ATE552260T1 - Substituierte porphyrine und deren therapeutische verwendung - Google Patents
Substituierte porphyrine und deren therapeutische verwendungInfo
- Publication number
- ATE552260T1 ATE552260T1 AT05014279T AT05014279T ATE552260T1 AT E552260 T1 ATE552260 T1 AT E552260T1 AT 05014279 T AT05014279 T AT 05014279T AT 05014279 T AT05014279 T AT 05014279T AT E552260 T1 ATE552260 T1 AT E552260T1
- Authority
- AT
- Austria
- Prior art keywords
- therapeutic use
- substituted porphyrins
- oxidants
- relates
- processes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B47/00—Porphines; Azaporphines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11701099P | 1999-01-25 | 1999-01-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE552260T1 true ATE552260T1 (de) | 2012-04-15 |
Family
ID=22370524
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00905776T ATE312103T1 (de) | 1999-01-25 | 2000-01-25 | Substituierte porphyrine und deren therapeutische verwendungen |
AT05014279T ATE552260T1 (de) | 1999-01-25 | 2000-01-25 | Substituierte porphyrine und deren therapeutische verwendung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00905776T ATE312103T1 (de) | 1999-01-25 | 2000-01-25 | Substituierte porphyrine und deren therapeutische verwendungen |
Country Status (18)
Country | Link |
---|---|
US (7) | US6544975B1 (de) |
EP (3) | EP1155019B1 (de) |
JP (1) | JP4501128B2 (de) |
KR (1) | KR100753184B1 (de) |
CN (1) | CN1156478C (de) |
AT (2) | ATE312103T1 (de) |
AU (1) | AU779283B2 (de) |
BR (1) | BR0007720B1 (de) |
CA (1) | CA2359116C (de) |
DE (1) | DE60024588T2 (de) |
DK (2) | DK1616869T3 (de) |
ES (2) | ES2254142T3 (de) |
HK (2) | HK1047744A1 (de) |
IL (3) | IL144503A0 (de) |
MX (1) | MXPA01007451A (de) |
NZ (1) | NZ513164A (de) |
WO (1) | WO2000043395A1 (de) |
ZA (1) | ZA200106107B (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
US5747026A (en) * | 1993-10-15 | 1998-05-05 | University Of Alabama At Birmingham Research Foundation | Antioxidants |
DE69813898T2 (de) * | 1997-11-03 | 2004-03-11 | Duke University | Substituierte porphyrinen |
ATE311206T1 (de) | 1998-04-24 | 2005-12-15 | Univ Duke | Substituierte porphyrine |
ATE312103T1 (de) * | 1999-01-25 | 2005-12-15 | Nat Jewish Med & Res Center | Substituierte porphyrine und deren therapeutische verwendungen |
US20030032634A1 (en) * | 2001-06-01 | 2003-02-13 | Piganelli Jon D. | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
FR2806911B1 (fr) * | 2000-03-28 | 2003-01-10 | Univ Rene Descartes | Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires |
US20030069281A1 (en) * | 2000-06-14 | 2003-04-10 | Irwin Fridovich | Tetrapyrroles |
ES2330728T3 (es) | 2001-01-19 | 2009-12-15 | National Jewish Health | Medicamento para proteccion en radioterapia. |
ES2280530T3 (es) * | 2001-04-27 | 2007-09-16 | Zenyaku Kogyo Kabushiki Kaisha | Compuesto heterociclico y agente antitumoral que contiene el mismo como principio activo. |
US20030086916A1 (en) * | 2001-10-12 | 2003-05-08 | Goligorsky Michael S. | Use of peroxynitrite scavengers or peroxynitrite formation inhibitors that do not diminish nitric oxide synthesis or activity to reverse or prevent premature vascular senescence |
EP1513537A4 (de) * | 2002-06-07 | 2006-09-06 | Univ Duke | Substituierte porphyrine |
US20040127479A1 (en) * | 2002-08-27 | 2004-07-01 | Merck Patent Gmbh | Peroxynitrite rearrangement catalysts |
CN1717234A (zh) * | 2002-12-06 | 2006-01-04 | 爱尔康公司 | 用于治疗眼紊乱和疾病的超氧化物岐化酶模拟物 |
GB2397067B (en) * | 2002-12-23 | 2005-05-11 | Destiny Pharma Ltd | Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation |
EP1452175A1 (de) * | 2003-02-28 | 2004-09-01 | Medesis Pharma S.A. | Organometallische Komplexe entahltend Mangan, pharmazeutische Formulierungen und Diätetika |
WO2005037990A2 (en) * | 2003-05-29 | 2005-04-28 | Albert Einstein College Of Medecine Of Yeshiva University | Use of parp inhibitors for prevention and treatment of diabetic and insulin resistance complications |
US7299082B2 (en) | 2003-10-31 | 2007-11-20 | Abbott Diabetes Care, Inc. | Method of calibrating an analyte-measurement device, and associated methods, devices and systems |
US8165651B2 (en) * | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
US7699964B2 (en) | 2004-02-09 | 2010-04-20 | Abbott Diabetes Care Inc. | Membrane suitable for use in an analyte sensor, analyte sensor, and associated method |
US7807825B2 (en) | 2004-02-09 | 2010-10-05 | Duke University | Substituted porphyrins |
JP2007530695A (ja) * | 2004-03-29 | 2007-11-01 | イノテック ファーマシューティカルズ コーポレイション | ピリジル置換ポルフィリン化合物およびその使用方法 |
GB2415372A (en) | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
WO2006037050A2 (en) * | 2004-09-24 | 2006-04-06 | Metaphore Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
GB0424294D0 (en) * | 2004-11-03 | 2004-12-01 | Elam T Ltd | Buffer layer |
US7582751B2 (en) * | 2005-07-29 | 2009-09-01 | North Carolina State University | Methods and intermediates for the synthesis of porphyrins |
US7501508B2 (en) * | 2005-07-29 | 2009-03-10 | North Caroline State University | Methods and intermediates for the synthesis of porphyrins |
US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
US20090018094A1 (en) * | 2006-12-01 | 2009-01-15 | Loma Linda University Medical Center | Inhibition of brain enzymes involved in cerebral amyloid angiopathy and macular degeneration |
US20080289053A1 (en) * | 2007-05-15 | 2008-11-20 | The Regents Of The University Of California | Methods and systems for identifying modulators of longevity |
WO2009004339A2 (en) * | 2007-07-03 | 2009-01-08 | Imperial Innovations Limited | Compositions and methods relating to manipulation of the myeloid immune compartment during respiratory infection |
WO2009027965A1 (en) * | 2007-08-28 | 2009-03-05 | Technion Research And Development Foundation Ltd. | Transition metal complexes of corroles for preventing cardiovascular diseases or disorders |
US8598150B1 (en) | 2008-04-02 | 2013-12-03 | Jonathan R. Brestoff | Composition and method for affecting obesity and related conditions |
US8987245B2 (en) | 2008-04-02 | 2015-03-24 | Jonathan R. Brestoff Parker | Composition and method for affecting obesity and related conditions |
RU2506083C2 (ru) * | 2008-05-23 | 2014-02-10 | Нэшнл Джуиш Хелт | Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ |
WO2010138633A1 (en) * | 2009-05-26 | 2010-12-02 | Duke University | Method of providing neuroprotection using substituted porphyrins |
WO2011028935A2 (en) * | 2009-09-02 | 2011-03-10 | The Regents Of The University Of Colorado | Methods of treating mitochondrial disorders using metalloporhyrins |
ES2574789T3 (es) * | 2010-10-06 | 2016-06-22 | Aeolus Sciences, Inc. | Tratamiento de porfirina de enfermedades neurodegenerativas |
WO2012105483A1 (ja) * | 2011-01-31 | 2012-08-09 | 国立大学法人宇都宮大学 | ポルフィリン型骨格を有する化合物の金属錯体の製造方法 |
WO2013130150A2 (en) | 2011-12-02 | 2013-09-06 | The Regents Of The University Of Colorado, A Body Corporate | Metalloporphyrin neurological treatments |
CN102775415B (zh) * | 2012-07-10 | 2014-10-22 | 西北大学 | 一种卟啉的合成方法 |
WO2014028823A1 (en) * | 2012-08-16 | 2014-02-20 | Leading Energy Designs, Ltd. | Led bracket apparatus for high-output led lighting systems |
US9375494B2 (en) | 2013-03-14 | 2016-06-28 | Profusa, Inc. | Oxygen sensors |
US20160113940A1 (en) * | 2013-09-03 | 2016-04-28 | Biomimetix J.V., Llc | Methods of treating biofilms |
BR112016011632A2 (pt) * | 2013-11-22 | 2017-08-08 | Aeolus Sciences Inc | Método para sintetizar um derivado de porfirina, método para sintetizar um composto, método para sintetizar um composto hidrato, método de síntese, recipiente compreendendo uma pluralidade de compostos, formulação farmacêutica, método para purificar um composto, cristal, e, forma cristalina de complexo [5,10,15,20-tetrakis(1,3-dietilimidazólio-2-il)porfirinato]manganês(iii) cloreto hidrato |
AU2014374361B9 (en) | 2013-12-31 | 2019-07-04 | Abbott Diabetes Care Inc. | Self-powered analyte sensor and devices using the same |
US10064871B2 (en) | 2014-01-22 | 2018-09-04 | Biomimetix Jv, Llc | Methods of treating skin disorders |
WO2015112586A1 (en) | 2014-01-22 | 2015-07-30 | Duke University | Methods of treating pruritus |
AT516549B1 (de) * | 2014-11-20 | 2017-05-15 | Wenatex Forschung - Entw - Produktion Gmbh | Antimikrobielles Mittel zum biociden Ausrüsten von Polymeren |
US10385082B2 (en) | 2015-08-18 | 2019-08-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Antioxidant compounds and their use |
MX2019007301A (es) * | 2016-12-20 | 2019-10-30 | Univ Duke | Metodos para elaborar composiciones y compuestos farmaceuticos de porfirina sustituida. |
EP3558118A4 (de) | 2016-12-21 | 2021-02-24 | Profusa, Inc. | Polymerisierbare nahinfrarot-farbstoffe |
CN110028514B (zh) * | 2019-05-30 | 2021-07-02 | 湖南科技大学 | 5,10,15,20-四芳基-2,3-咪唑稠合-21-碳叶绿素化合物及制备方法 |
CA3143430A1 (en) * | 2019-06-14 | 2020-12-17 | Universidade De Coimbra | Small cationic ortho-5,15-di-heteroaryl-porphyrins derivatives and their applications in photoinactivation of microorganisms |
CN116284017B (zh) * | 2023-03-27 | 2024-03-22 | 中国科学院青岛生物能源与过程研究所 | 一种利用仿酶高效催化氧化制备酰胺化合物的方法 |
Family Cites Families (123)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US437221A (en) * | 1890-09-30 | Circular-saw-smithing machine | ||
US2951799A (en) * | 1957-11-13 | 1960-09-06 | Monsanto Chemicals | Photoxidation processes using heterocyclic photosensitizers |
JPS5641611B2 (de) * | 1973-04-19 | 1981-09-29 | ||
DE3464252D1 (en) | 1983-06-03 | 1987-07-23 | Hoffmann La Roche | Labelled molecules for fluorescence immunoassays and processes and intermediates for their preparation |
US4829984A (en) * | 1983-12-15 | 1989-05-16 | Gordon Robert T | Method for the improvement of transplantation techniques and for the preservation of tissue |
US4963367A (en) | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
US5087438A (en) * | 1984-07-03 | 1992-02-11 | Gordon Robert T | Method for affecting intracellular and extracellular electric and magnetic dipoles |
US4911920A (en) * | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
GB8429845D0 (en) | 1984-11-26 | 1985-01-03 | Efamol Ltd | Porphyrins & cancer treatment |
US4758422A (en) | 1985-01-04 | 1988-07-19 | Salutar Inc. | Ferrioxamine paramagnetic contrast agents for MR imaging |
US4657902A (en) | 1985-03-25 | 1987-04-14 | The Rockefeller University | Therapeutic use of tin mesoporphyrin |
JPS63500175A (ja) | 1985-05-22 | 1988-01-21 | リポソ−ム テクノロジ−,インコ−ポレイテツド | リポソ−ム吸入法および吸入システム |
US5248603A (en) | 1985-09-03 | 1993-09-28 | Symbicom Aktiebolag | Superoxide dismutase |
DK402785D0 (da) | 1985-09-03 | 1985-09-03 | Syn Tek Ab | Fremgangsmaade til fremstilling af et enzym |
FR2588189B1 (fr) * | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
US4866054A (en) * | 1986-05-13 | 1989-09-12 | Chai-Tech Corporation | Antioxidant metallo-organic treatment of inflammation |
US4746735A (en) | 1986-11-21 | 1988-05-24 | The Dow Chemical Company | Regiospecific aryl nitration of meso-substituted tetraarylporphyrins |
US5162231A (en) | 1989-10-25 | 1992-11-10 | Cole Dean A | Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung |
EP0282899B1 (de) | 1987-03-14 | 1996-01-10 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Humane Mangan-Superoxiddismutase (hMn-SOD) |
DE3800973C2 (de) * | 1987-03-25 | 1992-03-19 | Degussa Ag, 6000 Frankfurt, De | Oxowolfram(v)-porphyrin-komplexe wo(p)x |
US5227405A (en) | 1987-03-31 | 1993-07-13 | Duke University | Superoxide dismutase mimic |
US5223538A (en) | 1987-03-31 | 1993-06-29 | Duke University | Superoxide dismutase mimic |
US4892941A (en) | 1987-04-17 | 1990-01-09 | Dolphin David H | Porphyrins |
US4851403A (en) | 1987-04-21 | 1989-07-25 | Johnson Matthey, Inc. | Radiation sensitizers |
US4885114A (en) | 1987-04-22 | 1989-12-05 | Barnes Engineering Co. | Metallized tetra((meso)-5-methyl-2-thiophene)porphines, platinum (5-bromo octaethylporphine) and optical filters containing same |
US5051337A (en) | 1987-06-10 | 1991-09-24 | Director-General Of Agency Of Industrial Science And Technology | Optical recording material |
DE3805697A1 (de) * | 1988-02-24 | 1989-09-07 | Bayer Ag | Verfahren zur herstellung von p-hydroxy-benzaldehyden |
US5162519A (en) | 1988-03-11 | 1992-11-10 | Efamol Holdings Plc | Porphyrins and cancer treatment |
GB8805849D0 (en) | 1988-03-11 | 1988-04-13 | Efamol Holdings | Porphyrins & cancer treatment |
US5284647A (en) | 1988-03-18 | 1994-02-08 | Schering Aktiengesellschaft | Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them |
DE3809671A1 (de) | 1988-03-18 | 1989-09-28 | Schering Ag | Porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
US5192788A (en) * | 1988-05-23 | 1993-03-09 | Georgia State University Foundation, Inc. | Porphyrin antiviral compositions |
US5109016A (en) | 1988-05-23 | 1992-04-28 | Georgia State University Foundation, Inc. | Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions |
FR2632187B1 (fr) | 1988-06-02 | 1990-09-14 | Centre Nat Rech Scient | Derives de metalloporphyrines, leur preparation, leur application en therapeutique et leur utilisation pour la preparation de molecules hybrides |
US5171680A (en) | 1988-06-14 | 1992-12-15 | Chiron Corporation | Superoxide dismutase analogs having novel binding properties |
JPH0746212B2 (ja) | 1988-12-03 | 1995-05-17 | 工業技術院長 | 異方性lb膜の製造法 |
JPH02213088A (ja) * | 1989-02-13 | 1990-08-24 | Nec Corp | 有機薄膜el素子及びその製造方法 |
DE69027383T2 (de) | 1989-03-06 | 1996-11-14 | Masayasu Inoue | Neue superoxyd-dismutase |
DK455789D0 (da) | 1989-09-15 | 1989-09-15 | Symbicom Ab | Polypeptid |
US5010073A (en) * | 1989-10-05 | 1991-04-23 | The Rockefeller University | Use of liposomes as carriers for metalloporphyrins |
EP0424033A3 (en) | 1989-10-19 | 1991-07-31 | Pola Chemical Industries Inc | External skin preparation |
US5236915A (en) | 1990-05-31 | 1993-08-17 | Health Research, Inc. | Meso poly(4-sulfonatophenyl) porphines as MRI image enhancing agents |
EP0462836A3 (en) | 1990-06-20 | 1992-08-26 | Mitsui Toatsu Chemicals, Inc. | Recombinant vector plasmid capable of expressing human manganese superoxide dismutase, and process of producing this enzyme |
US5417111A (en) * | 1990-08-17 | 1995-05-23 | Analog Devices, Inc. | Monolithic chip containing integrated circuitry and suspended microstructure |
US5202317A (en) | 1990-09-13 | 1993-04-13 | The Regents Of The University Of California | Synthetic drug molecules that mimic metalloenzymes |
US5217966A (en) | 1990-09-13 | 1993-06-08 | The Regents Of The University Of California | Synthetic drug molecules that mimic metalloenzymes |
WO1992007935A1 (en) | 1990-11-01 | 1992-05-14 | The Scripps Research Institute | Glycosaminoglycan-targeted fusion proteins, their design, construction and compositions |
JPH06504041A (ja) * | 1990-11-14 | 1994-05-12 | ユー・エー・ビー・リサーチ ファウンデーション | 虚血性傷害を減少させる方法と組成 |
US5192757A (en) * | 1990-12-20 | 1993-03-09 | Glaxo Inc. | Cobalt porphyrins |
JP2594486B2 (ja) * | 1991-01-15 | 1997-03-26 | アルコン ラボラトリーズ インコーポレイテッド | 局所的眼薬組成物 |
GB9103991D0 (en) | 1991-02-26 | 1991-04-10 | Nat Res Dev | Molecular electronic devices |
US5212162A (en) * | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
FR2676738B1 (fr) | 1991-05-22 | 1995-05-05 | Ir2M | Nouveau derive organique de metal de transition a structure porphyrinique, composition therapeutique le contenant, en particulier a activite hypoglycemiante. |
CA2072934C (en) * | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
EP0524161A1 (de) | 1991-07-19 | 1993-01-20 | Monsanto Company | Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutase-Katalysatoren |
US5262532A (en) | 1991-07-22 | 1993-11-16 | E.R. Squibb & Sons, Inc. | Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging |
US5212300A (en) | 1991-09-12 | 1993-05-18 | Sun Company, Inc. (R&M) | Cyano- and polycyanometallo-porphyrins as catalysts for alkane oxidation |
US6011146A (en) * | 1991-11-15 | 2000-01-04 | Institut Pasteur | Altered major histocompatibility complex (MHC) determinant and methods of using the determinant |
US5493017A (en) | 1992-08-14 | 1996-02-20 | The Trustees Of The University Of Pennsylvania | Ring-metalated porphyrins |
US5599924A (en) | 1992-08-14 | 1997-02-04 | Trustees Of The University Of Pennsylvania | Electron-deficient porphyrins and processes and intermediates for preparing same |
US5371199B1 (en) | 1992-08-14 | 1995-12-26 | Univ Pennsylvania | Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor |
EP0658109B1 (de) | 1992-09-03 | 2001-05-30 | The Regents Of The University Of California | Metallporphyrinzusammensetzungen |
US5834509A (en) * | 1992-12-07 | 1998-11-10 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
US5403834A (en) * | 1992-12-07 | 1995-04-04 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
US5696109A (en) | 1992-12-07 | 1997-12-09 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
US6204259B1 (en) * | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
DE4305523A1 (de) | 1993-02-17 | 1994-08-18 | Diagnostikforschung Inst | Meso-Tetraphenylporphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
US5428037A (en) | 1993-04-09 | 1995-06-27 | Syntex Pharmaceuticals, Ltd. | Heterocyclic derivatives in the treatment of Ischaemia and related diseases |
JP3273082B2 (ja) | 1993-06-18 | 2002-04-08 | 三和電気工業株式会社 | 光コネクタ用スリ−ブホルダ |
JPH0743337A (ja) * | 1993-07-30 | 1995-02-14 | Toppan Printing Co Ltd | マンガンポルフィリン錯体を感応物質とする陰イオン選択性電極 |
US6417182B1 (en) * | 1993-08-25 | 2002-07-09 | Anormed Inc. | Pharmaceutical compositions comprising metal complexes |
