EA200400219A1 - Производные хинолина и их использование в качестве противоопухолевых средств - Google Patents

Производные хинолина и их использование в качестве противоопухолевых средств

Info

Publication number
EA200400219A1
EA200400219A1 EA200400219A EA200400219A EA200400219A1 EA 200400219 A1 EA200400219 A1 EA 200400219A1 EA 200400219 A EA200400219 A EA 200400219A EA 200400219 A EA200400219 A EA 200400219A EA 200400219 A1 EA200400219 A1 EA 200400219A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compound
tumor
facilities
quinoline derivatives
Prior art date
Application number
EA200400219A
Other languages
English (en)
Other versions
EA007205B1 (ru
Inventor
Джером П. Хорвитц
Стюарт Т. Хейзелдайн
Томас Х. Корбетт
Лиза Полин
Original Assignee
Вейне Стейт Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вейне Стейт Юниверсити filed Critical Вейне Стейт Юниверсити
Publication of EA200400219A1 publication Critical patent/EA200400219A1/ru
Publication of EA007205B1 publication Critical patent/EA007205B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Данное изобретение относится к соединениям формулы (I)где Y представляет собой F, Cl, Br, метил или метокси; и их фармацевтически приемлемым солям. Эти соединения являются эффективными противоопухолевыми средствами. Данное изобретение также относится к фармацевтическим композициям, включающим соединение формулы (I) или его соль, к полупродуктам, которые используются для получения соединения формулы (I), и к терапевтическим способам, включающим введение соединения формулы (I) или его соли млекопитающему, нуждающемуся в таком лечении.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400219A 2001-07-31 2002-07-31 Производные хинолина и их использование в качестве противоопухолевых средств EA007205B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30914401P 2001-07-31 2001-07-31
PCT/US2002/024442 WO2003011832A1 (en) 2001-07-31 2002-07-31 Quinoline derivatives and use thereof as antitumor agents

Publications (2)

Publication Number Publication Date
EA200400219A1 true EA200400219A1 (ru) 2004-12-30
EA007205B1 EA007205B1 (ru) 2006-08-25

Family

ID=23196886

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400219A EA007205B1 (ru) 2001-07-31 2002-07-31 Производные хинолина и их использование в качестве противоопухолевых средств

Country Status (22)

Country Link
US (3) US6867219B2 (ru)
EP (1) EP1412332B1 (ru)
JP (1) JP4310185B2 (ru)
KR (1) KR20040055774A (ru)
AT (1) ATE287397T1 (ru)
AU (1) AU2002355747B2 (ru)
CA (1) CA2456173A1 (ru)
DE (1) DE60202682T2 (ru)
DK (1) DK1412332T3 (ru)
EA (1) EA007205B1 (ru)
ES (1) ES2236548T3 (ru)
GE (1) GEP20063754B (ru)
HU (1) HUP0401562A2 (ru)
IL (2) IL160082A0 (ru)
MX (1) MXPA04000968A (ru)
NO (1) NO326463B1 (ru)
NZ (1) NZ530806A (ru)
PL (1) PL367340A1 (ru)
PT (1) PT1412332E (ru)
UA (1) UA75691C2 (ru)
WO (1) WO2003011832A1 (ru)
ZA (1) ZA200401185B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2401778C (en) * 2000-02-29 2010-12-21 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
ATE287397T1 (de) * 2001-07-31 2005-02-15 Univ Wayne State Chinoline derivate und ihre anwendung als antitumor agentien
UA79293C2 (en) * 2002-07-03 2007-06-11 Univ Wayne State 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents
RU2322236C2 (ru) * 2002-08-24 2008-04-20 Центарис Гмбх Лекарственное средство для лечения доброкачественных и злокачественных опухолевых заболеваний, содержащее производное дисоразола
US8183379B2 (en) 2005-09-07 2012-05-22 Wayne State University Antitumor agents
US7470788B2 (en) * 2005-09-07 2008-12-30 Wayne State University Antitumor agents
US20070054938A1 (en) * 2005-09-07 2007-03-08 Horwitz Jerome P Antitumor agents
EP1897542A1 (en) * 2006-09-07 2008-03-12 Sanofi-Aventis Aqueous formulation comprising an antitumor agent
JO2685B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
WO2009002955A1 (en) * 2007-06-27 2008-12-31 Sanofi-Aventis U.S. Llc Process for the preparation of (2r)-2-[4-(7-bromo-2-quinolyloxy)phenoxy]propanoic acid
CA2838387A1 (en) 2011-06-06 2012-12-13 Chevron Phillips Chemical Company Lp Use of metallocene compounds for cancer treatment
WO2024132001A1 (en) * 2022-12-21 2024-06-27 Charles University, Faculty Of Pharmacy In Hradec Kralove Multitarget nuclear receptor ligands based on 2-(4-(quinolin-2-yloxy)phenoxy)propanoic acid and 2-(4-(quinoxalin-2-yloxy)phenoxy)propanoic acid for the treatment of metabolic and liver diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6033389B2 (ja) 1979-02-22 1985-08-02 日産化学工業株式会社 複素環エ−テル系フェノシキ脂肪酸誘導体、その製造法および該誘導体を含有する除草剤
US6197728B1 (en) * 1980-08-06 2001-03-06 Nissan Chemical Industries Ltd. Quinoxaline derivatives and herbicidal composition
US5364831A (en) * 1980-08-06 1994-11-15 Nissan Chemical Industries Ltd. Quinoxaline derivatives and herbicidal composition
US5250690A (en) * 1985-05-02 1993-10-05 Dowelanco Haloalkoxy anilide derivatives of 2-4(-heterocyclic oxyphenoxy)alkanoic or alkenoic acids and their use as herbicides
ATE287397T1 (de) * 2001-07-31 2005-02-15 Univ Wayne State Chinoline derivate und ihre anwendung als antitumor agentien
UA79293C2 (en) * 2002-07-03 2007-06-11 Univ Wayne State 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents
US7470788B2 (en) * 2005-09-07 2008-12-30 Wayne State University Antitumor agents

Also Published As

Publication number Publication date
US20050159447A1 (en) 2005-07-21
MXPA04000968A (es) 2005-02-17
HUP0401562A2 (hu) 2004-12-28
PL367340A1 (en) 2005-02-21
JP2004538314A (ja) 2004-12-24
US20070232643A1 (en) 2007-10-04
PT1412332E (pt) 2005-06-30
DE60202682D1 (de) 2005-02-24
NO20040382L (no) 2004-03-26
ES2236548T3 (es) 2005-07-16
US20030144321A1 (en) 2003-07-31
NO326463B1 (no) 2008-12-08
EA007205B1 (ru) 2006-08-25
NZ530806A (en) 2006-05-26
UA75691C2 (en) 2006-05-15
WO2003011832A1 (en) 2003-02-13
US7507749B2 (en) 2009-03-24
IL160082A0 (en) 2004-06-20
CA2456173A1 (en) 2003-02-13
JP4310185B2 (ja) 2009-08-05
DE60202682T2 (de) 2005-12-29
US7241894B2 (en) 2007-07-10
GEP20063754B (en) 2006-02-27
US6867219B2 (en) 2005-03-15
EP1412332B1 (en) 2005-01-19
DK1412332T3 (da) 2005-05-30
ATE287397T1 (de) 2005-02-15
KR20040055774A (ko) 2004-06-26
AU2002355747B2 (en) 2007-12-20
IL160082A (en) 2009-06-15
ZA200401185B (en) 2004-10-21
EP1412332A1 (en) 2004-04-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU