ATE89743T1 - Conjugate dichter sterne. - Google Patents

Conjugate dichter sterne.

Info

Publication number
ATE89743T1
ATE89743T1 AT87307266T AT87307266T ATE89743T1 AT E89743 T1 ATE89743 T1 AT E89743T1 AT 87307266 T AT87307266 T AT 87307266T AT 87307266 T AT87307266 T AT 87307266T AT E89743 T1 ATE89743 T1 AT E89743T1
Authority
AT
Austria
Prior art keywords
poets
stars
conjugate
dendrimer
conjugates
Prior art date
Application number
AT87307266T
Other languages
English (en)
Inventor
Donald A Tomalia
Donald A Kaplan
William J Kruper
Roberta C Cheng
Ian A Tomlinson
Michael J Fazio
Larry R Wilson
David M Hedstrand
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25407923&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE89743(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Application granted granted Critical
Publication of ATE89743T1 publication Critical patent/ATE89743T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/005—Dendritic macromolecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Dentistry (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Luminescent Compositions (AREA)
AT87307266T 1986-08-18 1987-08-17 Conjugate dichter sterne. ATE89743T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89745586A 1986-08-18 1986-08-18
EP87307266A EP0271180B2 (de) 1986-08-18 1987-08-17 Conjugate dichter Sterne

Publications (1)

Publication Number Publication Date
ATE89743T1 true ATE89743T1 (de) 1993-06-15

Family

ID=25407923

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87307266T ATE89743T1 (de) 1986-08-18 1987-08-17 Conjugate dichter sterne.

Country Status (21)

Country Link
EP (1) EP0271180B2 (de)
JP (6) JPH0757735B2 (de)
KR (1) KR970011151B1 (de)
AT (1) ATE89743T1 (de)
AU (2) AU609051B2 (de)
BR (3) BR8707432A (de)
DE (1) DE3786000T3 (de)
DK (1) DK174053B1 (de)
ES (1) ES2054678T5 (de)
FI (2) FI103410B (de)
GR (1) GR3024215T3 (de)
HK (1) HK54396A (de)
HU (2) HU209252B (de)
IE (1) IE61356B1 (de)
IL (1) IL83567A (de)
MX (1) MX169992B (de)
MY (1) MY102878A (de)
NO (1) NO176306C (de)
NZ (1) NZ221484A (de)
WO (3) WO1988001178A1 (de)
ZA (1) ZA876114B (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5914095A (en) * 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
US5292868A (en) * 1989-05-26 1994-03-08 Akzo N.V. Chelating agents for attaching metal ions to proteins
US5808003A (en) * 1989-05-26 1998-09-15 Perimmune Holdings, Inc. Polyaminocarboxylate chelators
JP2865112B2 (ja) * 1989-05-26 1999-03-08 アクゾ・エヌ・ヴエー 金属イオンをタンパク質に結合するためのキレート化剤
DE3930674A1 (de) * 1989-09-11 1991-03-21 Diagnostikforschung Inst Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie
DE3938992A1 (de) 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
AU642980B2 (en) * 1990-03-21 1993-11-04 Quest International B.V. Ultilization of enzymes
AU642979B2 (en) * 1990-03-21 1993-11-04 Quest International B.V. Utilization and delivery of enzymes
GB9021671D0 (en) * 1990-10-05 1990-11-21 Unilever Plc Delivery of agents
AU641736B2 (en) * 1990-03-21 1993-09-30 Quest International B.V. Delivery of agents
IL99234A (en) * 1990-08-27 1994-05-30 Michigan Molecular Inst Non-cross-linked multi-branch polymers and their preparation
GB9112536D0 (en) * 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
US5871713A (en) * 1991-12-04 1999-02-16 Guerbet S.A. Macromolecular polyamine iodine-containing compound, process for its preparation and its use as a contrast agent
CA2125188A1 (fr) * 1991-12-04 1993-06-10 Dominique Meyer Nouveau compose macromoleculaire polyamine iode, son procede de preparation et son utilisation comme agent de contraste
FR2688508A1 (fr) * 1992-03-13 1993-09-17 Guerbet Sa Nouveau produit de contraste iode, son procede de preparation et son utilisation comme agent de contraste.
WO1993021259A1 (en) 1992-04-14 1993-10-28 Cornell Research Foundation Inc. Dendritic based macromolecules and method of production
US5387617A (en) * 1993-01-22 1995-02-07 The Dow Chemical Company Small cell foams and blends and a process for their preparation
US6121056A (en) * 1993-02-24 2000-09-19 Dade Behring Inc. Random detection of antigens with antibodies immobilized on soluble submicron particles
US5898005A (en) * 1993-02-24 1999-04-27 Dade Behring Inc. Rapid detection of analytes with receptors immobilized on soluble submicron particles
ATE178717T1 (de) * 1993-02-24 1999-04-15 Dade Behring Inc Immobilisierung von reagenzien für spezifische bindungsassay
FR2703055B1 (fr) * 1993-03-22 1995-07-07 Guerbet Sa Nouveaux composés polyiodés, leur préparation et leur utilisation en tant que produits de contraste pour la radiologie .
US7097839B1 (en) 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
ES2104518T1 (es) * 1994-03-07 1997-10-16 Dow Chemical Co Conjugados dendrimeros bioactivos y/o directores hacia diana.
AU750411B2 (en) * 1994-03-07 2002-07-18 Dendritic Nanotechnologies, Inc. Bioactive and/or targeted dendrimer conjugates
GB9407812D0 (en) * 1994-04-20 1994-06-15 Nycomed Salutar Inc Compounds
NL9400880A (nl) * 1994-05-27 1996-01-02 Dsm Nv Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijstellen van de actieve stof.
NL9401886A (nl) * 1994-05-27 1996-01-02 Dsm Nv Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijgeven van de actieve stof.
AUPM623994A0 (en) 1994-06-15 1994-07-07 Biomolecular Research Institute Limited Antiviral dendrimers
JPH10510822A (ja) * 1994-12-21 1998-10-20 ノバルティス アクチェンゲゼルシャフト オリゴヌクレオチド−デンドリマー複合体
FR2734268B1 (fr) * 1995-05-19 1997-07-04 Centre Nat Rech Scient Nouveaux dendrimeres fonctionnels a terminaisons phosphorees et leur procede de preparation
US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
US6083708A (en) * 1995-08-11 2000-07-04 Dade Behring Inc. Polypeptide: dendrimer complexes
US5658574A (en) * 1995-10-13 1997-08-19 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Cleansing compositions with dendrimers as mildness agents
NL1001753C2 (nl) * 1995-11-28 1997-05-30 Dsm Nv Samenstelling omvattende een kunststof en een additief.
DE19625982A1 (de) * 1996-06-28 1998-01-02 Wella Ag Kosmetisches Mittel zur Haarbehandlung mit Dendrimeren
CA2274458A1 (en) * 1997-01-13 1998-07-16 Dendritech, Inc. Nanocomposites of dendritic polymers
WO1998056427A1 (fr) * 1997-06-12 1998-12-17 Mitsubishi Chemical Corporation Agent de contrast
DE19728954C1 (de) * 1997-06-30 1999-04-22 Schering Ag Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
FR2790642A1 (fr) * 1999-03-08 2000-09-15 Aventis Cropscience Sa Nouvelles compositions pesticides et/ou regulatrices de croissance
AU5522600A (en) * 1999-06-29 2001-01-22 Dako A/S Detection using dendrimers bearing labels and probes
KR20020057946A (ko) 1999-07-29 2002-07-12 로퍼, 랜달 비. 다부위 결합을 통해 멀티머 영상제를 표적화하는 방법
FI19991705A (fi) * 1999-08-11 2001-02-12 Neste Chemicals Oy Antimikrobinen hyperhaaroittunut polymeerikoostumus
FR2797563A1 (fr) * 1999-08-18 2001-02-23 Rhodianyl Composes biocides et leur utilisation dans des polymeres thermoplastiques
AU784130B2 (en) * 1999-12-10 2006-02-09 Gerald M. Rosen Use of poly-nitroxyl-functionalized dendrimers as contrast enhancing agents in MRI imaging of joints
US6905605B2 (en) 2000-04-07 2005-06-14 Shell Oil Company Method for inhibiting the plugging of conduits by gas hydrates
US6471968B1 (en) * 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
CU23011A1 (es) * 2000-11-03 2004-12-17 Ct Ingenieria Genetica Biotech Método de obtención de estructuras antigénicas quemétodo de obtención de estructuras antigénicas que potencian la reactividad cruzada específica y su potencian la reactividad cruzada específica y su uso en formulaciones uso en formulaciones
CA2450162A1 (en) 2001-06-14 2002-12-27 Shell Internationale Research Maatschappij B.V. Method for solubilising asphaltenes in a hydrocarbon mixture
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
GB0209022D0 (en) 2002-04-19 2002-05-29 Imp College Innovations Ltd Compounds
BR0313973B1 (pt) 2002-09-03 2012-05-02 método e composição para inibir a formação de hidratos de hidrocarboneto, e, mistura inibidora de hidrato.
EP1525890A1 (de) 2003-10-02 2005-04-27 Complex Biosystems GmbH Protein-Proteophor Komplex
JP5268255B2 (ja) * 2003-11-21 2013-08-21 エイエヌピー テクノロジーズ， インコーポレイテッド 非対称分岐ポリマー抱合体およびマイクロアレイアッセイ
PL1737899T3 (pl) * 2004-04-20 2016-01-29 Dendritic Nanotechnologies Inc Polimery dendrytyczne o ulepszonej amplifikacji i wewnętrznych grupach funkcyjnych
US7985424B2 (en) 2004-04-20 2011-07-26 Dendritic Nanotechnologies Inc. Dendritic polymers with enhanced amplification and interior functionality
EP1780224B1 (de) 2004-08-13 2015-02-18 Nippon Soda Co., Ltd. Mehrfach verzweigte polymere und herstellungsverfahren dafür
JP2008510829A (ja) * 2004-08-25 2008-04-10 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン デンドリマーに基づく組成物およびそれらの使用法
DE602005006704D1 (de) 2004-11-08 2008-06-26 Fujifilm Corp Verwendung eines Mittels zur Beseitigung vom Sauerstoff
US8481632B2 (en) 2004-11-24 2013-07-09 Shell Oil Company Method for improving the flowability of a mixture that contains wax and other hydrocarbons
EP2325236A1 (de) * 2005-04-20 2011-05-25 Dendritic Nanotechnologies Inc. Dendritische Polymere mit verbesserter Amplifikation und innerer Funktionalität
US7575687B2 (en) * 2005-08-16 2009-08-18 Ge Osmonics, Inc. Membranes and methods useful for caustic applications
CN101258184B (zh) 2005-09-07 2012-05-23 日本曹达株式会社 星形聚合物及其制造方法
EP2676691B1 (de) 2005-11-17 2016-07-06 Zogenix, Inc. Abgabe von viskosen Formulierungen durch nadellose Injektion
JP5420902B2 (ja) 2006-07-11 2014-02-19 日本曹達株式会社 スターポリマー及びその製造方法
US20080020043A1 (en) * 2006-07-20 2008-01-24 Marc Gingras Dendrimer-Drug Conjugates
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8658148B2 (en) 2007-06-22 2014-02-25 Genzyme Corporation Chemically modified dendrimers
EP2186838B1 (de) 2007-08-31 2014-08-27 Nippon Soda Co., Ltd. Verfahren zur herstellung von sternpolymeren
US8252834B2 (en) 2008-03-12 2012-08-28 The Regents Of The University Of Michigan Dendrimer conjugates
AU2009241847B2 (en) 2008-04-28 2014-07-10 Zogenix, Inc. Novel formulations for treatment of migraine
US8889635B2 (en) 2008-09-30 2014-11-18 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010054321A2 (en) 2008-11-07 2010-05-14 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
AU2010318637A1 (en) 2009-10-13 2012-05-31 The Regents Of The University Of Michigan Dendrimer compositions and methods of synthesis
WO2011053605A1 (en) * 2009-10-26 2011-05-05 Dendritic Nanotechnologies, Inc. Peham dendrimers for use in agriculture
WO2011059586A2 (en) 2009-10-30 2011-05-19 The Regents Of The University Of Michigan Multifunctional small molecules
CN102858367B (zh) 2010-02-26 2014-12-17 国立大学法人长崎大学 抗原或药物递送复合物
WO2013085718A1 (en) 2011-12-08 2013-06-13 The Regents Of The University Of Michigan Multifunctional small molecules
US9921205B2 (en) 2012-11-13 2018-03-20 Chevron U.S.A. Inc. Method for determining the effectiveness of asphaltene dispersant additives for inhibiting or preventing asphaltene precipitation in a hydrocarbon-containing material subjected to elevated temperature and presssure conditions
GB201405660D0 (en) 2014-03-28 2014-05-14 Gama Healthcare Ltd A liquid disinfecting composition
BR112018012244B1 (pt) * 2015-12-16 2022-02-01 Priostar Pty Ltd Formulação, método para controlar uma praga, e, uso
US10907473B2 (en) 2017-11-14 2021-02-02 Chevron U.S.A., Inc. Low volume in-line filtration methods for analyzing hydrocarbon-containing fluid to evaluate asphaltene content and behavior during production operations
CN109287624A (zh) * 2018-10-08 2019-02-01 威海晨源分子新材料有限公司 一种树枝状聚酰胺-胺在农药中的应用
EP3906414A1 (de) 2019-01-03 2021-11-10 Ionpath, Inc. Zusammensetzungen und reagenzien zur ionenstrahlabbildung
CN114292217A (zh) * 2021-12-31 2022-04-08 安源基因科技(上海)有限公司 生物活***联剂、生物交联物、试剂盒及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289872A (en) * 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
IL64277A0 (en) * 1981-11-11 1982-02-28 Basht Ltd Apparatus for removal of integrated circuits from circuit boards
CA1225930A (en) * 1982-06-07 1987-08-25 Otto A. Gansow Metal chelate conjugated monoclonal antibodies
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4558120A (en) * 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4631337A (en) * 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4507466A (en) * 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4606907A (en) * 1984-07-02 1986-08-19 The Dow Chemical Company Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines
US4599400A (en) * 1984-12-18 1986-07-08 The Dow Chemical Company Star/comb-branched polyamide
US4694064A (en) * 1986-02-28 1987-09-15 The Dow Chemical Company Rod-shaped dendrimer

Also Published As

Publication number Publication date
JPH0757736B2 (ja) 1995-06-21
IL83567A (en) 1992-02-16
DE3786000T3 (de) 1997-08-21
EP0271180A1 (de) 1988-06-15
FI981807A0 (fi) 1998-08-24
FI105693B (fi) 2000-09-29
NO176306B (no) 1994-12-05
JPH07108860B2 (ja) 1995-11-22
AU8139191A (en) 1991-10-03
EP0271180B1 (de) 1993-05-26
JPH06219966A (ja) 1994-08-09
JPH069778A (ja) 1994-01-18
JPS63501876A (ja) 1988-07-28
DE3786000D1 (de) 1993-07-01
EP0271180B2 (de) 1997-06-18
BR8707432A (pt) 1988-11-01
JP2848218B2 (ja) 1999-01-20
FI981807A (fi) 1998-08-24
HU209252B (en) 1994-04-28
WO1988001179A1 (en) 1988-02-25
HU9303379D0 (en) 1994-03-28
NO881639L (no) 1988-06-15
FI881768A (fi) 1988-04-15
MY102878A (en) 1993-03-31
HK54396A (en) 1996-04-03
NO176306C (no) 1995-03-15
BR8707433A (pt) 1988-11-01
JPH072840B2 (ja) 1995-01-18
IE61356B1 (en) 1994-11-02
HUT55245A (en) 1991-05-28
DE3786000T2 (de) 1993-09-02
ZA876114B (en) 1989-04-26
IE872210L (en) 1988-02-18
FI103410B1 (fi) 1999-06-30
GR3024215T3 (en) 1997-10-31
HU220205B (hu) 2001-11-28
JPH0757735B2 (ja) 1995-06-21
BR8707431A (pt) 1988-11-01
WO1988001178A1 (en) 1988-02-25
KR880701564A (ko) 1988-11-03
AU7715987A (en) 1988-03-03
DK205388A (da) 1988-06-14
IL83567A0 (en) 1988-01-31
DK174053B1 (da) 2002-05-13
NO881639D0 (no) 1988-04-15
ES2054678T3 (es) 1994-08-16
WO1988001180A1 (en) 1988-02-25
JPS63502350A (ja) 1988-09-08
FI881768A0 (fi) 1988-04-15
ES2054678T5 (es) 1997-09-16
AU609051B2 (en) 1991-04-26
KR970011151B1 (ko) 1997-07-07
AU638153B2 (en) 1993-06-17
JPS63501878A (ja) 1988-07-28
JP2771404B2 (ja) 1998-07-02
MX169992B (es) 1993-08-04
NZ221484A (en) 1991-01-29
FI103410B (fi) 1999-06-30
JPH06220190A (ja) 1994-08-09
DK205388D0 (da) 1988-04-14

Similar Documents

Publication Publication Date Title
ATE89743T1 (de) Conjugate dichter sterne.
ATE2667T1 (de) Antidepressiv wirkende derivate des trans-4phenyl-1,2,3,4-tetrahydro-1-naphthalin-amins und pharmazeutische zusammensetzungen daraus.
EP0372752A3 (en) Cd4 polypeptide derivatives
DE69333107T2 (de) Dualer träger für immunogene konstrukte
DE69019164D1 (de) Verbessertes meningokokkale polysaccharidkonjugatvakzin.
DE69007371D1 (de) Polymerzusammensetzung, Klebemittel und etikettiertes Glasmaterial.
DE68906762D1 (de) Prostaglandin-polysaccharid-konjugat.
EP0230264A3 (en) Pharmaceutical composition for nasal application, process for its preparation and its use
NO902747D0 (no) Kationiske, overflateaktive fiberkondisjoneringsblandinger omfattende forbindelser med langkjedete hydrocarbylgrupper.
KR910000519U (ko) 왕복엽서, 왕복서한 등의 왕복 통신용 시이트
FI901326A0 (fi) Nya komplex haerledda fraon platina, foerfarande foer deras framstaellning och farmaceutiska kompositioner innehaollande dessa.
DE68900131D1 (de) Biozide 4,5-dichlor-1,2-dithiol-3-on-zusammensetzung.
DE69008805D1 (de) 1,3,5-Trioxan-Packung.
NO884941L (no) Konjugat av metallothionein eller et metallothioneinfragment og et maalsoekende biologisk aktivt molekyl, som er anvendelig som mellomprodukt ved fremstilling av lignende merkede konjugater.
IT8919498A0 (it) Derivati del 3,4 deidro piperidin 5 one ad attivita' erbicida.
BR6700068U (pt) Maleta-mesa,conjugada com banqueta

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time