ATE546545T1 - Polynukleotide zur verwendung als tags und tag komplemente, herstellung und verwendung derselben - Google Patents

Polynukleotide zur verwendung als tags und tag komplemente, herstellung und verwendung derselben

Info

Publication number
ATE546545T1
ATE546545T1 AT02709941T AT02709941T ATE546545T1 AT E546545 T1 ATE546545 T1 AT E546545T1 AT 02709941 T AT02709941 T AT 02709941T AT 02709941 T AT02709941 T AT 02709941T AT E546545 T1 ATE546545 T1 AT E546545T1
Authority
AT
Austria
Prior art keywords
polynucleotides
tags
preparation
tag complements
family
Prior art date
Application number
AT02709941T
Other languages
English (en)
Inventor
Daniel Kobler
Daniel Fieldhouse
Original Assignee
Luminex Molecular Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luminex Molecular Diagnostics Inc filed Critical Luminex Molecular Diagnostics Inc
Application granted granted Critical
Publication of ATE546545T1 publication Critical patent/ATE546545T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
AT02709941T 2001-01-25 2002-01-25 Polynukleotide zur verwendung als tags und tag komplemente, herstellung und verwendung derselben ATE546545T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26371001P 2001-01-25 2001-01-25
US30379901P 2001-07-10 2001-07-10
PCT/CA2002/000089 WO2002059355A2 (en) 2001-01-25 2002-01-25 Polynucleotides for use as tags and tag complements, manufacture and use thereof

Publications (1)

Publication Number Publication Date
ATE546545T1 true ATE546545T1 (de) 2012-03-15

Family

ID=26950006

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02709941T ATE546545T1 (de) 2001-01-25 2002-01-25 Polynukleotide zur verwendung als tags und tag komplemente, herstellung und verwendung derselben

Country Status (10)

