BR0016236A - Agentes terapêuticos - Google Patents
Agentes terapêuticosInfo
- Publication number
- BR0016236A BR0016236A BR0016236-1A BR0016236A BR0016236A BR 0016236 A BR0016236 A BR 0016236A BR 0016236 A BR0016236 A BR 0016236A BR 0016236 A BR0016236 A BR 0016236A
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- nsaid
- therapeutic agents
- melting
- fact
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
"AGENTES TERAPêUTICOS". Composição de comprimido prensado compreendendo um componente granular dotado de uma série de grânulos solidificados em fusão, de uma droga antiinflamatória não esteroidal (NSAID) com um ponto de fusão na faixa de 30-300<198>C, incorporando um desintegrante uniformemente aí disperso; caracterizada pelo fato dos grânulos compreenderem uma fase contínua da droga antiinflamatória não esteroidal e caracterizada ainda pelo fato da composição de comprimido compreender dióxido de silício presente numa proporção de 0,05-5,0% em peso da composição. De preferência a composição contém também um componente extra granular compreendendo o dióxido de silício e um lubrificante. Ainda preferivelmente, o NSAID é ibuprofen dotado de um ponto de fusão na faixa de 75-77<198>C. Opcionalmente, o processo em fusão pode ser feito numa extrusora. São obtidos comprimidos contendo, vantajosamente, características de propriedades de processamento e dissolução.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9929078.5A GB9929078D0 (en) | 1999-12-09 | 1999-12-09 | Therapeutic agents |
GBGB9929077.7A GB9929077D0 (en) | 1999-12-09 | 1999-12-09 | Therapeutic agents |
PCT/EP2000/012193 WO2001041733A2 (en) | 1999-12-09 | 2000-11-30 | Compressed tablet composition comprising a nsaid |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0016236A true BR0016236A (pt) | 2002-12-24 |
Family
ID=26316111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0016236-1A BR0016236A (pt) | 1999-12-09 | 2000-11-30 | Agentes terapêuticos |
Country Status (27)
Country | Link |
---|---|
US (1) | US8124124B2 (pt) |
EP (1) | EP1235558B1 (pt) |
JP (1) | JP4040878B2 (pt) |
KR (1) | KR20020082464A (pt) |
CN (1) | CN100346774C (pt) |
AR (1) | AR026917A1 (pt) |
AT (1) | ATE324868T1 (pt) |
AU (1) | AU776308B2 (pt) |
BG (1) | BG66007B1 (pt) |
BR (1) | BR0016236A (pt) |
CA (1) | CA2393585C (pt) |
CY (1) | CY1106136T1 (pt) |
CZ (1) | CZ300558B6 (pt) |
DE (1) | DE60027761T2 (pt) |
DK (1) | DK1235558T3 (pt) |
ES (1) | ES2263510T3 (pt) |
HK (1) | HK1046644B (pt) |
HU (1) | HU227045B1 (pt) |
IL (2) | IL150030A0 (pt) |
MX (1) | MXPA02005663A (pt) |
NO (1) | NO332259B1 (pt) |
NZ (1) | NZ519485A (pt) |
PL (1) | PL201223B1 (pt) |
PT (1) | PT1235558E (pt) |
RU (1) | RU2246294C2 (pt) |
SK (1) | SK285706B6 (pt) |
WO (1) | WO2001041733A2 (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0113839D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
GB0113843D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
GB0113841D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
BR0307516A (pt) * | 2002-02-01 | 2004-12-07 | Pfizer Prod Inc | Formas de dosagem de liberação imediata contendo dispersões de uma droga sólida |
GB0209265D0 (en) | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
GB0423103D0 (en) * | 2004-10-19 | 2004-11-17 | Boots Healthcare Int Ltd | Therapeutic agents |
WO2006082499A1 (en) * | 2005-02-03 | 2006-08-10 | Nycomed Pharma As | Melt granulation of a composition containing a calcium-containing compound |
DE102005037630A1 (de) | 2005-08-09 | 2007-02-15 | Glatt Gmbh | Verfahren zur Herstellung von Teilchen aus pharmazeutischen Substanzen, Teilchen aus pharmazeutischen Substanzen sowie deren Verwendung |
GB0519350D0 (en) | 2005-09-22 | 2005-11-02 | Boots Healthcare Int Ltd | Therapeutic agents |
CN101330904B (zh) * | 2005-12-16 | 2012-04-18 | 韩美控股株式会社 | 含有低熔点活性成分的固体分散体以及含有它的口服给药片剂 |
PL1905427T3 (pl) | 2006-09-28 | 2011-05-31 | Losan Pharma Gmbh | Szybko rozpuszczająca się formulacja niesteroidowych leków przeciwzapalnych |
GB2447898B (en) * | 2007-03-24 | 2011-08-17 | Reckitt Benckiser Healthcare | A tablet having improved stability with at least two actives |
DE102008048729A1 (de) * | 2008-09-24 | 2010-03-25 | Add Technologies Ltd Advanced Drug Delivery | Multipartikuläre Tabletten und Verfahren zur deren Herstellung |
US8662705B2 (en) | 2010-03-30 | 2014-03-04 | Virwall Systems, Inc. | Flexible ultraviolet LED sanitizing apparatus |
WO2011135106A1 (es) * | 2010-04-26 | 2011-11-03 | Smart Pharma Solutions, S.L | Granulado altamente dispersable para la preparación de formulaciones de sustancias activas de altas dosis y procedimiento de obtención del mismo |
JP5750856B2 (ja) * | 2010-10-04 | 2015-07-22 | ライオン株式会社 | 固形医薬組成物及び医薬製剤 |
JP5974469B2 (ja) * | 2010-12-24 | 2016-08-23 | ライオン株式会社 | 錠剤の製造方法 |
WO2013095315A1 (en) * | 2011-12-19 | 2013-06-27 | Mahmut Bilgic | Formulations comprising dexketoprofen (particle size 300-2500 micrometer) |
EP2793853B1 (en) * | 2011-12-23 | 2015-12-16 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Pharmaceutical formulations of flurbiprofen and glucosamin |
EP2704696A1 (en) | 2012-03-26 | 2014-03-12 | Glatt AG | Taste-masked ibuprofen granules |
WO2014078435A1 (en) | 2012-11-14 | 2014-05-22 | W. R. Grace & Co.-Conn. | Compositions containing a biologically active material and a non-ordered inorganic oxide |
EP2845850A1 (en) | 2013-09-10 | 2015-03-11 | ObsEva S.A. | Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists |
EP2886107A1 (en) | 2013-12-17 | 2015-06-24 | ObsEva S.A. | Oral formulations of pyrrolydine derivatives |
CZ304685B6 (cs) * | 2013-12-18 | 2014-08-27 | Technická univerzita v Liberci | Způsob rozvádění příze při jejím navíjení na cívku uloženou v navíjecím ústrojí pracovního místa textilního stroje a zařízení k jeho provádění |
EP3164384B1 (en) | 2014-07-02 | 2019-12-04 | ObsEva S.A. | Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime useful in methods of treating conditions related to the ot-r activity |
US20190022013A1 (en) * | 2015-12-19 | 2019-01-24 | First Time Us Generics Llc | Soft-chew tablet pharmaceutical formulations |
CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
BE1023057B1 (nl) * | 2016-06-06 | 2016-11-16 | Nordic Specialty Pharma Bvba | Ibuprofen tablet |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56120616A (en) * | 1980-02-27 | 1981-09-22 | Kaken Pharmaceut Co Ltd | Ibuprofen-containing granule, its preparation, and internal medicine comprising it |
US4609675A (en) | 1984-08-17 | 1986-09-02 | The Upjohn Company | Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing |
US5240712A (en) * | 1987-07-17 | 1993-08-31 | The Boots Company Plc | Therapeutic agents |
SE463541B (sv) * | 1987-08-31 | 1990-12-10 | Lejus Medical Ab | Granulaer produkt oeverdragen av en smaelta av sig sjaelv samt foerfarande foer dess framstaellning |
DE3833448A1 (de) * | 1988-10-01 | 1990-04-12 | Hoechst Ag | Verfahren zur gewinnung von ibuprofen fuer die direkttablettierung |
WO1991015194A1 (en) | 1990-04-11 | 1991-10-17 | The Upjohn Company | Taste masking of ibuprofen by fluid bed coating |
CA2061520C (en) * | 1991-03-27 | 2003-04-22 | Lawrence J. Daher | Delivery system for enhanced onset and increased potency |
DK138592D0 (da) * | 1992-11-17 | 1992-11-17 | Nycomed Dak As | Tabletter |
AT401871B (de) * | 1994-01-28 | 1996-12-27 | Gebro Broschek Gmbh | Verfahren zur herstellung von s(+)-ibuprofen- partikeln mit verbesserten fliesseigenschaften und deren verwendung zur arzneimittelherstellung |
DE4418837A1 (de) * | 1994-05-30 | 1995-12-07 | Bayer Ag | Thermisches Granulierverfahren |
GB9702392D0 (en) * | 1997-02-06 | 1997-03-26 | Boots Co Plc | Therapeutic agents |
DE19721467A1 (de) * | 1997-05-22 | 1998-11-26 | Basf Ag | Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe |
GB9710521D0 (en) | 1997-05-22 | 1997-07-16 | Boots Co Plc | Process |
CA2214895C (en) * | 1997-09-19 | 1999-04-20 | Bernard Charles Sherman | Improved pharmaceutical composition comprising fenofibrate |
IE980115A1 (en) * | 1998-02-16 | 2000-02-09 | Biovail Internat Ltd | Solubilizing delivery systems and method of manufacture |
-
2000
- 2000-11-30 HU HU0203553A patent/HU227045B1/hu not_active IP Right Cessation
- 2000-11-30 KR KR1020027007351A patent/KR20020082464A/ko not_active Application Discontinuation
- 2000-11-30 CZ CZ20021971A patent/CZ300558B6/cs not_active IP Right Cessation
- 2000-11-30 WO PCT/EP2000/012193 patent/WO2001041733A2/en active IP Right Grant
- 2000-11-30 NZ NZ519485A patent/NZ519485A/en not_active IP Right Cessation
- 2000-11-30 DK DK00990644T patent/DK1235558T3/da active
- 2000-11-30 ES ES00990644T patent/ES2263510T3/es not_active Expired - Lifetime
- 2000-11-30 EP EP00990644A patent/EP1235558B1/en not_active Expired - Lifetime
- 2000-11-30 CA CA002393585A patent/CA2393585C/en not_active Expired - Fee Related
- 2000-11-30 DE DE60027761T patent/DE60027761T2/de not_active Expired - Lifetime
- 2000-11-30 SK SK802-2002A patent/SK285706B6/sk not_active IP Right Cessation
- 2000-11-30 PL PL355491A patent/PL201223B1/pl unknown
- 2000-11-30 CN CNB008188122A patent/CN100346774C/zh not_active Expired - Fee Related
- 2000-11-30 RU RU2002118210/15A patent/RU2246294C2/ru active
- 2000-11-30 BR BR0016236-1A patent/BR0016236A/pt not_active IP Right Cessation
- 2000-11-30 JP JP2001542901A patent/JP4040878B2/ja not_active Expired - Fee Related
- 2000-11-30 PT PT00990644T patent/PT1235558E/pt unknown
- 2000-11-30 US US10/148,206 patent/US8124124B2/en not_active Expired - Fee Related
- 2000-11-30 AT AT00990644T patent/ATE324868T1/de active
- 2000-11-30 IL IL15003000A patent/IL150030A0/xx active IP Right Grant
- 2000-11-30 AU AU30060/01A patent/AU776308B2/en not_active Withdrawn - After Issue
- 2000-12-07 AR ARP000106517A patent/AR026917A1/es not_active Application Discontinuation
