ATE537151T1 - Pyrazolinverbindungen als mineralocorticoidrezeptorantagonisten - Google Patents

Pyrazolinverbindungen als mineralocorticoidrezeptorantagonisten

Info

Publication number: ATE537151T1
Authority: AT; Austria
Prior art keywords: receptor antagonists; mineralocorticoid receptor; pyrazoline compounds; pyrazoline; compounds
Prior art date: 2006-10-31

Application number

AT07825488T

Other languages

English (en)

Inventor

Marvin Jay Meyers

Graciela Barbieri Arhancet

Xiangyang Chen

Susan Landis Hockerman

Scott Long

Matthew Mahoney

David Reitz

Joseph Gerace Rico

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-31

Filing date

2007-10-17

Publication date

2011-12-15

2007-10-17 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE537151T1 publication Critical patent/ATE537151T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

AT07825488T 2006-10-31 2007-10-17 Pyrazolinverbindungen als mineralocorticoidrezeptorantagonisten ATE537151T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86360606P	2006-10-31	2006-10-31
PCT/IB2007/003207 WO2008053300A1 (en)	2006-10-31	2007-10-17	Pyrazoline compounds as mineralocorticoid receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE537151T1 true ATE537151T1 (de)	2011-12-15

Family

ID=39027523

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07825488T ATE537151T1 (de)	2006-10-31	2007-10-17	Pyrazolinverbindungen als mineralocorticoidrezeptorantagonisten

Country Status (40)

Country	Link
US (3)	US7781428B2 (de)
EP (1)	EP2089367B1 (de)
JP (1)	JP4977760B2 (de)
KR (1)	KR101107800B1 (de)
CN (1)	CN101541757A (de)
AP (1)	AP2527A (de)
AR (1)	AR063529A1 (de)
AT (1)	ATE537151T1 (de)
AU (1)	AU2007315884B2 (de)
BR (1)	BRPI0717937A2 (de)
CA (1)	CA2667966C (de)
CL (1)	CL2007003154A1 (de)
CO (1)	CO6160307A2 (de)
CR (1)	CR10725A (de)
CU (1)	CU23779B7 (de)
CY (1)	CY1112311T1 (de)
DK (1)	DK2089367T3 (de)
EA (1)	EA016370B1 (de)
ES (1)	ES2375877T3 (de)
GE (1)	GEP20115239B (de)
GT (1)	GT200700096A (de)
HN (1)	HN2007000437A (de)
HR (1)	HRP20120078T1 (de)
IL (1)	IL198241A0 (de)
MA (1)	MA30821B1 (de)
MX (1)	MX2009004662A (de)
MY (1)	MY145795A (de)
NI (1)	NI200900071A (de)
NO (1)	NO20091741L (de)
NZ (1)	NZ575923A (de)
PE (1)	PE20081472A1 (de)
PL (1)	PL2089367T3 (de)
PT (1)	PT2089367E (de)
RS (2)	RS20090208A (de)
SI (1)	SI2089367T1 (de)
TN (1)	TN2009000160A1 (de)
TW (1)	TWI357327B (de)
UA (1)	UA92670C2 (de)
UY (1)	UY30670A1 (de)
WO (1)	WO2008053300A1 (de)

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TWI431010B (zh)	2007-12-19	2014-03-21	Lilly Co Eli	礦皮質素受體拮抗劑及使用方法
EP2597089A1 (de) *	2009-10-29	2013-05-29	Bristol-Myers Squibb Company	Tricyclische heterocyclische Verbindungen
WO2011141456A1 (en)	2010-05-10	2011-11-17	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and compositions for the treatment of fluid accumulation in and/ or under the retina
EP2569310A1 (de)	2010-05-11	2013-03-20	Pfizer Inc	Morpholinverbindugne als mineralocorticoid-rezeptorantagonisten
US9241944B2 (en)	2010-06-16	2016-01-26	Institut National De La Santé Et De La Recherche Médicale (Inserm)	Methods and compositions for stimulating reepithelialisation during wound healing
CN102372710A (zh)	2010-08-18	2012-03-14	山东轩竹医药科技有限公司	作为盐皮质激素受体拮抗剂的并环类化合物
WO2012048022A2 (en) *	2010-10-05	2012-04-12	Nova Southeastern University	Methods and compositions for therapeutic modulation of aldosterone levels in heart disease
DK3160948T3 (en)	2014-06-30	2019-02-18	Astrazeneca Ab	BENZOXAZINONAMIDES AS MODULATORS OF MINERALOCORTICOID RECEPTORS
JP6835836B2 (ja)	2015-10-13	2021-02-24	アンスティチュナショナルドゥラサンテエドゥラルシェルシュメディカル	脈絡膜血管新生の処置のための方法及び医薬組成物
EP3490606B8 (de)	2016-07-26	2024-04-10	INSERM (Institut National de la Santé et de la Recherche Médicale)	Mineralocorticoid-receptor-antagonist zur behandlung von osteoarthritis
CN110234633A (zh)	2016-09-02	2019-09-13	百时美施贵宝公司	取代的三环杂环化合物
WO2019032632A1 (en)	2017-08-09	2019-02-14	Bristol-Myers Squibb Company	ALKYLPHENYL COMPOUNDS
WO2019032631A1 (en)	2017-08-09	2019-02-14	Bristol-Myers Squibb Company	OXIME ETHER COMPOUNDS
CN109051490A (zh)	2018-09-18	2018-12-21	深圳市鲸仓科技有限公司	可移动式密集存拣装置
US20230151425A1 (en)	2020-03-11	2023-05-18	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods of determining whether a subject has or is at risk of having a central serous chorioretinopathy
WO2023031277A1 (en)	2021-08-31	2023-03-09	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for the treatment of ocular rosacea
CN113679716B (zh)	2021-10-13	2024-03-26	史大永	溴酚-吡唑啉化合物在治疗猫冠状病毒疾病中的应用
CN114230457B (zh) *	2022-01-04	2023-06-09	中山大学	一类2-亚苄基四氢萘酮衍生物及其制备方法和应用

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2007
- 2007-10-17 EA EA200970341A patent/EA016370B1/ru not_active IP Right Cessation
- 2007-10-17 WO PCT/IB2007/003207 patent/WO2008053300A1/en active Application Filing
- 2007-10-17 EP EP07825488A patent/EP2089367B1/de active Active
- 2007-10-17 BR BRPI0717937-5A2A patent/BRPI0717937A2/pt not_active IP Right Cessation
- 2007-10-17 AP AP2009004822A patent/AP2527A/xx active
- 2007-10-17 CN CNA2007800433330A patent/CN101541757A/zh active Pending
- 2007-10-17 RS RSP-2009/0208A patent/RS20090208A/sr unknown
- 2007-10-17 JP JP2009533977A patent/JP4977760B2/ja not_active Expired - Fee Related
- 2007-10-17 CA CA2667966A patent/CA2667966C/en not_active Expired - Fee Related
- 2007-10-17 ES ES07825488T patent/ES2375877T3/es active Active
- 2007-10-17 NZ NZ575923A patent/NZ575923A/en not_active IP Right Cessation
- 2007-10-17 MX MX2009004662A patent/MX2009004662A/es active IP Right Grant
- 2007-10-17 SI SI200730830T patent/SI2089367T1/sl unknown
- 2007-10-17 KR KR1020097008836A patent/KR101107800B1/ko not_active IP Right Cessation
- 2007-10-17 AT AT07825488T patent/ATE537151T1/de active
- 2007-10-17 PT PT07825488T patent/PT2089367E/pt unknown
- 2007-10-17 UA UAA200903302A patent/UA92670C2/ru unknown
- 2007-10-17 RS RS20120051A patent/RS52203B/en unknown
- 2007-10-17 GE GEAP200711240A patent/GEP20115239B/en unknown
- 2007-10-17 DK DK07825488.5T patent/DK2089367T3/da active
- 2007-10-17 MY MYPI20091613A patent/MY145795A/en unknown
- 2007-10-17 PL PL07825488T patent/PL2089367T3/pl unknown
- 2007-10-17 AU AU2007315884A patent/AU2007315884B2/en not_active Ceased
- 2007-10-24 US US11/923,248 patent/US7781428B2/en not_active Expired - Fee Related
- 2007-10-29 UY UY30670A patent/UY30670A1/es not_active Application Discontinuation
- 2007-10-29 AR ARP070104787A patent/AR063529A1/es not_active Application Discontinuation
- 2007-10-30 GT GT200700096A patent/GT200700096A/es unknown
- 2007-10-30 TW TW096140838A patent/TWI357327B/zh not_active IP Right Cessation
- 2007-10-30 PE PE2007001482A patent/PE20081472A1/es not_active Application Discontinuation
- 2007-10-31 CL CL200703154A patent/CL2007003154A1/es unknown
- 2007-10-31 HN HN2007000437A patent/HN2007000437A/es unknown
2009
- 2009-04-17 CU CU20090058A patent/CU23779B7/es not_active IP Right Cessation
- 2009-04-17 CR CR10725A patent/CR10725A/es not_active Application Discontinuation
- 2009-04-20 IL IL198241A patent/IL198241A0/en unknown
- 2009-04-21 CO CO09040130A patent/CO6160307A2/es unknown
- 2009-04-24 TN TNP2009000160A patent/TN2009000160A1/fr unknown
- 2009-04-29 NI NI200900071A patent/NI200900071A/es unknown
- 2009-04-30 MA MA31831A patent/MA30821B1/fr unknown
- 2009-05-04 NO NO20091741A patent/NO20091741L/no not_active Application Discontinuation
2010
- 2010-07-12 US US12/834,117 patent/US20100280016A1/en not_active Abandoned
2011
- 2011-10-20 US US13/277,270 patent/US20120035131A1/en not_active Abandoned
2012
- 2012-01-23 HR HR20120078T patent/HRP20120078T1/hr unknown
- 2012-01-23 CY CY20121100076T patent/CY1112311T1/el unknown

Also Published As

Publication number	Publication date
NI200900071A (es)	2010-03-08
TW200822924A (en)	2008-06-01
TWI357327B (en)	2012-02-01
CR10725A (es)	2009-05-12
MX2009004662A (es)	2009-05-22
RS20090208A (en)	2010-06-30
GEP20115239B (en)	2011-06-10
AP2009004822A0 (en)	2009-04-30
EA016370B1 (ru)	2012-04-30
WO2008053300A1 (en)	2008-05-08
PL2089367T3 (pl)	2012-04-30
US7781428B2 (en)	2010-08-24
AU2007315884B2 (en)	2012-10-04
KR20090060371A (ko)	2009-06-11
CY1112311T1 (el)	2015-12-09
US20120035131A1 (en)	2012-02-09
EP2089367A1 (de)	2009-08-19
TN2009000160A1 (fr)	2010-10-18
EP2089367B1 (de)	2011-12-14
IL198241A0 (en)	2009-12-24
CA2667966A1 (en)	2008-05-08
PE20081472A1 (es)	2008-10-18
PT2089367E (pt)	2012-02-01
DK2089367T3 (da)	2012-02-06
AP2527A (en)	2012-12-06
SI2089367T1 (sl)	2012-02-29
EA200970341A1 (ru)	2009-10-30
AU2007315884A1 (en)	2008-05-08
NO20091741L (no)	2009-05-29
NZ575923A (en)	2011-01-28
CL2007003154A1 (es)	2008-05-09
UY30670A1 (es)	2008-05-31
US20080167294A1 (en)	2008-07-10
MY145795A (en)	2012-04-30
US20100280016A1 (en)	2010-11-04
ES2375877T3 (es)	2012-03-07
CN101541757A (zh)	2009-09-23
BRPI0717937A2 (pt)	2013-12-03
CU20090058A7 (es)	2011-07-11
AR063529A1 (es)	2009-01-28
CU23779B7 (es)	2012-02-15
KR101107800B1 (ko)	2012-01-25
CA2667966C (en)	2011-08-02
HRP20120078T1 (hr)	2012-02-29
JP4977760B2 (ja)	2012-07-18
JP2010508257A (ja)	2010-03-18
MA30821B1 (fr)	2009-10-01
CO6160307A2 (es)	2010-05-20
HN2007000437A (es)	2011-01-17
RS52203B (en)	2012-10-31
GT200700096A (es)	2010-07-15
UA92670C2 (ru)	2010-11-25

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DK2089382T3 (da)	2013-02-04	Substituerede diazepan-forbindelser som orexin-receptor-antagonister
ATE481405T1 (de)	2010-10-15	Thiazolpyrazolopyrimidine als antagonisten des crf1-rezeptors
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DK2081951T3 (da)	2010-08-09	Progesteron-receptorantagonister
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ATE509022T1 (de)	2011-05-15	Nikotin-acetylcholin-rezeptorsubtyp-selektive diazabicycloalkanamide
ATE555111T1 (de)	2012-05-15	Chinuclidinol-derivate als muscarinrezeptor- antagonisten
ATE505467T1 (de)	2011-04-15	2-aza-bicycloä3.1.0ühexanderivate als orexin- rezeptorantagonisten
ATE509928T1 (de)	2011-06-15	8-azabicycloä3.2.1üoktan-verbindungen als mu- opioid-rezeptorantagonisten
DK1973886T3 (da)	2013-03-18	Prokineticin-1-receptor-antagonister
BRPI0910592A2 (pt)	2015-09-22	antagonistas de receptor 2 de somatostatina
DK2252581T3 (da)	2012-07-16	Kappa-selektiv opioidreceptorantagonist
ATE517100T1 (de)	2011-08-15	Pyrrolidinarylether als nk3-rezeptorantagonisten
ATE519738T1 (de)	2011-08-15	Pyrrolidinarylether als nk3-rezeptorantagonisten
ATE545633T1 (de)	2012-03-15	Als vasopressinantagonisten geeignete benzazepinderivate
BRPI0910118A2 (pt)	2015-12-29	antagonistas de receptores do glucagon
ATE538091T1 (de)	2012-01-15	Tetrahydrocyclopentaäbüindolverbindungen als androgenrezeptormodulatoren
ATE485270T1 (de)	2010-11-15	2-phenylindole als antagonisten des prostaglandin-d2-rezeptors
ATE429428T1 (de)	2009-05-15	Indanderivate als antagonisten des mch-rezeptors
BRPI0810926A2 (pt)	2014-11-04	Antagonista de crig
BRPI0923237A2 (pt)	2019-09-24	compostos de 4-azetidinil-1-heteroaril-ciclohexanol antagonistas de ccr2
ATE547407T1 (de)	2012-03-15	Alkylthiopyrimidine als crth2-antagonisten