BR0109814A - Derivados de indolin-2-ona e sua utilização como ligantes dos receptores da ocitocina - Google Patents

Derivados de indolin-2-ona e sua utilização como ligantes dos receptores da ocitocina

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Publication number
BR0109814A
BR0109814A BR0109814-4A BR0109814A BR0109814A BR 0109814 A BR0109814 A BR 0109814A BR 0109814 A BR0109814 A BR 0109814A BR 0109814 A BR0109814 A BR 0109814A
Authority
BR
Brazil
Prior art keywords
indolin
derivatives
oxytocin receptor
receptor binders
binders
Prior art date
Application number
BR0109814-4A
Other languages
English (en)
Inventor
Loic Foulon
Georges Garcia
Claudine Serradeil-Legal
Gerard Valette
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of BR0109814A publication Critical patent/BR0109814A/pt

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

"DERIVADOS DE INDOLIN-2-ONA E SUA UTILIZAçãO COMO LIGANTES DOS RECEPTORES DA OCITOCINA". A presente invenção refere-se aos novos derivados de indolin-2-ona de fórmula (I), à preparação e às composições farmacêuticas que os contêm. Esses compostos são afins para os receptores da ocitocina.
BR0109814-4A 2000-04-03 2001-04-02 Derivados de indolin-2-ona e sua utilização como ligantes dos receptores da ocitocina BR0109814A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004193A FR2807038B1 (fr) 2000-04-03 2000-04-03 Nouveaux derives d'indolin-2-one, leur preparation et les compositions pharmaceutiques les contenant
PCT/FR2001/000980 WO2001074775A1 (fr) 2000-04-03 2001-04-02 Derives d'indolin-2-one et leur utilisation en tant que ligands des recepteurs de l'ocytocine

Publications (1)

Publication Number Publication Date
BR0109814A true BR0109814A (pt) 2003-01-21

Family

ID=8848777

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0109814-4A BR0109814A (pt) 2000-04-03 2001-04-02 Derivados de indolin-2-ona e sua utilização como ligantes dos receptores da ocitocina

Country Status (35)

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US (2) US20040059132A1 (pt)
EP (1) EP1272468B1 (pt)
JP (1) JP2003529586A (pt)
KR (1) KR100765028B1 (pt)
CN (1) CN1224614C (pt)
AR (1) AR034547A1 (pt)
AT (1) ATE282593T1 (pt)
AU (2) AU2001246671B2 (pt)
BR (1) BR0109814A (pt)
CA (1) CA2404592A1 (pt)
CZ (1) CZ20023297A3 (pt)
DE (1) DE60107221T2 (pt)
DK (1) DK1272468T3 (pt)
EA (1) EA005093B1 (pt)
EE (1) EE05002B1 (pt)
ES (1) ES2232610T3 (pt)
FR (1) FR2807038B1 (pt)
HK (1) HK1050004A1 (pt)
HU (1) HUP0303109A3 (pt)
IL (1) IL152085A0 (pt)
IS (1) IS2458B (pt)
ME (1) MEP24308A (pt)
MX (1) MXPA02009773A (pt)
NO (1) NO324314B1 (pt)
NZ (1) NZ521617A (pt)
PL (1) PL358222A1 (pt)
PT (1) PT1272468E (pt)
SI (1) SI1272468T1 (pt)
SK (1) SK14272002A3 (pt)
TR (1) TR200202288T2 (pt)
TW (1) TWI225860B (pt)
UA (1) UA73163C2 (pt)
WO (1) WO2001074775A1 (pt)
YU (1) YU80902A (pt)
ZA (1) ZA200207802B (pt)

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FR2909668B1 (fr) * 2006-12-12 2009-01-23 Sanofi Aventis Sa Derives de 5-alkyloxy-indolin-2-one,leur preparation et leurs applications en therapeutique
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CN104402886B (zh) * 2014-09-18 2017-01-25 陕西科技大学 一种具有抗肿瘤活性的7‑氮杂靛红类双螺环化合物及其合成方法
CN104230786B (zh) * 2014-09-26 2017-03-22 陕西科技大学 一种具有抗肿瘤活性的含吲哚结构的化合物及其合成方法
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MA43799A (fr) * 2016-01-20 2021-03-31 Chemocentryx Inc Composés de 2-oxindole
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CN109678781B (zh) * 2018-12-20 2022-03-29 苏州麦迪耐斯医药科技有限公司 一种刺猬通路抑制剂
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FR2708605A1 (fr) * 1993-07-30 1995-02-10 Sanofi Sa Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
US5686624A (en) * 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2714378B1 (fr) * 1993-12-24 1996-03-15 Sanofi Sa Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant.
JPH10338672A (ja) * 1996-07-16 1998-12-22 Takeda Chem Ind Ltd 排尿調節剤および２環性化合物

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FR2807038B1 (fr) 2002-08-16
CN1427825A (zh) 2003-07-02
EE05002B1 (et) 2008-04-15
KR20020089427A (ko) 2002-11-29
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TR200202288T2 (tr) 2003-01-21
PL358222A1 (en) 2004-08-09
US20040059132A1 (en) 2004-03-25
HUP0303109A3 (en) 2010-04-28
NO324314B1 (no) 2007-09-24
EP1272468B1 (fr) 2004-11-17
AU2001246671B2 (en) 2006-03-16
NZ521617A (en) 2003-05-30
EA200200912A1 (ru) 2003-06-26
WO2001074775A1 (fr) 2001-10-11
TWI225860B (en) 2005-01-01
EA005093B1 (ru) 2004-10-28
ATE282593T1 (de) 2004-12-15
IS2458B (is) 2008-11-15
HUP0303109A2 (hu) 2004-01-28
US20070203184A1 (en) 2007-08-30
SK14272002A3 (sk) 2003-05-02
EP1272468A1 (fr) 2003-01-08
UA73163C2 (en) 2005-06-15
AR034547A1 (es) 2004-03-03
NO20024749L (no) 2002-12-03
AU4667101A (en) 2001-10-15
PT1272468E (pt) 2005-03-31
HK1050004A1 (en) 2003-06-06
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MXPA02009773A (es) 2003-06-17
DE60107221T2 (de) 2005-11-03
DE60107221D1 (de) 2004-12-23
CZ20023297A3 (cs) 2003-01-15
FR2807038A1 (fr) 2001-10-05
CA2404592A1 (fr) 2001-10-11
IL152085A0 (en) 2003-05-29
IS6566A (is) 2002-09-24
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ES2232610T3 (es) 2005-06-01
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KR100765028B1 (ko) 2007-10-09

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