ATE556323T1 - Neurofibrilläre marker - Google Patents
Neurofibrilläre markerInfo
- Publication number
- ATE556323T1 ATE556323T1 AT02720102T AT02720102T ATE556323T1 AT E556323 T1 ATE556323 T1 AT E556323T1 AT 02720102 T AT02720102 T AT 02720102T AT 02720102 T AT02720102 T AT 02720102T AT E556323 T1 ATE556323 T1 AT E556323T1
- Authority
- AT
- Austria
- Prior art keywords
- tau
- tau protein
- derivative
- agent
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0106953.3A GB0106953D0 (en) | 2001-03-20 | 2001-03-20 | Neufofibrillary labels |
PCT/GB2002/001318 WO2002075318A2 (en) | 2001-03-20 | 2002-03-20 | Neurofibrillary labels |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE556323T1 true ATE556323T1 (de) | 2012-05-15 |
Family
ID=9911161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02720102T ATE556323T1 (de) | 2001-03-20 | 2002-03-20 | Neurofibrilläre marker |
Country Status (13)
Country | Link |
---|---|
US (3) | US7335652B2 (de) |
EP (1) | EP1421389B1 (de) |
JP (2) | JP4288073B2 (de) |
CN (2) | CN101696977B (de) |
AT (1) | ATE556323T1 (de) |
AU (1) | AU2002251172B2 (de) |
CA (1) | CA2440794C (de) |
DK (1) | DK1421389T3 (de) |
ES (1) | ES2386773T3 (de) |
GB (1) | GB0106953D0 (de) |
HK (1) | HK1062044A1 (de) |
PT (1) | PT1421389E (de) |
WO (1) | WO2002075318A2 (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
GB0100119D0 (en) | 2001-01-03 | 2001-02-14 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
GB0106953D0 (en) * | 2001-03-20 | 2001-05-09 | Univ Aberdeen | Neufofibrillary labels |
GB0113121D0 (en) | 2001-05-30 | 2001-07-18 | Univ Leeds | Biologically active photosensitisers |
GB0117326D0 (en) | 2001-07-16 | 2001-09-05 | Univ Aberdeen | Napthoquinone-type inhibitors of protein aggregation |
EP1643994A4 (de) * | 2003-06-19 | 2010-09-08 | Neuronautics Inc | Verfahren zur hemmung oder umkehr von tau-filament-fibrillisierung |
GB0322756D0 (en) * | 2003-09-29 | 2003-10-29 | Univ Aberdeen | Methods of chemical synthesis |
WO2006032879A2 (en) | 2004-09-23 | 2006-03-30 | Wista Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
JP5186212B2 (ja) | 2004-09-23 | 2013-04-17 | ウィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物(mtc)などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
CN104119294B (zh) | 2006-03-29 | 2018-10-30 | 维斯塔实验室有限公司 | 3,7-二氨基-10h-吩噻嗪化合物的制备方法 |
CN101460222B (zh) * | 2006-03-29 | 2013-12-04 | 维斯塔实验室有限公司 | 锍化合物及其用途 |
CN103735554B (zh) | 2006-03-29 | 2018-03-20 | 维斯塔实验室有限公司 | 蛋白聚集抑制剂 |
JP5132090B2 (ja) * | 2006-06-16 | 2013-01-30 | 東和薬品株式会社 | 塩酸エピナスチンドライシロップ剤 |
CN101511803B (zh) | 2006-07-11 | 2012-10-31 | 维斯塔实验室有限公司 | 二氨基吩噻嗪*化合物的合成和/或纯化方法 |
EP2954932B1 (de) | 2007-10-03 | 2018-09-19 | WisTa Laboratories Ltd. | Therapeutische verwendung von diaminophenothiazinen |
EP2268314A2 (de) * | 2008-03-21 | 2011-01-05 | Adlyfe, Inc. | Verwendung von pyrol zum befördern von peptiden durch die blut-gehirn-schranke |
WO2009117042A1 (en) * | 2008-03-21 | 2009-09-24 | Adlyfe, Inc. | Use of pyrene to carry non-peptide agents across the blood brain barrier |
RU2518892C2 (ru) * | 2008-09-23 | 2014-06-10 | Виста Лабораториз Лтд. | Лиганды для агрегированных молекул тау-белка |
CN102307878B (zh) | 2008-12-10 | 2014-10-15 | 维斯塔实验室有限公司 | 3,6-二取代的呫吨鎓盐 |
WO2010067085A2 (en) | 2008-12-12 | 2010-06-17 | Wista Laboratories Ltd. | Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-υ-carboline and analogues and intermediates |
CU23844B1 (es) | 2009-04-17 | 2012-10-15 | Ct De Neurociencias De Cuba | Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer |
SI2430007T1 (sl) | 2009-05-12 | 2014-05-30 | Wista Laboratories Ltd. | Postopki kemijske sinteze diaminofenotiazinijevih spojin, ki vključujejo uporabo persulfatnih oksidantov |
US8828986B2 (en) | 2011-04-20 | 2014-09-09 | Prosetta Antiviral Inc. | Antiviral compounds |
WO2011137447A1 (en) | 2010-04-30 | 2011-11-03 | Prostetta Antiviral Inc. | Antiviral compounds |
CN103209695A (zh) | 2010-09-15 | 2013-07-17 | 弗·哈夫曼-拉罗切有限公司 | 氮杂苯并噻唑化合物、组合物及应用方法 |
CN103298789A (zh) * | 2010-11-16 | 2013-09-11 | 通用电气健康护理有限公司 | 作为τ蛋白病理成像探针的杂环化合物 |
CA2818068C (en) | 2010-11-30 | 2019-06-11 | Wista Laboratories Ltd. | Formulations comprising methylthioninium chloride |
CA2826286C (en) | 2011-01-31 | 2021-09-21 | Intellect Neurosciences Inc. | Treatment of tauopathies |
SI2673266T1 (sl) | 2011-02-11 | 2016-11-30 | Wista Laboratories Ltd. | Fenotiazin diaminijeve soli in njihova uporaba |
WO2013036749A1 (en) * | 2011-09-07 | 2013-03-14 | University Of Kansas | Hcv helicase inhibitors and methods of use thereof |
CN102942537B (zh) * | 2012-11-09 | 2014-07-02 | 浙江大学 | 一种用作pH荧光探针的苯并噻唑-苯胺类化合物及其制备方法 |
US9233961B2 (en) | 2013-03-15 | 2016-01-12 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
US9186361B2 (en) | 2013-03-15 | 2015-11-17 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
US9588129B2 (en) | 2013-03-15 | 2017-03-07 | Amira Medical Technologies Inc. | Methods for analyzing blood to detect diseases associated with abnormal protein aggregation |
GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
US10765755B1 (en) | 2013-11-20 | 2020-09-08 | University Of South Florida | Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies |
SG11201604618TA (en) | 2013-12-19 | 2016-07-28 | Novartis Ag | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis |
CN107163022B (zh) * | 2016-03-07 | 2021-07-16 | 上海如絮生物科技有限公司 | 一种异喹啉类化合物、其中间体、制备方法和应用 |
MX2019005007A (es) | 2016-11-01 | 2019-07-18 | Arvinas Inc | Protac dirigidos a la proteína tau y métodos asociados de uso. |
SE1750924A1 (sv) * | 2017-07-14 | 2018-10-02 | A method for analyzing the 3d structure of biomolecules | |
JP2021512153A (ja) | 2018-01-26 | 2021-05-13 | イエール ユニバーシティ | タンパク質分解のイミド系モジュレーターおよび使用方法 |
US11155609B2 (en) | 2019-04-05 | 2021-10-26 | TauC3 Biologies Limited | Anti-TAUC3 antibodies and uses thereof |
GB201909493D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Therapeutic interactions |
US11912699B2 (en) | 2019-07-17 | 2024-02-27 | Arvinas Operations, Inc. | Tau-protein targeting compounds and associated |
KR20220119094A (ko) | 2019-12-19 | 2022-08-26 | 아비나스 오퍼레이션스, 인코포레이티드 | 안드로겐 수용체의 표적화된 분해를 위한 화합물 및 방법 |
GB202010620D0 (en) | 2020-07-10 | 2020-08-26 | Wista Lab Ltd | System |
GB202010652D0 (en) | 2020-07-10 | 2020-08-26 | Wista Lab Ltd | Anti-tau antibodies |
WO2023135200A1 (en) | 2022-01-12 | 2023-07-20 | Gtinvent Limited | Method for detecting a tau protein in a saliva sample |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
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DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US4389393A (en) * | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
CA1302250C (en) * | 1986-04-04 | 1992-06-02 | Khalid Iqbal | Diagnostic for alzheimer's disease |
EP0287909B1 (de) * | 1987-04-08 | 1992-09-02 | Salutar, Inc. | Nachweis für Amyloidose und Alzheimer'sche Krankheit sowie Reagens hierfür |
US5008099A (en) * | 1987-04-08 | 1991-04-16 | Salutar, Inc. | Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor |
GB8724412D0 (en) | 1987-10-19 | 1987-11-25 | Medical Res Council | Protein |
FI101344B1 (fi) * | 1988-03-31 | 1998-06-15 | Tanabe Seiyaku Co | Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseuttisesti aktiivista ainetta |
KR100231226B1 (ko) | 1991-07-10 | 1999-11-15 | 스프레이그 로버트 월터 | 발수 처리용 및 발유 처리용 플루오로케미칼 조성물 |
EP0600951A4 (en) * | 1991-08-01 | 1996-10-30 | Paul H Voorheis | Diagnostic method for alzheimer's disease. |
CA2125298A1 (en) | 1991-12-06 | 1993-06-10 | Eva-Maria Mandelkow | Tools for the diagnosis and treatment of alzheimer's disease |
WO1993019143A1 (en) * | 1992-03-17 | 1993-09-30 | Lord Corporation | Colorant-containing electrorheological materials |
US5536761A (en) | 1992-12-07 | 1996-07-16 | Sakura Color Products Corporation | Water base dye ink composition |
GB9317193D0 (en) | 1993-08-18 | 1993-10-06 | Zeneca Ltd | Method |
CA2196529A1 (en) * | 1994-08-08 | 1996-02-22 | Peter Davies | Methods for treating and/or preventing alzheimer's disease using phenothiazines and/or thioxanthenes |
DE4430091A1 (de) * | 1994-08-25 | 1996-02-29 | Bayer Ag | Verwendung von N-substituierten Phenothiazinen |
GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
US5697985A (en) * | 1995-06-07 | 1997-12-16 | Bayer Corporation | Process for the preparation storage-stable dye dispersions |
WO1999062548A1 (en) | 1998-06-01 | 1999-12-09 | Advanced Research And Technology Institute | Methods and compositions for diagnosing tauopathies |
JP2000344685A (ja) | 1999-03-26 | 2000-12-12 | Bf Kenkyusho:Kk | アズールa類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物 |
JP2000344684A (ja) | 1999-03-26 | 2000-12-12 | Bf Kenkyusho:Kk | ピロニンb類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物 |
EP1048302A3 (de) * | 1999-04-30 | 2002-07-17 | Pfizer Products Inc. | Radiotracer zur Untersuchung von Acetylcholinesterase und Alzheimer Erkrankung |
AU2001244549A1 (en) | 2000-03-22 | 2001-10-03 | Bf Research Institute, Inc. | Azure a analogues useful as probes in the diagnostic imaging for diseases due toaccumulation of amyloid and compositions for diagnostic imaging containing the analogues |
