ATE517100T1 - Pyrrolidinarylether als nk3-rezeptorantagonisten - Google Patents
Pyrrolidinarylether als nk3-rezeptorantagonistenInfo
- Publication number
- ATE517100T1 ATE517100T1 AT08786547T AT08786547T ATE517100T1 AT E517100 T1 ATE517100 T1 AT E517100T1 AT 08786547 T AT08786547 T AT 08786547T AT 08786547 T AT08786547 T AT 08786547T AT E517100 T1 ATE517100 T1 AT E517100T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrolidinaryl
- ether
- receptor antagonists
- antagonists
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07113942 | 2007-08-07 | ||
PCT/EP2008/059908 WO2009019163A1 (en) | 2007-08-07 | 2008-07-29 | Pyrrolidine aryl-ether as nk3 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE517100T1 true ATE517100T1 (de) | 2011-08-15 |
Family
ID=39865446
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08786547T ATE517100T1 (de) | 2007-08-07 | 2008-07-29 | Pyrrolidinarylether als nk3-rezeptorantagonisten |
Country Status (19)
Country | Link |
---|---|
US (1) | US8012998B2 (de) |
EP (1) | EP2185540B1 (de) |
JP (1) | JP2010535733A (de) |
KR (1) | KR101167774B1 (de) |
CN (1) | CN101778837A (de) |
AR (1) | AR067808A1 (de) |
AT (1) | ATE517100T1 (de) |
AU (1) | AU2008285718A1 (de) |
BR (1) | BRPI0815658A2 (de) |
CA (1) | CA2695211A1 (de) |
CL (1) | CL2008002293A1 (de) |
ES (1) | ES2367464T3 (de) |
IL (1) | IL203363A (de) |
MX (1) | MX2010001080A (de) |
PE (1) | PE20090898A1 (de) |
RU (1) | RU2010106974A (de) |
TW (1) | TW200916456A (de) |
WO (1) | WO2009019163A1 (de) |
ZA (1) | ZA201000676B (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009024502A1 (en) * | 2007-08-22 | 2009-02-26 | F. Hoffmann-La Roche Ag | Pyrrolidine aryl-ether as nk3 receptor antagonists |
BRPI1008349A2 (pt) | 2009-01-30 | 2016-02-23 | Hoffmann La Roche | derivados de piperidina tal como antagonistas de receptor de nk3 |
US8318759B2 (en) * | 2009-02-18 | 2012-11-27 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives as NK3 receptor antagonists |
US8394834B2 (en) * | 2009-08-25 | 2013-03-12 | Hoffman-La Roche Inc. | Pyrrolidines as NK3 receptor antagonists |
JP2013508350A (ja) * | 2009-10-20 | 2013-03-07 | ファイザー・インク | ガンマ−セクレターゼモジュレーターとしての新規なヘテロアリールイミダゾールおよびヘテロアリールトリアゾール |
US8507535B2 (en) * | 2010-07-07 | 2013-08-13 | Hoffmann-La Roche Inc. | Methyl-pyrrolidine ether derivatives |
EP3183248B1 (de) | 2014-08-21 | 2020-11-11 | Bristol-Myers Squibb Company | Rückgekoppelte benzamidderivate als potente rock-inhibitoren |
LT3344248T (lt) | 2015-09-02 | 2022-06-27 | Trevena, Inc. | 6-narių azaheterociklinių junginių, kurių sudėtyje yra deltaopioidų receptorius moduliuojančių junginių, panaudojimo ir gamybos būdai |
WO2017072629A1 (en) | 2015-10-29 | 2017-05-04 | Cadila Healthcare Limited | Pharmaceutical combination of nk3 receptor antagonist and biguanides |
CN105399661A (zh) * | 2015-12-14 | 2016-03-16 | 华东师范大学 | 2,6-二溴甲基吡啶的制备方法 |
WO2017195703A1 (ja) * | 2016-05-09 | 2017-11-16 | 日本曹達株式会社 | 環状アミン化合物および有害生物防除剤 |
CA3052479A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
CA3052480A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
WO2021030335A1 (en) * | 2019-08-12 | 2021-02-18 | Millendo Therapeutics, Inc. | A stereoisomerically pure nk-3 receptor antagonist and crystalline forms thereof |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU506399B2 (en) | 1975-12-30 | 1980-01-03 | Showa Denko Kabushiki Kaisha | 3-(2-aryl-2-propyl) ureas |
IN148482B (de) | 1977-06-03 | 1981-03-07 | Pfizer | |
GB9321557D0 (en) | 1992-11-03 | 1993-12-08 | Zeneca Ltd | Carboxamide derivatives |
IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
CA2178219C (en) | 1993-12-29 | 2005-03-22 | Raymond Baker | Substituted morpholine derivatives and their use as therapeutic agents |
IL112778A0 (en) | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
GB9714129D0 (en) * | 1997-07-04 | 1997-09-10 | Pfizer Ltd | Azetidines |
US5972938A (en) | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
EP1192952A3 (de) | 2000-09-28 | 2003-03-26 | Pfizer Products Inc. | Ein NK-3 rezeptorantagonisten und ein ZNS-penetrierende NK-1 rezeptorantagonisten enthaltende Zusammensetzung zur Behandlung von Depression und Angst |
US6531597B2 (en) | 2001-02-13 | 2003-03-11 | Hoffmann-La Roche Inc. | Process for preparation of 2-phenyl acetic acid derivatives |
US7622487B2 (en) * | 2002-05-31 | 2009-11-24 | Takeda Pharmaceutical Company Limited | Piperidine derivative, process for producing the same, and use |
BRPI0412291A (pt) | 2003-07-03 | 2006-09-19 | Hoffmann La Roche | antagonistas duplos de nka/nk3 para o tratamento de esquizofrenia |
CN1859914A (zh) * | 2003-09-30 | 2006-11-08 | 默克公司 | 苯基吡咯烷醚速激肽受体拮抗剂 |
EP1705176A4 (de) * | 2004-01-14 | 2009-06-03 | Takeda Pharmaceutical | Carbonsäureamidderivat und dessen anwendung |
US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
KR100939347B1 (ko) | 2005-07-20 | 2010-01-29 | (주)카이로드 | 광학적으로 순수한 (s)-3-히드록시 피롤리딘의 제조방법 |
-
2008
- 2008-07-29 MX MX2010001080A patent/MX2010001080A/es active IP Right Grant
- 2008-07-29 BR BRPI0815658-1A2A patent/BRPI0815658A2/pt not_active IP Right Cessation
- 2008-07-29 RU RU2010106974/04A patent/RU2010106974A/ru unknown
- 2008-07-29 KR KR1020107004881A patent/KR101167774B1/ko not_active IP Right Cessation
- 2008-07-29 CN CN200880102376A patent/CN101778837A/zh active Pending
- 2008-07-29 AT AT08786547T patent/ATE517100T1/de active
- 2008-07-29 EP EP08786547A patent/EP2185540B1/de not_active Not-in-force
- 2008-07-29 AU AU2008285718A patent/AU2008285718A1/en not_active Abandoned
- 2008-07-29 WO PCT/EP2008/059908 patent/WO2009019163A1/en active Application Filing
- 2008-07-29 ES ES08786547T patent/ES2367464T3/es active Active
- 2008-07-29 CA CA2695211A patent/CA2695211A1/en not_active Abandoned
- 2008-07-29 JP JP2010519428A patent/JP2010535733A/ja active Pending
- 2008-08-04 US US12/185,157 patent/US8012998B2/en not_active Expired - Fee Related
- 2008-08-04 CL CL2008002293A patent/CL2008002293A1/es unknown
- 2008-08-05 PE PE2008001308A patent/PE20090898A1/es not_active Application Discontinuation
- 2008-08-05 AR ARP080103406A patent/AR067808A1/es unknown
- 2008-08-06 TW TW097129930A patent/TW200916456A/zh unknown
-
2010
- 2010-01-18 IL IL203363A patent/IL203363A/en not_active IP Right Cessation
- 2010-01-28 ZA ZA201000676A patent/ZA201000676B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP2185540A1 (de) | 2010-05-19 |
CL2008002293A1 (es) | 2009-05-29 |
RU2010106974A (ru) | 2011-09-20 |
ZA201000676B (en) | 2010-10-27 |
BRPI0815658A2 (pt) | 2015-02-18 |
CN101778837A (zh) | 2010-07-14 |
JP2010535733A (ja) | 2010-11-25 |
IL203363A (en) | 2013-03-24 |
MX2010001080A (es) | 2010-03-01 |
WO2009019163A1 (en) | 2009-02-12 |
EP2185540B1 (de) | 2011-07-20 |
PE20090898A1 (es) | 2009-07-13 |
AU2008285718A1 (en) | 2009-02-12 |
AR067808A1 (es) | 2009-10-21 |
KR20100045502A (ko) | 2010-05-03 |
ES2367464T3 (es) | 2011-11-03 |
KR101167774B1 (ko) | 2012-07-24 |
TW200916456A (en) | 2009-04-16 |
US20090042896A1 (en) | 2009-02-12 |
US8012998B2 (en) | 2011-09-06 |
CA2695211A1 (en) | 2009-02-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
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