AUPS120902A0 - Iron chelators as anti-proliferative agents against tumour cells - Google Patents

Iron chelators as anti-proliferative agents against tumour cells

Info

Publication number
AUPS120902A0
AUPS120902A0 AUPS1209A AUPS120902A AUPS120902A0 AU PS120902 A0 AUPS120902 A0 AU PS120902A0 AU PS1209 A AUPS1209 A AU PS1209A AU PS120902 A AUPS120902 A AU PS120902A AU PS120902 A0 AUPS120902 A0 AU PS120902A0
Authority
AU
Australia
Prior art keywords
tumour cells
agents against
proliferative agents
iron chelators
against tumour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AUPS1209A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unisearch Ltd
Original Assignee
Heart Research Institute Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heart Research Institute Ltd filed Critical Heart Research Institute Ltd
Priority to AUPS1209A priority Critical patent/AUPS120902A0/en
Publication of AUPS120902A0 publication Critical patent/AUPS120902A0/en
Priority to AU2003209845A priority patent/AU2003209845A1/en
Priority to PCT/AU2003/000328 priority patent/WO2003078386A1/en
Assigned to UNISEARCH LIMITED reassignment UNISEARCH LIMITED Assignment by Applicant under S 113 Assignors: HEART RESEARCH INSTITUTE LTD., THE
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/88Nicotinoylhydrazones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72Hydrazones
    • C07C251/86Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C07C281/14Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being further bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06Compounds containing any of the groups, e.g. thiosemicarbazides
    • C07C337/08Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
AUPS1209A 2002-03-19 2002-03-19 Iron chelators as anti-proliferative agents against tumour cells Abandoned AUPS120902A0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AUPS1209A AUPS120902A0 (en) 2002-03-19 2002-03-19 Iron chelators as anti-proliferative agents against tumour cells
AU2003209845A AU2003209845A1 (en) 2002-03-19 2003-03-19 Naphthylsemicarbazone, naphthylhydrazone, naphthylthiosemicarbazone, and naphthylthiohydrazone compounds and therapeutic use thereof
PCT/AU2003/000328 WO2003078386A1 (en) 2002-03-19 2003-03-19 Naphthylsemicarbazone, naphthylhydrazone, naphthylthiosemicarbazone, and naphthylthiohydrazone compounds and therapeutic use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPS1209A AUPS120902A0 (en) 2002-03-19 2002-03-19 Iron chelators as anti-proliferative agents against tumour cells

Publications (1)

Publication Number Publication Date
AUPS120902A0 true AUPS120902A0 (en) 2002-04-18

Family

ID=3834806

Family Applications (1)

Application Number Title Priority Date Filing Date
AUPS1209A Abandoned AUPS120902A0 (en) 2002-03-19 2002-03-19 Iron chelators as anti-proliferative agents against tumour cells

Country Status (2)

Country Link
AU (1) AUPS120902A0 (en)
WO (1) WO2003078386A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2046122A4 (en) * 2006-07-24 2009-12-23 Univ Maryland Heme oxygenase inhibitors and methods of therapeutic use
US8283351B2 (en) 2007-04-02 2012-10-09 Institute For Oneworld Health Cyclic and acyclic hydrazine derivatives compositions including them and uses thereof
WO2009131957A2 (en) 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
WO2009131951A2 (en) 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
US8343976B2 (en) 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
CN102625795A (en) * 2009-09-04 2012-08-01 分子发现***公司 Cytotoxic compounds
CN102127106B (en) * 2010-12-30 2013-05-22 聊城大学 Dichlorodiphenyl-stannane complex and preparation method and application thereof
EP2945629A4 (en) * 2012-11-22 2016-09-28 Oncochel Therapeutics LLC Chemotherapy for drug-resistant cancer cells
CN105218399B (en) * 2014-05-30 2018-02-09 中国人民解放军军事医学科学院毒物药物研究所 A kind of substituted acethydrazide derivatives, preparation method and the usage

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4334015A (en) * 1979-05-23 1982-06-08 Minnesota Mining And Manufacturing Company Imaging compositions
US4277500A (en) * 1980-03-24 1981-07-07 Stauffer Chemical Company Certain 2-hydroxy-1-naphthaldehyde acylhydrazones and their use as fungicides
DE3372780D1 (en) * 1982-03-09 1987-09-03 Ciba Geigy Ag Use of metal complexes of hydrazones as pigments
AU749271B2 (en) * 1997-07-01 2002-06-20 Agouron Pharmaceuticals, Inc. Glucagon antagonists/inverse agonists
CA2351516A1 (en) * 1998-11-18 2000-05-25 Valery Alakhov Copolymer compositions for treating viral infections
AUPQ262499A0 (en) * 1999-09-02 1999-09-23 University Of Queensland, The Novel iron chelators
JP2003527417A (en) * 2000-03-23 2003-09-16 インフラクス,インコーポレイテッド Bactericidal antibacterial methods and compositions for use in treating Gram-positive bacterial infections
WO2002049413A2 (en) * 2000-12-19 2002-06-27 Smithkline Beecham Corporation Thrombopoietin mimetics

Also Published As

Publication number Publication date
WO2003078386A1 (en) 2003-09-25

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: UNISEARCH LIMITED

Free format text: THE FORMER OWNER WAS: THE HEART RESEARCH INSTITUTE LTD.