BR0211910A - Derivados de tiazolila 2,4,5-trissubstituìdos e a atividade antiinflamatória dos mesmos - Google Patents

Derivados de tiazolila 2,4,5-trissubstituìdos e a atividade antiinflamatória dos mesmos

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Publication number
BR0211910A
BR0211910A BR0211910-2A BR0211910A BR0211910A BR 0211910 A BR0211910 A BR 0211910A BR 0211910 A BR0211910 A BR 0211910A BR 0211910 A BR0211910 A BR 0211910A
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BR
Brazil
Prior art keywords
alkyl
aminocarbonyl
mono
amino
optionally substituted
Prior art date
Application number
BR0211910-2A
Other languages
English (en)
Inventor
Christopher John Love
Jean Pierre Frans Van Wauwe
Marc J De Brabander
Roger Clive Moses
Mykhalyo Goncharenko
Ludwig Paul Cooymans
Nele Vandermaesen
Gaston Stanilslas Marcel Diels
Anthony William Sibley
Caterina Noula
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR0211910A publication Critical patent/BR0211910A/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P17/06—Antipsoriatics
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Abstract

"DERIVADOS DE TIAZOLILA 2,4,5-TRISSUBSTITUìDOS E A ATIVIDADE ANTIINFLAMATóRIA DOS MESMOS". A presente invenção refere-se ao uso de um composto da fórmula (I), um N-óxido, um sal de adição farmaceuticamente aceitável, uma amina quaternária e uma forma estereoquimicamente isomérica do mesmo, no qual Z é haio; C~ 1-6~alquila; C~ 1-6~alquila substituída com hidróxi, carboxila, ciano, amino, mono- ou di(C~ 1-6~alquil)amino, aminocarbonila, mono- ou di(C~ 1-6~alquil)aminocarbonila, C~ 1-6~-alquiloxicarbonila ou C~ 1-6~alquilóxi; polihaloC~ 1-4~alquila; C~ 1-4~alquilóxi; ciano; amino; aminocarbonila; mono- ou di(C~ 1-6~alquil)aminocarbonila); C~ 1-6~alquiloxicarbonila; C~ 1-6~alquilcarbonilóxi; H~ 2~N-S(=0)~ 2~; mono-ou di(C~ 1-6~alquil)amino-S(=0)~ 2; -C(=N-Rx)NR~^ Y^R^ z^; Q é um carbociclo opcionalmente substituído ou um heterociclo opcionalmente substituído; L é fenila substituída ou um heterociclo monocíclico opcionalmente substituído de 5 ou 6 membros parcialmente saturado ou aromático ou um heterociclo bicíclico, parcialmente saturado ou aromático; arila é fenila opcionalmente substituída; para a produção de um medicamento para a prevenção ou tratamento de doenças mediadas através de TNF-<244> e/ou IL-12.
BR0211910-2A 2001-08-13 2002-08-09 Derivados de tiazolila 2,4,5-trissubstituìdos e a atividade antiinflamatória dos mesmos BR0211910A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203088 2001-08-13
PCT/EP2002/008956 WO2003015776A1 (en) 2001-08-13 2002-08-09 2,4,5-trisubstituted thiazolyl derivatives and their antiinflammatory activity

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BR0211910A true BR0211910A (pt) 2004-10-19

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BR0211910-2A BR0211910A (pt) 2001-08-13 2002-08-09 Derivados de tiazolila 2,4,5-trissubstituìdos e a atividade antiinflamatória dos mesmos

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US (1) US7138403B2 (pt)
EP (1) EP1418911B1 (pt)
JP (1) JP4491231B2 (pt)
KR (1) KR100922538B1 (pt)
CN (1) CN100502863C (pt)
AR (1) AR037232A1 (pt)
AT (1) ATE325608T1 (pt)
AU (1) AU2002331227B2 (pt)
BR (1) BR0211910A (pt)
CA (1) CA2451981C (pt)
DE (1) DE60211348T2 (pt)
EA (1) EA007933B1 (pt)
ES (1) ES2264734T3 (pt)
HK (1) HK1077507A1 (pt)
HR (1) HRP20040098B1 (pt)
HU (1) HUP0401160A3 (pt)
IL (2) IL160327A0 (pt)
MX (1) MXPA04001400A (pt)
MY (1) MY130780A (pt)
NO (1) NO327345B1 (pt)
NZ (1) NZ530772A (pt)
PL (1) PL210475B1 (pt)
TW (1) TWI268152B (pt)
UA (1) UA79756C2 (pt)
WO (1) WO2003015776A1 (pt)
ZA (1) ZA200401164B (pt)

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DE60211348T2 (de) 2007-02-08
KR20040043134A (ko) 2004-05-22
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