GR3024215T3 - Starburst conjugates - Google Patents

Starburst conjugates

Info

Publication number
GR3024215T3
GR3024215T3 GR970401861T GR970401861T GR3024215T3 GR 3024215 T3 GR3024215 T3 GR 3024215T3 GR 970401861 T GR970401861 T GR 970401861T GR 970401861 T GR970401861 T GR 970401861T GR 3024215 T3 GR3024215 T3 GR 3024215T3
Authority
GR
Greece
Prior art keywords
conjugates
starburst conjugates
starburst
dendrimer
agricutural
Prior art date
Application number
GR970401861T
Other languages
Greek (el)
Inventor
Donald A Tomalia
Donald A Kaplan
William J Kruper
Roberta C Cheng
Ian A Tomlinson
Michael J Fazio
Larry R Wilson
David M Hedstrand
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25407923&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3024215(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of GR3024215T3 publication Critical patent/GR3024215T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/005—Dendritic macromolecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Pest Control & Pesticides (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Luminescent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricutural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
GR970401861T 1986-08-18 1997-07-23 Starburst conjugates GR3024215T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89745586A 1986-08-18 1986-08-18

Publications (1)

Publication Number Publication Date
GR3024215T3 true GR3024215T3 (en) 1997-10-31

Family

ID=25407923

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970401861T GR3024215T3 (en) 1986-08-18 1997-07-23 Starburst conjugates

Country Status (21)

