BR0307206A - Agentes de formação de imagem direcionados por integrina - Google Patents

Agentes de formação de imagem direcionados por integrina

Info

Publication number
BR0307206A
BR0307206A BR0307206-1A BR0307206A BR0307206A BR 0307206 A BR0307206 A BR 0307206A BR 0307206 A BR0307206 A BR 0307206A BR 0307206 A BR0307206 A BR 0307206A
Authority
BR
Brazil
Prior art keywords
integrin
nanoparticles
imaging agents
agents
directed imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
BR0307206-1A
Other languages
English (en)
Inventor
Gregory Lanza
Samuel A Wickline
Tom Harris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Barnes Hospital
Bristol-Myers Squibb Medical Imaging Inc
Original Assignee
Barnes Hospital
Bristol-Myers Squibb Medical Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Barnes Hospital, Bristol-Myers Squibb Medical Imaging Inc filed Critical Barnes Hospital
Publication of BR0307206A publication Critical patent/BR0307206A/pt
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"AGENTES DE FORMAçãO DE IMAGEM DIRECIONADOS POR INTEGRINA". Emulsões, preferencialmente de nanopartículas formadas a partir de substâncias perfluoroquímicas líquidas com alto ponto de ebulição, as referidas partículas revestidas com um revestimento de lipídio/tensoativo são feitas especificamente para regiões de células endoteliais, ativadas pela ligação das referidas nanopartículas a um ligando específico para integrina QvP3 que não seja um anticorpo. As nanopartículas podem ainda incluir agentes biologicamente ativos, radionuclídeos ou outros agentes de formação de imagem.
BR0307206-1A 2002-01-24 2003-01-24 Agentes de formação de imagem direcionados por integrina Expired - Fee Related BR0307206A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35139002P 2002-01-24 2002-01-24
PCT/US2003/002380 WO2003062198A1 (en) 2002-01-24 2003-01-24 Integrin targeted imaging agents

Publications (1)

Publication Number Publication Date
BR0307206A true BR0307206A (pt) 2004-12-21

Family

ID=27613494

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0307206-1A Expired - Fee Related BR0307206A (pt) 2002-01-24 2003-01-24 Agentes de formação de imagem direcionados por integrina

Country Status (14)

Country Link
US (3) US7255875B2 (pt)
EP (2) EP1572639A4 (pt)
JP (2) JP4731117B2 (pt)
KR (1) KR100978126B1 (pt)
CN (2) CN101249269A (pt)
AU (2) AU2003209392B2 (pt)
BR (1) BR0307206A (pt)
CA (1) CA2474386C (pt)
CO (1) CO5601001A2 (pt)
MX (1) MXPA04007188A (pt)
NZ (1) NZ534500A (pt)
TR (1) TR200401834T2 (pt)
WO (1) WO2003062198A1 (pt)
ZA (1) ZA200406686B (pt)

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Also Published As

Publication number Publication date
NZ534500A (en) 2007-07-27
AU2003209392B2 (en) 2008-10-09
US20040058951A1 (en) 2004-03-25
CA2474386C (en) 2011-07-05
CA2474386A1 (en) 2003-07-31
WO2003062198A3 (en) 2005-08-04
JP2010248248A (ja) 2010-11-04
CN1738815A (zh) 2006-02-22
US7566442B2 (en) 2009-07-28
JP4731117B2 (ja) 2011-07-20
MXPA04007188A (es) 2005-10-18
TR200401834T2 (tr) 2005-10-21
US20060147380A1 (en) 2006-07-06
CO5601001A2 (es) 2006-01-31
US7255875B2 (en) 2007-08-14
JP2005525319A (ja) 2005-08-25
EP2269659A1 (en) 2011-01-05
CN101249269A (zh) 2008-08-27
ZA200406686B (en) 2005-09-19
EP1572639A1 (en) 2005-09-14
US7344698B2 (en) 2008-03-18
KR100978126B1 (ko) 2010-08-26
EP1572639A4 (en) 2006-08-09
WO2003062198A8 (en) 2003-11-06
WO2003062198A1 (en) 2003-07-31
KR20040090986A (ko) 2004-10-27
JP5444154B2 (ja) 2014-03-19
CN100356984C (zh) 2007-12-26
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