AU2002239718A1 - Thrombopoietin mimetics - Google Patents

Thrombopoietin mimetics

Info

Publication number
AU2002239718A1
AU2002239718A1 AU2002239718A AU3971802A AU2002239718A1 AU 2002239718 A1 AU2002239718 A1 AU 2002239718A1 AU 2002239718 A AU2002239718 A AU 2002239718A AU 3971802 A AU3971802 A AU 3971802A AU 2002239718 A1 AU2002239718 A1 AU 2002239718A1
Authority
AU
Australia
Prior art keywords
thrombopoietin mimetics
thrombopoietin
mimetics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002239718A
Inventor
Kevin J. Duffy
Julian Jenkins
Juan I. Luengo
Stephen G Miller
Alan T. Price
Antony N. Shaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ligand Pharmaceuticals Inc
SmithKline Beecham Corp
Original Assignee
Ligand Pharmaceuticals Inc
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharmaceuticals Inc, SmithKline Beecham Corp filed Critical Ligand Pharmaceuticals Inc
Publication of AU2002239718A1 publication Critical patent/AU2002239718A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
AU2002239718A 2000-12-19 2001-12-19 Thrombopoietin mimetics Abandoned AU2002239718A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25662200P 2000-12-19 2000-12-19
US60/256,622 2000-12-19
PCT/US2001/050774 WO2002049413A2 (en) 2000-12-19 2001-12-19 Thrombopoietin mimetics

Publications (1)

Publication Number Publication Date
AU2002239718A1 true AU2002239718A1 (en) 2002-07-01

Family

ID=22972928

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002239718A Abandoned AU2002239718A1 (en) 2000-12-19 2001-12-19 Thrombopoietin mimetics

Country Status (6)