Country Link
US (2) US7645868B2 (de)
EP (4) EP2327794A3 (de)
JP (3) JP4422963B2 (de)
AT (1) ATE546545T1 (de)
AU (3) AU2002227829C1 (de)
BR (2) BRPI0206747B1 (de)
CA (2) CA2435612C (de)
DK (1) DK1364065T3 (de)
ES (1) ES2382542T3 (de)
WO (2) WO2002059355A2 (de)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4422963B2 (ja) 2001-01-25 2010-03-03 ルミネックス モレキュラー ダイアグノスティックス， インク． 標識および標識補体として使用するための非クロス交雑しているポリヌクレオチドのファミリー、製品、ならびにその使用方法
US7226737B2 (en) 2001-01-25 2007-06-05 Luminex Molecular Diagnostics, Inc. Polynucleotides for use as tags and tag complements, manufacture and use thereof
DE60231543D1 (de) 2001-11-19 2009-04-23 Parallele Bioscience Inc Multiplex-oligonukleotidaddition und zielamplifikation
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
GB0308852D0 (en) * 2003-04-16 2003-05-21 Lingvitae As Method
CA2546171A1 (en) 2003-11-17 2005-05-26 Tm Bioscience Corporation Method of detecting mutations associated with thrombosis
EP1766062A4 (de) * 2004-06-01 2008-07-09 Tm Bioscience Corp Verfahren zum nachweis von mit zystischer fibrose assoziierten mutationen
CA2571817A1 (en) * 2004-06-30 2006-01-12 Tm Bioscience Pgx, Inc. Method of detecting mutations in the gene encoding cytochrome p450-2c9
DE602005021971D1 (de) * 2004-06-30 2010-08-05 Luminex Molecular Diagnostics Verfahren zum nachweis von mutationen im für cytochrom p450-2d6 codierenden gen
JP2008507955A (ja) * 2004-07-30 2008-03-21 ティーエム バイオサイエンス ピージーエクス インコーポレイティッド チトクロムｐ４５０−２ｃ１９をコードする遺伝子における突然変異を検出する方法
US20090117552A1 (en) * 2005-07-07 2009-05-07 Pamgene Bv Method for Detection and Quantification of Target Nucleic Acids in a Sample
US7807359B2 (en) * 2006-12-01 2010-10-05 Quest Diagnostics Investments Incorporated Methods of detecting TPMT mutations
AU2007333040B2 (en) * 2006-12-13 2013-02-07 Luminex Corporation Systems and methods for multiplex analysis of PCR in real time
US7958066B2 (en) * 2007-11-02 2011-06-07 Hunch Inc. Interactive machine learning advice facility
WO2009074882A2 (en) * 2007-11-02 2009-06-18 Luminex Molecular Diagnostics, Inc. One-step target detection assay
US8008019B2 (en) * 2007-11-28 2011-08-30 Luminex Molecular Diagnostics Use of dual-tags for the evaluation of genomic variable repeat regions
US8039794B2 (en) 2008-12-16 2011-10-18 Quest Diagnostics Investments Incorporated Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
JP5785942B2 (ja) 2009-06-29 2015-09-30 ルミネックス コーポレーション ヘアピンコンフォメーションを有するキメラプライマーおよびその使用法
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
WO2011127099A1 (en) 2010-04-05 2011-10-13 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
CN102010900B (zh) * 2010-06-08 2013-04-24 广州益善生物技术有限公司 GPIIIa和COX-1基因SNP检测液相芯片以及特异性引物
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
CN103748236B (zh) * 2011-04-15 2018-12-25 约翰·霍普金斯大学 安全测序***
KR20140066782A (ko) 2011-09-29 2014-06-02 루미넥스 코포레이션 가수분해 프로브
US10941396B2 (en) 2012-02-27 2021-03-09 Becton, Dickinson And Company Compositions and kits for molecular counting
CN103374598A (zh) * 2012-04-11 2013-10-30 广州益善生物技术有限公司 Hla-a基因突变检测特异性引物和液相芯片
CN103374601A (zh) * 2012-04-11 2013-10-30 广州益善生物技术有限公司 染色体5p15区段SNP检测特异性引物和液相芯片
CN103374606B (zh) * 2012-04-12 2015-04-22 益善生物技术股份有限公司 Chek1基因突变检测特异性引物和液相芯片
CN103374605A (zh) * 2012-04-12 2013-10-30 广州益善生物技术有限公司 Atr基因突变检测特异性引物和液相芯片
CN103374610A (zh) * 2012-04-12 2013-10-30 广州益善生物技术有限公司 Chrna3基因突变检测特异性引物和液相芯片
CN103451272A (zh) * 2012-05-31 2013-12-18 益善生物技术股份有限公司 Bat3基因突变检测特异性引物和液相芯片
CN103451274A (zh) * 2012-05-31 2013-12-18 益善生物技术股份有限公司 Chrna5基因突变检测特异性引物和液相芯片
WO2013188756A1 (en) 2012-06-15 2013-12-19 The University Of Chicago Oligonucleotide-mediated quantitative multiplexed immunoassays
CN103571918A (zh) * 2012-07-18 2014-02-12 益善生物技术股份有限公司 Fyco1基因突变检测特异性引物和液相芯片
CN103571931A (zh) * 2012-07-18 2014-02-12 益善生物技术股份有限公司 Ehbp1基因突变检测特异性引物和液相芯片
CN103571917A (zh) * 2012-07-18 2014-02-12 益善生物技术股份有限公司 Adh1b基因突变检测特异性引物和液相芯片
PL2912468T3 (pl) 2012-10-29 2019-04-30 Univ Johns Hopkins Test papanicolaou pod kątem raka jajnika i endometrium
CN103849942B (zh) * 2012-12-04 2016-07-13 益善生物技术股份有限公司 Tox3基因突变检测特异性引物和液相芯片
CN103849941B (zh) * 2012-12-04 2016-06-01 益善生物技术股份有限公司 Tyr基因突变检测特异性引物和液相芯片
CN103849940B (zh) * 2012-12-04 2016-09-14 益善生物技术股份有限公司 Bard1基因突变检测特异性引物和液相芯片
CN103849943B (zh) * 2012-12-04 2016-08-03 益善生物技术股份有限公司 Mc1r基因突变检测特异性引物和液相芯片
CN103849938B (zh) * 2012-12-04 2016-08-03 益善生物技术股份有限公司 Map3k1基因突变检测特异性引物和液相芯片
CN103849939B (zh) * 2012-12-04 2016-06-22 益善生物技术股份有限公司 Rad51l1基因突变检测特异性引物和液相芯片
EP3957743A1 (de) 2013-06-19 2022-02-23 Luminex Corporation Multiplexierter echtzeithydrolysesondentest
WO2014210225A1 (en) 2013-06-25 2014-12-31 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
CN105555971B (zh) 2013-08-09 2017-08-29 卢米耐克斯公司 用于在核酸测定中改善熔链分辨和多重性的探针
ES2711168T3 (es) 2013-08-28 2019-04-30 Becton Dickinson Co Análisis masivo en paralelo de células individuales
JP2017504307A (ja) 2013-10-07 2017-02-09 セルラー リサーチ， インコーポレイテッド アレイ上のフィーチャーをデジタルカウントするための方法およびシステム
MX2014003938A (es) * 2014-04-01 2015-09-30 Univ Nac Autónoma De México Macroarreglos para deteccion en muestras ambientales y biologicas de microorganismos enteropatogenos.
CN105316398A (zh) * 2014-07-30 2016-02-10 益善生物技术股份有限公司 食源性致病微生物检测的扩增引物和液相芯片试剂盒
CA3190291A1 (en) 2014-08-11 2016-02-18 Luminex Corporation Probes for improved melt discrimination and multiplexing in nucleic acid assays
ES2975332T3 (es) 2015-02-19 2024-07-04 Becton Dickinson Co Análisis unicelular de alto rendimiento que combina información proteómica y genómica
ES2836802T3 (es) 2015-02-27 2021-06-28 Becton Dickinson Co Códigos de barras moleculares espacialmente direccionables
EP3277843A2 (de) 2015-03-30 2018-02-07 Cellular Research, Inc. Verfahren und zusammensetzungen für kombinatorische barcodierung
JP6828007B2 (ja) 2015-04-10 2021-02-10 スペーシャル トランスクリプトミクス アクチボラグ 生物学的試料の空間識別されるマルチプレックスな核酸分析
WO2016172373A1 (en) 2015-04-23 2016-10-27 Cellular Research, Inc. Methods and compositions for whole transcriptome amplification
US11124823B2 (en) 2015-06-01 2021-09-21 Becton, Dickinson And Company Methods for RNA quantification
EP3325666B1 (de) 2015-07-17 2020-04-29 Luminex Corporation Verfahren für katalytische assays
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
WO2017044574A1 (en) 2015-09-11 2017-03-16 Cellular Research, Inc. Methods and compositions for nucleic acid library normalization
US10822643B2 (en) * 2016-05-02 2020-11-03 Cellular Research, Inc. Accurate molecular barcoding
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
EP4407625A2 (de) 2016-05-26 2024-07-31 Becton, Dickinson and Company Verfahren zur anpassung des zählens von molekularen kennzeichen
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
KR102522023B1 (ko) 2016-09-26 2023-04-17 셀룰러 리서치, 인크. 바코딩된 올리고뉴클레오티드 서열을 갖는 시약을 이용한 단백질 발현의 측정
WO2018132610A1 (en) 2017-01-13 2018-07-19 Cellular Research, Inc. Hydrophilic coating of fluidic channels
CN110382708A (zh) 2017-02-01 2019-10-25 赛卢拉研究公司 使用阻断性寡核苷酸进行选择性扩增
CN110719959B (zh) 2017-06-05 2021-08-06 贝克顿迪金森公司 针对单细胞的样品索引
US11946095B2 (en) 2017-12-19 2024-04-02 Becton, Dickinson And Company Particles associated with oligonucleotides
CN110573184A (zh) * 2018-02-09 2019-12-13 俄亥俄州立创新基金会 Rna纳米结构，其制备方法和用途
JP7358388B2 (ja) 2018-05-03 2023-10-10 ベクトン・ディキンソン・アンド・カンパニー 反対側の転写物末端における分子バーコーディング
US11773441B2 (en) 2018-05-03 2023-10-03 Becton, Dickinson And Company High throughput multiomics sample analysis
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
EP3861134A1 (de) 2018-10-01 2021-08-11 Becton, Dickinson and Company Bestimmung von 5'-transkriptsequenzen
CN112969789A (zh) 2018-11-08 2021-06-15 贝克顿迪金森公司 使用随机引发的单细胞全转录组分析
EP3894552A1 (de) 2018-12-13 2021-10-20 Becton, Dickinson and Company Selektive verlängerung in der vollständigen transkriptomanalyse von einzelzellen
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
WO2020150356A1 (en) 2019-01-16 2020-07-23 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
CN113574178A (zh) 2019-01-23 2021-10-29 贝克顿迪金森公司 与抗体关联的寡核苷酸
WO2020214642A1 (en) 2019-04-19 2020-10-22 Becton, Dickinson And Company Methods of associating phenotypical data and single cell sequencing data
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2021016239A1 (en) 2019-07-22 2021-01-28 Becton, Dickinson And Company Single cell chromatin immunoprecipitation sequencing assay
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
US11773436B2 (en) 2019-11-08 2023-10-03 Becton, Dickinson And Company Using random priming to obtain full-length V(D)J information for immune repertoire sequencing
EP4055185A1 (de) 2019-11-08 2022-09-14 10X Genomics, Inc. Räumlich markierte analytfänger für analyt-multiplexing
CN114885610A (zh) 2019-12-23 2022-08-09 10X基因组学有限公司 使用rna模板化连接进行空间分析的方法
WO2021146207A1 (en) 2020-01-13 2021-07-22 Becton, Dickinson And Company Methods and compositions for quantitation of proteins and rna
