636A patent/NZ538636A/en unknown
- 2003-09-10 CN CNA038238500A patent/CN1688304A/zh active Pending
- 2003-09-10 PT PT03772489T patent/PT1536783E/pt unknown
- 2003-09-10 KR KR1020057004142A patent/KR20050059170A/ko not_active Application Discontinuation
- 2003-09-10 ES ES03772489T patent/ES2309363T5/es not_active Expired - Lifetime
- 2003-09-10 GT GT200300193A patent/GT200300193A/es unknown
- 2003-09-10 RU RU2005110663/15A patent/RU2005110663A/ru not_active Application Discontinuation
- 2003-09-10 AR ARP030103269A patent/AR041193A1/es not_active Application Discontinuation
- 2003-09-10 EP EP03772489A patent/EP1536783B2/en not_active Expired - Lifetime
- 2003-09-10 JP JP2004535803A patent/JP2006503032A/ja active Pending
- 2003-09-10 PA PA20038581801A patent/PA8581801A1/es unknown
- 2003-09-10 AU AU2003280108A patent/AU2003280108B2/en not_active Ceased
- 2003-09-10 WO PCT/IB2003/005293 patent/WO2004024127A2/en active IP Right Grant
- 2003-09-10 SI SI200331328T patent/SI1536783T1/sl unknown
- 2003-09-10 PL PL03375978A patent/PL375978A1/xx not_active Application Discontinuation
- 2003-09-10 BR BR0314182-9A patent/BR0314182A/pt not_active IP Right Cessation
- 2003-09-10 AT AT03772489T patent/ATE403425T1/de not_active IP Right Cessation
- 2003-09-10 MX MXPA05002690A patent/MXPA05002690A/es not_active Application Discontinuation
-
2005
- 2005-03-04 ZA ZA200501897A patent/ZA200501897B/en unknown
- 2005-04-04 NO NO20051670A patent/NO20051670L/no not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA:INT.CI. A61K 31/404, A61K 9/16, A61P 35/00 Ipc: A61K 31/404 (2011.01), A61K 9/16 (2011.01), A61P 3 |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |