ATE530554T1 - Serinprotease-hemmer - Google Patents
Serinprotease-hemmerInfo
- Publication number
- ATE530554T1 ATE530554T1 AT06813916T AT06813916T ATE530554T1 AT E530554 T1 ATE530554 T1 AT E530554T1 AT 06813916 T AT06813916 T AT 06813916T AT 06813916 T AT06813916 T AT 06813916T AT E530554 T1 ATE530554 T1 AT E530554T1
- Authority
- AT
- Austria
- Prior art keywords
- protease inhibitors
- serine protease
- serine
- inhibitors
- protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71153005P | 2005-08-26 | 2005-08-26 | |
PCT/US2006/033770 WO2007025307A2 (en) | 2005-08-26 | 2006-08-28 | Inhibitors of serine proteases |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE530554T1 true ATE530554T1 (de) | 2011-11-15 |
Family
ID=37684363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06813916T ATE530554T1 (de) | 2005-08-26 | 2006-08-28 | Serinprotease-hemmer |
Country Status (21)
Country | Link |
---|---|
US (2) | US7985762B2 (de) |
EP (3) | EP2364984A1 (de) |
JP (1) | JP5394063B2 (de) |
KR (1) | KR20080041715A (de) |
CN (1) | CN101316852A (de) |
AR (1) | AR055395A1 (de) |
AT (1) | ATE530554T1 (de) |
AU (1) | AU2006282771B2 (de) |
BR (1) | BRPI0615223A2 (de) |
CA (1) | CA2620621A1 (de) |
EA (1) | EA200800670A1 (de) |
EC (1) | ECSP088258A (de) |
ES (1) | ES2374943T3 (de) |
GE (1) | GEP20115280B (de) |
IL (1) | IL189668A0 (de) |
MX (1) | MX2008002606A (de) |
NO (1) | NO20081467L (de) |
NZ (1) | NZ566197A (de) |
TW (1) | TW200730533A (de) |
WO (1) | WO2007025307A2 (de) |
ZA (1) | ZA200801793B (de) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL194025B1 (pl) * | 1996-10-18 | 2007-04-30 | Vertex Pharma | Inhibitory proteaz serynowych, a zwłaszcza proteazy wirusa NS3 zapalenia wątroby C, kompozycja farmaceutyczna i zastosowanie inhibitorów proteaz serynowych |
ES2240446T3 (es) * | 2000-04-03 | 2005-10-16 | Vertex Pharma | Inhibidores de serina proteasas, particularmente la proteasa ns3 del virus de la hepatitis c. |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
TW200510391A (en) * | 2003-04-11 | 2005-03-16 | Vertex Pharma | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
CN1852920B (zh) * | 2003-07-18 | 2010-12-15 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶抑制剂、特别是hcv ns3-ns4a蛋白酶抑制剂 |
PE20050374A1 (es) * | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
AU2004274468B2 (en) * | 2003-09-18 | 2009-07-23 | Vertex Pharmaceuticals, Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
KR20120010278A (ko) * | 2003-10-10 | 2012-02-02 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 hcv ns3-ns4a 프로테아제의 억제제 |
DK1677827T3 (da) * | 2003-10-27 | 2009-03-30 | Vertex Pharma | Kombinationer til HCV-behandling |
WO2005077969A2 (en) * | 2004-02-04 | 2005-08-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
EP2305696A3 (de) | 2005-07-25 | 2011-10-12 | Intermune, Inc. | Makrocyclische Inhibitoren der Replikation des Hepatitis-C-Virus |
US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
US7964624B1 (en) * | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
AU2007217355B2 (en) | 2006-02-27 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Co-crystals comprising VX-950 and pharmaceutical compositions comprising the same |
MX2008011868A (es) | 2006-03-16 | 2008-12-15 | Vertex Pharma | Inhibidores deuterados de la proteasa de la hepatitis c. |
NZ571826A (en) * | 2006-04-11 | 2012-01-12 | Novartis Ag | HCV/HIV inhibitors and their uses |
EP2049474B1 (de) | 2006-07-11 | 2015-11-04 | Bristol-Myers Squibb Company | Hemmer des hepatitis-c-virus |
EP2057278A2 (de) * | 2006-08-28 | 2009-05-13 | Vertex Pharmceuticals Incorporated | Verfahren zur identifikation von protease-hemmern |
WO2008035315A2 (en) * | 2006-09-22 | 2008-03-27 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type-iv |
US8343477B2 (en) | 2006-11-01 | 2013-01-01 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
US7772180B2 (en) | 2006-11-09 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7763584B2 (en) | 2006-11-16 | 2010-07-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7888464B2 (en) | 2006-11-16 | 2011-02-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8003604B2 (en) | 2006-11-16 | 2011-08-23 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2495249A1 (de) * | 2007-02-26 | 2012-09-05 | Achillion Pharmaceuticals, Inc. | Tertiäraminsubstituierte Peptide als HCV-Replikationshemmer |
ES2379905T3 (es) | 2007-02-27 | 2012-05-04 | Vertex Pharmceuticals Incorporated | Co-cristales y composiciones farmacéuticas que los comprenden |
US8575208B2 (en) | 2007-02-27 | 2013-11-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
FR2914920B1 (fr) * | 2007-04-11 | 2011-09-09 | Clariant Specialty Fine Chem F | Procede de deacetalisation d'alpha-aminoacetals. |
ATE548044T1 (de) | 2007-05-04 | 2012-03-15 | Vertex Pharma | Kombinationstherapie zur behandlung von hiv- infektionen |
AP2009005057A0 (en) * | 2007-05-10 | 2009-12-31 | Array Biopharma Inc | Novel peptide inhibitors of hepatitis c virus replication |
EP2100881A1 (de) * | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Pyrimidinyl- oder Pyridinylaminobenzoesäurederivate |
UY31272A1 (es) * | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
NZ583699A (en) | 2007-08-30 | 2012-04-27 | Vertex Pharma | Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same |
AR068756A1 (es) | 2007-10-10 | 2009-12-02 | Novartis Ag | Compuestos peptidicos, formulacion farmaceutica y sus usos como moduladores del virus de la hepatitis c |
WO2009053828A2 (en) * | 2007-10-22 | 2009-04-30 | Enanta Pharmaceuticals, Inc. | P3 hydroxyamino macrocyclic hepatitis c serine protease inhibitors |
US8383583B2 (en) | 2007-10-26 | 2013-02-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors |
US8202996B2 (en) | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
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US8563505B2 (en) | 2008-09-29 | 2013-10-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8044087B2 (en) | 2008-09-29 | 2011-10-25 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EA201170441A1 (ru) * | 2008-10-15 | 2012-05-30 | Интермьюн, Инк. | Терапевтические противовирусные пептиды |
US8283310B2 (en) | 2008-12-15 | 2012-10-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2210615A1 (de) * | 2009-01-21 | 2010-07-28 | Almirall, S.A. | Kombinationen, die Methotrexat und DHODH-Inhibitoren umfassen |
EP2417134B1 (de) | 2009-04-08 | 2017-05-17 | Idenix Pharmaceuticals LLC. | Macrocyclische serinproteaseinhibitoren |
US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
US8232246B2 (en) * | 2009-06-30 | 2012-07-31 | Abbott Laboratories | Anti-viral compounds |
WO2011017389A1 (en) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv |
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WO2011156545A1 (en) | 2010-06-09 | 2011-12-15 | Vertex Pharmaceuticals Incorporated | Viral dynamic model for hcv combination therapy |
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CN103534256B (zh) | 2010-12-30 | 2016-08-10 | 益安药业 | 大环丙型肝炎丝氨酸蛋白酶抑制剂 |
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AR085352A1 (es) | 2011-02-10 | 2013-09-25 | Idenix Pharmaceuticals Inc | Inhibidores macrociclicos de serina proteasa, sus composiciones farmaceuticas y su uso para tratar infecciones por hcv |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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JP6154474B2 (ja) | 2012-10-19 | 2017-06-28 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | C型肝炎ウイルス阻害剤 |
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FR3000064A1 (fr) * | 2012-12-21 | 2014-06-27 | Univ Lille Ii Droit & Sante | Composes de type spiroisoxazoline ayant une activite potentialisatrice de l'activite d'un antibiotique-composition et produit pharmaceutiques comprenant de tels composes |
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EP2883876A1 (de) | 2013-12-16 | 2015-06-17 | Actelion Pharmaceuticals Ltd. | Stereoselektive Synthese von substituierten Pyrrolidinen |
EP3089757A1 (de) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Feste antivirale darreichungsformen |
WO2016144654A1 (en) | 2015-03-09 | 2016-09-15 | Washington University | Inhibitors of growth factor activation enzymes |
CU20170166A7 (es) | 2015-07-31 | 2018-03-13 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1, 1, 1-trifluoro-4-hidroxibutan-2-il carbamato como inhibidores de magl |
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RU2720203C1 (ru) | 2017-01-20 | 2020-04-27 | Пфайзер Инк. | 1,1,1-трифтор-3-гидроксипропан-2-илкарбаматные производные как ингибиторы magl |
RU2726631C1 (ru) | 2017-01-23 | 2020-07-15 | Пфайзер Инк. | Гетероциклические спиросоединения в качестве ингибиторов magl |
RU2650610C1 (ru) | 2017-02-28 | 2018-04-16 | Васильевич Иващенко Александр | Противовирусная композиция и способ ее применения |
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- 2006-08-25 AR ARP060103711A patent/AR055395A1/es unknown
- 2006-08-28 EP EP10176969A patent/EP2364984A1/de not_active Withdrawn
- 2006-08-28 JP JP2008528258A patent/JP5394063B2/ja not_active Expired - Fee Related
- 2006-08-28 ES ES06813916T patent/ES2374943T3/es active Active
- 2006-08-28 GE GEAP200610581A patent/GEP20115280B/en unknown
- 2006-08-28 TW TW095131649A patent/TW200730533A/zh unknown
- 2006-08-28 BR BRPI0615223-6A patent/BRPI0615223A2/pt not_active IP Right Cessation
- 2006-08-28 MX MX2008002606A patent/MX2008002606A/es active IP Right Grant
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- 2006-08-28 WO PCT/US2006/033770 patent/WO2007025307A2/en active Application Filing
- 2006-08-28 AU AU2006282771A patent/AU2006282771B2/en not_active Ceased
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- 2006-08-28 CN CNA2006800390595A patent/CN101316852A/zh active Pending
- 2006-08-28 CA CA002620621A patent/CA2620621A1/en not_active Abandoned
- 2006-08-28 EP EP06813916A patent/EP1917269B1/de active Active
- 2006-08-28 AT AT06813916T patent/ATE530554T1/de not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
---|---|
US7985762B2 (en) | 2011-07-26 |
AU2006282771B2 (en) | 2012-08-09 |
TW200730533A (en) | 2007-08-16 |
WO2007025307A3 (en) | 2007-04-26 |
ECSP088258A (es) | 2008-06-30 |
JP2009506078A (ja) | 2009-02-12 |
BRPI0615223A2 (pt) | 2009-07-14 |
EA200800670A1 (ru) | 2009-12-30 |
NZ566197A (en) | 2011-07-29 |
EP2366704A1 (de) | 2011-09-21 |
MX2008002606A (es) | 2008-03-14 |
NO20081467L (no) | 2008-05-15 |
CN101316852A (zh) | 2008-12-03 |
AU2006282771A1 (en) | 2007-03-01 |
CA2620621A1 (en) | 2007-03-01 |
EP1917269A2 (de) | 2008-05-07 |
US20110165120A1 (en) | 2011-07-07 |
KR20080041715A (ko) | 2008-05-13 |
US8440706B2 (en) | 2013-05-14 |
JP5394063B2 (ja) | 2014-01-22 |
US20070179167A1 (en) | 2007-08-02 |
EP2366704B1 (de) | 2013-10-23 |
EP1917269B1 (de) | 2011-10-26 |
IL189668A0 (en) | 2008-06-05 |
AR055395A1 (es) | 2007-08-22 |
ES2374943T3 (es) | 2012-02-23 |
GEP20115280B (en) | 2011-09-12 |
EP2364984A1 (de) | 2011-09-14 |
WO2007025307A2 (en) | 2007-03-01 |
ZA200801793B (en) | 2008-12-31 |
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