BR0313122A - Antranilamidopiridinas inibidoras de vegfr-2 e vegfr-3 - Google Patents

Antranilamidopiridinas inibidoras de vegfr-2 e vegfr-3

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Publication number
BR0313122A
BR0313122A BR0313122-0A BR0313122A BR0313122A BR 0313122 A BR0313122 A BR 0313122A BR 0313122 A BR0313122 A BR 0313122A BR 0313122 A BR0313122 A BR 0313122A
Authority
BR
Brazil
Prior art keywords
vegfr
diseases
arthritis
preparation
compounds according
Prior art date
Application number
BR0313122-0A
Other languages
English (en)
Inventor
Andreas Huth
Martin Kr Ger
Ludwig Zorn
Stuart Ince
Karl-Heinz Thierauch
Andreas Menrad
Martin Haberey
Holger Hess-Stump
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10235690A external-priority patent/DE10235690A1/de
Priority claimed from DE10328036A external-priority patent/DE10328036A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of BR0313122A publication Critical patent/BR0313122A/pt

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

"ANTRANILAMIDOPIRIDINAS INIBIDORAS DE VEGFR-2 E VEGFR-3". A presente invenção refere-se à antranilamidopiridinamidas inibidoras de VEGFR-2 e VEGFR-3, sua preparação e emprego como medicamento para o tratamento de doenças, que são provocadas pela angiogênese persistente bem como produtos intermediários para a preparação dos compostos. Os compostos de acordo com a invenção, são empregáveis como ou no crescimento do tumor ou metástase, psoríase, sarcoma de Kaposi, restenose tal como restenose induzida pelo stent, endometriose, doença de Crohn, doença de Hodgkins, leucemia, artrite, tal como artrite reumatóide, hemangioma, angiofibroma, doenças dos olhos, tais como retinopatia diabética, glaucoma neovascular, doenças renais, tais como glomerulonefrite, nefropatia diabética, nefroscierose maligna, síndrome microangiopática trómbica, rejeições de transplantes e glomerulopatia, doenças fibróticas, tal como cirrose hepática, doenças proliferativas das células mesangiais, arteriosclerose, lesões do tecido nervoso e inibição da reoclusão de vasos após tratamento com cateter de balão, na prótese vascular ou após o implante de dispositivos mecânicos para manter a abertura dos vasos, tal como por exemplo, stents, como imunossupressívos, para o auxílio na cura de feridas sem cicatriz, manchas de velhice e dermatite de contato. Os compostos de acordo com a invenção, são igualmente aplicáveis como inibidores de VEGFR-3 na linfangiogênese.
BR0313122-0A 2002-07-31 2003-07-22 Antranilamidopiridinas inibidoras de vegfr-2 e vegfr-3 BR0313122A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10235690A DE10235690A1 (de) 2002-07-31 2002-07-31 VEGFR-2 und VEGFR-3 inhibitorische Anthranylamidpyridinamide
DE10328036A DE10328036A1 (de) 2003-06-19 2003-06-19 VEGFR-2 und VEGFR-3 inhibitorische Anthranylamidpyridine
PCT/EP2003/007964 WO2004013102A1 (de) 2002-07-31 2003-07-22 Vegfr-2 und vegfr-3 inhibitorische anthranylamidpyrimidene

Publications (1)

Publication Number Publication Date
BR0313122A true BR0313122A (pt) 2005-07-05

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BR0313122-0A BR0313122A (pt) 2002-07-31 2003-07-22 Antranilamidopiridinas inibidoras de vegfr-2 e vegfr-3

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EP (1) EP1594841A1 (pt)
JP (2) JP4777648B2 (pt)
KR (1) KR20050026535A (pt)
CN (1) CN1671666A (pt)
AU (1) AU2003281855A1 (pt)
BR (1) BR0313122A (pt)
CA (1) CA2493026C (pt)
CO (1) CO5720998A2 (pt)
CR (1) CR7673A (pt)
EC (1) ECSP055631A (pt)
HR (1) HRP20050187A2 (pt)
IL (1) IL166377A0 (pt)
MX (1) MXPA04012948A (pt)
NO (1) NO20051035L (pt)
PL (1) PL374610A1 (pt)
RS (1) RS20050084A (pt)
RU (1) RU2005105683A (pt)
WO (1) WO2004013102A1 (pt)

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