BE901879A - ANALOGUE PRODUCTS OF 1ALPHA-HYDROXYVITAMIN D2, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. - Google Patents

ANALOGUE PRODUCTS OF 1ALPHA-HYDROXYVITAMIN D2, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Info

Publication number
BE901879A
BE901879A BE0/214606A BE214606A BE901879A BE 901879 A BE901879 A BE 901879A BE 0/214606 A BE0/214606 A BE 0/214606A BE 214606 A BE214606 A BE 214606A BE 901879 A BE901879 A BE 901879A
Authority
BE
Belgium
Prior art keywords
1alpha
vitamin
hydroxyvitamin
pharmaceutical compositions
preparation process
Prior art date
Application number
BE0/214606A
Other languages
French (fr)
Inventor
H F Deluca
H K Schnoes
R R Sicinski
Y Tanaka
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of BE901879A publication Critical patent/BE901879A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention fournit de noveaux produits analogues des composés de la vitamine D2 qui ne comportent pas le substituant méthyle sur la position 24 et qui sont la 1-hydroxy-28-norvitamine D2 et la 1alpha,25-dihydroxy-28-norvitamine D2 de formule I. Les composés de la présente invention sont caractérisés par une forte activité inattendue, semblable à celle d'une vitamine D ainsi que par un nouveau modèle d'activité et, comme tels, sont des produits de remplacement de la vitamine D ou de dives métabolites de la vitamine D connus dans leurs applications variées pour le traitement des troubles du calcium.The present invention provides novel analog products of the vitamin D2 compounds which do not have the methyl substituent at position 24 and which are 1-hydroxy-28-norvitamin D2 and 1alpha, 25-dihydroxy-28-norvitamin D2. formula I. The compounds of the present invention are characterized by an unexpectedly strong activity, similar to that of a vitamin D as well as by a new activity model and, as such, are substitutes for vitamin D or various metabolites of vitamin D known in their various applications for the treatment of calcium disorders.

BE0/214606A 1984-03-05 1985-03-05 ANALOGUE PRODUCTS OF 1ALPHA-HYDROXYVITAMIN D2, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. BE901879A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58616084A 1984-03-05 1984-03-05

Publications (1)

Publication Number Publication Date
BE901879A true BE901879A (en) 1985-07-01

Family

ID=24344548

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214606A BE901879A (en) 1984-03-05 1985-03-05 ANALOGUE PRODUCTS OF 1ALPHA-HYDROXYVITAMIN D2, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Country Status (12)

Country Link
JP (1) JPH064536B2 (en)
AU (1) AU584071B2 (en)
BE (1) BE901879A (en)
CH (1) CH667658A5 (en)
DE (2) DE3590080T (en)
DK (1) DK153145C (en)
FR (1) FR2560597B1 (en)
GB (1) GB2155478B (en)
IE (1) IE57951B1 (en)
IL (1) IL74168A (en)
NL (1) NL8520021A (en)
WO (1) WO1985003939A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
IN171426B (en) * 1990-02-14 1992-10-10 Wisconsin Alumni Res Found
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907843A (en) * 1974-06-14 1975-09-23 Wisconsin Alumni Res Found 1{60 -Hydroxyergocalciferol and processes for preparing same
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
US4195027A (en) * 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4206131A (en) * 1978-06-19 1980-06-03 The Upjohn Company Compounds and process
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
CH665835A5 (en) * 1984-01-30 1988-06-15 Wisconsin Alumni Res Found 1ALPHA, 25-DIHYDROXY-22Z-DEHYDROVITAMIN D-CONNECTION.

Also Published As

Publication number Publication date
JPS61501447A (en) 1986-07-17
IL74168A0 (en) 1985-04-30
AU584071B2 (en) 1989-05-18
IE57951B1 (en) 1993-05-19
WO1985003939A1 (en) 1985-09-12
DK506985D0 (en) 1985-11-04
GB2155478A (en) 1985-09-25
AU3889585A (en) 1985-09-24
GB2155478B (en) 1987-12-16
JPH064536B2 (en) 1994-01-19
DE3590080T (en) 1986-02-20
GB8505486D0 (en) 1985-04-03
DK153145B (en) 1988-06-20
DK506985A (en) 1985-11-06
DE3590080C2 (en) 1992-08-06
CH667658A5 (en) 1988-10-31
IE850520L (en) 1985-09-05
FR2560597A1 (en) 1985-09-06
IL74168A (en) 1988-11-15
NL8520021A (en) 1986-02-03
DK153145C (en) 1988-10-31
FR2560597B1 (en) 1987-12-04

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: WISCONSIN ALUMNI RESEARCH FOUNDATION

Effective date: 19990331