BR0213037A - Derivados de pirimidina - Google Patents
Derivados de pirimidinaInfo
- Publication number
- BR0213037A BR0213037A BR0213037-8A BR0213037A BR0213037A BR 0213037 A BR0213037 A BR 0213037A BR 0213037 A BR0213037 A BR 0213037A BR 0213037 A BR0213037 A BR 0213037A
- Authority
- BR
- Brazil
- Prior art keywords
- pyrimidine derivatives
- treatment
- inhibition
- therapy
- diseases
- Prior art date
Links
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract 3
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
"DERIVADOS DE PIRIMIDINA". A invenção refere-se a derivados de pirimidina da fórmula (I) e os sais fisiologicamente aceitáveis dos mesmos, em que R^ 1^, R^ 2^, R^ 3^, R^ 4^, W X, Y e Z são como definido na reivindicação 1, exibem inibição da fosfodiesterase V e podem ser empregados para o tratamento de doenças do sistema cardiovascular e para o tratamento e/ou para a terapia de distúrbios d potência.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10148883A DE10148883A1 (de) | 2001-10-04 | 2001-10-04 | Pyrimidinderivate |
PCT/EP2002/009935 WO2003031447A2 (de) | 2001-10-04 | 2002-09-05 | Pyrimidinderivate mit pde-v hemmender wirkung |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0213037A true BR0213037A (pt) | 2004-10-05 |
Family
ID=7701322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0213037-8A BR0213037A (pt) | 2001-10-04 | 2002-09-05 | Derivados de pirimidina |
Country Status (16)
Country | Link |
---|---|
US (1) | US7312224B2 (pt) |
EP (1) | EP1432715B1 (pt) |
JP (1) | JP4782376B2 (pt) |
KR (1) | KR20040041166A (pt) |
CN (1) | CN1863803A (pt) |
AT (1) | ATE389655T1 (pt) |
AU (1) | AU2002362806B2 (pt) |
BR (1) | BR0213037A (pt) |
CA (1) | CA2462799C (pt) |
DE (2) | DE10148883A1 (pt) |
ES (1) | ES2303564T3 (pt) |
HU (1) | HUP0401654A3 (pt) |
PL (1) | PL369819A1 (pt) |
RU (1) | RU2004114239A (pt) |
WO (1) | WO2003031447A2 (pt) |
ZA (1) | ZA200403334B (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005061171A1 (de) * | 2005-12-21 | 2007-07-05 | Bayer Healthcare Ag | Neue, cyclisch substituierte Furopyrimidin-Derivate und ihre Verwendung |
DE102005061170A1 (de) * | 2005-12-21 | 2007-07-05 | Bayer Healthcare Ag | Neue, acyclisch substituierte Furopyrimidin-Derivate und ihre Verwendung |
AR062501A1 (es) * | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | Composiciones terapeuticas |
CA2671782C (en) * | 2006-12-07 | 2017-01-10 | F. Hoffmann-La Roche Ag | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
DE102007027799A1 (de) * | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte Furopyrimidine und ihre Verwendung |
DE102007027800A1 (de) * | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung |
DE102007051762A1 (de) * | 2007-10-30 | 2009-05-07 | Bayer Healthcare Ag | Substituierte Pyrrolotriazine und ihre Verwendung |
DE102007054786A1 (de) * | 2007-11-16 | 2009-05-20 | Bayer Healthcare Ag | Trisubstituierte Furopyrimidine und ihre Verwendung |
WO2011143607A1 (en) * | 2010-05-14 | 2011-11-17 | The Regents Of The University Of California | Modulation of bioactive epoxy-fatty acid levels by phosphodiesterase inhibitors |
JP6042331B2 (ja) | 2010-07-23 | 2016-12-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | プロテアソーム活性を向上させる三環系化合物 |
EP2806875B1 (en) * | 2012-01-25 | 2017-07-19 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating compounds |
WO2016042349A1 (en) | 2014-09-17 | 2016-03-24 | Pécsi Tudományegyetem | New agents for treating neurogenic inflammation and neuropathic hyperalgesia related disorders |
US10813894B2 (en) | 2015-02-20 | 2020-10-27 | The Regents Of The University Of California | Methods of inhibiting pain |
CN108137614B (zh) * | 2015-12-02 | 2021-01-05 | 深圳市塔吉瑞生物医药有限公司 | 一种稠合嘧啶化合物及包含该化合物的组合物及其用途 |
CN105461728A (zh) * | 2015-12-29 | 2016-04-06 | 中山大学 | 一种4-取代胺基-6-甲氧羰基苯并呋喃并[2,3-d]嘧啶类化合物及制备方法 |
RU2625316C1 (ru) * | 2016-04-13 | 2017-07-13 | Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) | 2-АМИНОЗАМЕЩЕННЫЕ 6-МЕТОКСИ-4-ТРИФТОРМЕТИЛ-9Н-ПИРИМИДО[4,5b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ, ПРИМЕНЕНИЕ И ПРЕДШЕСТВЕННИКИ |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3037980A (en) * | 1955-08-18 | 1962-06-05 | Burroughs Wellcome Co | Pyrrolopyrimidine vasodilators and method of making them |
GB915304A (en) * | 1958-03-13 | 1963-01-09 | Wellcome Found | Pyrrolo[2,3-d]pyrimidine derivatives |
JPS5542999B2 (pt) * | 1972-02-14 | 1980-11-04 | ||
CH592668A5 (pt) * | 1973-10-02 | 1977-10-31 | Delalande Sa | |
ZA815765B (en) * | 1980-08-22 | 1983-04-27 | Du Pont | Herbicidal sulfonamides |
US4487626A (en) | 1980-08-22 | 1984-12-11 | E. I. Du Pont De Nemours And Company | Herbicidal sulfonamides |
DE69027862T2 (de) | 1989-09-19 | 1997-03-06 | Teijin Ltd | Pyrrolo[2,3-d]pyrimidinderivate, verfahren zur herstellung und arzneimittelzusammensetzungen die diese enthalten |
JP2562520B2 (ja) * | 1989-09-19 | 1996-12-11 | 帝人株式会社 | ピロロ〔2,3ーd〕ピリミジン誘導体、その製造方法およびそれを有効成分とする医薬製剤 |
US5869486A (en) | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
DE19644228A1 (de) | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
DE19752952A1 (de) | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
DE19819023A1 (de) | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
AU763658B2 (en) | 1998-06-02 | 2003-07-31 | Osi Pharmaceuticals, Inc. | Pyrrolo(2,3d)pyrimidine compositions and their use |
DE19942474A1 (de) | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
DE19944604A1 (de) | 1999-09-17 | 2001-03-22 | Merck Patent Gmbh | Aminderivate |
ATE335489T1 (de) | 1999-12-02 | 2006-09-15 | Osi Pharm Inc | Für adenosin a3, a2a und a3 rezeptoren spezifische verbindungen und deren verwendungen |
MEP35308A (en) | 2000-12-01 | 2011-02-10 | Osi Pharm Inc | COMPOUNDS SPECIFIC TO ADENOSINE A1, A2a, AND A3 RECEPTOR AND USES THEREOF |
-
2001
- 2001-10-04 DE DE10148883A patent/DE10148883A1/de not_active Withdrawn
-
2002
- 2002-09-04 US US10/491,680 patent/US7312224B2/en not_active Expired - Fee Related
- 2002-09-05 BR BR0213037-8A patent/BR0213037A/pt not_active Application Discontinuation
- 2002-09-05 CN CNA028195817A patent/CN1863803A/zh active Pending
- 2002-09-05 JP JP2003534430A patent/JP4782376B2/ja not_active Expired - Fee Related
- 2002-09-05 WO PCT/EP2002/009935 patent/WO2003031447A2/de active IP Right Grant
- 2002-09-05 ES ES02800556T patent/ES2303564T3/es not_active Expired - Lifetime
- 2002-09-05 DE DE50211929T patent/DE50211929D1/de not_active Expired - Lifetime
- 2002-09-05 KR KR10-2004-7003997A patent/KR20040041166A/ko not_active Application Discontinuation
- 2002-09-05 AT AT02800556T patent/ATE389655T1/de not_active IP Right Cessation
- 2002-09-05 AU AU2002362806A patent/AU2002362806B2/en not_active Ceased
- 2002-09-05 EP EP02800556A patent/EP1432715B1/de not_active Expired - Lifetime
- 2002-09-05 PL PL02369819A patent/PL369819A1/xx unknown
- 2002-09-05 CA CA2462799A patent/CA2462799C/en not_active Expired - Fee Related
- 2002-09-05 HU HU0401654A patent/HUP0401654A3/hu unknown
- 2002-09-05 RU RU2004114239/04A patent/RU2004114239A/ru not_active Application Discontinuation
-
2004
- 2004-05-03 ZA ZA200403334A patent/ZA200403334B/en unknown
Also Published As
Publication number | Publication date |
---|---|
US7312224B2 (en) | 2007-12-25 |
DE10148883A1 (de) | 2003-04-10 |
RU2004114239A (ru) | 2005-10-27 |
JP4782376B2 (ja) | 2011-09-28 |
ATE389655T1 (de) | 2008-04-15 |
AU2002362806B2 (en) | 2008-09-18 |
PL369819A1 (en) | 2005-05-02 |
WO2003031447A2 (de) | 2003-04-17 |
JP2005504847A (ja) | 2005-02-17 |
WO2003031447A3 (de) | 2003-08-28 |
HUP0401654A3 (en) | 2006-02-28 |
EP1432715A2 (de) | 2004-06-30 |
HUP0401654A2 (hu) | 2004-11-29 |
CA2462799C (en) | 2010-11-02 |
EP1432715B1 (de) | 2008-03-19 |
ES2303564T3 (es) | 2008-08-16 |
DE50211929D1 (en) | 2008-04-30 |
US20040242595A1 (en) | 2004-12-02 |
KR20040041166A (ko) | 2004-05-14 |
CN1863803A (zh) | 2006-11-15 |
ZA200403334B (en) | 2006-05-31 |
CA2462799A1 (en) | 2003-04-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |