BG96194A - Метод за получаване на простагландинови производни - Google Patents

Метод за получаване на простагландинови производни

Info

Publication number
BG96194A
BG96194A BG096194A BG9619492A BG96194A BG 96194 A BG96194 A BG 96194A BG 096194 A BG096194 A BG 096194A BG 9619492 A BG9619492 A BG 9619492A BG 96194 A BG96194 A BG 96194A
Authority
BG
Bulgaria
Prior art keywords
compound
group
hydroxyl
obtaining
alkyl
Prior art date
Application number
BG096194A
Other languages
English (en)
Other versions
BG61143B1 (bg
Inventor
Bahram Resul
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of BG96194A publication Critical patent/BG96194A/bg
Publication of BG61143B1 publication Critical patent/BG61143B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретението се отнася до метод за получаване на 13,14-дихидро-17-фенилови аналози на рgf2а или рgе2, при който съединение 4 се подлага на алкална хидролиза до съединение 6 в което се въвежда защитна група за защита на хидроксилните групи, и се получава съединение 7 което се редуцира до съединение 8 в посочените формули r е водороден или халогенен атом, хидроксилна цианидна, алкилова, хидроксиалкилова или трифлуорметилова група и ароматен или хетероароматен заместител в ароматното ядро, r1 и r2 означават поотделно водороден или халогенен атом, алкилова, хидроксилна или хидроксиалкилова група, р е защитна група и ррв е парафенилбензоил. 1 претенции
BG96194A 1990-08-08 1992-04-07 Метод за получаване на простагландинови производни BG61143B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9002596A SE9002596D0 (sv) 1990-08-08 1990-08-08 A method for synthesis of prostaglandin derivatives
PCT/SE1991/000525 WO1992002496A1 (en) 1990-08-08 1991-08-08 A method for synthesis of prostaglandin derivatives

Publications (2)

Publication Number Publication Date
BG96194A true BG96194A (bg) 1993-12-24
BG61143B1 BG61143B1 (bg) 1996-12-31

Family

ID=20380110

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96194A BG61143B1 (bg) 1990-08-08 1992-04-07 Метод за получаване на простагландинови производни

Country Status (11)

Country Link
EP (1) EP0495069B1 (bg)
JP (1) JP2670521B2 (bg)
AT (1) ATE133162T1 (bg)
BG (1) BG61143B1 (bg)
CA (1) CA2067341C (bg)
DE (1) DE69116541T2 (bg)
HU (1) HUT62874A (bg)
RO (1) RO109332B1 (bg)
RU (1) RU2073668C1 (bg)
SE (1) SE9002596D0 (bg)
WO (1) WO1992002496A1 (bg)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223537A (en) * 1991-07-23 1993-06-29 Kabi Pharmacia Ab Method and composition for treatment of gastric and duodenal disorders
US5516796A (en) * 1994-03-24 1996-05-14 Kabi Pharmacia Ab Thioprostaglandins and -prostaglandin-like compounds and therapeutic uses thereof
US6169111B1 (en) 1995-06-07 2001-01-02 Alcon Laboratories, Inc. Conformationally rigid aryl prostaglandins for use in glaucoma therapy
GB0112699D0 (en) 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
GB0126076D0 (en) * 2001-10-31 2001-12-19 Cascade Biochem Ltd Improvements relating to prostaglandins and their analogues
JP2008037782A (ja) * 2006-08-04 2008-02-21 Daiichi Fine Chemical Co Ltd プロスタグランジン誘導体の製造方法
US7642370B2 (en) 2006-08-07 2010-01-05 Daiichi Fine Chemical Co., Ltd. Method for preparing prostaglandin derivative
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
NZ599316A (en) 2009-10-16 2013-02-22 Cayman Chemical Co Inc Process for the preparation of f-series prostaglandins
US9238621B2 (en) * 2011-06-02 2016-01-19 Chinoin Zrt Processes for the preparation of prostaglandin amides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES416865A1 (es) * 1972-07-13 1976-03-01 Pfizer Procedimiento para preparar w-pentanorprostaglandinas sus- tituidas en la posicion 15.
US3962312A (en) * 1972-09-21 1976-06-08 Ono Pharmaceutical Company 9,11,15-Trihydroxy prost-5-enoic acid analogues

Also Published As

Publication number Publication date
CA2067341C (en) 1997-09-30
RU2073668C1 (ru) 1997-02-20
AU8391591A (en) 1992-03-02
AU645129B2 (en) 1994-01-06
EP0495069B1 (en) 1996-01-17
EP0495069A1 (en) 1992-07-22
BG61143B1 (bg) 1996-12-31
ATE133162T1 (de) 1996-02-15
SE9002596D0 (sv) 1990-08-08
RO109332B1 (ro) 1995-01-30
DE69116541D1 (en) 1996-02-29
JP2670521B2 (ja) 1997-10-29
WO1992002496A1 (en) 1992-02-20
CA2067341A1 (en) 1992-02-09
JPH05502043A (ja) 1993-04-15
HUT62874A (en) 1993-06-28
DE69116541T2 (de) 1996-09-19

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