ATE545430T1 - Hsa-freie interferon-beta formulierungen - Google Patents
Hsa-freie interferon-beta formulierungenInfo
- Publication number
- ATE545430T1 ATE545430T1 AT01988466T AT01988466T ATE545430T1 AT E545430 T1 ATE545430 T1 AT E545430T1 AT 01988466 T AT01988466 T AT 01988466T AT 01988466 T AT01988466 T AT 01988466T AT E545430 T1 ATE545430 T1 AT E545430T1
- Authority
- AT
- Austria
- Prior art keywords
- hsa
- interferon beta
- ifn
- free interferon
- beta formulations
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28261401P | 2001-04-09 | 2001-04-09 | |
US33040401P | 2001-10-18 | 2001-10-18 | |
US10/035,397 US6887462B2 (en) | 2001-04-09 | 2001-10-25 | HSA-free formulations of interferon-beta |
PCT/US2001/051074 WO2002080976A2 (en) | 2001-04-09 | 2001-10-26 | Hsa-free formulations of interferon-beta |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE545430T1 true ATE545430T1 (de) | 2012-03-15 |
Family
ID=27364838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01988466T ATE545430T1 (de) | 2001-04-09 | 2001-10-26 | Hsa-freie interferon-beta formulierungen |
Country Status (19)
Country | Link |
---|---|
US (5) | US6887462B2 (de) |
EP (3) | EP2283896B1 (de) |
JP (5) | JP2004529917A (de) |
KR (1) | KR100900753B1 (de) |
CN (1) | CN1313148C (de) |
AT (1) | ATE545430T1 (de) |
BG (1) | BG66300B1 (de) |
CA (2) | CA2442854C (de) |
CY (2) | CY1113609T1 (de) |
CZ (1) | CZ305994B6 (de) |
DK (1) | DK1381432T3 (de) |
ES (3) | ES2453623T3 (de) |
HU (1) | HU228581B1 (de) |
IL (2) | IL157963A0 (de) |
LU (1) | LU92060I2 (de) |
NO (1) | NO330259B1 (de) |
PL (1) | PL213297B1 (de) |
PT (2) | PT1381432E (de) |
WO (1) | WO2002080976A2 (de) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999051272A1 (en) * | 1998-04-03 | 1999-10-14 | Chiron Corporation | Injectable igf-formulations containing succinate as buffering agent |
US7544354B2 (en) * | 2000-10-27 | 2009-06-09 | Novartis Vaccines And Diagnostics | Methods of protein purification and recovery |
CA2428144C (en) * | 2000-11-07 | 2012-01-10 | Chiron Corporation | Compositions of interferon-beta stabilized with highly purified mannitol |
US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
AR034749A1 (es) * | 2001-07-09 | 2004-03-17 | Schering Ag | Formulaciones de interferon beta humano |
AU2003214019A1 (en) * | 2002-03-12 | 2003-09-22 | Maxygen Aps | Interferon beta-like molecules for treatment of stroke |
US20040037809A1 (en) * | 2002-06-28 | 2004-02-26 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of interferon beta |
DE10240894A1 (de) * | 2002-09-04 | 2004-03-11 | Procom Biotechnologische Produktions Gmbh | Verstärkung der Resorption von Subtanzen über die Haut und Schleimhaut |
US8129330B2 (en) * | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
PT1667708E (pt) * | 2002-12-26 | 2012-09-14 | Mountain View Pharmaceuticals | Conjugados de interferão-beta-1b e polietileno glicol apresentando uma potência biológica in vitro aumentada |
EA013535B1 (ru) * | 2002-12-26 | 2010-06-30 | Маунтин Вью Фамэсьютикэлс, Инк. | Полимерный конъюгат биоактивного компонента (варианты), способ его получения и использования, фармацевтические продукты на его основе |
TWI272948B (en) * | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
US20050208151A1 (en) * | 2003-10-30 | 2005-09-22 | Entelos, Inc. | Treatment of rheumatoid arthritis with FLIP antagonists |