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
EP4150118A1 (de) 2020-05-14 2023-03-22 Becton Dickinson and Company Primer zur profilierung von immunrepertoire
EP4153776A1 (de) 2020-05-22 2023-03-29 10X Genomics, Inc. Räumliche analyse zur erkennung von sequenzvarianten
EP4153775B1 (de) 2020-05-22 2024-07-24 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
AU2021283174A1 (en) 2020-06-02 2023-01-05 10X Genomics, Inc. Nucleic acid library methods
CN116249785A (zh) 2020-06-02 2023-06-09 10X基因组学有限公司 用于抗原-受体的空间转录组学
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
WO2021252591A1 (en) 2020-06-10 2021-12-16 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
WO2021263111A1 (en) 2020-06-25 2021-12-30 10X Genomics, Inc. Spatial analysis of dna methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
US11739443B2 (en) 2020-11-20 2023-08-29 Becton, Dickinson And Company Profiling of highly expressed and lowly expressed proteins
EP4121555A1 (de) 2020-12-21 2023-01-25 10X Genomics, Inc. Verfahren, zusammensetzungen und systeme zur erfassung von sonden und/oder barcodes
CN112553379B (zh) * 2020-12-30 2022-08-19 湖北新纵科病毒疾病工程技术有限公司 基于液相芯片检测呼吸道传染病病毒的方法及试剂盒
WO2022198068A1 (en) 2021-03-18 2022-09-22 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851331A (en) 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
US4942124A (en) 1987-08-11 1990-07-17 President And Fellows Of Harvard College Multiplex sequencing
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
US5002867A (en) 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
AU5640090A (en) 1989-03-21 1990-11-05 Collaborative Research Inc. A dna diagnostic test using an exonuclease activity
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
CA2130562A1 (en) 1992-02-19 1993-09-02 Alexander B. Chetverin Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
US5981176A (en) 1992-06-17 1999-11-09 City Of Hope Method of detecting and discriminating between nucleic acid sequences
EP0698792B1 (de) * 1993-05-10 2003-07-02 Nissui Pharmaceutical Co., Ltd. Verfahren zur bestimmung von mehr als einem immunologischen liganden und bestimmungsreagenz sowie satz dafuer
US5604097A (en) * 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
GB9507238D0 (en) 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
PL324000A1 (en) * 1995-06-07 1998-04-27 Lynx Therapeutics Oligionucleotidic labels for sorting and identofication purpose
US5830539A (en) * 1995-11-17 1998-11-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for functionalizing and coating substrates and devices made according to the methods
EP2573101B1 (de) 1996-02-09 2016-04-20 Cornell Research Foundation, Inc. Erkennung von Nukleinsäurensequenz-Unterschieden mittels der Ligaseerkennungsreaktion mit adressierbaren Arrays
US6458530B1 (en) * 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
GB9609441D0 (en) * 1996-05-04 1996-07-10 Zeneca Ltd Process
TW349909B (en) 1997-01-22 1999-01-11 Alps Electric Co Ltd Hot transfer printer
US6205444B1 (en) 1997-10-17 2001-03-20 International Business Machines Corporation Multiple sequence alignment system and method
US6238869B1 (en) * 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US6395481B1 (en) * 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter
WO2000058516A2 (en) * 1999-03-26 2000-10-05 Whitehead Institute For Biomedical Research Universal arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US6287778B1 (en) 1999-10-19 2001-09-11 Affymetrix, Inc. Allele detection using primer extension with sequence-coded identity tags
WO2001059151A2 (en) * 2000-02-10 2001-08-16 Tm Bioscience Corporation Method of designing and selecting polynucleotide sequences
US7157564B1 (en) 2000-04-06 2007-01-02 Affymetrix, Inc. Tag nucleic acids and probe arrays
DE60133198T2 (de) * 2000-06-22 2009-03-12 Theravance, Inc., South San Francisco Glykopeptidderivate mit carboxysacchariden
US20030180953A1 (en) 2000-12-29 2003-09-25 Elitra Pharmaceuticals, Inc. Gene disruption methodologies for drug target discovery
JP4422963B2 (ja) 2001-01-25 2010-03-03 ルミネックス モレキュラー ダイアグノスティックス， インク． 標識および標識補体として使用するための非クロス交雑しているポリヌクレオチドのファミリー、製品、ならびにその使用方法
US7226737B2 (en) 2001-01-25 2007-06-05 Luminex Molecular Diagnostics, Inc. Polynucleotides for use as tags and tag complements, manufacture and use thereof