Country Link
EP (1) EP0271180B2 (en)
JP (6) JPH0757736B2 (en)
KR (1) KR970011151B1 (en)
AT (1) ATE89743T1 (en)
AU (2) AU609051B2 (en)
BR (3) BR8707432A (en)
DE (1) DE3786000T3 (en)
DK (1) DK174053B1 (en)
ES (1) ES2054678T5 (en)
FI (2) FI103410B1 (en)
GR (1) GR3024215T3 (en)
HK (1) HK54396A (en)
HU (2) HU209252B (en)
IE (1) IE61356B1 (en)
IL (1) IL83567A (en)
MX (1) MX169992B (en)
MY (1) MY102878A (en)
NO (1) NO176306C (en)
NZ (1) NZ221484A (en)
WO (3) WO1988001180A1 (en)
ZA (1) ZA876114B (en)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
WO1995024221A1 (en) * 1986-08-18 1995-09-14 The Dow Chemical Company Bioactive and/or targeted dendrimer conjugates
US5914095A (en) * 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
US5808003A (en) * 1989-05-26 1998-09-15 Perimmune Holdings, Inc. Polyaminocarboxylate chelators
DK0429644T3 (en) * 1989-05-26 1996-01-22 Ramaswamy Subramanian Chelating agents for binding metal ions to proteins
US5292868A (en) * 1989-05-26 1994-03-08 Akzo N.V. Chelating agents for attaching metal ions to proteins
DE3930674A1 (en) * 1989-09-11 1991-03-21 Diagnostikforschung Inst BIFUNCTIONAL CHELATE FORMERS FOR COMPLEXING TC AND RE-ISOTOPES, METHOD FOR THE PRODUCTION AND DISPLAY OF CONJUGATES THEREOF AND THEIR USE IN DIAGNOSTICS AND THERAPY
DE3938992A1 (en) * 1989-11-21 1991-05-23 Schering Ag Cascade polymer-bound complex formers, their complexes and conjugates, process for their preparation and pharmaceutical compositions containing them
AU641736B2 (en) * 1990-03-21 1993-09-30 Quest International B.V. Delivery of agents
AU642980B2 (en) * 1990-03-21 1993-11-04 Quest International B.V. Ultilization of enzymes
AU642979B2 (en) * 1990-03-21 1993-11-04 Quest International B.V. Utilization and delivery of enzymes
GB9021671D0 (en) * 1990-10-05 1990-11-21 Unilever Plc Delivery of agents
IL99234A (en) * 1990-08-27 1994-05-30 Michigan Molecular Inst Non-crosslinked, poly-branched polymers and their preparation
GB9112536D0 (en) * 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
US5871713A (en) * 1991-12-04 1999-02-16 Guerbet S.A. Macromolecular polyamine iodine-containing compound, process for its preparation and its use as a contrast agent
FR2688508A1 (en) * 1992-03-13 1993-09-17 Guerbet Sa New iodo contrast product, process for its preparation and its use as contrast agent
WO1993010824A1 (en) * 1991-12-04 1993-06-10 Guerbet S.A. Novel macromolecular polyamine iodine-containing compound, process for its preparation and its use as a contrast agent
EP0636156B1 (en) * 1992-04-14 1997-07-30 Cornell Research Foundation, Inc. Dendritic based macromolecules and method of production
US5387617A (en) * 1993-01-22 1995-02-07 The Dow Chemical Company Small cell foams and blends and a process for their preparation
US6121056A (en) * 1993-02-24 2000-09-19 Dade Behring Inc. Random detection of antigens with antibodies immobilized on soluble submicron particles
ES2132392T3 (en) * 1993-02-24 1999-08-16 Dade Behring Inc IMMOBILIZATION OF SPECIFIC LINK TEST REAGENTS.
US5898005A (en) * 1993-02-24 1999-04-27 Dade Behring Inc. Rapid detection of analytes with receptors immobilized on soluble submicron particles
FR2703055B1 (en) * 1993-03-22 1995-07-07 Guerbet Sa New polyiodinated compounds, their preparation and their use as contrast agents for radiology.
US7097839B1 (en) 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
AU750411B2 (en) * 1994-03-07 2002-07-18 Dendritic Nanotechnologies, Inc. Bioactive and/or targeted dendrimer conjugates
GB9407812D0 (en) * 1994-04-20 1994-06-15 Nycomed Salutar Inc Compounds
NL9400880A (en) * 1994-05-27 1996-01-02 Dsm Nv Composition consisting of a dendrimer and an active substance enclosed in the dendrimer, a method for preparing such a composition, and a method for releasing the active substance
NL9401886A (en) * 1994-05-27 1996-01-02 Dsm Nv Composition consisting of a dendrimer and an active substance contained in the dendrimer, a method of preparing such a composition and a method of releasing the active substance.
AUPM623994A0 (en) 1994-06-15 1994-07-07 Biomolecular Research Institute Limited Antiviral dendrimers
HUT77521A (en) * 1994-12-21 1998-05-28 Novartis Ag. Oligonucleotide-dendrimer conjugates and pharmaceutical compositions containing them
FR2734268B1 (en) * 1995-05-19 1997-07-04 Centre Nat Rech Scient NEW FUNCTIONAL DENDRIMERS WITH PHOSPHOROUS TERMINATIONS AND THEIR PREPARATION PROCESS
US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
US6083708A (en) * 1995-08-11 2000-07-04 Dade Behring Inc. Polypeptide: dendrimer complexes
US5658574A (en) * 1995-10-13 1997-08-19 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Cleansing compositions with dendrimers as mildness agents
NL1001753C2 (en) * 1995-11-28 1997-05-30 Dsm Nv Composition comprising a plastic and an additive.
DE19625982A1 (en) * 1996-06-28 1998-01-02 Wella Ag Cosmetic agent for hair treatment with dendrimers
EP0951486B1 (en) * 1997-01-13 2006-01-11 The Dow Chemical Company Nanocomposites of dendritic polymers
WO1998056427A1 (en) * 1997-06-12 1998-12-17 Mitsubishi Chemical Corporation Novel contrast media
DE19728954C1 (en) * 1997-06-30 1999-04-22 Schering Ag Saccharide conjugates, pharmaceutical compositions containing them, processes for their preparation and their use
FR2790642A1 (en) * 1999-03-08 2000-09-15 Aventis Cropscience Sa NEW PESTICIDE AND / OR REGULATORY GROWTH COMPOSITIONS
WO2001002861A1 (en) * 1999-06-29 2001-01-11 Dako A/S Detection using dendrimers bearing labels and probes
CZ2002343A3 (en) 1999-07-29 2002-08-14 Epix Medical, Inc. Targeting multimeric imaging agents exhibiting multilocus binding ability
FI19991705A (en) * 1999-08-11 2001-02-12 Neste Chemicals Oy An antimicrobial hyperbranched polymer composition
FR2797563A1 (en) * 1999-08-18 2001-02-23 Rhodianyl BIOCIDAL COMPOUNDS AND THEIR USE IN THERMOPLASTIC POLYMERS
DE60041555D1 (en) * 1999-12-10 2009-03-26 Gerald M Rosen USE OF POLY-NITROXYL-FUNCTIONALIZED DENDRIMERS AS CONTRASTING AGENTS FOR MRI IMAGING OF JOINTS
BR0109886B1 (en) 2000-04-07 2011-10-04 method for inhibiting the obstruction of a conduit.
US6471968B1 (en) * 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
CU23011A1 (en) * 2000-11-03 2004-12-17 Ct Ingenieria Genetica Biotech METHOD OF OBTAINING ANTIGENIC STRUCTURES BURNING METHOD OF OBTAINING ANTIGENIC STRUCTURES THAT ENHANCE SPECIFIC CROSS REACTIVITY AND ITS POTENTIAL SPECIFIC CROSS REACTIVITY USE AND USE IN FORMULATIONS
EP1401988B1 (en) 2001-06-14 2008-06-04 Shell Internationale Researchmaatschappij B.V. Method for solubilising asphaltenes in a hydrocarbon mixture
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
GB0209022D0 (en) 2002-04-19 2002-05-29 Imp College Innovations Ltd Compounds
CN100343479C (en) 2002-09-03 2007-10-17 国际壳牌研究有限公司 Method and compositions for inhibiting formation of hydrocarbon hydrates
EP1525890A1 (en) 2003-10-02 2005-04-27 Complex Biosystems GmbH Protein-Proteophore complexes
EP2264191A1 (en) * 2003-11-21 2010-12-22 ANP Technologies, Inc. Asymmetrically branched polymer conjugates and microarray assays
MXPA06012207A (en) * 2004-04-20 2007-02-13 Dendritic Nanotechnologies Inc Dendritic polymers with enhanced amplification and interior functionality.
US7985424B2 (en) 2004-04-20 2011-07-26 Dendritic Nanotechnologies Inc. Dendritic polymers with enhanced amplification and interior functionality
US7919570B2 (en) 2004-08-13 2011-04-05 Nippon Soda Co., Ltd. Multibranched polymer and method for producing the same
AU2005287375B8 (en) * 2004-08-25 2009-11-12 The Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
DE602005006704D1 (en) 2004-11-08 2008-06-26 Fujifilm Corp Use of an agent for the removal of oxygen
CA2590495C (en) 2004-11-24 2013-09-03 Shell Canada Limited Method for improving the flowability of a mixture that contains wax and other hydrocarbons
JP2008545621A (en) * 2005-04-20 2008-12-18 デンドリティック ナノテクノロジーズ，インコーポレイテッド Dendritic polymers with enhanced expandability and internal functionality
US7575687B2 (en) * 2005-08-16 2009-08-18 Ge Osmonics, Inc. Membranes and methods useful for caustic applications
WO2007029794A1 (en) 2005-09-07 2007-03-15 Nippon Soda Co., Ltd. Star polymer and process for production thereof
EP3058972A1 (en) 2005-11-17 2016-08-24 Zogenix, Inc. Delivery of viscous formulations by needle-free injection
US8247498B2 (en) 2006-07-11 2012-08-21 Nippon Soda Co., Ltd. Star polymer and method for producing the same
US20080020043A1 (en) * 2006-07-20 2008-01-24 Marc Gingras Dendrimer-Drug Conjugates
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8658148B2 (en) 2007-06-22 2014-02-25 Genzyme Corporation Chemically modified dendrimers
US20100210805A1 (en) 2007-08-31 2010-08-19 Nippon Soda Co., Ltd. Method for producing star polymer
US8252834B2 (en) 2008-03-12 2012-08-28 The Regents Of The University Of Michigan Dendrimer conjugates
ES2563061T3 (en) 2008-04-28 2016-03-10 Zogenix, Inc. New formulations for the treatment of migraine
US8889635B2 (en) 2008-09-30 2014-11-18 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010054321A2 (en) 2008-11-07 2010-05-14 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
AU2010318637A1 (en) 2009-10-13 2012-05-31 The Regents Of The University Of Michigan Dendrimer compositions and methods of synthesis
CN102781231B (en) * 2009-10-26 2014-12-24 德瑞迪克纳米科技公司 PEHAM dendrimers for use in agriculture
US8912323B2 (en) 2009-10-30 2014-12-16 The Regents Of The University Of Michigan Multifunctional small molecules
JP5835741B2 (en) 2010-02-26 2015-12-24 国立大学法人 長崎大学 Antigen or drug delivery complex
US9402911B2 (en) 2011-12-08 2016-08-02 The Regents Of The University Of Michigan Multifunctional small molecules
US9921205B2 (en) 2012-11-13 2018-03-20 Chevron U.S.A. Inc. Method for determining the effectiveness of asphaltene dispersant additives for inhibiting or preventing asphaltene precipitation in a hydrocarbon-containing material subjected to elevated temperature and presssure conditions
GB201405660D0 (en) 2014-03-28 2014-05-14 Gama Healthcare Ltd A liquid disinfecting composition
CA3008648C (en) * 2015-12-16 2023-01-10 Priostar Pty Ltd Dendrimer and formulations thereof
US10907473B2 (en) 2017-11-14 2021-02-02 Chevron U.S.A., Inc. Low volume in-line filtration methods for analyzing hydrocarbon-containing fluid to evaluate asphaltene content and behavior during production operations
CN109287624A (en) * 2018-10-08 2019-02-01 威海晨源分子新材料有限公司 A kind of application of dendritic interphase in pesticide
WO2020142664A1 (en) 2019-01-03 2020-07-09 Ionpath, Inc. Compositions and reagents for ion beam imaging
CN114292217A (en) * 2021-12-31 2022-04-08 安源基因科技(上海)有限公司 Bioactive cross-linking agent, biological cross-linked substance, kit and application

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289872A (en) * 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
IL64277A0 (en) * 1981-11-11 1982-02-28 Basht Ltd Apparatus for removal of integrated circuits from circuit boards
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
CA1225930A (en) * 1982-06-07 1987-08-25 Otto A. Gansow Metal chelate conjugated monoclonal antibodies
US4507466A (en) * 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4558120A (en) * 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4631337A (en) * 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4606907A (en) * 1984-07-02 1986-08-19 The Dow Chemical Company Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines
US4599400A (en) * 1984-12-18 1986-07-08 The Dow Chemical Company Star/comb-branched polyamide
US4694064A (en) * 1986-02-28 1987-09-15 The Dow Chemical Company Rod-shaped dendrimer

Also Published As

Publication number Publication date
BR8707432A (en) 1988-11-01
FI881768A0 (en) 1988-04-15
DK205388D0 (en) 1988-04-14
JPH06219966A (en) 1994-08-09
NO176306B (en) 1994-12-05
JPH072840B2 (en) 1995-01-18
JPS63502350A (en) 1988-09-08
EP0271180A1 (en) 1988-06-15
ZA876114B (en) 1989-04-26
JPH0757736B2 (en) 1995-06-21
FI105693B (en) 2000-09-29
IL83567A (en) 1992-02-16
HU9303379D0 (en) 1994-03-28
FI103410B (en) 1999-06-30
JP2771404B2 (en) 1998-07-02
DE3786000D1 (en) 1993-07-01
BR8707431A (en) 1988-11-01
DE3786000T2 (en) 1993-09-02
HU209252B (en) 1994-04-28
AU638153B2 (en) 1993-06-17
JPS63501878A (en) 1988-07-28
HK54396A (en) 1996-04-03
JPH069778A (en) 1994-01-18
JPS63501876A (en) 1988-07-28
ATE89743T1 (en) 1993-06-15
FI103410B1 (en) 1999-06-30
JPH0757735B2 (en) 1995-06-21
WO1988001178A1 (en) 1988-02-25
MY102878A (en) 1993-03-31
IE61356B1 (en) 1994-11-02
NO881639D0 (en) 1988-04-15
AU7715987A (en) 1988-03-03
WO1988001179A1 (en) 1988-02-25
WO1988001180A1 (en) 1988-02-25
KR970011151B1 (en) 1997-07-07
EP0271180B1 (en) 1993-05-26
JPH07108860B2 (en) 1995-11-22
NO176306C (en) 1995-03-15
FI881768A (en) 1988-04-15
FI981807A (en) 1998-08-24
IE872210L (en) 1988-02-18
DK174053B1 (en) 2002-05-13
HUT55245A (en) 1991-05-28
HU220205B (en) 2001-11-28
MX169992B (en) 1993-08-04
NZ221484A (en) 1991-01-29
DE3786000T3 (en) 1997-08-21
ES2054678T3 (en) 1994-08-16
NO881639L (en) 1988-06-15
FI981807A0 (en) 1998-08-24
IL83567A0 (en) 1988-01-31
KR880701564A (en) 1988-11-03
AU8139191A (en) 1991-10-03
EP0271180B2 (en) 1997-06-18
JPH06220190A (en) 1994-08-09
JP2848218B2 (en) 1999-01-20
DK205388A (en) 1988-06-14
AU609051B2 (en) 1991-04-26
BR8707433A (en) 1988-11-01
ES2054678T5 (en) 1997-09-16

Similar Documents

Publication Publication Date Title
GR3024215T3 (en) Starburst conjugates
DE68904101T2 (en) POLYMER COMPOSITIONS.
NO891982L (en) POLYMER COMPOSITION.
DE68920021T2 (en) POLYMER COMPOSITION.
DE69013711D1 (en) Polymer composition.
DE68916717D1 (en) Self-extinguishing polymer composition.
DE3882313D1 (en) POLYMER COMPOSITION.
DE68900131D1 (en) BIOCIDES 4,5-DICHLOR-1,2-DITHIOL-3-ON COMPOSITION.
DE69010556T2 (en) Polyketone polymer compositions.
NO905336D0 (en) PHOTOGRADABLE POLYMER COMPOSITION.