AU2001292861A1 - Modified factor VIII - Google Patents
Modified factor VIIIInfo
- Publication number
- AU2001292861A1 AU2001292861A1 AU2001292861A AU9286101A AU2001292861A1 AU 2001292861 A1 AU2001292861 A1 AU 2001292861A1 AU 2001292861 A AU2001292861 A AU 2001292861A AU 9286101 A AU9286101 A AU 9286101A AU 2001292861 A1 AU2001292861 A1 AU 2001292861A1
- Authority
- AU
- Australia
- Prior art keywords
- factor viii
- human
- modified
- amino acid
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/10—Factor VIII, AHF; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23404700P | 2000-09-19 | 2000-09-19 | |
US60/234,047 | 2000-09-19 | ||
US23646000P | 2000-09-29 | 2000-09-29 | |
US60/236,460 | 2000-09-29 | ||
PCT/US2001/029431 WO2002024723A1 (en) | 2000-09-19 | 2001-09-19 | Modified factor viii |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001292861A1 true AU2001292861A1 (en) | 2002-04-02 |
Family
ID=26927505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001292861A Abandoned AU2001292861A1 (en) | 2000-09-19 | 2001-09-19 | Modified factor VIII |
Country Status (12)
Country | Link |
---|---|
US (1) | US6770744B2 (zh) |
EP (1) | EP1319016A4 (zh) |
JP (1) | JP2004525608A (zh) |
KR (1) | KR100638184B1 (zh) |
CN (1) | CN1205221C (zh) |
AU (1) | AU2001292861A1 (zh) |
CA (1) | CA2422902A1 (zh) |
HU (1) | HUP0301179A3 (zh) |
MX (1) | MXPA03002256A (zh) |
PL (1) | PL206105B1 (zh) |
RU (1) | RU2003107100A (zh) |
WO (1) | WO2002024723A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113970279A (zh) * | 2021-10-26 | 2022-01-25 | 珠海城市职业技术学院 | 数字式螺旋测微仪 |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7560107B2 (en) | 1996-06-26 | 2009-07-14 | Emory University | Modified factor VIII |
US6458563B1 (en) * | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
MXPA04005079A (es) * | 2001-11-30 | 2004-08-19 | Univ Emory | Variantes del dominio c2 del factor viii. |
US7485291B2 (en) | 2003-06-03 | 2009-02-03 | Cell Genesys, Inc. | Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof |
US7498024B2 (en) | 2003-06-03 | 2009-03-03 | Cell Genesys, Inc. | Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site |
WO2005046583A2 (en) * | 2003-10-30 | 2005-05-26 | Emory University | Modified fviii having reduced immunogenicity through mutagenesis of a2 and c2 epitopes |
DE602004026474D1 (de) * | 2003-12-03 | 2010-05-20 | Univ Rochester | Rekombinanter faktor viii mit erhöhter spezifischer aktivität |
WO2005107776A1 (en) * | 2004-05-03 | 2005-11-17 | Emory University | METHOD OF ADMINISTERING PORCINE B-DOMAINLESS fVIII |
KR101483917B1 (ko) | 2004-11-12 | 2015-01-16 | 바이엘 헬스케어 엘엘씨 | Fviii의 부위 지향 변형 |
US20100256062A1 (en) * | 2004-12-06 | 2010-10-07 | Howard Tommy E | Allelic Variants of Human Factor VIII |
FR2913020B1 (fr) | 2007-02-23 | 2012-11-23 | Biomethodes | Nouveaux facteurs viii pour le traitement des hemophiles de type a |
EP2209908B1 (en) * | 2007-11-01 | 2014-09-03 | University Of Rochester | Recombinant factor viii having increased stability |
CN104045716A (zh) * | 2008-05-16 | 2014-09-17 | 拜耳医药保健有限公司 | 靶向性凝固因子及其使用方法 |
US20110046060A1 (en) | 2009-08-24 | 2011-02-24 | Amunix Operating, Inc., | Coagulation factor IX compositions and methods of making and using same |
WO2011060371A2 (en) * | 2009-11-13 | 2011-05-19 | Puget Sound Blood Center | Factor viii t cell epitope variants having reduced immunogenicity |
EP2524054A2 (en) * | 2010-01-14 | 2012-11-21 | Haplomics, Inc. | Predicting and reducing alloimmunogenicity of protein therapeutics |
MY165089A (en) | 2010-11-05 | 2018-02-28 | Baxalta Inc | A new variant of antihemophilic factor viii having increased specific activity |
SI2822577T1 (sl) | 2012-02-15 | 2019-07-31 | Bioverativ Therapeutics Inc. | Rekombinantni proteini faktorja VIII |
US10421798B2 (en) | 2012-02-15 | 2019-09-24 | Bioverativ Therapeutics Inc. | Factor VIII compositions and methods of making and using same |
US10272163B2 (en) | 2012-12-07 | 2019-04-30 | The Regents Of The University Of California | Factor VIII mutation repair and tolerance induction |
EP3001836B1 (en) | 2013-05-10 | 2019-08-07 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Design and use of specific regulatory t-cells to induce immune tolerance |
DK3013855T3 (da) | 2013-06-24 | 2021-01-11 | Xiao Weidong | Mutante faktor VIII-sammensætninger og fremgangsmåder |
TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子viii-xten融合物及其用途 |
US10745680B2 (en) | 2015-08-03 | 2020-08-18 | Bioverativ Therapeutics Inc. | Factor IX fusion proteins and methods of making and using same |
PE20231949A1 (es) * | 2015-10-30 | 2023-12-05 | Spark Therapeutics Inc | VARIANTES DEL FACTOR VIII REDUCIDO CON CpG, COMPOSICIONES Y METODOS Y USOS PARA EL TRATAMIENTO DE TRASTORNOS DE LA HEMOSTASIA |
WO2019210187A1 (en) * | 2018-04-26 | 2019-10-31 | The University Of North Carolina At Chapel Hill | Methods and compositions for treatment of hemophilia |
WO2022211791A1 (en) | 2021-03-30 | 2022-10-06 | AAVnerGene Inc. | Modified plasma clotting factor viii and method of use thereof |
US11795207B2 (en) | 2021-03-30 | 2023-10-24 | AAVnerGene Inc. | Modified plasma clotting factor VIII and method of use thereof |
CN114196677A (zh) * | 2021-12-30 | 2022-03-18 | 广西医科大学第一附属医院 | 一种高活性的凝血因子Ⅷ或Ⅷa多肽变体Gly710Ala |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5663060A (en) * | 1992-04-07 | 1997-09-02 | Emory University | Hybrid human/animal factor VIII |
US6180371B1 (en) | 1996-06-26 | 2001-01-30 | Emory University | Modified factor VIII |
US5888974A (en) * | 1992-04-07 | 1999-03-30 | Emory University | Hybrid human/animal factor VIII |
US5859204A (en) | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
US5744446A (en) | 1992-04-07 | 1998-04-28 | Emory University | Hybrid human/animal factor VIII |
CA2225189C (en) * | 1997-03-06 | 2010-05-25 | Queen's University At Kingston | Canine factor viii gene, protein and methods of use |
WO2001012836A1 (en) * | 1999-08-13 | 2001-02-22 | Fred Hutchinson Cancer Research Center | Crystal of a truncated protein construct containing a coagulation factor viii c2 domain in the presence or absence of a bound ligand and methods of use thereof |
AU2001254715B2 (en) * | 2000-03-22 | 2006-02-02 | Octaphama Ag | Production of recombinant blood clotting factors in human cell lines |
-
2001
- 2001-09-19 EP EP01973263A patent/EP1319016A4/en not_active Withdrawn
- 2001-09-19 JP JP2002529131A patent/JP2004525608A/ja active Pending
- 2001-09-19 KR KR1020037003993A patent/KR100638184B1/ko not_active IP Right Cessation
- 2001-09-19 WO PCT/US2001/029431 patent/WO2002024723A1/en not_active Application Discontinuation
- 2001-09-19 HU HU0301179A patent/HUP0301179A3/hu unknown
- 2001-09-19 PL PL366199A patent/PL206105B1/pl not_active IP Right Cessation
- 2001-09-19 RU RU2003107100/13A patent/RU2003107100A/ru not_active Application Discontinuation
- 2001-09-19 CN CNB018191495A patent/CN1205221C/zh not_active Expired - Fee Related
- 2001-09-19 MX MXPA03002256A patent/MXPA03002256A/es active IP Right Grant
- 2001-09-19 AU AU2001292861A patent/AU2001292861A1/en not_active Abandoned
- 2001-09-19 CA CA002422902A patent/CA2422902A1/en not_active Abandoned
- 2001-09-19 US US09/957,641 patent/US6770744B2/en not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113970279A (zh) * | 2021-10-26 | 2022-01-25 | 珠海城市职业技术学院 | 数字式螺旋测微仪 |
CN113970279B (zh) * | 2021-10-26 | 2023-07-07 | 珠海城市职业技术学院 | 数字式螺旋测微仪 |
Also Published As
Publication number | Publication date |
---|---|
CA2422902A1 (en) | 2002-03-28 |
CN1474830A (zh) | 2004-02-11 |
PL366199A1 (en) | 2005-01-24 |
KR100638184B1 (ko) | 2006-10-26 |
WO2002024723A9 (en) | 2003-04-03 |
EP1319016A4 (en) | 2006-05-10 |
KR20030033074A (ko) | 2003-04-26 |
JP2004525608A (ja) | 2004-08-26 |
EP1319016A1 (en) | 2003-06-18 |
HUP0301179A2 (hu) | 2003-10-28 |
MXPA03002256A (es) | 2003-09-10 |
HUP0301179A3 (en) | 2006-11-28 |
WO2002024723A1 (en) | 2002-03-28 |
RU2003107100A (ru) | 2004-08-27 |
US6770744B2 (en) | 2004-08-03 |
US20020182670A1 (en) | 2002-12-05 |
PL206105B1 (pl) | 2010-07-30 |
CN1205221C (zh) | 2005-06-08 |
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EP1200105B1 (en) | Modified factor viii | |
US8951515B2 (en) | Modified factor VIII | |
US20050123997A1 (en) | Modified fVIII having reduced immunogenicity through mutagenesis of A2 and C2 epitopes | |
AU2001238416A1 (en) | Modified factor VIII | |
EP1062224A1 (en) | Modified factor viii | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |