EP1370252A4 - Thrombopoietin mimetics - Google Patents

Thrombopoietin mimetics

Info

Publication number
EP1370252A4
EP1370252A4 EP02728383A EP02728383A EP1370252A4 EP 1370252 A4 EP1370252 A4 EP 1370252A4 EP 02728383 A EP02728383 A EP 02728383A EP 02728383 A EP02728383 A EP 02728383A EP 1370252 A4 EP1370252 A4 EP 1370252A4
Authority
EP
European Patent Office
Prior art keywords
thrombopoietin mimetics
thrombopoietin
mimetics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02728383A
Other languages
German (de)
French (fr)
Other versions
EP1370252A1 (en
Inventor
Kevin J Duffy
Juan I Luengo
Antony N Shaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1370252A1 publication Critical patent/EP1370252A1/en
Publication of EP1370252A4 publication Critical patent/EP1370252A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
EP02728383A 2001-03-01 2002-03-01 Thrombopoietin mimetics Withdrawn EP1370252A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26995801P 2001-03-01 2001-03-01
US269958P 2001-03-01
PCT/US2002/006259 WO2002085343A1 (en) 2001-03-01 2002-03-01 Thrombopoietin mimetics

Publications (2)

Publication Number Publication Date
EP1370252A1 EP1370252A1 (en) 2003-12-17
EP1370252A4 true EP1370252A4 (en) 2006-04-05

Family

ID=23029313

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02728383A Withdrawn EP1370252A4 (en) 2001-03-01 2002-03-01 Thrombopoietin mimetics

Country Status (2)

Country Link
EP (1) EP1370252A4 (en)
WO (1) WO2002085343A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY2010012I2 (en) 2000-05-25 2020-05-29 Novartis Ag THROMBOPOIETIN MIMETICS
TWI280128B (en) 2002-05-22 2007-05-01 Smithkline Beecham Corp 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US7851503B2 (en) 2002-08-14 2010-12-14 Nissan Chemical Industries, Ltd. Thrombopoetin receptor activator and process for producing the same
TWI324593B (en) 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
WO2004096154A2 (en) * 2003-04-29 2004-11-11 Smithkline Beecham Corporation Methods for treating degenerative diseases/injuries
UA82695C2 (en) 2003-06-06 2008-05-12 Нисан Кемикал Индастриз, Лтд. Heteroaromatic compounds as thrombopoietin receptor activators
CN101386596B (en) * 2003-06-06 2011-10-26 日产化学工业株式会社 3-alkylidenehydrazino substituted heteroaryl compounds as thrombopoietin receptor activators
TW200526638A (en) 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
RU2395505C2 (en) * 2004-12-08 2010-07-27 Ниссан Кемикал Индастриз, ЛТД 3-ethylidenehydrazine-substituted heterocyclic compounds as thrombopoietin receptor activators
CA2590204C (en) 2004-12-14 2012-12-04 Nissan Chemical Industries, Ltd. Amide compounds and thrombopoietin receptor activators
AU2006270801B2 (en) 2005-07-15 2011-12-22 Nissan Chemical Industries, Ltd. Thiophene compounds and thrombopoietin receptor activators
US7960425B2 (en) 2005-07-20 2011-06-14 Nissan Chemical Industries, Ltd. Pyrazole compounds and thrombopoietin receptor activators
EP1947101A4 (en) 2005-11-07 2009-09-16 Nissan Chemical Ind Ltd Hydrazide compound and thrombopoietin receptor activator
WO2007062078A2 (en) * 2005-11-23 2007-05-31 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
EP2025671A4 (en) 2006-06-07 2011-04-06 Nissan Chemical Ind Ltd Nitrogen-containing heterocyclic compound and thrombopoietin receptor activator
ECSP077628A (en) 2007-05-03 2008-12-30 Smithkline Beechman Corp NEW PHARMACEUTICAL COMPOSITION
PE20100362A1 (en) 2008-10-30 2010-05-27 Irm Llc PURINE DERIVATIVES THAT EXPAND HEMATOPOYETIC STEM CELLS
ES2605593T3 (en) 2009-05-29 2017-03-15 Novartis Ag Methods of administration of thrombopoietin agonist compounds
WO2011098095A1 (en) 2010-02-09 2011-08-18 Aplagen Gmbh Peptides binding the tpo receptor
UA109287C2 (en) * 2010-11-02 2015-08-10 ORGANIC AMIN SALTS OF THE AMINOBENSIC ACID DERIVATIVES AND THE METHOD OF PREPARATION thereof
WO2012102937A2 (en) 2011-01-25 2012-08-02 Irm Llc Compounds that expand hematopoietic stem cells
AU2012347534B2 (en) 2011-12-08 2018-01-25 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
US9409906B2 (en) 2012-01-27 2016-08-09 Universite De Montreal Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells
CN104628647A (en) * 2013-11-12 2015-05-20 上海医药工业研究院 Preparation method of 3-methyl-1-(3,4-dimethylphenyl)-2-pyrazoline-5-one
EP3134409B1 (en) 2014-04-22 2020-02-12 Université de Montréal Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells
JP6658535B2 (en) 2014-10-31 2020-03-04 日産化学株式会社 Ligand-bound fiber and cell culture substrate using the fiber
CN110467531B (en) * 2018-05-09 2022-04-19 新发药业有限公司 Preparation method of 3 '-nitro-2' -hydroxybiphenyl-3-formic acid

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000035446A1 (en) * 1998-12-17 2000-06-22 Smithkline Beecham Corporation Thrombopoietin mimetics
WO2001017349A1 (en) * 1999-09-10 2001-03-15 Smithkline Beckman Corporation Thrombopoietin mimetics
WO2001089457A2 (en) * 2000-05-25 2001-11-29 Smithkline Beecham Corporation Thrombopoietin mimetics

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000035446A1 (en) * 1998-12-17 2000-06-22 Smithkline Beecham Corporation Thrombopoietin mimetics
WO2001017349A1 (en) * 1999-09-10 2001-03-15 Smithkline Beckman Corporation Thrombopoietin mimetics
WO2001089457A2 (en) * 2000-05-25 2001-11-29 Smithkline Beecham Corporation Thrombopoietin mimetics

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EL LATIF, F. M. A.: "An improved synthesis of pyrazolo(3,4-b)(1,5) , benzoxazepine, -benzothiazepine and -benzodiazepine derivatives via a convenient one-pot synthesis.", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 37, no. 6, 2000, US HETEROCORPORATION. PROVO., pages 1659 - 1662, XP002366337 *
See also references of WO02085343A1 *

Also Published As

Publication number Publication date
WO2002085343A1 (en) 2002-10-31
EP1370252A1 (en) 2003-12-17

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