BR0010496A - Regulação da expressão genica viral - Google Patents

Regulação da expressão genica viral

Info

Publication number
BR0010496A
BR0010496A BR0010496-5A BR0010496A BR0010496A BR 0010496 A BR0010496 A BR 0010496A BR 0010496 A BR0010496 A BR 0010496A BR 0010496 A BR0010496 A BR 0010496A
Authority
BR
Brazil
Prior art keywords
viral gene
regulation
gene expression
expression
present
Prior art date
Application number
BR0010496-5A
Other languages
English (en)
Inventor
Peter Bernard Heifetz
David Andrew Patton
Joshua Zvi Levin
Qiudeng Que
Petrus Theodorus De Haan
Johannes Jacobus Ludger Gielen
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/309,038 external-priority patent/US7019195B1/en
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of BR0010496A publication Critical patent/BR0010496A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8283Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for virus resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Patente de Invenção: "REGULAçãO DA EXPRESSãO GêNICA VIRAL". A presente invenção refere-se a processos para alterar a expressão de um gene viral em uma célula utilizando fragmentos de RNA sentido e antisenso do gene. Os fragmentos de RNA sentido e anti-sentido são capazes de formar pares e formar moléculas de RNA de filamento duplo, alterando desta forma a expressão do gene. A presente invenção refere-se também a células, plantas ou a animais, a sua progênie e a sementes derivadas das mesmas, obtidas utilizando um processo da presente invenção. Preferencialmente, tais células, plantas ou animais são resistentes ou tolerantes a vírus.
BR0010496-5A 1999-05-10 2000-05-08 Regulação da expressão genica viral BR0010496A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/309,038 US7019195B1 (en) 1998-05-26 1999-05-10 Method for conferring resistance or tolerance aganist furovirus, potyvirus, tospovirus, and cucomovirus to plant cells
PCT/EP2000/004117 WO2000068374A1 (en) 1999-05-10 2000-05-08 Regulation of viral gene expression

Publications (1)

Publication Number Publication Date
BR0010496A true BR0010496A (pt) 2002-04-02

Family

ID=23196412

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010496-5A BR0010496A (pt) 1999-05-10 2000-05-08 Regulação da expressão genica viral

Country Status (18)

Country Link
EP (2) EP1177283A1 (pt)
JP (3) JP2002543783A (pt)
KR (1) KR20010112952A (pt)
CN (2) CN101348785A (pt)
AR (1) AR023885A1 (pt)
AU (1) AU4563300A (pt)
BR (1) BR0010496A (pt)
CA (1) CA2369422A1 (pt)
CZ (1) CZ20014028A3 (pt)
EA (1) EA200101186A1 (pt)
HK (2) HK1045325A1 (pt)
HU (1) HUP0201235A3 (pt)
IL (2) IL145538A0 (pt)
PL (1) PL351385A1 (pt)
SK (1) SK16222001A3 (pt)
TR (1) TR200103088T2 (pt)
WO (1) WO2000068374A1 (pt)
ZA (1) ZA200109152B (pt)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
US7067722B2 (en) 1999-08-26 2006-06-27 Monsanto Technology Llc Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids
US7531718B2 (en) 1999-08-26 2009-05-12 Monsanto Technology, L.L.C. Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids
DE60037735T2 (de) 1999-08-26 2009-01-02 Calgene Llc, Davis Pflanzen mit veränderten mehrfachungesättigten fettsäuren
DE10100586C1 (de) 2001-01-09 2002-04-11 Ribopharma Ag Verfahren zur Hemmung der Expression eines Ziegens
CH695778A5 (de) * 2000-11-29 2006-08-31 Hoffmann La Roche Hemmung der Transkription eines Zielgens in einer Zelle oder in Geweben.
US7767802B2 (en) 2001-01-09 2010-08-03 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US7423142B2 (en) 2001-01-09 2008-09-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US8546143B2 (en) 2001-01-09 2013-10-01 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a target gene
US8022272B2 (en) 2001-07-13 2011-09-20 Sungene Gmbh & Co. Kgaa Expression cassettes for transgenic expression of nucleic acids
US7456335B2 (en) 2001-09-03 2008-11-25 Basf Plant Science Gmbh Nucleic acid sequences and their use in methods for achieving pathogen resistance in plants
US7745418B2 (en) 2001-10-12 2010-06-29 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting viral replication
DE10163098B4 (de) 2001-10-12 2005-06-02 Alnylam Europe Ag Verfahren zur Hemmung der Replikation von Viren
DE10202419A1 (de) 2002-01-22 2003-08-07 Ribopharma Ag Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens
US7566813B2 (en) 2002-03-21 2009-07-28 Monsanto Technology, L.L.C. Nucleic acid constructs and methods for producing altered seed oil compositions
US7166771B2 (en) 2002-06-21 2007-01-23 Monsanto Technology Llc Coordinated decrease and increase of gene expression of more than one gene using transgenic constructs
CA2479587A1 (en) 2002-03-21 2003-10-02 Monsanto Technology Llc Nucleic acid constructs and methods for producing altered seed oil compositions
WO2004013333A2 (de) 2002-07-26 2004-02-12 Basf Plant Science Gmbh Revertierung der negativ-selektiven wirkung von negativen markerproteinen als selektionsverfahren
WO2004018687A2 (en) 2002-08-07 2004-03-04 Basf Plant Science Gmbh Nucleic acid sequences encoding proteins associated with abiotic stress response
EP1654368A2 (en) 2003-08-01 2006-05-10 BASF Plant Science GmbH Process for the production of fine chemicals
EP2080769A3 (en) 2004-07-02 2010-12-01 Metanomics GmbH Process for the production of fine chemicals
CN101001951B (zh) 2004-08-02 2011-06-15 巴斯福植物科学有限公司 分离转录终止序列的方法
CA2579927A1 (en) 2004-09-24 2006-03-30 Basf Plant Science Gmbh Plant cells and plants with increased tolerance to environmental stress
EP2166097B1 (en) 2004-10-05 2014-08-06 SunGene GmbH Constitutive expression cassettes for regulation of plant expression
CA2584960A1 (en) * 2004-10-21 2006-05-04 Charles L. Niblett Methods and materials for conferring resistance to pests and pathogens of plants
EP1655364A3 (en) 2004-11-05 2006-08-02 BASF Plant Science GmbH Expression cassettes for seed-preferential expression in plants
EP2163631B1 (en) 2004-11-25 2013-05-22 SunGene GmbH Expression cassettes for guard cell-preferential expression in plants
EP1666599A3 (en) 2004-12-04 2006-07-12 SunGene GmbH Expression cassettes for mesophyll- and/or epidermis-preferential expression in plants
EP2072620B1 (en) 2004-12-08 2013-05-08 SunGene GmbH Expression casstettes for vascular tissue-preferential expression in plants
EP1669456A3 (en) 2004-12-11 2006-07-12 SunGene GmbH Expression cassettes for meristem-preferential expression in plants
MX2007007040A (es) 2004-12-17 2008-10-24 Metanomics Gmbh Proceso para el control de produccion de productos quimicos finos.
WO2006084868A2 (en) 2005-02-09 2006-08-17 Basf Plant Science Gmbh Expression cassettes for regulation of expression in monocotyledonous plants
CN101128591B (zh) 2005-02-26 2013-02-13 巴斯福植物科学有限公司 用于植物中种子偏好性表达的表达盒
EP2166100B1 (en) 2005-03-08 2012-07-18 BASF Plant Science GmbH Expression enhancing intron sequences
WO2006120197A2 (en) 2005-05-10 2006-11-16 Basf Plant Science Gmbh Expression cassettes for seed-preferential expression in plants
WO2006128572A1 (en) * 2005-06-02 2006-12-07 Syngenta Participations Ag Ce46-02a insecticidal cotton
BRPI0612671A2 (pt) 2005-06-23 2010-11-30 Basf Plant Science Gmbh métodos melhorados para a produção de plantas férteis zea mays (milho) estavelmente transformadas
EP2980220A1 (en) 2005-09-20 2016-02-03 BASF Plant Science GmbH Improved methods controlling gene expression
CA2628505A1 (en) 2005-11-08 2007-05-18 Basf Plant Science Gmbh Use of armadillo repeat (arm1) polynucleotides for obtaining resistance to pathogens in plants
ES2464315T3 (es) 2006-01-12 2014-06-02 Basf Plant Science Gmbh Uso de polinucleótidos de estomatina (STM1) para alcanzar una resistencia a patógenos en plantas
CN101421406B (zh) 2006-02-13 2016-08-31 孟山都技术有限公司 用于产生改变的种子油组成的核酸构建体和方法
CA2644273A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
KR100809736B1 (ko) 2006-05-15 2008-03-05 대한민국 안토시아닌 생합성 억제 활성을 가진 myb60 유전자와상기 유전자가 도입된 형질전환 상추 및 그 제조방법
WO2008074025A2 (en) * 2006-12-13 2008-06-19 Idiverse, Inc. Novel genes and rna molecules that confer stress tolerance
WO2008087141A2 (en) 2007-01-15 2008-07-24 Basf Plant Science Gmbh Use of subtilisin (rnr9) polynucleotides for achieving a pathogen resistance in plants
WO2008099013A1 (en) 2007-02-16 2008-08-21 Basf Plant Science Gmbh Nucleic acid sequences for regulation of embryo-specific expression in monocotyledonous plants
US20100162432A1 (en) 2007-05-22 2010-06-24 Basf Plant Science Gmbh Plant cells and plants with increased tolerance and/or resistance to environmental stress and increased biomass production-ko
DE112008003433T5 (de) 2007-12-21 2010-11-04 Basf Plant Science Gmbh Pflanzen mit erhöhtem Ertrag (KO NUE)
UY32145A (es) 2008-09-29 2010-04-30 Monsanto Technology Llc Evento transgénico de soja mon87705 y métodos para detectar el mismo
EP2208785A1 (en) * 2009-01-15 2010-07-21 Newbiotechnic, S.A. Methods and kits to generate miRNA- and smallRNA-expressing vectors, and its application to develop lentiviral expression libraries
BRPI1012750B1 (pt) 2009-04-22 2019-04-16 Basf Plant Science Company Gmbh Polinucleotídeo, vetor, célula hospedeira, método para expressar um ácido nucléico de interesse, e, uso do polinucleotídeo.
CA2766858A1 (en) 2009-07-10 2011-01-13 Basf Plant Science Company Gmbh Expression cassettes for endosperm-specific expression in plants
BR112012013156A2 (pt) 2009-12-03 2017-06-13 Basf Plant Science Co Gmbh cassete de expressão, vetor, célula horpedeira, tecido de planta transgênica e método para a produção de um tecido de planta transgênica
KR101457958B1 (ko) * 2010-07-14 2014-11-04 대한민국 다종 바이러스 저항성을 갖는 형질전환 감자 식물체의 제조방법 및 이를 이용하여 제조된 감자 식물체
CN103667322B (zh) * 2013-11-21 2015-11-11 上海市农业科学院 一种抗番茄黄化曲叶病毒的多基因嵌合体avctc及其制备方法和应用
US20170029835A1 (en) * 2014-03-12 2017-02-02 The University Of Sydney Rna production in higher plants
BR112019024615A2 (pt) * 2017-05-22 2020-06-23 Pebble Labs Usa Inc. Regulação transbiótica de expressão genética bacteriana

