BE1002151A5 - Nouveaux derives de l'acide furannuronique, leur preparation et leur utilisation comme medicaments. - Google Patents

Nouveaux derives de l'acide furannuronique, leur preparation et leur utilisation comme medicaments. Download PDF

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Publication number
BE1002151A5
BE1002151A5 BE8800374A BE8800374A BE1002151A5 BE 1002151 A5 BE1002151 A5 BE 1002151A5 BE 8800374 A BE8800374 A BE 8800374A BE 8800374 A BE8800374 A BE 8800374A BE 1002151 A5 BE1002151 A5 BE 1002151A5
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BE
Belgium
Prior art keywords
medicaments
furannuronic
preparation
acid
novel derivatives
Prior art date
Application number
BE8800374A
Other languages
English (en)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1002151A5 publication Critical patent/BE1002151A5/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention a pour objet des amides et thioamides d'un acide 1'-désoxy-1'-(6-amino-9-purinyl)-beta-D-ribofurannuronique substitué en position 2. Ces composés peuvent être utilisés comme médicaments.
BE8800374A 1987-04-06 1988-03-30 Nouveaux derives de l'acide furannuronique, leur preparation et leur utilisation comme medicaments. BE1002151A5 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3711561 1987-04-06
DE3711564 1987-04-06
DE3711563 1987-04-06
DE3711562 1987-04-06

Publications (1)

Publication Number Publication Date
BE1002151A5 true BE1002151A5 (fr) 1990-08-07

Family

ID=27433888

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8800374A BE1002151A5 (fr) 1987-04-06 1988-03-30 Nouveaux derives de l'acide furannuronique, leur preparation et leur utilisation comme medicaments.

Country Status (22)

Country Link
JP (1) JPS63258892A (fr)
KR (1) KR880012629A (fr)
AT (1) AT393507B (fr)
AU (1) AU609109B2 (fr)
BE (1) BE1002151A5 (fr)
CA (1) CA1326017C (fr)
CH (1) CH676121A5 (fr)
DK (1) DK183488A (fr)
ES (1) ES2007177A6 (fr)
FI (1) FI87463C (fr)
FR (1) FR2613367A1 (fr)
GB (1) GB2203149B (fr)
HU (1) HU201955B (fr)
IL (1) IL85969A (fr)
IT (1) IT1219892B (fr)
LU (1) LU87181A1 (fr)
MY (1) MY102323A (fr)
NL (1) NL8800862A (fr)
NZ (1) NZ224131A (fr)
PH (1) PH25424A (fr)
PT (1) PT87153B (fr)
SE (1) SE8801236A0 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755594A (en) * 1986-01-31 1988-07-05 Warner-Lambert Company N6 -substituted adenosines
US5063233A (en) * 1986-11-14 1991-11-05 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists
US4954504A (en) * 1986-11-14 1990-09-04 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity
HU198950B (en) * 1986-12-15 1989-12-28 Sandoz Ag Process for producing new furanuronic acid derivatives and pharmaceutical compositions comprising such compounds
PT86660B (pt) * 1987-02-04 1992-02-28 Ciba Geigy Ag Processo para a preparacao de derivados de adenosina-5'-carboxamida
US4968697A (en) * 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
US5140015A (en) * 1990-02-20 1992-08-18 Whitby Research, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
USRE36494E (en) * 1990-02-20 2000-01-11 Discovery Therapeutics, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
IT1254915B (it) * 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
EP1090022B1 (fr) 1998-06-23 2003-08-06 Glaxo Group Limited Derives du 2-(purin-9-yl)-tetrahydrofuran-3,4 diol
US6593078B1 (en) 1999-04-16 2003-07-15 Schering Corporation Use of azetidinone compounds
US20050033044A1 (en) 2003-05-19 2005-02-10 Bristol-Myers Squibb Pharma Company Methods for preparing 2-alkynyladenosine derivatives
PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
BRPI0515506A (pt) * 2004-09-20 2008-07-29 Inotek Pharmaceuticals Corp derivados de purina e métodos de uso dos mesmos
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4167565A (en) * 1976-11-08 1979-09-11 Abbott Laboratories Adenosine-5'-carboxamides and method of use
EP0277917A2 (fr) * 1987-02-04 1988-08-10 Ciba-Geigy Ag Certains dérivés d'adénosine-5'-carboxamide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH606084A5 (en) * 1975-02-18 1978-10-13 Hoffmann La Roche (Di) nitrates of adenosine -5'-carboxylic acid derivs
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
HU198950B (en) * 1986-12-15 1989-12-28 Sandoz Ag Process for producing new furanuronic acid derivatives and pharmaceutical compositions comprising such compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4167565A (en) * 1976-11-08 1979-09-11 Abbott Laboratories Adenosine-5'-carboxamides and method of use
EP0277917A2 (fr) * 1987-02-04 1988-08-10 Ciba-Geigy Ag Certains dérivés d'adénosine-5'-carboxamide

Also Published As

Publication number Publication date
DK183488A (da) 1988-10-07
DK183488D0 (da) 1988-04-05
JPS63258892A (ja) 1988-10-26
SE8801236L (sv) 1988-10-17
AT393507B (de) 1991-11-11
HU201955B (en) 1991-01-28
CH676121A5 (fr) 1990-12-14
FR2613367A1 (fr) 1988-10-07
IL85969A (en) 1992-03-29
SE8801236D0 (sv) 1988-04-05
PT87153A (pt) 1988-05-01
GB8807750D0 (en) 1988-05-05
IL85969A0 (en) 1988-09-30
FI881571A (fi) 1988-10-07
AU1415188A (en) 1988-10-06
NL8800862A (nl) 1988-11-01
IT1219892B (it) 1990-05-24
NZ224131A (en) 1991-12-23
ES2007177A6 (es) 1989-06-01
GB2203149B (en) 1991-02-13
LU87181A1 (fr) 1988-11-17
FI881571A0 (fi) 1988-04-05
IT8847794A0 (it) 1988-03-30
FI87463C (fi) 1993-01-11
PH25424A (fr) 1991-07-01
KR880012629A (ko) 1988-11-28
PT87153B (pt) 1992-07-31
AU609109B2 (en) 1991-04-26
SE8801236A0 (sv) 1988-10-17
FI87463B (fi) 1992-09-30
HUT48902A (en) 1989-07-28
CA1326017C (fr) 1994-01-11
GB2203149A (en) 1988-10-12
MY102323A (en) 1992-05-28
ATA87388A (de) 1991-04-15

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: S.A. SANDOZ

Effective date: 19950331