HUT71403A - The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy - Google Patents

The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy

Info

Publication number: HUT71403A
Authority: HU; Hungary
Prior art keywords: therapy; pharmaceutical compositions; sulphate salt; substituted triazole; receptors
Prior art date: 1992-06-05

Application number

HU9403478A

Other languages

English (en)

Other versions

HU9403478D0 (en

Inventor

Raymond Baker

Victor Giulio Matassa

Carole Olive

Kendal George Pitt

David Edward Storey

Leslie Joseph Street

Alexander Richard Guiblin

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-05

Filing date

1993-05-28

Publication date

1995-11-28

1992-06-05 Priority claimed from GB929211903A external-priority patent/GB9211903D0/en

1993-04-07 Priority claimed from GB939307306A external-priority patent/GB9307306D0/en

1993-05-28 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

1995-02-28 Publication of HU9403478D0 publication Critical patent/HU9403478D0/hu

1995-11-28 Publication of HUT71403A publication Critical patent/HUT71403A/hu

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)

HU9403478A 1992-06-05 1993-05-28 The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy HUT71403A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929211903A GB9211903D0 (en)	1992-06-05	1992-06-05	Pharmaceutical composition
GB939307306A GB9307306D0 (en)	1993-04-07	1993-04-07	Therapeutic agents

Publications (2)

Publication Number	Publication Date
HU9403478D0 HU9403478D0 (en)	1995-02-28
HUT71403A true HUT71403A (en)	1995-11-28

Family

ID=26301005

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9403478A HUT71403A (en)	1992-06-05	1993-05-28	The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy

Country Status (27)

Country	Link
US (1)	US5527817A (hu)
EP (1)	EP0573221B1 (hu)
JP (2)	JP2619197B2 (hu)
KR (1)	KR100286411B1 (hu)
CN (1)	CN1043532C (hu)
AT (1)	ATE165602T1 (hu)
AU (2)	AU659311B2 (hu)
BG (1)	BG61976B1 (hu)
CA (1)	CA2097208C (hu)
CZ (1)	CZ282060B6 (hu)
DE (1)	DE69318212T2 (hu)
DK (1)	DK0573221T3 (hu)
ES (1)	ES2116411T3 (hu)
FI (3)	FI106201B (hu)
HK (1)	HK1010050A1 (hu)
HU (1)	HUT71403A (hu)
IL (1)	IL105847A (hu)
LV (1)	LV12210B (hu)
MX (1)	MX9303373A (hu)
NO (1)	NO307420B1 (hu)
NZ (1)	NZ253210A (hu)
RO (1)	RO114326B1 (hu)
RU (1)	RU2130022C1 (hu)
SG (1)	SG50406A1 (hu)
SK (1)	SK279211B6 (hu)
UA (1)	UA27908C2 (hu)
WO (1)	WO1993025547A1 (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69616335T2 (de) *	1995-07-11	2002-07-11	Merck & Co Inc	Ein triazolylmethyl-indol-ethylamin-bisulfat-salz
ZA965837B (en) *	1995-07-11	1997-01-31	Merck & Co Inc	A triazolylmethyl-indole ethylamine bisulfate salt
US6192882B1 (en) *	1997-02-24	2001-02-27	Aradigm Corporation	Formulation and devices for monitoring the efficacy of the delivery of aerosols
US6349719B2 (en)	1997-02-24	2002-02-26	Aradigm Corporation	Formulation and devices for monitoring the efficacy of the delivery of aerosols
ES2234324T3 (es) *	1998-11-02	2005-06-16	MERCK & CO., INC.	Combinaciones de un agonista 5ht1b/1d y un inhibidor selectivo de cox-2 para el tratamiento de la migraña.
ES2453164T3 (es)	2001-08-15	2014-04-04	Pharmacia & Upjohn Company Llc	Cristales que incluyen una sal de ácido málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida, procedimientos para su preparación y sus composiciones
WO2006137083A1 (en) *	2005-06-20	2006-12-28	Natco Pharma Limited	Improved process for the preparation of rizatriptan benzoate
ES2270717B1 (es) *	2005-08-08	2008-03-01	Ragactives, S.L.	Procedimiento para la obtencion de derivados de triptamina.
US20090062550A1 (en) *	2005-11-14	2009-03-05	Matrix Laboratories Ltd	Process for the Large Scale Production of Rizatriptan Benzoate
EP2160390A1 (en) *	2007-06-04	2010-03-10	Generics Ýuk¨Limited	Novel process
JP7126260B2 (ja)	2016-01-27	2022-08-26	インスターテクノロジーズアクチオヴァスプルチュノスト	治療処置用の口腔粘膜ナノファイバ担体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8724912D0 (en) *	1987-10-23	1987-11-25	Wellcome Found	Indole derivatives
GB9026998D0 (en) *	1990-12-12	1991-01-30	Glaxo Group Ltd	Medicaments
CZ283018B6 (cs) *	1991-02-01	1997-12-17	Merck Sharp And Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi

1993
- 1993-05-28 RU RU94046380/04A patent/RU2130022C1/ru not_active IP Right Cessation
- 1993-05-28 UA UA94129126A patent/UA27908C2/uk unknown
- 1993-05-28 NZ NZ253210A patent/NZ253210A/en unknown
- 1993-05-28 WO PCT/GB1993/001132 patent/WO1993025547A1/en active IP Right Grant
- 1993-05-28 EP EP93304158A patent/EP0573221B1/en not_active Expired - Lifetime
- 1993-05-28 DK DK93304158T patent/DK0573221T3/da active
- 1993-05-28 KR KR1019940704402A patent/KR100286411B1/ko not_active IP Right Cessation
- 1993-05-28 JP JP5127463A patent/JP2619197B2/ja not_active Expired - Fee Related
- 1993-05-28 CZ CZ943044A patent/CZ282060B6/cs not_active IP Right Cessation
- 1993-05-28 AU AU39875/93A patent/AU659311B2/en not_active Ceased
- 1993-05-28 HU HU9403478A patent/HUT71403A/hu unknown
- 1993-05-28 AT AT93304158T patent/ATE165602T1/de not_active IP Right Cessation
- 1993-05-28 SG SG1996000374A patent/SG50406A1/en unknown
- 1993-05-28 ES ES93304158T patent/ES2116411T3/es not_active Expired - Lifetime
- 1993-05-28 DE DE69318212T patent/DE69318212T2/de not_active Expired - Fee Related
- 1993-05-28 AU AU43372/93A patent/AU4337293A/en not_active Abandoned
- 1993-05-28 RO RO94-01910A patent/RO114326B1/ro unknown
- 1993-05-28 CA CA002097208A patent/CA2097208C/en not_active Expired - Fee Related
- 1993-05-28 SK SK1479-94A patent/SK279211B6/sk unknown
- 1993-05-31 IL IL10584793A patent/IL105847A/en not_active IP Right Cessation
- 1993-06-04 MX MX9303373A patent/MX9303373A/es not_active IP Right Cessation
- 1993-06-05 CN CN93108728A patent/CN1043532C/zh not_active Expired - Fee Related
1994
- 1994-10-21 BG BG99132A patent/BG61976B1/bg unknown
- 1994-12-02 NO NO944656A patent/NO307420B1/no not_active IP Right Cessation
- 1994-12-02 FI FI945694A patent/FI106201B/fi active
- 1994-12-07 US US08/350,760 patent/US5527817A/en not_active Expired - Lifetime
1996
- 1996-08-30 JP JP8230809A patent/JP2972150B2/ja not_active Expired - Fee Related
1998
- 1998-09-05 HK HK98110478A patent/HK1010050A1/xx not_active IP Right Cessation
- 1998-10-26 LV LVP-98-237A patent/LV12210B/en unknown
2000
- 2000-08-10 FI FI20001777A patent/FI20001777A/fi unknown
- 2000-08-10 FI FI20001776A patent/FI20001776A/fi unknown

Also Published As

Publication number	Publication date
EP0573221A1 (en)	1993-12-08
FI106201B (fi)	2000-12-15
IL105847A0 (en)	1993-09-22
WO1993025547A1 (en)	1993-12-23
NO944656D0 (no)	1994-12-02
CA2097208C (en)	2005-02-08
CZ282060B6 (cs)	1997-05-14
RU2130022C1 (ru)	1999-05-10
SG50406A1 (en)	1998-07-20
LV12210A (lv)	1999-01-20
CA2097208A1 (en)	1993-12-06
AU4337293A (en)	1994-01-04
NZ253210A (en)	1995-09-26
IL105847A (en)	1998-09-24
KR100286411B1 (ko)	2001-04-16
FI20001777A (fi)	2000-08-10
DE69318212D1 (de)	1998-06-04
EP0573221B1 (en)	1998-04-29
BG99132A (bg)	1995-07-28
FI20001776A (fi)	2000-08-10
ATE165602T1 (de)	1998-05-15
UA27908C2 (uk)	2000-10-16
CN1089263A (zh)	1994-07-13
BG61976B1 (bg)	1998-11-30
US5527817A (en)	1996-06-18
KR950701922A (ko)	1995-05-17
NO944656L (no)	1994-12-02
HK1010050A1 (en)	1999-06-11
JP2619197B2 (ja)	1997-06-11
FI945694A (fi)	1994-12-02
RU94046380A (ru)	1996-12-10
CN1043532C (zh)	1999-06-02
JPH0641121A (ja)	1994-02-15
LV12210B (en)	1999-03-20
ES2116411T3 (es)	1998-07-16
DK0573221T3 (da)	1998-10-07
FI945694A0 (fi)	1994-12-02
SK147994A3 (en)	1995-07-11
JP2972150B2 (ja)	1999-11-08
DE69318212T2 (de)	1998-11-19
AU659311B2 (en)	1995-05-11
MX9303373A (es)	1995-01-31
SK279211B6 (sk)	1998-08-05
CZ304494A3 (en)	1995-09-13
HU9403478D0 (en)	1995-02-28
AU3987593A (en)	1993-12-09
NO307420B1 (no)	2000-04-03
RO114326B1 (ro)	1999-03-30
JPH09176155A (ja)	1997-07-08

Publication	Publication Date	Title
IL96891A0 (en)	1992-03-29	Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
HK1010050A1 (en)	1999-06-11	The sulphate salt of a substituted triazole pharmaceutical compositions thereof and their use in therapy
AU4215593A (en)	1994-02-03	4-substituted 1,2,4-triazole derivatives
HU9202231D0 (en)	1992-10-28	Fungicidal preparative of synergetic effect
ITRM950480A0 (it)	1995-07-13	Metodo per aumentare la rapidita' di allevamento di neonati mediante impiego di mangime per scrofe da riproduzione.
CA2135709A1 (en)	1995-05-19	Melatonin derivatives for use in treating sleep disorders
ZA962715B (en)	1997-10-06	Pharmaceutical agents for the treatment of Alzheimer's disease.
GB9207396D0 (en)	1992-05-13	Therapeutic agents
NZ303993A (en)	2000-12-22	Pharmaceutical compositions containing aminotetralin derivatives for treating cardiac disorders
MY110795A (en)	1999-04-30	The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy
ITRM940322A0 (it)	1994-05-24	"composizione farmaceutica contenente carbazolone per il trattamento di emicrania e disturbi psicotici e relativo metodo di preparazione edapplicazione".
DE3473447D1 (en)	1988-09-22	Triazole antifungal agents
AU6542896A (en)	1997-02-10	A triazolylmethyl-indole ethylamine bisulfate salt
MY108739A (en)	1996-11-30	Imidazole, triazole and tetrazole derivatives