BR0116263A - Derivados de diidroindol e tetraidroquinolina - Google Patents

Derivados de diidroindol e tetraidroquinolina

Info

Publication number
BR0116263A
BR0116263A BR0116263-2A BR0116263A BR0116263A BR 0116263 A BR0116263 A BR 0116263A BR 0116263 A BR0116263 A BR 0116263A BR 0116263 A BR0116263 A BR 0116263A
Authority
BR
Brazil
Prior art keywords
tetrahydroquinoline derivatives
dihydroindole
compounds
treatment
pharmaceutically acceptable
Prior art date
Application number
BR0116263-2A
Other languages
English (en)
Inventor
Johannes Aebi
Jean Ackermann
Alexander Chucholowski
Henrietta Dehmlow
Olivier Morand
Sabine Wallbaum
Thomas Weller
Narendra Panday
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0116263A publication Critical patent/BR0116263A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Abstract

"DERIVADOS DE DIIDROINDOL E TETRAIDROQUINOLINA". A presente invenção diz respeito a compostos de fórmula (I) em que U, A^ 1^, A^ 2^, A^ 3^, A^ 5^, L, V, W, X, m e n são como definidos na descrição e reivindicações, e sais farmaceuticamente aceitáveis e/ou ésteres farmaceuticamente aceitáveis destes. Os compostos são úteis para o tratamento e/ou profilaxia de doenças que são associadas com 2,3-oxidoesqualenolanosterol ciclase tais como hipercolesterolemia, hiperlipemia, arteriosclerose, doenças vasculares, micoses, cálculos biliares, tumores e/ou distúrbios hiperproliferativas, e tratamento e/ou profilaxia de tolerância a glicose prejudicada e diabetes.
BR0116263-2A 2000-12-21 2001-12-12 Derivados de diidroindol e tetraidroquinolina BR0116263A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00128063 2000-12-21
PCT/EP2001/014620 WO2002050041A1 (en) 2000-12-21 2001-12-12 Dihydroindole and tetrahydroquinoline derivatives

Publications (1)

Publication Number Publication Date
BR0116263A true BR0116263A (pt) 2003-12-30

Family

ID=8170751

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116263-2A BR0116263A (pt) 2000-12-21 2001-12-12 Derivados de diidroindol e tetraidroquinolina

Country Status (15)

Country Link
US (2) US6706751B2 (pt)
EP (1) EP1358162B1 (pt)
JP (1) JP4068459B2 (pt)
KR (1) KR100530408B1 (pt)
CN (1) CN1208322C (pt)
AR (1) AR035408A1 (pt)
AT (1) ATE317386T1 (pt)
AU (2) AU2002219176B2 (pt)
BR (1) BR0116263A (pt)
CA (1) CA2431100C (pt)
DE (1) DE60117096T2 (pt)
ES (1) ES2257381T3 (pt)
MX (1) MXPA03005395A (pt)
WO (1) WO2002050041A1 (pt)
ZA (1) ZA200304646B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR037647A1 (es) 2002-05-29 2004-12-01 Novartis Ag Derivados de diarilurea utiles para el tratamiento de enfermedades dependientes de la cinasa de proteina
ES2342596T3 (es) * 2002-08-29 2010-07-09 MERCK SHARP & DOHME CORP. Indoles con actividad anti-diabetica.
WO2005014755A1 (ja) * 2003-08-08 2005-02-17 Ube Industries, Ltd. アルキニル基置換縮合ヘテロ環化合物及びその製法並びにそれを使用する有機エレクトロルミネッセンス素子
TWI329102B (en) * 2006-08-15 2010-08-21 Nat Health Research Institutes Thiourea compounds and method for inhibiting hepatitis c virus infection
US7985763B2 (en) * 2007-04-10 2011-07-26 National Health Research Institutes Hepatitis C virus inhibitors
TW200848016A (en) * 2007-06-08 2008-12-16 Nat Health Research Institutes Thiourea compound and composition of treating hepatitis C virus infection
TWI361808B (en) * 2008-01-08 2012-04-11 Nat Health Research Institutes Imidazolidinone and imidazolidinethione derivatives
US8198284B2 (en) * 2008-04-30 2012-06-12 National Health Research Institutes Treatment of neurodegenerative disorders with thiourea compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997542A (en) * 1975-06-23 1976-12-14 Sterling Drug Inc. 1-(Halogenated-acetyl)-1,2,3,4-tetrahydro-6-quinolinols and esters thereof
NZ227042A (en) 1987-11-27 1991-05-28 Banyu Pharma Co Ltd Substituted alkylamine derivatives and pharmaceutical compositions
US5288749A (en) 1991-12-20 1994-02-22 Abbott Laboratories Tertiary and secondary amines as alpha-2 antagonists and serotonin uptake inhibitors
TW438774B (en) 1993-07-14 2001-06-07 Hoffmann La Roche Pharmaceutical composition for lowering cholesterol containing phenalkylamines and certain novel phenalkylamines
WO1997028128A1 (en) 1996-02-02 1997-08-07 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
DE19727117A1 (de) 1997-06-26 1999-01-07 Boehringer Ingelheim Pharma Phenylalkylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
CA2408913A1 (en) 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Melanin-concentrating hormone antagonist