-
2002
- 2002-06-04 IL IL150030A patent/IL150030A/en not_active IP Right Cessation
- 2002-06-06 NO NO20022692A patent/NO332259B1/no not_active IP Right Cessation
- 2002-06-07 MX MXPA02005663A patent/MXPA02005663A/es unknown
- 2002-06-19 BG BG106839A patent/BG66007B1/bg unknown
- 2002-11-18 HK HK02108342.6A patent/HK1046644B/zh not_active IP Right Cessation
-
2006
- 2006-08-02 CY CY20061101083T patent/CY1106136T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0016236A (pt) | Agentes terapêuticos | |
Koh et al. | Intravenous non-opioid analgesia for peri-and postoperative pain management: a scientific review of intravenous acetaminophen and ibuprofen | |
RU2008115507A (ru) | Композиция, включающая нпвс и парацетамол | |
Altman et al. | Topical therapy for osteoarthritis: clinical and pharmacologic perspectives | |
Mohammed et al. | Klucel™ EF and ELF polymers for immediate-release oral dosage forms prepared by melt extrusion technology | |
CY1105648T1 (el) | Filbanserin για την θεραπεια εξτραπυραμιδικων διαταραχων κινησης | |
Trujillo et al. | Clinical use of rivaroxaban: pharmacokinetic and pharmacodynamic rationale for dosing regimens in different indications | |
MX2007001597A (es) | Granulos que comprenden paracetamol, un farmaco antiinflamatorio no esteroidal y un alcohol de azucar hecho por extrusion por fusion. | |
MX9207495A (es) | Compuestos de tetrahidroisoquinolina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. | |
JP2003516341A5 (pt) | ||
BR0307420A (pt) | Compostos, composições farmacêuticas e métodos para impedir e/ou tratar doença em mamìfero | |
Alsulays et al. | Preparation and evaluation of enteric coated tablets of hot-melt extruded lansoprazole | |
JP2007091633A (ja) | メキタジン、イブプロフェン及びトラネキサム酸含有医薬組成物 | |
RU2013139701A (ru) | Способ контролируемой кристаллизации активного фармацевтического ингредиента из состояния переохлажденной жидкости экструзией горячего распада | |
Widanapathirana et al. | Dissolution and solubility enhancement of the highly lipophilic drug phenytoin via interaction with poly (N-isopropylacrylamide-co-vinylpyrrolidone) excipients | |
Frighetto et al. | Cost-effectiveness of prophylactic dolasetron or droperidol vs rescue therapy in the prevention of PONV in ambulatory gynecologic surgery | |
BR0313428A (pt) | Composições farmacêuticas de drogas semi-ordenados e polìmeros | |
AR034438A1 (es) | Agentes terapeuticos | |
Nimmaanrat et al. | Premedication with oral paracetamol for reduction of propofol injection pain: a randomized placebo-controlled trial | |
BRPI0412364A (pt) | composição farmacêutica sólida, compreendendo amisulpride | |
BRPI0407438A (pt) | Sistema terapêutico compreendendo amoxicilina e ácido clavulânico | |
de Souza et al. | Intratablet S-nitrosation: a new approach for the oral administration of S-nitrosothiols as nitric oxide donors | |
Manvelian et al. | A phase 2 study of lower-dose, indomethacin submicron particle capsules demonstrates early onset of acute pain relief | |
Tucci et al. | Paracetamol and ibuprofen for paediatric pain and fever | |
BRPI0413777A (pt) | composições de modafinil |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A, 5A, 6A, E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1929 DE 26/12/2007. |