PL215711B1 (pl) | 2000-08-24 | 2014-01-31 | Univ Pittsburgh | Nowe zwiazki pochodne tioflawiny, sposób syntezy zwiazków i ich zastosowanie, kompozycja farmaceutyczna zawierajaca zwiazki i zastosowanie kompozycji |
GB0100119D0 (en) | 2001-01-03 | 2001-02-14 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
GB0106953D0 (en) * | 2001-03-20 | 2001-05-09 | Univ Aberdeen | Neufofibrillary labels |
GB0117326D0 (en) | 2001-07-16 | 2001-09-05 | Univ Aberdeen | Napthoquinone-type inhibitors of protein aggregation |
US6953974B2 (en) * | 2003-08-26 | 2005-10-11 | Texas Instruments Incorporated | EEPROM device and method for providing lower programming voltage |
GB0322756D0 (en) | 2003-09-29 | 2003-10-29 | Univ Aberdeen | Methods of chemical synthesis |
WO2006032879A2 (en) | 2004-09-23 | 2006-03-30 | Wista Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
-
2001
- 2001-03-20 GB GBGB0106953.3A patent/GB0106953D0/en not_active Ceased
-
2002
- 2002-03-20 CN CN200810185342.XA patent/CN101696977B/zh not_active Expired - Lifetime
- 2002-03-20 CA CA2440794A patent/CA2440794C/en not_active Expired - Lifetime
- 2002-03-20 DK DK02720102.9T patent/DK1421389T3/da active
- 2002-03-20 EP EP02720102A patent/EP1421389B1/de not_active Expired - Lifetime
- 2002-03-20 AT AT02720102T patent/ATE556323T1/de active
- 2002-03-20 AU AU2002251172A patent/AU2002251172B2/en not_active Expired
- 2002-03-20 CN CN02810291.6A patent/CN1578910A/zh active Pending
- 2002-03-20 ES ES02720102T patent/ES2386773T3/es not_active Expired - Lifetime
- 2002-03-20 JP JP2002573679A patent/JP4288073B2/ja not_active Expired - Lifetime
- 2002-03-20 WO PCT/GB2002/001318 patent/WO2002075318A2/en active Application Filing
- 2002-03-20 PT PT02720102T patent/PT1421389E/pt unknown
-
2003
- 2003-09-22 US US10/665,008 patent/US7335652B2/en not_active Expired - Lifetime
-
2004
- 2004-05-27 HK HK04103802.8A patent/HK1062044A1/xx not_active IP Right Cessation
-
2008
- 2008-02-25 US US12/071,693 patent/US7713962B2/en not_active Expired - Lifetime
- 2008-09-24 JP JP2008243567A patent/JP2009035566A/ja active Pending
-
2010
- 2010-05-10 US US12/662,887 patent/US8097615B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20080219929A1 (en) | 2008-09-11 |
JP2004537034A (ja) | 2004-12-09 |
CN101696977A (zh) | 2010-04-21 |
CA2440794A1 (en) | 2002-09-26 |
JP4288073B2 (ja) | 2009-07-01 |
US20040213736A1 (en) | 2004-10-28 |
EP1421389A2 (de) | 2004-05-26 |
US8097615B2 (en) | 2012-01-17 |
CA2440794C (en) | 2012-05-01 |
WO2002075318A2 (en) | 2002-09-26 |
EP1421389B1 (de) | 2012-05-02 |
AU2002251172B2 (en) | 2007-12-06 |
PT1421389E (pt) | 2012-07-10 |
US20100285605A1 (en) | 2010-11-11 |
WO2002075318A3 (en) | 2004-03-11 |
GB0106953D0 (en) | 2001-05-09 |
DK1421389T3 (da) | 2012-08-13 |
CN101696977B (zh) | 2014-02-19 |
ES2386773T3 (es) | 2012-08-30 |
JP2009035566A (ja) | 2009-02-19 |
HK1062044A1 (en) | 2004-10-15 |
US7713962B2 (en) | 2010-05-11 |
CN1578910A (zh) | 2005-02-09 |
US7335652B2 (en) | 2008-02-26 |
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