Also Published As

Publication number Publication date
DE60117096T2 (de) 2006-11-23
ATE317386T1 (de) 2006-02-15
US20030004156A1 (en) 2003-01-02
US20050020624A1 (en) 2005-01-27
JP2004519441A (ja) 2004-07-02
EP1358162B1 (en) 2006-02-08
ES2257381T3 (es) 2006-08-01
JP4068459B2 (ja) 2008-03-26
AU2002219176B2 (en) 2006-02-09
KR100530408B1 (ko) 2005-11-22
CA2431100C (en) 2009-03-24
EP1358162A1 (en) 2003-11-05
WO2002050041A1 (en) 2002-06-27
ZA200304646B (en) 2004-09-13
MXPA03005395A (es) 2003-09-25
AU1917602A (en) 2002-07-01
CN1208322C (zh) 2005-06-29
CA2431100A1 (en) 2002-06-27
DE60117096D1 (de) 2006-04-20
US7102007B2 (en) 2006-09-05
KR20030063453A (ko) 2003-07-28
US6706751B2 (en) 2004-03-16
CN1481366A (zh) 2004-03-10
AR035408A1 (es) 2004-05-26

Similar Documents

Publication Publication Date Title
BR0209957A (pt) Composto, processo para a preparação de um composto, composição farmacêutica que compreende um composto, utilização desse composto e processo para o tratamento e profilaxia de artrite, diabetes, distúrbios alimentares e obesidade
BR0113710A (pt) Compostos, processo para a preparação e utilização dos mesmos, composição farmacêutica, processo para o tratamento e profilaxia de artrite, enfermidades cardiovasculares, diabetes, insuficiência renal, distúrbios alimentares e obesidade
BR0215240A (pt) Derivados de calcona e seu uso no tratamento de doenças
DE50011582D1 (de) Neuartige dicarbonsäurederivate mit pharmazeutischen eigenschaften
BR0112395A (pt) Derivados de benzotiazol
BR0212929A (pt) Compostos, processo para a preparação de um composto, composição farmacêutica que compreende o mesmo, utilização de compostos, e método para o tratamento e profilaxia de artrite, enfermidades cardiovasculares, diabetes, disfunção renal, distúrbios alimentares e obesidade
BR0215396A (pt) Compostos, processo para a manufatura de compostos, composições farmacêuticas, método para o tratamento e/ou profilaxia de enfermidades que estão associadas com "dpp-iv" e utilização dos compostos
TR200000129T2 (tr) Yepyeni spiroazabisiklik heterosiklik bileşikler.
HU9600834D0 (en) Quinazoline derivatives
BR0316723A (pt) Derivados de anilinopirazol úteis para o tratamento de diabetes
BR0015322A (pt) Derivados de indeno-, nafto- e benzociclohepta-dihidrotiazol, sua preparação e seu emprego como medicamentos anoréticos
BRPI0414630A (pt) derivados ciclohexìlicos substituìdos com aminoalquilamida
BR0115045A (pt) Compostos, processo para sua preparação, composição farmacêutica que compreende os mesmos, sua utilização, processo para o tratamento e profilaxia de artrite, diabetes, distúrbios alimentares e obesidade
BR0213037A (pt) Derivados de pirimidina
BR0113408A (pt) Derivados de aminociclohexano
BR0308108A (pt) Compostos; processo para a preparação de composto; composição farmacêutica que compreende o mesmo, utilização dos compostos e método de tratamento e profilaxia de enfermidades e de obesidade
BR0116263A (pt) Derivados de diidroindol e tetraidroquinolina
BR0013313A (pt) Derivados substituìdos de pirrolidino-2,3,4- triona-3-oxina eficazes como antagonistas de receptores de nmda
BR0115075A (pt) Benzo'b!tiofenos e benzo'd!isotiazóis para baixamento de colesterol
BR0215257A (pt) Compostos, processos para a manufatura de compostos, composições farmacêuticas, método para o tratamento e/ou profilaxia de enfermidades que estão associadas com "osc" e utilização dos compostos
BR9805437A (pt) Derivados de benzocicloalquenos heterocìclicos, processo para fabricação de derivados de benzocicloalquenos heterocìclicos e uso de derivados de benzocicloalquenos heterocìclicos.
BR0112609A (pt) Derivados de anilina
EE200200088A (et) Bis-sulfoonamiidide kasutamine ravimite valmistamiseks, mis on ette nähtud hüperlipideemia ärahoidmiseks või raviks
BR0113752A (pt) Derivados piperidina para uso inibidores 2,3-óxido esqualeno lanoesterol ciclase
HUP9904030A2 (hu) Tiagabin felhasználása pszichotikus rendellenességek kezelésére alkalmas gyógyszer előállítására

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUI DADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2125 DE 27/09/2011.