AU2004288854B2 (en) * | 2003-11-10 | 2009-10-01 | Arriva-Pharmaceuticals, Inc. | Dry recombinant human alpha 1-antitrypsin formulation |
EP1532983A1 (de) * | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulinpräparationen mit erhöhter Stabilität |
PT1691825E (pt) * | 2003-12-11 | 2011-10-12 | Ares Trading Sa | Formulações líquidas de interferão estabilizadas |
CN1557479A (zh) * | 2004-01-16 | 2004-12-29 | 深圳市海王英特龙生物技术股份有限公 | 干扰素脂质体乳膏 |
DE102004008168B4 (de) * | 2004-02-19 | 2015-12-10 | Voxeljet Ag | Verfahren und Vorrichtung zum Auftragen von Fluiden und Verwendung der Vorrichtung |
US20090214472A1 (en) * | 2004-03-01 | 2009-08-27 | Enzon Pharmaceuticals Inc. | Interferon-beta polymer conjugates |
US20050220764A1 (en) * | 2004-04-01 | 2005-10-06 | Schering Aktiengesellschaft | Higher-doses of interferon-beta for treatment of multiple sclerosis |
EA012205B1 (ru) * | 2004-05-17 | 2009-08-28 | Арес Трейдинг С.А. | Гидрогелевые препараты интерферона |
KR101191536B1 (ko) * | 2004-06-01 | 2012-10-15 | 아레스 트레이딩 에스.에이. | 안정화된 인터페론 액상 제제 |
CA2567310A1 (en) * | 2004-06-01 | 2005-12-15 | Ares Trading S.A. | Stabilized interferon liquid formulations |
EA012281B1 (ru) * | 2004-06-01 | 2009-08-28 | Арес Трейдинг С.А. | Способ стабилизации белков |
WO2005120540A2 (en) * | 2004-06-09 | 2005-12-22 | Schering Aktiengesellschaft | Interferon alpha or beta for treatment of cardiomyopathy and endothelial dysfunction |
CA2574953A1 (en) | 2004-07-26 | 2006-02-09 | Dow Global Technolgies Inc. | Process for improved protein expression by strain engineering |
EP1786917A4 (de) | 2004-07-26 | 2008-05-28 | Enzon Pharmaceuticals Inc | Optimiertes interferon-beta-gen |
AU2005272862B2 (en) * | 2004-08-12 | 2011-03-10 | Merck Sharp & Dohme Corp. | Stable pegylated interferon formulation |
US20080076729A1 (en) * | 2005-05-19 | 2008-03-27 | Schering Aktiengesellachaft | Interferon-beta gene therapy using an improved, regulated expression system |
US20060281703A1 (en) * | 2005-05-19 | 2006-12-14 | Schering Aktiengesellschaft | Treatment of disease using an improved regulated expression system |
US20070179113A1 (en) * | 2005-05-19 | 2007-08-02 | Schering Aktiengesellachaft | GM-CSF gene therapy for Crohn's disease using an improved regulated expression system |
TW200716749A (en) * | 2005-05-19 | 2007-05-01 | Schering Ag | Interferon-beta gene therapy using an improved, regulated expression system |
CU23432B6 (es) * | 2005-11-02 | 2009-10-16 | Ct Ingenieria Genetica Biotech | Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras |
US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US8048849B2 (en) * | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
US8304386B2 (en) * | 2006-02-03 | 2012-11-06 | Prolor Biotech, Inc. | Long-acting growth hormone and methods of producing same |
US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US8476234B2 (en) * | 2006-02-03 | 2013-07-02 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
US7553941B2 (en) | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting polypeptides and methods of producing same |
US8048848B2 (en) * | 2006-02-03 | 2011-11-01 | Prolor Biotech Ltd. | Long-acting interferons and derivatives thereof and methods thereof |
US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
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JP5444553B2 (ja) | 2007-04-27 | 2014-03-19 | フェネックス インコーポレイテッド | 微生物宿主を迅速にスクリーニングして、異種タンパク質発現の収率および/または質が改善されている特定の株を同定する方法 |