Country Link
US (1) US7241783B2 (en)
EP (1) EP1349613A4 (en)
JP (1) JP2004520302A (en)
AU (1) AU2002239718A1 (en)
CA (1) CA2436288A1 (en)
WO (1) WO2002049413A2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY2010012I2 (en) 2000-05-25 2020-05-29 Novartis Ag THROMBOPOIETIN MIMETICS
AUPS120902A0 (en) * 2002-03-19 2002-04-18 Unisearch Limited Iron chelators as anti-proliferative agents against tumour cells
AR040083A1 (en) 2002-05-22 2005-03-16 Smithkline Beecham Corp BIS- (MONOETHANOLAMINE) ACID COMPOUND 3 '- [(2Z) - [1- (3,4-DIMETHYLPHENYL) -1,5-DIHIDRO-3-METHYL-5-OXO-4H-PIRAZOL-4-ILIDEN] HYDRAZINE ] -2'-HYDROXI- [1,1'-BIFENIL] -3-CARBOXILICO, PROCEDURE TO PREPARE IT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, PROCEDURE TO PREPARE SUCH FARMAC COMPOSITION
JP4412173B2 (en) 2002-08-14 2010-02-10 日産化学工業株式会社 Thrombopoietin receptor activators and methods for their production
TWI324593B (en) * 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
CN101386596B (en) * 2003-06-06 2011-10-26 日产化学工业株式会社 3-alkylidenehydrazino substituted heteroaryl compounds as thrombopoietin receptor activators
UA82695C2 (en) 2003-06-06 2008-05-12 Нисан Кемикал Индастриз, Лтд. Heteroaromatic compounds as thrombopoietin receptor activators
TW200526638A (en) 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
JP4716672B2 (en) * 2004-05-19 2011-07-06 大塚製薬株式会社 Megakaryocyte production inducer
WO2005118551A2 (en) * 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
DE602005024599D1 (en) * 2004-10-25 2010-12-16 Ligand Pharm Inc COMPOUNDS MODULATING THROMBOPOIETINACTIVITY AND METHOD
TW200633997A (en) * 2004-12-08 2006-10-01 Nissan Chemical Ind Ltd Substituted heterocyclic compounds and thrombopoietin receptor activators
TW200633998A (en) * 2004-12-08 2006-10-01 Nissan Chemical Ind Ltd Substituted heterocyclic compounds and thrombopoietin receptor activators
RU2395505C2 (en) * 2004-12-08 2010-07-27 Ниссан Кемикал Индастриз, ЛТД 3-ethylidenehydrazine-substituted heterocyclic compounds as thrombopoietin receptor activators
EP1845090A4 (en) * 2004-12-14 2009-11-11 Nissan Chemical Ind Ltd Amide compound and thrombopoietin receptor activator
US7968542B2 (en) 2005-07-15 2011-06-28 Nissan Chemical Industries, Ltd. Thiophene compounds and thrombopoietin receptor activators
EP1904488B1 (en) 2005-07-20 2013-03-06 Nissan Chemical Industries, Ltd. Pyrazole compounds and thrombopoietin receptor activators
US8026368B2 (en) 2005-11-07 2011-09-27 Nissan Chemical Industries, Ltd. Hydrazide compounds and thrombopoietin receptor activators
JP5157900B2 (en) 2006-06-07 2013-03-06 日産化学工業株式会社 Nitrogen-containing heterocyclic compounds and thrombopoietin receptor activators
ECSP077628A (en) 2007-05-03 2008-12-30 Smithkline Beechman Corp NEW PHARMACEUTICAL COMPOSITION
WO2009079797A1 (en) 2007-12-26 2009-07-02 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
EP2318406B1 (en) 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
PE20100362A1 (en) 2008-10-30 2010-05-27 Irm Llc PURINE DERIVATIVES THAT EXPAND HEMATOPOYETIC STEM CELLS
US8680150B2 (en) * 2009-05-28 2014-03-25 Ligand Pharmaceuticals, Inc. Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors
AU2010254046C1 (en) 2009-05-29 2014-03-06 Novartis Ag Methods of administration of thrombopoietin agonist compounds
US8889732B2 (en) 2009-10-23 2014-11-18 Nissan Chemical Industries, Ltd. Fused heterocyclic compounds and thrombopoietin receptor activators
EP2552915B1 (en) 2010-04-01 2017-07-19 Critical Outcome Technologies Inc. Compounds for the treatment of hiv
UA109287C2 (en) * 2010-11-02 2015-08-10 ORGANIC AMIN SALTS OF THE AMINOBENSIC ACID DERIVATIVES AND THE METHOD OF PREPARATION thereof
WO2012102937A2 (en) 2011-01-25 2012-08-02 Irm Llc Compounds that expand hematopoietic stem cells
AU2012347534B2 (en) 2011-12-08 2018-01-25 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
EP2807165B1 (en) 2012-01-27 2019-05-15 Université de Montréal Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
ES2788977T3 (en) 2014-04-22 2020-10-23 Univ Montreal Compounds and their use in the expansion of hematopoietic stem cells and / or hematopoietic progenitor cells
WO2016068270A1 (en) 2014-10-31 2016-05-06 日産化学工業株式会社 Ligand-binding fiber and cell culture substrate using said fiber

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE290184C (en) *
DE286580C (en) *
EP0433526A1 (en) * 1989-12-19 1991-06-26 Richter, Peter, Prof. Dr.sc.nat. Medicine for the treatment of heart-circulatory illnesses, of arrhythmics in particular
US5376451A (en) * 1990-06-29 1994-12-27 Minnesota Mining And Manufacturing Company Yellow color-formers
WO1999011262A1 (en) 1997-09-02 1999-03-11 Roche Diagnostics Gmbh Mpl-receptor ligands, process for their preparation, medicaments containing them and their use for the treatment and prevention of thrombocytopaenia and anaemia
EP1133291B1 (en) 1998-11-17 2006-01-11 Smithkline Beecham Corporation Cyclic polyamines for treating thrombocytopenia
EP1223944B1 (en) * 1999-09-24 2007-01-03 SmithKline Beecham Corporation Thrombopoietin mimetics
JP2003513965A (en) 1999-11-05 2003-04-15 スミスクライン・ビーチャム・コーポレイション Semicarbazone derivatives and their use as thrombopoietin mimetics
US6720345B1 (en) * 1999-11-05 2004-04-13 Smithkline Beecham Corporation Semicarbazone derivatives and their use as thrombopoietin mimetics

Also Published As

Publication number Publication date
WO2002049413A3 (en) 2003-01-23
CA2436288A1 (en) 2002-06-27
EP1349613A2 (en) 2003-10-08
US7241783B2 (en) 2007-07-10
EP1349613A4 (en) 2005-09-21
JP2004520302A (en) 2004-07-08
WO2002049413A2 (en) 2002-06-27
US20040058990A1 (en) 2004-03-25

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