BR0300660A - Method to quantify cytochrome c mitochondrial release, composition to detect cytochrome c mitochondrial release, kit to detect cytochrome c mitochondrial release, use of cytochrome c mitochondrial release composition - Google Patents

Method to quantify cytochrome c mitochondrial release, composition to detect cytochrome c mitochondrial release, kit to detect cytochrome c mitochondrial release, use of cytochrome c mitochondrial release composition

Info

Publication number
BR0300660A
BR0300660A BR0300660-3A BR0300660A BR0300660A BR 0300660 A BR0300660 A BR 0300660A BR 0300660 A BR0300660 A BR 0300660A BR 0300660 A BR0300660 A BR 0300660A
Authority
BR
Brazil
Prior art keywords
cytochrome
release
composition
mitochondrial release
mitochondrial
Prior art date
Application number
BR0300660-3A
Other languages
Portuguese (pt)
Other versions
BRPI0300660B8 (en
BRPI0300660B1 (en
Inventor
Roger F Castilho
Ricardo G Cosso
Claudia Barbosa Ladeira Campos
Anibal E Vercesi
Hagai Rottenberg
Original Assignee
Fapesp Fundacao De Amparo A Pe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fapesp Fundacao De Amparo A Pe filed Critical Fapesp Fundacao De Amparo A Pe
Priority to BRPI0300660A priority Critical patent/BRPI0300660B8/en
Publication of BR0300660A publication Critical patent/BR0300660A/en
Priority to PCT/BR2004/000022 priority patent/WO2004077007A2/en
Publication of BRPI0300660B1 publication Critical patent/BRPI0300660B1/en
Publication of BRPI0300660B8 publication Critical patent/BRPI0300660B8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G01N33/5735—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes co-enzymes or co-factors, e.g. NAD, ATP
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G01N2333/80—Cytochromes

Abstract

"MéTODO PARA QUANTIFICAR LIBERAçãO MITOCONDRIAL DE CITOCROMO c, COMPOSIçãO PARA DETECTAR LIBERAçãO MITOCONDRIAL DE CITOCROMO c, KIT PARA DETECTAR LIBERAçãO MITOCONDRIAL DE CITOCROMO c, USO DE COMPOSIçãO PARA LIBERAçãO MITOCONDRIAL DE CITOCROMO c". é descrito método para quantificar a liberação mitocondrial de citocromo c durante a morte celular comportando permeabilização seletiva da membrana plasmática e imunodetecção de citocromo c. A invenção reporta-se, ainda, à composição para detectar liberação mitocondrial de citocromo c, kit para detectar liberação mitocondrial de citocromo c, bem como uso de composição para liberação mitocondrial de citocromo c."METHOD FOR QUANTIFYING CITROCHROME MITCHONDRIAL RELEASE, COMPOSITION FOR DETECTING CITROCHROME MITCHONDRIAL RELEASE, CITROCHROME MITCHONDRIAL RELEASE FOR CITRONIC COMPOSITION. A method for quantifying mitochondrial cytochrome c release during cell death is described by selective plasma membrane permeabilization and cytochrome c immunodetection. The invention further relates to the composition for detecting cytochrome c mitochondrial release, kit for detecting cytochrome c mitochondrial release as well as the use of mitochondrial cytochrome c release composition.

BRPI0300660A 2003-02-28 2003-02-28 method to quantify mitochondrial release of cytochrome c and kit to detect mitochondrial release of cytochrome c BRPI0300660B8 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRPI0300660A BRPI0300660B8 (en) 2003-02-28 2003-02-28 method to quantify mitochondrial release of cytochrome c and kit to detect mitochondrial release of cytochrome c
PCT/BR2004/000022 WO2004077007A2 (en) 2003-02-28 2004-02-26 Detection, quantification and composition for cytochrome c released from mitochondria

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0300660A BRPI0300660B8 (en) 2003-02-28 2003-02-28 method to quantify mitochondrial release of cytochrome c and kit to detect mitochondrial release of cytochrome c

Publications (3)

Publication Number Publication Date
BR0300660A true BR0300660A (en) 2003-10-14
BRPI0300660B1 BRPI0300660B1 (en) 2017-02-21
BRPI0300660B8 BRPI0300660B8 (en) 2021-07-27

Family

ID=28679778

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0300660A BRPI0300660B8 (en) 2003-02-28 2003-02-28 method to quantify mitochondrial release of cytochrome c and kit to detect mitochondrial release of cytochrome c

Country Status (2)

Country Link
BR (1) BRPI0300660B8 (en)
WO (1) WO2004077007A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2738493T3 (en) 2013-03-14 2020-01-23 Tolero Pharmaceuticals Inc JAK2 and ALK2 inhibitors and methods for their use
CA3103995A1 (en) 2018-07-26 2020-01-30 Sumitomo Dainippon Pharma Oncology, Inc. Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same

Also Published As

Publication number Publication date
WO2004077007A2 (en) 2004-09-10
WO2004077007A3 (en) 2004-10-14
BRPI0300660B8 (en) 2021-07-27
BRPI0300660B1 (en) 2017-02-21

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