WO2008137471A2 (en) | 2007-05-02 | 2008-11-13 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
CA2698173C (en) * | 2007-09-04 | 2015-02-03 | Biosteed Gene Expression Tech. Co., Ltd. | Interferon alpha 2b modified by polyethylene glycol, the preparation and use thereof |
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US20120269770A1 (en) * | 2010-11-22 | 2012-10-25 | Mark Brader | Stable Preserved Compositions of Interferon-Beta |
MX342675B (es) * | 2011-03-10 | 2016-10-07 | Xeris Pharmaceuticals Inc | Formulaciones estables para inyeccion parenteral de farmacos de peptido. |
BR112014025951A2 (pt) | 2012-04-19 | 2017-07-11 | Opko Biologics Ltd | variantes de oxintomodulina de longa ação e métodos de produção do mesmo |
AU2013349239B2 (en) | 2012-11-20 | 2018-04-12 | Opko Biologics Ltd. | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
JPWO2016052584A1 (ja) * | 2014-09-30 | 2017-07-13 | 東レ株式会社 | ポリエチレングリコール修飾インターフェロン−βの検出及び定量に使用する試料液の前処理方法、ポリエチレングリコール修飾インターフェロン−βの検出方法及び定量方法 |
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JP7096668B2 (ja) | 2015-06-19 | 2022-07-06 | オプコ バイオロジクス リミテッド | 長時間作用型凝固因子およびその製造方法 |
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2001
- 2001-10-25 US US10/035,397 patent/US6887462B2/en not_active Expired - Lifetime
- 2001-10-26 HU HU0303732A patent/HU228581B1/hu active Protection Beyond IP Right Term
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- 2001-10-26 JP JP2002579014A patent/JP2004529917A/ja not_active Withdrawn
- 2001-10-26 CZ CZ2003-2735A patent/CZ305994B6/cs unknown
- 2001-10-26 AT AT01988466T patent/ATE545430T1/de active
- 2001-10-26 EP EP10180630.5A patent/EP2283896B1/de not_active Expired - Lifetime
- 2001-10-26 KR KR1020037013202A patent/KR100900753B1/ko active IP Right Grant
- 2001-10-26 ES ES10180658.6T patent/ES2453623T3/es not_active Expired - Lifetime
- 2001-10-26 ES ES01988466T patent/ES2367761T3/es not_active Expired - Lifetime
- 2001-10-26 DK DK01988466.7T patent/DK1381432T3/da active
- 2001-10-26 EP EP10180658.6A patent/EP2283897B1/de not_active Expired - Lifetime
- 2001-10-26 CA CA2442854A patent/CA2442854C/en not_active Expired - Lifetime
- 2001-10-26 IL IL15796301A patent/IL157963A0/xx unknown
- 2001-10-26 PT PT01988466T patent/PT1381432E/pt unknown
- 2001-10-26 PT PT101806305T patent/PT2283896E/pt unknown
- 2001-10-26 CN CNB018231225A patent/CN1313148C/zh not_active Expired - Lifetime
- 2001-10-26 ES ES10180630.5T patent/ES2524322T3/es not_active Expired - Lifetime
- 2001-10-26 CA CA2762966A patent/CA2762966A1/en not_active Abandoned
- 2001-10-26 EP EP01988466A patent/EP1381432B9/de not_active Expired - Lifetime
- 2001-10-26 PL PL366790A patent/PL213297B1/pl unknown
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- 2003-10-07 NO NO20034492A patent/NO330259B1/no not_active IP Right Cessation
- 2003-11-07 BG BG108322A patent/BG66300B1/bg unknown
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- 2005-02-18 US US11/062,146 patent/US7371373B2/en not_active Expired - Fee Related
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- 2009-10-26 JP JP2009245975A patent/JP2010018633A/ja not_active Withdrawn
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- 2011-01-11 US US13/004,658 patent/US8333958B2/en not_active Expired - Lifetime
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