ATE513033T1 - Expression von proteinen in aus nabelschnurblut gewonnenen endothelzellen - Google Patents
Expression von proteinen in aus nabelschnurblut gewonnenen endothelzellenInfo
- Publication number
- ATE513033T1 ATE513033T1 AT04727532T AT04727532T ATE513033T1 AT E513033 T1 ATE513033 T1 AT E513033T1 AT 04727532 T AT04727532 T AT 04727532T AT 04727532 T AT04727532 T AT 04727532T AT E513033 T1 ATE513033 T1 AT E513033T1
- Authority
- AT
- Austria
- Prior art keywords
- endothelial cells
- cord blood
- proteins
- expression
- umbilical cord
- Prior art date
Links
- 210000002889 endothelial cell Anatomy 0.000 title abstract 2
- 210000004700 fetal blood Anatomy 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 2
- 239000003114 blood coagulation factor Substances 0.000 abstract 2
- 229940019700 blood coagulation factors Drugs 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 101150076489 B gene Proteins 0.000 abstract 1
- 102100026735 Coagulation factor VIII Human genes 0.000 abstract 1
- 201000003542 Factor VIII deficiency Diseases 0.000 abstract 1
- 208000009292 Hemophilia A Diseases 0.000 abstract 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03008076A EP1469064A1 (de) | 2003-04-15 | 2003-04-15 | Expression von Proteinen in endothelialen Zellen, die von Vorläuferzellen aus Nabelschnurblut abgeleitet wurden |
PCT/EP2004/003998 WO2004092355A1 (en) | 2003-04-15 | 2004-04-15 | Expression of proteins in cord blood-derived endothelial cells |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE513033T1 true ATE513033T1 (de) | 2011-07-15 |
Family
ID=32892865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04727532T ATE513033T1 (de) | 2003-04-15 | 2004-04-15 | Expression von proteinen in aus nabelschnurblut gewonnenen endothelzellen |
Country Status (6)
Country | Link |
---|---|
US (1) | US20060034813A1 (de) |
EP (2) | EP1469064A1 (de) |
JP (1) | JP2006523446A (de) |
AT (1) | ATE513033T1 (de) |
ES (1) | ES2366092T3 (de) |
WO (1) | WO2004092355A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005078073A2 (en) * | 2004-02-09 | 2005-08-25 | Indiana University Research And Technology Corporation | Isolation, expansion and of clonogenic endothelial progenitor cells |
EP1989290B1 (de) * | 2006-03-07 | 2015-07-08 | Humacyte | Verfahren zur extraktion von endothelialen zellen aus fettgewebe |
US7754486B2 (en) * | 2006-12-26 | 2010-07-13 | Institut De Recherche En Hematologie Et Transplantation | Culture medium named MV06 for both endothelial and myocardiac cells |
US20100143476A1 (en) * | 2007-02-14 | 2010-06-10 | March Keith L | Composition for stimulating formation of vascular structures |
CA2690383A1 (en) * | 2007-06-13 | 2008-12-24 | Wake Forest University Health Sciences | Methods of restoration of erectile function |
EP4074342A1 (de) * | 2008-03-21 | 2022-10-19 | Kolon Tissuegene, Inc. | Behandlung von bandscheibendegeneration |
WO2010017378A2 (en) * | 2008-08-08 | 2010-02-11 | Indiana University Research And Technology Corporation | Methods and compositions for vasculogenic potential determination |
WO2011102890A1 (en) * | 2010-02-18 | 2011-08-25 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treatment of hemophilia |
BRPI1105317A2 (pt) | 2011-01-24 | 2013-04-30 | Fundacco Hemoct De Ribeirco Preto | produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1 |
CN103505727A (zh) * | 2012-06-28 | 2014-01-15 | 中国科学院生物物理研究所 | 靶向作为vegfr-2共受体cd146的新功能在抗肿瘤血管新生治疗中的应用 |
EP3027226A4 (de) * | 2013-08-02 | 2016-07-27 | Siemens Healthcare Diagnostics | Zellbasierte steuerung und verfahren |
WO2016183593A2 (en) * | 2015-05-14 | 2016-11-17 | The Regents Of The University Of California | Prenatal therapy |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6767737B1 (en) * | 1998-08-31 | 2004-07-27 | New York University | Stem cells bearing an FGF receptor on the cell surface |
WO2000032750A1 (en) | 1998-11-24 | 2000-06-08 | Regents Of The University Of Minnesota | Transgenic circulating endothelial cells |
BR0009505A (pt) * | 1999-04-02 | 2002-06-11 | Corixa Corp | Compostos e processos para terapia e diagnóstico de câncer de pulmão |
EP1136553A1 (de) | 2000-03-22 | 2001-09-26 | Octagene GmbH | Herstellung von rekombinanten Blutgerinnungsfaktoren in humanen Zellinien |
CN1454257B (zh) | 2000-03-22 | 2013-01-16 | 奥克塔金尼有限责任公司 | 重组凝血因子在人类细胞系中的生产 |
US6878371B2 (en) * | 2000-07-26 | 2005-04-12 | Boston Scientific Scimed, Inc. | Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue |
EP1420807A4 (de) | 2001-08-09 | 2005-08-17 | Cornell Res Foundation Inc | Thrombozyten-wachstumsfaktor zum schutz des kardialen myokards |
WO2003070083A2 (en) * | 2002-02-15 | 2003-08-28 | Cornell Research Foundation, Inc. | Endothelial precursor cells for enhancing and restoring vascular function |
US20040009589A1 (en) * | 2002-03-26 | 2004-01-15 | Shulamit Levenberg | Endothelial cells derived from human embryonic stem cells |
-
2003
- 2003-04-15 EP EP03008076A patent/EP1469064A1/de not_active Withdrawn
-
2004
- 2004-04-15 WO PCT/EP2004/003998 patent/WO2004092355A1/en active Search and Examination
- 2004-04-15 AT AT04727532T patent/ATE513033T1/de not_active IP Right Cessation
- 2004-04-15 JP JP2006505140A patent/JP2006523446A/ja active Pending
- 2004-04-15 ES ES04727532T patent/ES2366092T3/es not_active Expired - Lifetime
- 2004-04-15 EP EP04727532A patent/EP1616000B1/de not_active Expired - Lifetime
-
2005
- 2005-10-06 US US11/244,087 patent/US20060034813A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1469064A1 (de) | 2004-10-20 |
ES2366092T3 (es) | 2011-10-17 |
EP1616000B1 (de) | 2011-06-15 |
WO2004092355A1 (en) | 2004-10-28 |
US20060034813A1 (en) | 2006-02-16 |
EP1616000A1 (de) | 2006-01-18 |
JP2006523446A (ja) | 2006-10-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |