BG104100A - Производни на ацил-пиперазинил-пиримидини, тяхното получаване и използването им като лекарствени средства - Google Patents

Производни на ацил-пиперазинил-пиримидини, тяхното получаване и използването им като лекарствени средства

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Publication number
BG104100A
BG104100A BG104100A BG10410000A BG104100A BG 104100 A BG104100 A BG 104100A BG 104100 A BG104100 A BG 104100A BG 10410000 A BG10410000 A BG 10410000A BG 104100 A BG104100 A BG 104100A
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BG
Bulgaria
Prior art keywords
derivative
pyrimidins
acyl
derivatives
compounds
Prior art date
Application number
BG104100A
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English (en)
Other versions
BG64849B1 (bg
Inventor
Arjona Jordi Corbera
Domenech David Vano
Constansa Jordi Frigola
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Laboratorios Del Dr.Esteve S.A.
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Application filed by Laboratorios Del Dr.Esteve S.A. filed Critical Laboratorios Del Dr.Esteve S.A.
Publication of BG104100A publication Critical patent/BG104100A/bg
Publication of BG64849B1 publication Critical patent/BG64849B1/bg

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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Изобретението се отнася до ацил-пиперазинил-пиримидинови производни с обща формула I, посочена в описанието, в която Х е О или S, R1 e алкокси или трифлуорометил, R2 е алкил, циклоалкил, хетероциклоалкил, арил, арилалкил, хетероарил или хетероарилалкил. Съединенията с формула I, в която Х е О, се получават чрез взаимодействие на производно на пиримидин с производно на пиперазин или чрез взаимодействие на производно на пиперазин-пиримидин с карбоксилна киселина или нейна сол, или производно. Съединенията с формула I, в която Х е S, може да се получат чрез взаимодействие на съединение с формулаI, в която Х е О, с реактив на Lawesson или с фосфорен пентасулфид. Съединенията се използват за лечение на централната нервна система и имат седативно, антиконвулсивно, хипнотично действие или общаанестетична активност и се прилагат в хуманната и/или ветеринарната медицина.
BG104100A 1997-07-21 2000-01-21 Производни на ацил-пиперазинил-пиримидини, тяхното получаване и използването им като лекарствени средства BG64849B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009701627A ES2125206B1 (es) 1997-07-21 1997-07-21 Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.

Publications (2)

Publication Number Publication Date
BG104100A true BG104100A (bg) 2001-05-31
BG64849B1 BG64849B1 (bg) 2006-06-30

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US (1) US6372746B1 (bg)
EP (1) EP1006110B8 (bg)
JP (1) JP2001510831A (bg)
KR (1) KR100514148B1 (bg)
CN (1) CN1202087C (bg)
AR (1) AR017254A1 (bg)
AT (1) ATE259357T1 (bg)
AU (1) AU744633B2 (bg)
BG (1) BG64849B1 (bg)
BR (1) BR9810772A (bg)
CA (1) CA2297417C (bg)
CO (1) CO5011090A1 (bg)
DE (1) DE69821623T2 (bg)
DK (1) DK1006110T3 (bg)
EE (1) EE04151B1 (bg)
ES (2) ES2125206B1 (bg)
GE (1) GEP20033090B (bg)
HK (1) HK1032958A1 (bg)
HU (1) HUP0002517A3 (bg)
IN (1) IN183820B (bg)
IS (1) IS2076B (bg)
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LV (1) LV12457B (bg)
NO (1) NO314996B1 (bg)
NZ (1) NZ502400A (bg)
PL (1) PL195632B1 (bg)
PT (1) PT1006110E (bg)
RU (1) RU2205827C2 (bg)
SI (1) SI20269B (bg)
SK (1) SK284675B6 (bg)
TW (1) TW530056B (bg)
UA (1) UA59403C2 (bg)
WO (1) WO1999005121A1 (bg)
ZA (1) ZA986437B (bg)

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