BG103122A - 3-заместени пиридо [4',3' : 4,5] тиено [2,3-d] пиримидинови производни, тяхното получаване и използване - Google Patents

3-заместени пиридо [4',3' : 4,5] тиено [2,3-d] пиримидинови производни, тяхното получаване и използване

Info

Publication number
BG103122A
BG103122A BG103122A BG10312299A BG103122A BG 103122 A BG103122 A BG 103122A BG 103122 A BG103122 A BG 103122A BG 10312299 A BG10312299 A BG 10312299A BG 103122 A BG103122 A BG 103122A
Authority
BG
Bulgaria
Prior art keywords
residue
alkyl
hydroxy
optionally
phenyl
Prior art date
Application number
BG103122A
Other languages
English (en)
Other versions
BG63602B1 (bg
Inventor
Gerd Steiner
Wilfried Lubisch
Alfred Bach
Franz Emling
Karsten Wicke
Hans-Juergen Teschendorf
Berthold Behl
Frank Kerrigan
Sharon Cheetham
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of BG103122A publication Critical patent/BG103122A/bg
Publication of BG63602B1 publication Critical patent/BG63602B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

3-заместените 3,4,5,6,7,8-хексахидро-пиридо[4',3':4,5]-тиено[2,3-d]пиримидиновите производни могатда се използват като лекарствени средства за заболявания, при които е понижена концентрацията на серотонин и при които в рамките на терапията трябва да се блокира активността на пресинаптичните рецептори 5-НТ1В-, 5-НТ1А-, 5-НТ1D-, без да се повлияятсилно други рецептори. Пример за такова болестно състояние е депресията. Съединенията имат формула, в която R1 е водород, С1-С4-алкиловагрупа, ацетил, бензоил, фенилалкил-С1-С4-остатък,при което ароматният остатък в даден случай е заместен с халоген, С1-С4-алкил, трифлуорметил, хидрокси-, С1-С4-алкокси-, амино-, циано- или нитрогрупи или е нафтален-С1-С3-алкилов остатък, фенилалканон-С2-С3-остатък или фенилкарбамоилалкил-С2-остатък, при което фениловата група може да се замести схалоген; R2 в даден случай е моно-, ди- или тризаместен с халогенни атоми, С1-С4-алкил, трифлуорметил, трифлуорметокси, хидрокси, С1-С4-алкокси, амино-, монометиламино-, диметиламино-, циано- или нитрогрупа, фенилов, пиридилов, пиримидинилов или пиразинилов остатък, който в даден случай може да бъде анелиран с един бензенов пръстен, който в даден случай може да бъде моно- или дизаместен с халогенен атом, С1-С4-алкил, хидрокси, трифлуорметил, С1-С4-алкокси-, амино-, циано- или нитрогрупа, и в даден случай може да съдържа един азотен атом, или да бъде анелиран с 5- или 6-членен пръстен, който може да съдържа един до два кислородни атома, или
BG103122A 1996-09-10 1999-01-27 3-заместени пиридо [4',3' : 4,5] тиено [2,3-d] пиримидинови производни, тяхното получаване и използване BG63602B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19636769A DE19636769A1 (de) 1996-09-10 1996-09-10 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung
PCT/EP1997/004593 WO1998011110A1 (de) 1996-09-10 1997-08-22 3-substituierte pyrido [4',3':4,5] thieno [2,3-d]pyrimidin-derivate, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
BG103122A true BG103122A (bg) 1999-09-30
BG63602B1 BG63602B1 (bg) 2002-06-28

Family

ID=7805168

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103122A BG63602B1 (bg) 1996-09-10 1999-01-27 3-заместени пиридо [4',3' : 4,5] тиено [2,3-d] пиримидинови производни, тяхното получаване и използване

Country Status (32)

