BR0207811A - Compostos de uréia aril e heteroaril substituìdos úteis no tratamento de doenças - Google Patents

Compostos de uréia aril e heteroaril substituìdos úteis no tratamento de doenças

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Publication number
BR0207811A
BR0207811A BR0207811-2A BR0207811A BR0207811A BR 0207811 A BR0207811 A BR 0207811A BR 0207811 A BR0207811 A BR 0207811A BR 0207811 A BR0207811 A BR 0207811A
Authority
BR
Brazil
Prior art keywords
compounds useful
urea compounds
substituted aryl
treating diseases
heteroaryl urea
Prior art date
Application number
BR0207811-2A
Other languages
English (en)
Inventor
Kathleen S Keegan
Edward A Kesicki
John Joseph Gaudino
Adam Wade Cook
Scott Douglas Cowen
Laurence Edward Burgess
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of BR0207811A publication Critical patent/BR0207811A/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P35/00—Antineoplastic agents
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/20—Oxygen atoms
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

"COMPOSTOS DE URéIA ARIL E HETEROARIL SUBSTITUìDOS úTEIS NO TRATAMENTO DE DOENçAS". São revelados compostos de uréia aril e heteroaril substituídos úteis no tratamento de doenças e condições relacionadas a dano do DNA ou lesões na replicação de DNA. Também são revelados métodos de fabricação dos compostos, e seu uso como agentes terapêuticos, por exemplo, no tratamento de câncer e de outras doenças caracterizadas por defeitos na replicação de DNA, segregação de cromossomo, ou divisão celular. Quando W<39> for um anel aromático de seis membros contendo pelo menos 2 átomos de nitrogênio e opcionalmente substituído como definido nas reivindicações, Z<39> é um anel aromático ou heteroaromático de cinco ou seis membros como definido nas reivindicações, Y<39> é O ou S.
BR0207811-2A 2001-03-02 2002-03-01 Compostos de uréia aril e heteroaril substituìdos úteis no tratamento de doenças BR0207811A (pt)

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HRP20030688A2 (en) 2005-10-31
DK1379510T3 (da) 2011-08-29
CN100374425C (zh) 2008-03-12
US20050245525A1 (en) 2005-11-03
KR20080046228A (ko) 2008-05-26
US7067506B2 (en) 2006-06-27
GEP20053659B (en) 2005-11-10
ATE511503T1 (de) 2011-06-15
HK1062438A1 (en) 2004-11-05
CN1507436A (zh) 2004-06-23
EA200300947A1 (ru) 2004-04-29
NO20033858L (no) 2003-10-10
IS6935A (is) 2003-08-29
EP1379510B1 (en) 2011-06-01
EP1379510A1 (en) 2004-01-14
JP2004523568A (ja) 2004-08-05
CY1111590T1 (el) 2015-10-07
UA76977C2 (en) 2006-10-16
PL364564A1 (en) 2004-12-13
CA2439709C (en) 2011-05-03
PT1379510E (pt) 2011-07-15
ES2365504T3 (es) 2011-10-06
SI1379510T1 (sl) 2011-10-28
HRP20030688B1 (hr) 2013-12-06
KR20030078957A (ko) 2003-10-08
NZ527787A (en) 2005-12-23
YU69003A (sh) 2006-05-25
JP4222833B2 (ja) 2009-02-12
WO2002070494A1 (en) 2002-09-12
CA2439709A1 (en) 2002-09-12
KR100861829B1 (ko) 2008-10-07
IL157563A0 (en) 2004-03-28
AU2002258451B2 (en) 2006-08-31
EA014954B1 (ru) 2011-04-29

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