Also Published As

Publication number Publication date
US8624014B2 (en) 2014-01-07
AU2008201349B2 (en) 2010-05-27
AU2008201349A1 (en) 2008-04-17
US7645868B2 (en) 2010-01-12
EP1364065A3 (de) 2003-10-02
JP4588976B2 (ja) 2010-12-01
WO2002059355A3 (en) 2003-10-02
EP2325336A1 (de) 2011-05-25
CA2435551C (en) 2011-10-25
EP2325336B1 (de) 2014-06-11
JP2010000086A (ja) 2010-01-07
AU2002227829C1 (en) 2009-03-05
BRPI0206746B1 (pt) 2017-05-02
CA2435612A1 (en) 2002-08-01
CA2435551A1 (en) 2002-08-01
EP1356117A2 (de) 2003-10-29
BR0206747A (pt) 2004-11-30
JP2004526433A (ja) 2004-09-02
AU2002229435C1 (en) 2002-08-06
CA2435612C (en) 2014-12-23
BRPI0206746B8 (pt) 2021-07-27
US20100311957A1 (en) 2010-12-09
AU2002227829B2 (en) 2007-12-20
EP2327794A3 (de) 2011-09-14
EP2327794A2 (de) 2011-06-01
AU2002229435B2 (en) 2007-06-07
JP4422963B2 (ja) 2010-03-03
BRPI0206747B1 (pt) 2017-03-21
ES2382542T3 (es) 2012-06-11
US20050191625A1 (en) 2005-09-01
WO2002059354A2 (en) 2002-08-01
WO2002059354A3 (en) 2003-06-26
JP2004522440A (ja) 2004-07-29
DK1364065T3 (da) 2012-05-14
EP1364065B1 (de) 2012-02-22
BR0206746A (pt) 2004-11-16
JP5189569B2 (ja) 2013-04-24
WO2002059355A2 (en) 2002-08-01
EP1364065A2 (de) 2003-11-26

Similar Documents

Publication Publication Date Title
ATE546545T1 (de) Polynukleotide zur verwendung als tags und tag komplemente, herstellung und verwendung derselben
ATE510024T1 (de) Verfahren zur herstellung eines gepaarten tag aus einer nukleinsäuresequenz sowie verfahren zur verwendung davon
ATE427223T1 (de) Datenseite und methode zu deren herstellung
DE60336867D1 (de) Verfahren zur Herstellung von 3-Halo-4,5-Dihydro-1H-Pyrazolen
DE60317328D1 (de) Methode zur Bereitstellung von Metadaten
SE0003286D0 (sv) Method and kit for human identification
BR0109188A (pt) Diarilaminas 5-amida substituìdas como inibidores de mex
EA200001133A1 (ru) Антипикорнавирусные композиции, их получение и применение
DE60227718D1 (de) Verwendung von 2-Fuoro-3-Ketoestern zur Herstellung von 3-Fuoro-6,7,8,9-tetrahydro-4H-pyrimidoÄ1,2-aÜpyrimidin-4-onen
EP1323743A3 (de) Harzzusammensetzung
ATE304035T1 (de) Azofarbstoffe
GB0305575D0 (en) Novel compounds
DE60329470D1 (de) Vorrichtung zur herstellung von broschüren
TR200302288T2 (tr) Terapi için yeni bileşikler ve metotlar.
ATE354557T1 (de) Integriertes verfahren zur herstellung von alkyl- und alkenylsubstituierten aromatischen verbindungen
BR0316702A (pt) xprocesso para preparação de (s)-pantoprazol
ATA118295A (de) (s)-hydroxynitrillyase aus hevea brasiliensis
ATE304000T1 (de) Verfahren zur herstellung von n-carboxyanhydriden von aminosäuren
DE602004023199D1 (de) Fluoreszenzprotein und pigmentprotein
DE69735039D1 (de) Acetylhydrolase des Plättchen aktivierenden Faktors, und entsprechendes Gen
PT1334210E (pt) Ensaio genetico para identificacao de portadores de malformacao vertebral complexa em gado bovino
BR0002493A (pt) Processo para a preparação de l-aminoácidos por fermentação e sequências de nucleotìdeos que codificam o gene accda
DE602004031129D1 (de) Verfahren zur herstellung von quetiapin
ATE484582T1 (de) Aus koji-schimmelpilz stammende phospholipase a2
DE69940242D1 (de) Erzeugung von chemischen Markierungen