BG61976B1 - Сулфатна сол на заместен триазол, фармацевтични състави нанейна основа и използването им в терапията - Google Patents

Сулфатна сол на заместен триазол, фармацевтични състави нанейна основа и използването им в терапията Download PDF

Info

Publication number: BG61976B1
Authority: BG; Bulgaria
Prior art keywords: salt; pharmaceutically acceptable; formula; composition; composition according
Prior art date: 1992-06-05

Application number

BG99132A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG99132A (bg

Inventor

Raymond Baker

Victor G. Matassa

Carole Olive

Kendal G. Pitt

David E. Storey

Leslie J. Street

Alexander R. Guiblin

Original Assignee

Merck Sharp & Dohme Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-05

Filing date

1994-10-21

Publication date

1998-11-30

1992-06-05 Priority claimed from GB929211903A external-priority patent/GB9211903D0/en

1993-04-07 Priority claimed from GB939307306A external-priority patent/GB9307306D0/en

1994-10-21 Application filed by Merck Sharp & Dohme Ltd filed Critical Merck Sharp & Dohme Ltd

1995-07-28 Publication of BG99132A publication Critical patent/BG99132A/bg

1998-11-30 Publication of BG61976B1 publication Critical patent/BG61976B1/bg

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)

BG99132A 1992-06-05 1994-10-21 Сулфатна сол на заместен триазол, фармацевтични състави нанейна основа и използването им в терапията BG61976B1 (bg)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB929211903A GB9211903D0 (en)	1992-06-05	1992-06-05	Pharmaceutical composition
GB939307306A GB9307306D0 (en)	1993-04-07	1993-04-07	Therapeutic agents
PCT/GB1993/001132 WO1993025547A1 (fr)	1992-06-05	1993-05-28	Sel sulfate d'un triazole substitue, compositions pharmaceutiques renfermant ce dernier et utilisations therapeutiques

Publications (2)

Publication Number	Publication Date
BG99132A BG99132A (bg)	1995-07-28
BG61976B1 true BG61976B1 (bg)	1998-11-30

Family

ID=26301005

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG99132A BG61976B1 (bg)	1992-06-05	1994-10-21	Сулфатна сол на заместен триазол, фармацевтични състави нанейна основа и използването им в терапията

Country Status (27)