US5994339A (en) | 1993-10-15 | 1999-11-30 | University Of Alabama At Birmingham Research Foundation | Oxidant scavengers |
US5747026A (en) | 1993-10-15 | 1998-05-05 | University Of Alabama At Birmingham Research Foundation | Antioxidants |
US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
US5488145A (en) | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
US5608054A (en) | 1993-12-29 | 1997-03-04 | Sun Company, Inc. (R&M) | Porphyrins and metal complexes thereof having haloalkyl side chains |
US5405369A (en) * | 1994-01-25 | 1995-04-11 | Medical College Of Ohio | Photochemical ablation of gastro-intestinal tissue for augmentation of an organ |
US5604199A (en) * | 1994-03-29 | 1997-02-18 | The Nemours Foundation | Method of treating fibrosis in skeletal muscle tissue |
US6245758B1 (en) * | 1994-05-13 | 2001-06-12 | Michael K. Stern | Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor |
WO1995031197A1 (en) * | 1994-05-13 | 1995-11-23 | Monsanto Company | Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor |
US5563132A (en) * | 1994-06-21 | 1996-10-08 | Bodaness; Richard S. | Two-step cancer treatment method |
WO1996009053A1 (en) | 1994-09-20 | 1996-03-28 | Duke University | Oxidoreductase activity of manganic porphyrins |
CA2132690A1 (en) | 1994-09-22 | 1996-03-23 | Dean Willis | Control and modulation of inflammatory response in humans in need of such control and modulation |
US6013241A (en) * | 1995-01-23 | 2000-01-11 | Schering Aktiengesellschaft | Use of porphyrin-complex or expanded porphyrin-complex compounds as an infarction localization diagnosticum |
ES2249784T3 (es) * | 1995-06-07 | 2006-04-01 | Duke University | Antioxidantges de oxidantes. |
JPH11511168A (ja) | 1995-08-17 | 1999-09-28 | モンサント カンパニー | 窒素含有大環状リガンドの金属錯体の生体分子結合体を使用する診断造影検査方法 |
PL324993A1 (en) | 1995-08-17 | 1998-07-06 | Monsanto Co | Bioconjugates of macrocyclic, nitrogen containing manganese complex ligands efficiently acting as catalysts of the superoxidic dismutation reaction |
AU6722496A (en) | 1995-08-17 | 1997-03-12 | Monsanto Company | Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands |
US5648523A (en) * | 1995-10-26 | 1997-07-15 | Chiang Long Y | Fullerene derivatives as free-radical scavengers |
US5948771A (en) * | 1996-01-31 | 1999-09-07 | The Trustees Of Columbia University In The City Of New York | Method for treating heart failure using tetrapyrroles and metallotetrapyrroles |
AU2065697A (en) | 1996-03-13 | 1997-10-01 | Monsanto Company | Iron complexes of nitrogen-containing macrocyclic ligands effective as cataly sts for dismutating superoxide |
BR9708179A (pt) | 1996-03-13 | 1999-07-27 | Monsanto Co | Bioconjugados de complexos de manganês ou ferro de ligantes macrociclicos contendo nitrogênio eficazes como catalizadores para desmutar superoxidos |
JPH1062350A (ja) * | 1996-08-14 | 1998-03-06 | Ebara Corp | ガス反応性色素を用いたガス検知方法及びガス検知装置 |
US5756492A (en) * | 1996-09-09 | 1998-05-26 | Sangstat Medical Corporation | Graft survival prolongation with porphyrins |
EP0988037A1 (de) | 1997-02-05 | 2000-03-29 | Board Of Regents, The University Of Texas System | Porphyrinverbindungen als telomerase inhibitoren |
US6180620B1 (en) * | 1997-06-20 | 2001-01-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
US6214817B1 (en) * | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
GB9716446D0 (en) | 1997-08-05 | 1997-10-08 | Agrevo Uk Ltd | Fungicides |
EP1010690B1 (de) | 1997-08-26 | 2005-03-30 | Kumiai Chemical Industry Co., Ltd. | Biarylalkylencarbaminsäurederivate als bakteriozide in landwirtschaft und gartenbau |
JP3564962B2 (ja) * | 1997-08-26 | 2004-09-15 | 松下電器産業株式会社 | 光記録媒体及びその光記録再生方法 |
DE69813898T2 (de) | 1997-11-03 | 2004-03-11 | Duke University | Substituierte porphyrinen |
ATE311206T1 (de) * | 1998-04-24 | 2005-12-15 | Univ Duke | Substituierte porphyrine |
EP1098659A4 (de) | 1998-07-23 | 2004-11-24 | Metaphore Inc | Polyhydroxamatbanken und ihre analoga |
WO2000023568A2 (en) | 1998-10-06 | 2000-04-27 | Albert Einstein College Of Medicine Of Yeshiva University | Methods and compositions for decreasing mitochondrial overproduction of reactive oxygen species in cells |
ATE312103T1 (de) * | 1999-01-25 | 2005-12-15 | Nat Jewish Med & Res Center | Substituierte porphyrine und deren therapeutische verwendungen |
EP1185312B1 (de) | 1999-05-27 | 2005-03-23 | Monsanto Company | Biomaterialien, modifiziert mit superoxid-dismutase imitatoren |
US6448239B1 (en) | 1999-06-03 | 2002-09-10 | Trustees Of Princeton University | Peroxynitrite decomposition catalysts and methods of use thereof |
US6608050B2 (en) * | 1999-07-20 | 2003-08-19 | Pharmacia & Upjohn Company | Lyophilizate of lipid complex of water insoluble porphyrins |
WO2001026655A1 (en) | 1999-10-13 | 2001-04-19 | Uab Research Foundation | Metalloporphyrin treatment of neurologic disease |
US6548045B2 (en) * | 1999-11-30 | 2003-04-15 | Photochemical Co., Ltd. | Nitroimidazole substituted porphyrin complex |
JP3383839B2 (ja) * | 2000-03-13 | 2003-03-10 | 奈良先端科学技術大学院大学長 | 新規なメルカプト置換イミダゾリルポルフィリン金属錯体単量体及びこれを繰り返し単位として有する重合体並びにこれらの製造方法 |
US6624187B1 (en) * | 2000-06-12 | 2003-09-23 | Health Research, Inc. | Long wave length absorbing bacteriochlorin alkyl ether analogs |
CA2412623A1 (en) | 2000-06-14 | 2001-12-20 | Brian J. Day | Tetrapyrroles |
US6403788B1 (en) * | 2000-07-11 | 2002-06-11 | Eukarion, Inc. | Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species |
US6573258B2 (en) * | 2000-09-27 | 2003-06-03 | Frontier Scientific, Inc. | Photodynamic porphyrin antimicrobial agents |
ES2330728T3 (es) * | 2001-01-19 | 2009-12-15 | National Jewish Health | Medicamento para proteccion en radioterapia. |
EP1370240A4 (de) | 2001-03-02 | 2004-09-22 | Neuron Therapeutics Inc | Neuroprotektor-formulierungen und verfahren |
WO2002096366A2 (en) | 2001-05-31 | 2002-12-05 | Miravant Pharmaceuticals, Inc. | Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy |
US6566517B2 (en) * | 2001-06-06 | 2003-05-20 | Brookhaven Science Associates, Llc | Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy |
DE10240343A1 (de) | 2002-08-27 | 2004-03-11 | Schering Ag | Peroxynitrit-Umlagerungskatalysatoren |
US7807825B2 (en) | 2004-02-09 | 2010-10-05 | Duke University | Substituted porphyrins |
US20090234011A1 (en) | 2005-04-21 | 2009-09-17 | Goldstein Glenn A | N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress |
WO2011028935A2 (en) | 2009-09-02 | 2011-03-10 | The Regents Of The University Of Colorado | Methods of treating mitochondrial disorders using metalloporhyrins |
-
2000
- 2000-01-25 AT AT00905776T patent/ATE312103T1/de not_active IP Right Cessation
- 2000-01-25 JP JP2000594811A patent/JP4501128B2/ja not_active Expired - Fee Related
- 2000-01-25 ES ES00905776T patent/ES2254142T3/es not_active Expired - Lifetime
- 2000-01-25 DK DK05014279.3T patent/DK1616869T3/da active
- 2000-01-25 EP EP00905776A patent/EP1155019B1/de not_active Expired - Lifetime
- 2000-01-25 DE DE60024588T patent/DE60024588T2/de not_active Expired - Lifetime
- 2000-01-25 MX MXPA01007451A patent/MXPA01007451A/es active IP Right Grant
- 2000-01-25 WO PCT/US2000/002062 patent/WO2000043395A1/en active Application Filing
- 2000-01-25 NZ NZ513164A patent/NZ513164A/xx not_active IP Right Cessation
- 2000-01-25 DK DK00905776T patent/DK1155019T3/da active
- 2000-01-25 EP EP10011098A patent/EP2295435A1/de not_active Withdrawn
- 2000-01-25 KR KR1020017009367A patent/KR100753184B1/ko not_active IP Right Cessation
- 2000-01-25 BR BRPI0007720-8B1A patent/BR0007720B1/pt not_active IP Right Cessation
- 2000-01-25 AT AT05014279T patent/ATE552260T1/de active
- 2000-01-25 AU AU27407/00A patent/AU779283B2/en not_active Ceased
- 2000-01-25 ES ES05014279T patent/ES2385486T3/es not_active Expired - Lifetime
- 2000-01-25 US US09/490,537 patent/US6544975B1/en not_active Expired - Lifetime
- 2000-01-25 IL IL14450300A patent/IL144503A0/xx active IP Right Grant
- 2000-01-25 CN CNB008054584A patent/CN1156478C/zh not_active Expired - Fee Related
- 2000-01-25 EP EP05014279A patent/EP1616869B1/de not_active Expired - Lifetime
- 2000-01-25 CA CA002359116A patent/CA2359116C/en not_active Expired - Fee Related
-
2001
- 2001-07-23 IL IL144503A patent/IL144503A/en not_active IP Right Cessation
- 2001-07-25 ZA ZA200106107A patent/ZA200106107B/xx unknown
-
2002
- 2002-12-23 HK HK02109292A patent/HK1047744A1/xx not_active IP Right Cessation
-
2003
- 2003-01-23 US US10/349,171 patent/US7189707B2/en not_active Expired - Fee Related
-
2006
- 2006-05-08 HK HK06105351.6A patent/HK1083626A1/xx not_active IP Right Cessation
- 2006-06-16 US US11/424,662 patent/US7820644B2/en not_active Expired - Fee Related
-
2007
- 2007-06-14 IL IL183953A patent/IL183953A/en not_active IP Right Cessation
-
2010
- 2010-09-17 US US12/885,198 patent/US8217026B2/en not_active Expired - Fee Related
-
2012
- 2012-04-26 US US13/457,232 patent/US8546562B2/en not_active Expired - Fee Related
-
2013
- 2013-09-05 US US14/019,295 patent/US8946202B2/en not_active Expired - Fee Related
-
2014
- 2014-12-18 US US14/575,694 patent/US9289434B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE552260T1 (de) | Substituierte porphyrine und deren therapeutische verwendung | |
ATE311206T1 (de) | Substituierte porphyrine | |
ATE238307T1 (de) | Substituierte porphyrinen | |
EP1432714A4 (de) | Chemische verbindungen | |
HK1085461A1 (en) | Compounds, compositions and methods of treatment for heart failure | |
BE2010C030I2 (de) | ||
DE60319406D1 (de) | Meso-substituierte porphyrine | |
ATE555789T1 (de) | Pyridazinderivate und deren verwendung als therapeutische mittel | |
MA28010A1 (fr) | Derives de piperazine et leur utilisation comme agents therapeutiques | |
DE69434313D1 (de) | Superoxiddismutase memetika | |
ATE420097T1 (de) | Substituierte sapogenine und ihre verwendung | |
ATE265455T1 (de) | Tetrahydropyridoverbindungen | |
ATE242242T1 (de) | Derivate von imidazo(1,2-a)pyridin zur behandlung von gastrointestinalen krankheiten | |
ATE298339T1 (de) | ß3,7-DIAZABICYCLO(3.3.0)OCTANE UND DEREN VERWENDUNG BEI DER BEHANDLUNG VON HERZRHYTHMUSSTÖRUNGENß | |
ATE343582T1 (de) | Derivate von (6, 7-dihydro -5h-imidazo(1,2 - a)imidazol -3 -sulfonylamino)-propionamid und deren verwendung als inhibitoren der interaktion von cams und leukointreginen | |
EP1436279A4 (de) | Chemische verbindungen | |
ID27656A (id) | Turunan azabisikloheptana n-tersubstitusi, pembuatan dan penggunaannya | |
DE59905342D1 (de) | N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung |