ATE532515T1 - Stabile laquinimod-zubereitungen - Google Patents

Stabile laquinimod-zubereitungen

Info

Publication number
ATE532515T1
ATE532515T1 AT07809468T AT07809468T ATE532515T1 AT E532515 T1 ATE532515 T1 AT E532515T1 AT 07809468 T AT07809468 T AT 07809468T AT 07809468 T AT07809468 T AT 07809468T AT E532515 T1 ATE532515 T1 AT E532515T1
Authority
AT
Austria
Prior art keywords
preparations
stable
stable laquinimod
laquinimod preparations
laquinimod
Prior art date
Application number
AT07809468T
Other languages
English (en)
Inventor
Shulamit Patashnik
Daniella Licht
Adrian Gilbert
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Application granted granted Critical
Publication of ATE532515T1 publication Critical patent/ATE532515T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
AT07809468T 2006-06-12 2007-06-12 Stabile laquinimod-zubereitungen ATE532515T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81324706P 2006-06-12 2006-06-12
PCT/US2007/013721 WO2007146248A2 (en) 2006-06-12 2007-06-12 Stable laquinimod preparations

Publications (1)

Publication Number Publication Date
ATE532515T1 true ATE532515T1 (de) 2011-11-15

Family

ID=38832466

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07809468T ATE532515T1 (de) 2006-06-12 2007-06-12 Stabile laquinimod-zubereitungen

Country Status (28)

Country Link
US (3) US7989473B2 (de)
EP (1) EP2035001B1 (de)
JP (1) JP5226678B2 (de)
KR (4) KR101495327B1 (de)
CN (1) CN101466379B (de)
AR (1) AR061348A1 (de)
AT (1) ATE532515T1 (de)
AU (1) AU2007258366B2 (de)
BR (1) BRPI0713694A2 (de)
CA (2) CA2654982C (de)
CY (1) CY1113003T1 (de)
DK (1) DK2035001T3 (de)
EA (1) EA018031B1 (de)
ES (1) ES2377149T3 (de)
HK (1) HK1121971A1 (de)
HR (1) HRP20120093T1 (de)
IL (1) IL195724A (de)
MX (1) MX2008015808A (de)
NO (1) NO342485B1 (de)
NZ (1) NZ573846A (de)
PL (1) PL2035001T3 (de)
PT (1) PT2035001E (de)
RS (1) RS52169B (de)
SI (1) SI2035001T1 (de)
TW (1) TWI400073B (de)
UA (1) UA96449C2 (de)
WO (1) WO2007146248A2 (de)
ZA (1) ZA200810790B (de)

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ES2377149T3 (es) 2006-06-12 2012-03-22 Teva Pharmaceutical Industries Limited Preparaciones de laquinimod estables
EP2977049A1 (de) * 2007-12-20 2016-01-27 Teva Pharmaceutical Industries, Ltd. Stabile laquinimod-präparate
CN104311486A (zh) * 2008-09-03 2015-01-28 泰华制药工业有限公司 2-羰基-1,2-二氢喹啉免疫功能调节剂
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RS54328B1 (en) * 2009-06-19 2016-02-29 Teva Pharmaceutical Industries Ltd. MULTIPLE TREATMENT OF LAKVINIMOD SCLEROSIS
PL2458992T3 (pl) * 2009-07-30 2016-07-29 Teva Pharma Leczenie choroby Leśniowskiego-Crohna z użyciem lakwinimodu
SI2467372T1 (sl) * 2009-08-10 2016-09-30 Teva Pharmaceutical Industries Ltd. Zdravljenje motenj, povezanih z BDNF, z uporabo lakvinimoda
DE102010026879A1 (de) 2010-02-11 2011-08-11 AMW GmbH, 83627 Transdermales System mit Immunmodulator
KR20160129093A (ko) 2010-03-03 2016-11-08 테바 파마슈티컬 인더스트리즈 리미티드 라퀴니모드를 이용한 루푸스 신장염의 치료
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DK2542079T3 (da) * 2010-03-03 2014-08-25 Teva Pharma Behandling af reumatoid artritis med en kombination af laquinimod og methotrexat
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EA201390827A1 (ru) * 2010-12-07 2013-12-30 Тева Фармасьютикал Индастриз Лтд. Применение лаквинимода для уменьшения утомляемости, улучшения функционального состояния и улучшения качества жизни пациентов с рассеянным склерозом
JP2014521659A (ja) * 2011-07-28 2014-08-28 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドおよびインターフェロンβを組み合わせた多発性硬化症の治療
IN2014MN00333A (de) * 2011-07-28 2015-09-25 Teva Pharma
WO2013055907A1 (en) * 2011-10-12 2013-04-18 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod
BR112014018485A8 (pt) 2012-02-03 2017-07-11 Teva Pharma Uso de laquinimod para tratar pacientes com a doença de crohn que falharam com a primeira linha de terapia anti-tnf
MX2014009889A (es) 2012-02-16 2014-11-13 Teva Pharma N-etil-n-fenil-1,2-dihidro-4,5-di-hidroxi-1-metil-2-oxo-3-quinoli ncarboxamida, preparacion y usos de los mismos.
US20130259856A1 (en) 2012-03-27 2013-10-03 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate
TW201350467A (zh) 2012-05-08 2013-12-16 Teva Pharma Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
WO2014004733A1 (en) * 2012-06-26 2014-01-03 The Regents Of The University Of California Composition for lupus nephritis and methods of making and using the same
AR091706A1 (es) * 2012-07-11 2015-02-25 Teva Pharma Formulaciones de laquinimod sin agentes alcalinizantes
TW201410243A (zh) * 2012-08-13 2014-03-16 Teva Pharma 用於治療***素受體型１（ｃｂ１）媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
TW201410244A (zh) * 2012-08-13 2014-03-16 Teva Pharma 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
AU2013341506A1 (en) * 2012-11-07 2015-06-04 Teva Pharmaceutical Industries Ltd. Amine salts of Laquinimod
MX2015010296A (es) * 2013-02-15 2016-05-05 Teva Pharma Tratamiento de formas progresivas de esclerosis multiple con laquinimod.
EP2968203A1 (de) 2013-03-14 2016-01-20 Teva Pharmaceutical Industries Ltd. Transdermale formulierungen aus laquinimod
SG11201506409RA (en) 2013-03-14 2015-09-29 Teva Pharma Crystals of laquinimod sodium and improved process for the manufacture thereof
US20150094332A1 (en) * 2013-09-27 2015-04-02 Teva Pharmaceutical Industries, Ltd. Laquinimod Combination Therapy For Treatment Of Multiple Sclerosis
CA2933380A1 (en) * 2013-12-20 2015-06-25 Esther Lukasiewicz Hagai Use of laquinimod to delay huntington's disease progression
EP3094330A4 (de) * 2014-01-17 2017-09-27 Teva Pharmaceutical Industries Ltd Behandlung von morbus crohn unter verwendung von niedrigdosiertem laquinimod
CN106573014A (zh) 2014-04-29 2017-04-19 梯瓦制药工业有限公司 用于治疗具有高残疾状况的复发‑缓解型多发性硬化症(rrms)的患者的拉喹莫德
CN110193014B (zh) * 2019-06-06 2021-05-11 温州医科大学 一种注射用拉喹莫德胶束冻干制剂及制备方法、拉喹莫德注射制剂

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RS54328B1 (en) 2009-06-19 2016-02-29 Teva Pharmaceutical Industries Ltd. MULTIPLE TREATMENT OF LAKVINIMOD SCLEROSIS
PL2458992T3 (pl) 2009-07-30 2016-07-29 Teva Pharma Leczenie choroby Leśniowskiego-Crohna z użyciem lakwinimodu
SI2467372T1 (sl) 2009-08-10 2016-09-30 Teva Pharmaceutical Industries Ltd. Zdravljenje motenj, povezanih z BDNF, z uporabo lakvinimoda
DK2542079T3 (da) 2010-03-03 2014-08-25 Teva Pharma Behandling af reumatoid artritis med en kombination af laquinimod og methotrexat
KR20160129093A (ko) 2010-03-03 2016-11-08 테바 파마슈티컬 인더스트리즈 리미티드 라퀴니모드를 이용한 루푸스 신장염의 치료
CN102781239B (zh) 2010-03-03 2015-01-21 泰华制药工业有限公司 使用拉喹莫德治疗狼疮关节炎
JP2013535437A (ja) 2010-07-09 2013-09-12 テバ ファーマシューティカル インダストリーズ リミティド 重水素化されたｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４−ヒドロキシ−５−クロロ−１−メチル−２−オキソキノリン−３−カルボキサミド、その塩および使用
EA201390074A1 (ru) 2010-07-09 2013-06-28 Тева Фармасьютикал Индастриз Лтд. 5-хлор-4-гидрокси-1-метил-2-оксо-n-фенил-1,2-дигидрохинолин-3-карбоксамид, его соли и применения

Also Published As

Publication number Publication date
JP5226678B2 (ja) 2013-07-03
US8383645B2 (en) 2013-02-26
ZA200810790B (en) 2010-03-31
TWI400073B (zh) 2013-07-01
BRPI0713694A2 (pt) 2012-10-30
WO2007146248A2 (en) 2007-12-21
ES2377149T3 (es) 2012-03-22
RS52169B (en) 2012-08-31
DK2035001T3 (da) 2012-02-27
AR061348A1 (es) 2008-08-20
US20110251235A1 (en) 2011-10-13
KR101495327B1 (ko) 2015-02-24
EA018031B1 (ru) 2013-05-30
KR20090017694A (ko) 2009-02-18
MX2008015808A (es) 2009-02-17
US7989473B2 (en) 2011-08-02
AU2007258366B2 (en) 2012-10-25
IL195724A (en) 2015-09-24
CY1113003T1 (el) 2016-04-13
CN101466379A (zh) 2009-06-24
KR20150065951A (ko) 2015-06-15
CN101466379B (zh) 2012-10-31
AU2007258366A1 (en) 2007-12-21
HRP20120093T1 (hr) 2012-03-31
PL2035001T3 (pl) 2012-05-31
PT2035001E (pt) 2012-02-06
KR20140091778A (ko) 2014-07-22
UA96449C2 (en) 2011-11-10
US20120302600A1 (en) 2012-11-29
EA200870599A1 (ru) 2009-06-30
CA2654982C (en) 2015-11-10
CA2654982A1 (en) 2007-12-21
NO342485B1 (no) 2018-05-28
JP2009539984A (ja) 2009-11-19
CA2899472A1 (en) 2007-12-21
TW200815006A (en) 2008-04-01
EP2035001A4 (de) 2009-09-23
HK1121971A1 (en) 2009-05-08
EP2035001B1 (de) 2011-11-09
CA2899472C (en) 2019-04-30
EP2035001A2 (de) 2009-03-18
WO2007146248A3 (en) 2008-12-24
NZ573846A (en) 2012-01-12
KR20160013273A (ko) 2016-02-03
IL195724A0 (en) 2009-09-01
SI2035001T1 (sl) 2012-03-30
NO20090175L (no) 2009-03-11
US20070293537A1 (en) 2007-12-20

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