Country	Link
US (1)	US5527817A (fr)
EP (1)	EP0573221B1 (fr)
JP (2)	JP2619197B2 (fr)
KR (1)	KR100286411B1 (fr)
CN (1)	CN1043532C (fr)
AT (1)	ATE165602T1 (fr)
AU (2)	AU659311B2 (fr)
BG (1)	BG61976B1 (fr)
CA (1)	CA2097208C (fr)
CZ (1)	CZ282060B6 (fr)
DE (1)	DE69318212T2 (fr)
DK (1)	DK0573221T3 (fr)
ES (1)	ES2116411T3 (fr)
FI (3)	FI106201B (fr)
HK (1)	HK1010050A1 (fr)
HU (1)	HUT71403A (fr)
IL (1)	IL105847A (fr)
LV (1)	LV12210B (fr)
MX (1)	MX9303373A (fr)
NO (1)	NO307420B1 (fr)
NZ (1)	NZ253210A (fr)
RO (1)	RO114326B1 (fr)
RU (1)	RU2130022C1 (fr)
SG (1)	SG50406A1 (fr)
SK (1)	SK279211B6 (fr)
UA (1)	UA27908C2 (fr)
WO (1)	WO1993025547A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69616335T2 (de) *	1995-07-11	2002-07-11	Merck & Co Inc	Ein triazolylmethyl-indol-ethylamin-bisulfat-salz
ZA965837B (en) *	1995-07-11	1997-01-31	Merck & Co Inc	A triazolylmethyl-indole ethylamine bisulfate salt
US6192882B1 (en) *	1997-02-24	2001-02-27	Aradigm Corporation	Formulation and devices for monitoring the efficacy of the delivery of aerosols
US6349719B2 (en)	1997-02-24	2002-02-26	Aradigm Corporation	Formulation and devices for monitoring the efficacy of the delivery of aerosols
ES2234324T3 (es) *	1998-11-02	2005-06-16	MERCK & CO., INC.	Combinaciones de un agonista 5ht1b/1d y un inhibidor selectivo de cox-2 para el tratamiento de la migraña.
ES2453164T3 (es)	2001-08-15	2014-04-04	Pharmacia & Upjohn Company Llc	Cristales que incluyen una sal de ácido málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida, procedimientos para su preparación y sus composiciones
WO2006137083A1 (fr) *	2005-06-20	2006-12-28	Natco Pharma Limited	Procede de preparation ameliore de rizatriptan benzoate
ES2270717B1 (es) *	2005-08-08	2008-03-01	Ragactives, S.L.	Procedimiento para la obtencion de derivados de triptamina.
US20090062550A1 (en) *	2005-11-14	2009-03-05	Matrix Laboratories Ltd	Process for the Large Scale Production of Rizatriptan Benzoate
EP2160390A1 (fr) *	2007-06-04	2010-03-10	Generics Ýuk¨Limited	Procédé nouveau
JP7126260B2 (ja)	2016-01-27	2022-08-26	インスターテクノロジーズアクチオヴァスプルチュノスト	治療処置用の口腔粘膜ナノファイバ担体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8724912D0 (en) *	1987-10-23	1987-11-25	Wellcome Found	Indole derivatives
GB9026998D0 (en) *	1990-12-12	1991-01-30	Glaxo Group Ltd	Medicaments
CZ283018B6 (cs) *	1991-02-01	1997-12-17	Merck Sharp And Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi

1993
- 1993-05-28 RU RU94046380/04A patent/RU2130022C1/ru not_active IP Right Cessation
- 1993-05-28 UA UA94129126A patent/UA27908C2/uk unknown
- 1993-05-28 NZ NZ253210A patent/NZ253210A/en unknown
- 1993-05-28 WO PCT/GB1993/001132 patent/WO1993025547A1/fr active IP Right Grant
- 1993-05-28 EP EP93304158A patent/EP0573221B1/fr not_active Expired - Lifetime
- 1993-05-28 DK DK93304158T patent/DK0573221T3/da active
- 1993-05-28 KR KR1019940704402A patent/KR100286411B1/ko not_active IP Right Cessation
- 1993-05-28 JP JP5127463A patent/JP2619197B2/ja not_active Expired - Fee Related
- 1993-05-28 CZ CZ943044A patent/CZ282060B6/cs not_active IP Right Cessation
- 1993-05-28 AU AU39875/93A patent/AU659311B2/en not_active Ceased
- 1993-05-28 HU HU9403478A patent/HUT71403A/hu unknown
- 1993-05-28 AT AT93304158T patent/ATE165602T1/de not_active IP Right Cessation
- 1993-05-28 SG SG1996000374A patent/SG50406A1/en unknown
- 1993-05-28 ES ES93304158T patent/ES2116411T3/es not_active Expired - Lifetime
- 1993-05-28 DE DE69318212T patent/DE69318212T2/de not_active Expired - Fee Related
- 1993-05-28 AU AU43372/93A patent/AU4337293A/en not_active Abandoned
- 1993-05-28 RO RO94-01910A patent/RO114326B1/ro unknown
- 1993-05-28 CA CA002097208A patent/CA2097208C/fr not_active Expired - Fee Related
- 1993-05-28 SK SK1479-94A patent/SK279211B6/sk unknown
- 1993-05-31 IL IL10584793A patent/IL105847A/en not_active IP Right Cessation
- 1993-06-04 MX MX9303373A patent/MX9303373A/es not_active IP Right Cessation
- 1993-06-05 CN CN93108728A patent/CN1043532C/zh not_active Expired - Fee Related
1994
- 1994-10-21 BG BG99132A patent/BG61976B1/bg unknown
- 1994-12-02 NO NO944656A patent/NO307420B1/no not_active IP Right Cessation
- 1994-12-02 FI FI945694A patent/FI106201B/fi active
- 1994-12-07 US US08/350,760 patent/US5527817A/en not_active Expired - Lifetime
1996
- 1996-08-30 JP JP8230809A patent/JP2972150B2/ja not_active Expired - Fee Related
1998
- 1998-09-05 HK HK98110478A patent/HK1010050A1/xx not_active IP Right Cessation
- 1998-10-26 LV LVP-98-237A patent/LV12210B/en unknown
2000
- 2000-08-10 FI FI20001777A patent/FI20001777A/fi unknown
- 2000-08-10 FI FI20001776A patent/FI20001776A/fi unknown

