BR0109836A - Processo de sìntese de perindopril e de seus sais farmaceuticamente aceitáveis - Google Patents
Processo de sìntese de perindopril e de seus sais farmaceuticamente aceitáveisInfo
- Publication number
- BR0109836A BR0109836A BR0109836-5A BR0109836A BR0109836A BR 0109836 A BR0109836 A BR 0109836A BR 0109836 A BR0109836 A BR 0109836A BR 0109836 A BR0109836 A BR 0109836A
- Authority
- BR
- Brazil
- Prior art keywords
- perindopril
- pharmaceutically acceptable
- acceptable salts
- synthesis process
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"PROCESSO DE SìNTESE DE PERINDOPRIL E DE SEUS SAIS FARMACEUTICAMENTE ACEITáVEIS". A invenção refere-se a um processo de síntese industrial do perindopril de fórmula (I) e de seus sais farmaceuticamente aceitáveis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0004379A FR2807431B1 (fr) | 2000-04-06 | 2000-04-06 | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
PCT/FR2001/001026 WO2001058868A1 (fr) | 2000-04-06 | 2001-04-05 | Procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
Publications (2)
Publication Number | Publication Date |
---|---|
BR0109836A true BR0109836A (pt) | 2003-06-24 |
BRPI0109836B1 BRPI0109836B1 (pt) | 2015-08-04 |
Family
ID=8848925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0109836-5A BRPI0109836B1 (pt) | 2000-04-06 | 2001-04-05 | Processo de síntese de perindopril e de seus sais farmaceuticamente aceitáveis |
Country Status (35)
Country | Link |
---|---|
US (1) | US6835843B2 (pt) |
EP (1) | EP1268424B1 (pt) |
JP (1) | JP3939553B2 (pt) |
KR (1) | KR100507616B1 (pt) |
CN (1) | CN1296355C (pt) |
AP (1) | AP1385A (pt) |
AT (1) | ATE369338T1 (pt) |
AU (2) | AU2001248470B2 (pt) |
BG (1) | BG65984B1 (pt) |
BR (1) | BRPI0109836B1 (pt) |
CA (1) | CA2405486C (pt) |
CY (1) | CY1108522T1 (pt) |
CZ (1) | CZ302575B6 (pt) |
DE (1) | DE60129800T2 (pt) |
DK (1) | DK1268424T3 (pt) |
EA (1) | EA005079B1 (pt) |
EE (1) | EE05032B1 (pt) |
ES (1) | ES2291307T3 (pt) |
FR (1) | FR2807431B1 (pt) |
GE (1) | GEP20063797B (pt) |
HK (1) | HK1053309A1 (pt) |
HR (1) | HRP20020876B1 (pt) |
HU (1) | HU227674B1 (pt) |
ME (1) | ME00441B (pt) |
MX (1) | MXPA02009706A (pt) |
NO (1) | NO324174B1 (pt) |
NZ (1) | NZ521454A (pt) |
OA (1) | OA12242A (pt) |
PL (1) | PL204471B1 (pt) |
PT (1) | PT1268424E (pt) |
RS (1) | RS50808B (pt) |
SK (1) | SK286921B6 (pt) |
UA (1) | UA75070C2 (pt) |
WO (1) | WO2001058868A1 (pt) |
ZA (1) | ZA200207419B (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
SI1333026T1 (sl) | 2002-01-30 | 2007-10-31 | Servier Lab | Postopek priprave perindoprila visoke äśistoäśe in intermediatov uporabnih v sintezi |
JP2005256847A (ja) * | 2002-02-28 | 2005-09-22 | Nsk Ltd | 車輪用軸受ユニット |
GB2395195A (en) * | 2002-11-18 | 2004-05-19 | Cipla Ltd | Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors |
EP1603558B1 (en) | 2003-02-28 | 2008-05-21 | Les Laboratoires Servier S.A. | Process for preparation of perindopril and salts thereof |
DE60301930T2 (de) * | 2003-02-28 | 2006-07-27 | Les Laboratoires Servier | Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze |
ES2249691T3 (es) * | 2003-02-28 | 2006-04-01 | Les Laboratoires Servier | Procedimiento de sintesis de derivados del acido (2s,3as,7as)-1-(s)-alanil)-octahidro-1h-indol-2-carboxilico y su utilizacion en la sintesis de perindopril. |