Country Link
US (1) US6222034B1 (bg)
EP (1) EP0927184B1 (bg)
JP (1) JP2001500138A (bg)
KR (1) KR20000035987A (bg)
CN (2) CN1230962A (bg)
AR (1) AR009572A1 (bg)
AT (1) ATE252587T1 (bg)
AU (1) AU736678B2 (bg)
BG (1) BG63602B1 (bg)
BR (1) BR9711724A (bg)
CA (1) CA2265509A1 (bg)
CO (1) CO4900071A1 (bg)
CZ (1) CZ288896B6 (bg)
DE (2) DE19636769A1 (bg)
DK (1) DK0927184T3 (bg)
ES (1) ES2210570T3 (bg)
HK (1) HK1043593A1 (bg)
HR (1) HRP970484A2 (bg)
HU (1) HUP9904107A3 (bg)
ID (1) ID18260A (bg)
IL (1) IL128142A0 (bg)
NO (1) NO991132L (bg)
NZ (1) NZ334350A (bg)
PL (1) PL332144A1 (bg)
PT (1) PT927184E (bg)
RU (1) RU2198888C2 (bg)
SK (1) SK283039B6 (bg)
TR (1) TR199900503T2 (bg)
TW (1) TW480264B (bg)
UA (1) UA54449C2 (bg)
WO (1) WO1998011110A1 (bg)
ZA (1) ZA978081B (bg)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19724980A1 (de) * 1997-06-13 1998-12-17 Basf Ag 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung
DE19724979A1 (de) * 1997-06-13 1998-12-17 Basf Ag 3-substituierte Pyrido [3,4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung
DE19734444A1 (de) * 1997-08-08 1999-02-11 Basf Ag 3-Substituierte 3,4,5,7-Tetrahydro-pyrrolo(3',4':4,5) thieno (2,3-d) pyrimidin-Derivate, ihre Herstellung und Verwendung
DE19900545A1 (de) * 1999-01-11 2000-07-13 Basf Ag Verwendung von Pyrimidinderivaten zur Prophylaxe und Therapie der zerebralen Ischämie
DE19900673A1 (de) * 1999-01-11 2000-07-13 Basf Ag Verwendung von Bindungspartnern für 5-HT5-Rezeptoren zur Behandlung neurodegenerativer und neuropsychiatrischer Störungen
FR2791980B1 (fr) * 1999-04-09 2001-07-06 Sod Conseils Rech Applic Pyrido-thieno-diazepines, leur procede de preparation, et les compositions pharmaceutiques les contenant
DE10031389A1 (de) * 2000-07-03 2002-01-17 Knoll Ag Pyrimidinderivate und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie
DE10031390A1 (de) * 2000-07-03 2002-01-17 Knoll Ag Pyrimidinderivate und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie
ES2291329T3 (es) 2000-07-18 2008-03-01 Dainippon Sumitomo Pharma Co., Ltd. Inhibidores de la recaptacion de serotonina.
DE10259382A1 (de) * 2002-12-18 2004-07-01 Abbott Gmbh & Co. Kg 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-4-on-Derivate, ihre Herstellung und Verwendung
US20050222175A1 (en) * 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7612078B2 (en) * 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
CN1777612A (zh) * 2003-03-31 2006-05-24 普雷迪克医药品控股公司 新的哌啶基氨基－噻吩并[2,3－d]嘧啶化合物
US20050165025A1 (en) * 2004-01-22 2005-07-28 Recordati Ireland Ltd. Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
US7488736B2 (en) * 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7576211B2 (en) * 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
US7407966B2 (en) * 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
EP2445877B1 (en) * 2008-12-03 2014-07-23 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
ES2605005T3 (es) * 2010-04-14 2017-03-10 Bayer Intellectual Property Gmbh Procedimiento para la preparación de ditiino-tetracarboximidas

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE272079C (bg) *
DE272086C (bg) *
DE272088C (bg) *
US3823151A (en) * 1968-08-02 1974-07-09 Ciba Geigy Corp 4,5,6,7-tetrahydrothieno(2,3-d)pyridines
DE1937459A1 (de) * 1968-08-02 1970-02-05 Ciba Geigy Neue Pyrimidinderivate und Verfahren zu ihrer Herstellung
JPS60146891A (ja) * 1984-01-05 1985-08-02 Mitsubishi Chem Ind Ltd 〔２，３−ｄ〕チエノピリミジン誘導体およびその塩
DE3752141T2 (de) * 1986-02-24 1998-03-26 Mitsui Petrochemical Ind Mittel zur behandlung von neuropathie
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US4835157A (en) 1988-03-15 1989-05-30 Ortho Pharmaceutical Corporation Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents

Also Published As

Publication number Publication date
DK0927184T3 (da) 2004-03-01
DE59710902D1 (de) 2003-11-27
EP0927184B1 (de) 2003-10-22
NO991132D0 (no) 1999-03-09
CZ288896B6 (cs) 2001-09-12
WO1998011110A1 (de) 1998-03-19
ATE252587T1 (de) 2003-11-15
AR009572A1 (es) 2000-04-26
HK1043593A1 (zh) 2002-09-20
ES2210570T3 (es) 2004-07-01
CN1230962A (zh) 1999-10-06
CN1332168A (zh) 2002-01-23
HUP9904107A2 (hu) 2000-05-28
US6222034B1 (en) 2001-04-24
TW480264B (en) 2002-03-21
BG63602B1 (bg) 2002-06-28
CA2265509A1 (en) 1998-03-19
CO4900071A1 (es) 2000-03-27
IL128142A0 (en) 1999-11-30
HRP970484A2 (en) 1998-10-31
AU4207197A (en) 1998-04-02
CZ75999A3 (cs) 1999-06-16
ZA978081B (en) 1999-03-09
PT927184E (pt) 2004-03-31
DE19636769A1 (de) 1998-03-12
BR9711724A (pt) 1999-08-24
PL332144A1 (en) 1999-08-30
SK23099A3 (en) 1999-08-06
KR20000035987A (ko) 2000-06-26
UA54449C2 (uk) 2003-03-17
HUP9904107A3 (en) 2001-10-29
NO991132L (no) 1999-03-09
AU736678B2 (en) 2001-08-02
RU2198888C2 (ru) 2003-02-20
TR199900503T2 (xx) 1999-07-21
ID18260A (id) 1998-03-19
JP2001500138A (ja) 2001-01-09
EP0927184A1 (de) 1999-07-07
SK283039B6 (sk) 2003-02-04
NZ334350A (en) 2000-07-28

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