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014090A1 (en) * 1989-05-19 1990-11-29 Hem Research, Inc. SHORT THERAPEUTIC dsRNA OF DEFINED STRUCTURE
EP0517833B2 (fr) * 1990-03-02 2008-07-16 Bayer BioScience N.V. Transformation genetique et regeneration de la betterave sucriere
GB9320548D0 (en) * 1993-10-06 1993-11-24 Sandoz Ltd Improvements in or relating to organic compounds
GB9703146D0 (en) * 1997-02-14 1997-04-02 Innes John Centre Innov Ltd Methods and means for gene silencing in transgenic plants
CN1252102A (zh) * 1997-02-19 2000-05-03 康乃尔研究基金会有限公司 能赋予植物多种性状的dna构建体
GB9710475D0 (en) * 1997-05-21 1997-07-16 Zeneca Ltd Gene silencing
GB9720148D0 (en) * 1997-09-22 1997-11-26 Innes John Centre Innov Ltd Gene silencing materials and methods
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
EP1555317B1 (en) * 1998-03-20 2011-09-28 Commonwealth Scientific And Industrial Research Organisation Synthetic genes and genetic constructs comprising the same
EP2267139B1 (en) * 1998-04-08 2017-03-22 Commonwealth Scientific and Industrial Research Organisation Methods and means for obtaining modified phenotypes
AR020078A1 (es) * 1998-05-26 2002-04-10 Syngenta Participations Ag Metodo para alterar la expresion de un gen objetivo en una celula de planta
CA2361201A1 (en) * 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna

Also Published As

Publication number Publication date
AR023885A1 (es) 2002-09-04
TR200103088T2 (tr) 2002-05-21
CA2369422A1 (en) 2000-11-16
CN100420748C (zh) 2008-09-24
CN1357040A (zh) 2002-07-03
CN101348785A (zh) 2009-01-21
CZ20014028A3 (cs) 2002-02-13
WO2000068374A1 (en) 2000-11-16
EP1801215B1 (en) 2013-02-27
EP1177283A1 (en) 2002-02-06
HK1045325A1 (zh) 2002-11-22
EA200101186A1 (ru) 2002-04-25
JP2010088435A (ja) 2010-04-22
AU4563300A (en) 2000-11-21
HK1047769A1 (en) 2003-03-07
ZA200109152B (en) 2002-09-06
EP1801215A2 (en) 2007-06-27
EP1801215A3 (en) 2008-12-17
KR20010112952A (ko) 2001-12-22
IL145538A (en) 2010-11-30
SK16222001A3 (sk) 2002-04-04
IL145538A0 (en) 2002-06-30
JP2002543783A (ja) 2002-12-24
JP2009022291A (ja) 2009-02-05
HUP0201235A2 (en) 2002-08-28
HK1047769B (zh) 2009-08-14
PL351385A1 (en) 2003-04-07
HUP0201235A3 (en) 2004-10-28

Similar Documents

Publication Publication Date Title
BR0010496A (pt) Regulação da expressão genica viral
BR9910729A (pt) Regulação mediada por dsrna de expressão de gene em plantas
BR0011499A (pt) Moléculas de ácido nucléico oriundas de plantas e células de,planta transgênicas de trigo e o seu uso para a produção de amido modificado
BR9915152A (pt) Moléculas de ácido nucléico de arroz e o seu uso para a produção de amido modificado
BR9811260A (pt) Pequenas moléculas úteis no tratamento de doença inflamatória
DE69534421D1 (de) Cytoplasmatische Inhibition des Genexpression
BR0007663A (pt) Derivados de acila para uso no tratamento de doenças relacionadas com o vla-4
NO962950L (no) Fremgangsmåte for fremstilling av adeno-assosierte viruser (AAV), og deres anvendelse
BR9206049A (pt) Composto, processos para preparar o composto, para o reconhecimento específico por sequência de um polinucleotídio de filamento duplo, para modular a expressão de um gene em um organismo, para tratar as condições associadas com produção de proteínas indesejada em um organismo, para induzir a degradação de DNA ou RNA em células de um organismo e para exterminar células ou vírus e composição farmacêutica
BR9907994A (pt) Transformação mediada por pêlos de agregados de células de plantas e tecidos vegetais e regeneração das plantas dos mesmos
DE60033959D1 (de) Regenerierung und transformation von zuckerrüben
BR0012685A (pt) Processo para conferir resistência a herbicida, peste ou doença em hospedeiros de plantas
DE59913833D1 (de) Strukturprotein von aav, seine herstellung und verwendung
ATE446373T1 (de) Sequenz-spezifische dna-rekombination in eukaryotischen zellen
DE69819124D1 (de) Lyophilisation von kultivierten, menschlichen zellen zur konservierung der rna und dna
ATE210466T1 (de) Methoden zur behandlung von atemwegserkrankungen
DE69500618D1 (de) Oligonukleotide mit wirkung gegen das respiratorische synzytial virus
DE60230774D1 (de) Isolierung von nervenstammzellen unter verwendung von gangliosiden und anderen oberflächenmarkern
BR9806183A (pt) Quinases de proteìna e usos das mesmas
HUP0101355A2 (hu) Fehérjetermelésre és célba juttatására szolgáló genomi szekvenciák
DE60327237D1 (de) Dc-sign blockern und deren verwendung zur vorbeugung oder behandlung von viraleninfektionen
DK1235916T3 (da) Isolerede polynukleotider med et formindsket indhold af 5'CpG3' epigenitiske kontrolmotiver og anvendelser deraf
IL131436A0 (en) Compositions for treatment of disorders involving programmed cell death
BR9610227A (pt) Células de plantas transgênicas e plantas com uma maior taxa de glicólise.
ATE239788T1 (de) Antisense-oligonukleotid zur hemmung der expression des adhäsionsmoleküls very late antigen 4 (vla-4) in menschlichen zellen

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11, 13, 18 (III), 24 E 25 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.