ES2250847T3 (es) * | 2003-02-28 | 2006-04-16 | Les Laboratoires Servier | Nuevo procedimiento de sintesis del acido (2s,3as,7as)-perhidroindol-2-carboxilico y sus eteres y su aplicacion a la sintesis de perindropil. |
DE60300116T2 (de) * | 2003-03-12 | 2005-12-22 | Les Laboratoires Servier | Verfahren zur Synthese von (2S,3aS,7aS)-Perhydroindol-2-carbonsäure und seinen Estern, und Verwendung in der Synthese von Perindopril |
SI1319668T1 (en) * | 2003-03-12 | 2005-02-28 | Les Laboratoires Servier | Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril |
SI1321471T1 (pt) * | 2003-03-12 | 2005-08-31 | Servier Lab | |
WO2004099138A2 (en) * | 2003-05-12 | 2004-11-18 | Cipla Limited | Process for the preparation of perindopril |
BRPI0411966A (pt) | 2003-06-24 | 2006-08-29 | Servier Lab | formas cristalinas de perindopril erbumina |
PT1367063E (pt) | 2003-07-31 | 2006-12-29 | Servier Lab | Novo processo de síntese do perindopril e dos seus sais farmacêuticamente aceitáveis |
PT1367062E (pt) * | 2003-07-31 | 2006-12-29 | Servier Lab | Novo processo de síntese do perindopril e dos seus sais aceitáveis do ponto de vista farmacêutico |
ATE452124T1 (de) * | 2003-10-21 | 2010-01-15 | Servier Lab | Verfahren zur herstellung kristallinem perindopril erbumin |
ATE386745T1 (de) * | 2003-12-10 | 2008-03-15 | Servier Lab | Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen |
HUE031058T2 (en) * | 2004-03-29 | 2017-06-28 | Servier Lab | A method of producing a solid pharmaceutical composition |
GB2413128A (en) * | 2004-04-13 | 2005-10-19 | Neopharma Ltd | Process for the preparation of perindopril |
SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
ES2255872B1 (es) * | 2004-12-31 | 2007-08-16 | Quimica Sintetica, S.A. | Procedimiento para la preparacion de perindopril erbumina. |
EP1987828A1 (en) | 2005-01-06 | 2008-11-05 | IPCA Laboratories Limited | salts of perindopril and their use in the therapy of hypertension |
US7291745B2 (en) * | 2005-03-21 | 2007-11-06 | Glenmark Pharmaceuticals Limited | Process for the preparation of perindopril |
JP2006290825A (ja) * | 2005-04-13 | 2006-10-26 | Shiono Chemical Co Ltd | アルファ型ペリンドプリルエルブミンの製造法 |
DE102005058166A1 (de) * | 2005-12-05 | 2007-06-06 | Hexal Ag | Matrixkontrolliertes transdermales System mit Amin-Salzen der ACE-Hemmer-Dicarbonsäuren |
WO2007085933A2 (en) * | 2006-01-25 | 2007-08-02 | Glenmark Pharmaceuticals Limited | Process for the preparation of n-[1-(s)-ethoxycarbonyl-1-butyl]-(s)-alanine-dmt complex and its use in the preparation of perindopril |
WO2008114270A1 (en) * | 2007-03-22 | 2008-09-25 | Aarti Healthcare Limited | Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof |
FR2961105B1 (fr) * | 2010-06-15 | 2013-02-08 | Servier Lab | Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque |
ES2670854T3 (es) * | 2012-10-10 | 2018-06-01 | Piramal Enterprises Limited | Un proceso mejorado para la preparación de perindoprilo intermedio |
WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
CN107098949B (zh) * | 2017-04-20 | 2021-03-16 | 上药东英(江苏)药业有限公司 | 一种制备培哚普利叔丁胺盐的绿色合成新工艺 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
DE3302125A1 (de) * | 1983-01-22 | 1984-07-26 | Boehringer Ingelheim KG, 6507 Ingelheim | Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung |
FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
FR2620700B1 (fr) * | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides |
-
2000
- 2000-04-06 FR FR0004379A patent/FR2807431B1/fr not_active Expired - Fee Related
-
2001
- 2001-03-20 PL PL346555A patent/PL204471B1/pl unknown
- 2001-03-30 HU HU0101336A patent/HU227674B1/hu not_active IP Right Cessation
- 2001-04-05 EE EEP200200575A patent/EE05032B1/xx not_active IP Right Cessation
- 2001-04-05 CN CNB018073727A patent/CN1296355C/zh not_active Expired - Fee Related
- 2001-04-05 CA CA002405486A patent/CA2405486C/fr not_active Expired - Fee Related
- 2001-04-05 AP APAP/P/2002/002630A patent/AP1385A/en active
- 2001-04-05 JP JP2001558419A patent/JP3939553B2/ja not_active Expired - Fee Related
- 2001-04-05 US US10/239,129 patent/US6835843B2/en not_active Expired - Lifetime
- 2001-04-05 EP EP01921486A patent/EP1268424B1/fr not_active Expired - Lifetime
- 2001-04-05 NZ NZ52145401A patent/NZ521454A/en not_active IP Right Cessation
- 2001-04-05 WO PCT/FR2001/001026 patent/WO2001058868A1/fr active IP Right Grant
- 2001-04-05 ME MEP-2008-670A patent/ME00441B/me unknown
- 2001-04-05 OA OA1200200306A patent/OA12242A/en unknown
- 2001-04-05 GE GEAP20016679A patent/GEP20063797B/en unknown
- 2001-04-05 ES ES01921486T patent/ES2291307T3/es not_active Expired - Lifetime
- 2001-04-05 SK SK1418-2002A patent/SK286921B6/sk not_active IP Right Cessation
- 2001-04-05 KR KR10-2002-7013376A patent/KR100507616B1/ko not_active IP Right Cessation
- 2001-04-05 CZ CZ20023291A patent/CZ302575B6/cs not_active IP Right Cessation
- 2001-04-05 AT AT01921486T patent/ATE369338T1/de active
- 2001-04-05 RS YUP-738/02A patent/RS50808B/sr unknown
- 2001-04-05 DE DE60129800T patent/DE60129800T2/de not_active Expired - Lifetime
- 2001-04-05 PT PT01921486T patent/PT1268424E/pt unknown
- 2001-04-05 AU AU2001248470A patent/AU2001248470B2/en not_active Ceased
- 2001-04-05 EA EA200201057A patent/EA005079B1/ru not_active IP Right Cessation
- 2001-04-05 BR BRPI0109836-5A patent/BRPI0109836B1/pt not_active IP Right Cessation
- 2001-04-05 DK DK01921486T patent/DK1268424T3/da active
- 2001-04-05 AU AU4847001A patent/AU4847001A/xx active Pending
- 2001-04-05 MX MXPA02009706A patent/MXPA02009706A/es active IP Right Grant
- 2001-05-04 UA UA2002118786A patent/UA75070C2/uk unknown
-
2002
- 2002-09-16 ZA ZA200207419A patent/ZA200207419B/en unknown
- 2002-10-04 NO NO20024808A patent/NO324174B1/no not_active IP Right Cessation
- 2002-11-04 BG BG107249A patent/BG65984B1/bg unknown
- 2002-11-06 HR HR20020876A patent/HRP20020876B1/xx not_active IP Right Cessation
-
2003
- 2003-08-01 HK HK03105542A patent/HK1053309A1/xx not_active IP Right Cessation
-
2007
- 2007-10-16 CY CY20071101338T patent/CY1108522T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/08/2015, OBSERVADAS AS CONDICOES LEGAIS. |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 18A ANUIDADE. |
|
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2508 DE 29-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |