BR0115075A - Benzo'b!tiofenos e benzo'd!isotiazóis para baixamento de colesterol - Google Patents

Benzo'b!tiofenos e benzo'd!isotiazóis para baixamento de colesterol

Info

Publication number
BR0115075A
BR0115075A BR0115075-8A BR0115075A BR0115075A BR 0115075 A BR0115075 A BR 0115075A BR 0115075 A BR0115075 A BR 0115075A BR 0115075 A BR0115075 A BR 0115075A
Authority
BR
Brazil
Prior art keywords
benzo
thiophenes
compounds
isothiazoles
cholesterol lowering
Prior art date
Application number
BR0115075-8A
Other languages
English (en)
Inventor
Johannes Aebi
Jean Ackermann
Henrietta Dehmlow
Hans-Peter Maerki
Olivier Morand
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0115075A publication Critical patent/BR0115075A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

"BENZO'B!TIOFENOS E BENZO'D!ISOTIAZóIS PARA BAIXAMENTO DE COLESTEROL". A presente invenção refere-se a compostos de fórmula (I), onde U, A^ 1^, A^ 2^, A^ 3^, A^ 4^, V, X, Y, Z, Q, m e n são como definidos na descrição e reivindicações, e a sais farmaceuticamente aceitáveis e/ou ésteres farmaceuticamente aceitáveis desses compostos. Os compostos são úteis para o tratamento e/ou profilaxia de doenças que são associadas a 2,3-oxidoesqualeno-lanosterol ciclase tais como hipercolesterolemia, hiperlipemia, arteriosclerose, doenças vasculares, micoses, cálculos biliares, tumores e/ou distúrbios hiperproliferativos, e tratamento e/ou profilaxia de tolerância prejudicada a glicose e de diabetes.
BR0115075-8A 2000-11-02 2001-10-26 Benzo'b!tiofenos e benzo'd!isotiazóis para baixamento de colesterol BR0115075A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00123826 2000-11-02
PCT/EP2001/012451 WO2002036584A1 (en) 2000-11-02 2001-10-26 Cholesterol lowering benzo`b! thiophenes and benzo`d! isothiazoles

Publications (1)

Publication Number Publication Date
BR0115075A true BR0115075A (pt) 2003-07-29

Family

ID=8170270

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0115075-8A BR0115075A (pt) 2000-11-02 2001-10-26 Benzo'b!tiofenos e benzo'd!isotiazóis para baixamento de colesterol

Country Status (21)

Country Link
US (3) US6951879B2 (pt)
EP (1) EP1334094B1 (pt)
JP (1) JP4012064B2 (pt)
KR (1) KR100545430B1 (pt)
CN (1) CN1261429C (pt)
AR (1) AR034271A1 (pt)
AT (1) ATE286042T1 (pt)
AU (2) AU2002214029B2 (pt)
BR (1) BR0115075A (pt)
CA (1) CA2426009C (pt)
DE (1) DE60108164T2 (pt)
DK (1) DK1334094T3 (pt)
ES (1) ES2233703T3 (pt)
GT (1) GT200100220A (pt)
MX (1) MXPA03003845A (pt)
PA (1) PA8531601A1 (pt)
PE (1) PE20020600A1 (pt)
PT (1) PT1334094E (pt)
UY (1) UY27009A1 (pt)
WO (1) WO2002036584A1 (pt)
ZA (1) ZA200302742B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2418744C (en) 2000-08-16 2010-04-20 F. Hoffmann-La Roche Ag Novel aminocyclohexane derivatives
US7012077B2 (en) * 2001-12-20 2006-03-14 Hoffmann-La Roche Inc. Substituted cyclohexane derivatives
EP1647549A1 (en) * 2004-10-14 2006-04-19 Laboratoire Theramex Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents
EP1807082A4 (en) * 2004-10-26 2010-12-01 Janssen Pharmaceutica Nv INHIBITOR COMPOUNDS OF XA FACTORS
CN101213172A (zh) * 2005-06-30 2008-07-02 拜尔农作物科学股份公司 具有杀虫作用的(二取代丙烯基)苯基烷基取代的杂环类化合物的改良的制备方法
FR2913019A1 (fr) * 2007-02-23 2008-08-29 Cerep Sa Composes heterocycliques comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire
WO2009069011A1 (en) * 2007-11-29 2009-06-04 Ranbaxy Laboratories Limited Process for the preparation of substituted 1,3-oxathiolanes
BRPI0820224A2 (pt) * 2007-11-29 2015-06-16 Ranbaxy Lab Ltd Composto de fórmula iii ou seus estereoisômeros; processo para sua preparação e seu uso; uso de um composto de formula iii(a) ou iii(b) em um processo para a preparação de lamivudina de fórmula i(a) ou um composto de fórmula i(c); processo para preparação de lamivudina de fórmula i(a)
WO2012092114A2 (en) 2010-12-27 2012-07-05 The Curators Of The University Of Missouri Oxidosqualene cyclase as a protein target for anticancer therapeutics

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598839A (en) * 1969-06-30 1971-08-10 Parke Davis & Co Phenylbenzothiophene compounds
GR75101B (pt) * 1980-10-23 1984-07-13 Pfizer
GB8417559D0 (en) * 1984-07-10 1984-08-15 Pfizer Ltd Anti-diarrhoeal agents
DE3905364A1 (de) 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool
EP0530149A1 (de) * 1991-08-30 1993-03-03 Ciba-Geigy Ag Schädlingsbekämpfungsmittel
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
CA2190699A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Tertiary amines
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні

Also Published As

Publication number Publication date
CA2426009A1 (en) 2002-05-10
AU2002214029B2 (en) 2004-12-23
US7449483B2 (en) 2008-11-11
CN1471522A (zh) 2004-01-28
PT1334094E (pt) 2005-05-31
PE20020600A1 (es) 2002-07-08
JP4012064B2 (ja) 2007-11-21
AU1402902A (en) 2002-05-15
EP1334094B1 (en) 2004-12-29
MXPA03003845A (es) 2003-07-28
US20020086891A1 (en) 2002-07-04
ATE286042T1 (de) 2005-01-15
DK1334094T3 (da) 2005-05-02
KR100545430B1 (ko) 2006-01-24
DE60108164D1 (de) 2005-02-03
AR034271A1 (es) 2004-02-18
UY27009A1 (es) 2002-06-20
CN1261429C (zh) 2006-06-28
PA8531601A1 (es) 2003-02-14
US20070099985A1 (en) 2007-05-03
GT200100220A (es) 2002-07-04
KR20030045166A (ko) 2003-06-09
EP1334094A1 (en) 2003-08-13
US6951879B2 (en) 2005-10-04
CA2426009C (en) 2008-10-07
US20050267200A1 (en) 2005-12-01
JP2004513124A (ja) 2004-04-30
WO2002036584A1 (en) 2002-05-10
ES2233703T3 (es) 2005-06-16
US7173043B2 (en) 2007-02-06
ZA200302742B (en) 2004-07-08
DE60108164T2 (de) 2006-03-02

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM ART. 8O COMBINADO COM ART. 13, ART. 10 E ART. 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.