Also Published As

Publication number	Publication date
EP0573221A1 (fr)	1993-12-08
FI106201B (fi)	2000-12-15
IL105847A0 (en)	1993-09-22
WO1993025547A1 (fr)	1993-12-23
NO944656D0 (no)	1994-12-02
CA2097208C (fr)	2005-02-08
CZ282060B6 (cs)	1997-05-14
RU2130022C1 (ru)	1999-05-10
SG50406A1 (en)	1998-07-20
LV12210A (lv)	1999-01-20
CA2097208A1 (fr)	1993-12-06
AU4337293A (en)	1994-01-04
NZ253210A (en)	1995-09-26
IL105847A (en)	1998-09-24
KR100286411B1 (ko)	2001-04-16
FI20001777A (fi)	2000-08-10
DE69318212D1 (de)	1998-06-04
EP0573221B1 (fr)	1998-04-29
BG99132A (bg)	1995-07-28
FI20001776A (fi)	2000-08-10
ATE165602T1 (de)	1998-05-15
UA27908C2 (uk)	2000-10-16
CN1089263A (zh)	1994-07-13
US5527817A (en)	1996-06-18
KR950701922A (ko)	1995-05-17
NO944656L (no)	1994-12-02
HK1010050A1 (en)	1999-06-11
JP2619197B2 (ja)	1997-06-11
FI945694A (fi)	1994-12-02
RU94046380A (ru)	1996-12-10
CN1043532C (zh)	1999-06-02
JPH0641121A (ja)	1994-02-15
LV12210B (en)	1999-03-20
ES2116411T3 (es)	1998-07-16
DK0573221T3 (da)	1998-10-07
FI945694A0 (fi)	1994-12-02
SK147994A3 (en)	1995-07-11
JP2972150B2 (ja)	1999-11-08
DE69318212T2 (de)	1998-11-19
AU659311B2 (en)	1995-05-11
MX9303373A (es)	1995-01-31
SK279211B6 (sk)	1998-08-05
CZ304494A3 (en)	1995-09-13
HU9403478D0 (en)	1995-02-28
HUT71403A (en)	1995-11-28
AU3987593A (en)	1993-12-09
NO307420B1 (no)	2000-04-03
RO114326B1 (ro)	1999-03-30
JPH09176155A (ja)	1997-07-08

Publication	Publication Date	Title
US5554639A (en)	1996-09-10	Medicaments
US5393773A (en)	1995-02-28	Method for the intranasal administration of 3-[2-(dimethylamino)-ethyl]-H-methyl-1H-indole-5-methanesulphonamide
BG61976B1 (bg)	1998-11-30	Сулфатна сол на заместен триазол, фармацевтични състави нанейна основа и използването им в терапията
US5834502A (en)	1998-11-10	Triazolylmethyl-indole ethylamine bisulfate salt
EP0840733B1 (fr)	2001-10-24	Sel de bisulfate de triazolymethyle-indole ethylamine
HRP940225A2 (en)	1997-08-31	The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy