BR0206552A - Utilização de pelo menos uma quinoleìna, quinoleìna, e, composição farmacêutica - Google Patents
Utilização de pelo menos uma quinoleìna, quinoleìna, e, composição farmacêuticaInfo
- Publication number
- BR0206552A BR0206552A BR0206552-5A BR0206552A BR0206552A BR 0206552 A BR0206552 A BR 0206552A BR 0206552 A BR0206552 A BR 0206552A BR 0206552 A BR0206552 A BR 0206552A
- Authority
- BR
- Brazil
- Prior art keywords
- sub
- alkenyl
- quinoline
- alkynyl
- cho
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 4
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 5
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 208000003322 Coinfection Diseases 0.000 abstract 1
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 229940111121 antirheumatic drug quinolines Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003248 quinolines Chemical class 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"UTILIZAçãO DE PELO MENOS UMA QUINOLEìNA, QUINOLEìNA, E, COMPOSIçãO FARMACêUTICA". A invenção refere-se à utilização de quinoleínas de fórmula geral (I) em que R~ 1~ representa H, C~ 1~ - C~ 15~, alquenila ou alquinila C~ 2~C~ 15~, -CHO; heteroarila, alquila C~ 1~ - C~ 15~, ou alquenila ou alquinila C~ 2~ - C~ 7~, contendo pelo menos um substituinte escolhido dentre O, halogênio, -OH, -CHO, COOH, ariloxicarbonila, alquiloxicarbonila C~ 2~ - C~ 8~, alqueniloxicarbonila C~ 3~ - C~ 9~, nitrila, arila, heteroarila, arilsulfona, alquilsulfona C~ 1~ - C~ 7~, tioalquila ou aminoalquila C~ 1~ - C~ 7~, alquenila C~ 2~ - C~ 7~, contendo pelo menos um substituinte escolhido dentre -NH~ 2~, alcóxi C~ 1~ - C~ 7~, fenóxi, cicloalquila C~ 3~ - C~ 6~ ou heteroariloxi; alquileno ou alquinila C~ 2~ - C~ 15~ contendo pelo menos uma trialquilsilila C~ 1~ - C~ 7~; R~ 2~, na posição 3, 6 ou 8, representa H; halogênio; -OH; -CHO; -COOH; alquila ou alcóxi C~ 1~ - C~ 7~ -NH2, alquenila C~ 2~ - C~ 7~, ou alquinila C~ 2~ - C~ 10~; R~ 1~ e R~ 2~ não sendo, todos os dois, H; para a preparação de um medicamento para tratar as co-infecções provocadas por protozoários e retrovírus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0100580A FR2819507B1 (fr) | 2001-01-17 | 2001-01-17 | Quinoleines substituees pour le traitement de co-infections a protozoaires et a retrovirus |
PCT/FR2002/000140 WO2002057238A1 (fr) | 2001-01-17 | 2002-01-15 | Quinoleines substituees pour le traitement de co-infections a protozoaires et a retrovirus |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0206552A true BR0206552A (pt) | 2004-03-23 |
Family
ID=8858905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0206552-5A BR0206552A (pt) | 2001-01-17 | 2002-01-15 | Utilização de pelo menos uma quinoleìna, quinoleìna, e, composição farmacêutica |
Country Status (9)
Country | Link |
---|---|
US (1) | US7342026B2 (pt) |
EP (1) | EP1351940B1 (pt) |
AT (1) | ATE368030T1 (pt) |
BR (1) | BR0206552A (pt) |
CA (1) | CA2434063C (pt) |
DE (1) | DE60221348T2 (pt) |
ES (1) | ES2291438T3 (pt) |
FR (1) | FR2819507B1 (pt) |
WO (1) | WO2002057238A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0603871B8 (pt) * | 2006-08-24 | 2021-05-25 | Fundacao Univ De Brasilia | composições farmacêuticas para o tratamento de tripanossomíases e de doença de chagas |
KR20100108337A (ko) * | 2007-11-15 | 2010-10-06 | 베링거 인겔하임 인터내셔날 게엠베하 | 사람 면역결핍 바이러스 복제의 억제제 |
CA2705318C (en) * | 2007-11-15 | 2013-12-31 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
JP5285709B2 (ja) * | 2007-11-16 | 2013-09-11 | ギリアード サイエンシス インコーポレーテッド | ヒト免疫不全ウイルスの複製阻害薬 |
EP2220084B1 (en) * | 2007-11-16 | 2014-02-19 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
FR2929943B1 (fr) * | 2008-04-15 | 2010-09-24 | Inst Rech Developpement Ird | Sels de quinoleines 2-substituees |
FR2931479B1 (fr) * | 2008-05-20 | 2012-12-07 | I R D | Nouveaux derives de quinoleines 2-substituees et un procede pour leur preparation |
FR2933977B1 (fr) * | 2008-07-18 | 2013-04-26 | Centre Nat Rech Scient | Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives |
WO2010144101A1 (en) * | 2009-06-09 | 2010-12-16 | The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of U.S. | Next generation quinoloine methanols |
CN103140474A (zh) | 2010-07-02 | 2013-06-05 | 吉里德科学公司 | 治疗aids的萘-2-基乙酸衍生物 |
CN103209963A (zh) * | 2010-07-02 | 2013-07-17 | 吉里德科学公司 | 作为hiv抗病毒化合物的2-喹啉基-乙酸衍生物 |
BR112013027096A2 (pt) | 2011-04-21 | 2016-12-27 | Gilead Sciences Inc | compostos de benzotiazol e seu uso farmacêutico |
US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
WO2013103738A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
MD20140063A2 (ro) | 2012-04-20 | 2014-12-31 | Gilead Sciences, Inc. | Derivaţi de acid benzotiazol-6-il acetic şi utilizarea acestora pentru tratarea unei infecţii HIV |
CN102690042A (zh) * | 2012-05-28 | 2012-09-26 | 常熟市建华模具有限责任公司 | 一种用于制作玻璃容器用的模具 |
US9302992B2 (en) | 2013-04-02 | 2016-04-05 | Annji Pharmaceutical Co., Ltd. | Multifunctional quinoline derivatives as anti-neurodegenerative agents |
WO2014163622A1 (en) * | 2013-04-02 | 2014-10-09 | Annji Pharmaceutical Co., Ltd. | Multifunctional quinoline derivatives as anti-neurodegenerative agents |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH471810A (de) * | 1964-10-22 | 1969-04-30 | Ciba Geigy | Verfahren zur Herstellung von neuen heterocyclischen Verbindungen |
ES8801209A1 (es) * | 1985-06-18 | 1988-01-01 | Merck Frosst Canada Inc | Un procedimiento para la preparacion de quinolinas 2-sustituidas. |
IL83715A0 (en) * | 1987-08-31 | 1988-01-31 | Yeda Res & Dev | Pharmaceutical anti-protozoal compositions |
US5153202A (en) * | 1988-06-30 | 1992-10-06 | Davis Michael H | Method of inhibiting the activity of human immuno deficiency virus (HIV) in vivo |
US5278173A (en) * | 1988-06-30 | 1994-01-11 | Davis Michael H | Method of inhibiting the activity of human immunodeficiency virus (HIV) in vivo |
US5360811A (en) * | 1990-03-13 | 1994-11-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents |
FR2682107B1 (fr) * | 1991-10-03 | 1995-04-21 | Orstom Inst Fs Rech Scient | Quinoleines 2-substituees pour le traitement des leishmanioses. |
GB9614347D0 (en) | 1996-07-09 | 1996-09-04 | Smithkline Beecham Spa | Novel compounds |
FR2761687B1 (fr) | 1997-04-08 | 2000-09-15 | Centre Nat Rech Scient | Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques |
WO2000044387A1 (fr) * | 1999-01-29 | 2000-08-03 | Nitto Kasei Co., Ltd. | Composes organobores presentant une activite de coccidiostats |
US6309663B1 (en) * | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
EP1206568A2 (en) * | 1999-08-30 | 2002-05-22 | K.U. Leuven Research & Development | Target for antiparasitic agents and inhibitors thereof |
-
2001
- 2001-01-17 FR FR0100580A patent/FR2819507B1/fr not_active Expired - Fee Related
-
2002
- 2002-01-15 AT AT02700323T patent/ATE368030T1/de active
- 2002-01-15 ES ES02700323T patent/ES2291438T3/es not_active Expired - Lifetime
- 2002-01-15 WO PCT/FR2002/000140 patent/WO2002057238A1/fr active IP Right Grant
- 2002-01-15 CA CA2434063A patent/CA2434063C/fr not_active Expired - Fee Related
- 2002-01-15 US US10/466,566 patent/US7342026B2/en not_active Expired - Fee Related
- 2002-01-15 EP EP02700323A patent/EP1351940B1/fr not_active Expired - Lifetime
- 2002-01-15 DE DE60221348T patent/DE60221348T2/de not_active Expired - Lifetime
- 2002-01-15 BR BR0206552-5A patent/BR0206552A/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20050165052A1 (en) | 2005-07-28 |
US7342026B2 (en) | 2008-03-11 |
WO2002057238A1 (fr) | 2002-07-25 |
DE60221348T2 (de) | 2008-04-10 |
FR2819507B1 (fr) | 2007-09-28 |
DE60221348D1 (de) | 2007-09-06 |
ES2291438T3 (es) | 2008-03-01 |
EP1351940A1 (fr) | 2003-10-15 |
EP1351940B1 (fr) | 2007-07-25 |
CA2434063A1 (fr) | 2002-07-25 |
ATE368030T1 (de) | 2007-08-15 |
FR2819507A1 (fr) | 2002-07-19 |
CA2434063C (fr) | 2011-08-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 12A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2258 DE 15/04/2014. |