ATE508188T1 - Oligonukleotid-zusammensetzungen mit verbesserter wirksamkeit - Google Patents

Oligonukleotid-zusammensetzungen mit verbesserter wirksamkeit

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Publication number
ATE508188T1
ATE508188T1 AT09166406T AT09166406T ATE508188T1 AT E508188 T1 ATE508188 T1 AT E508188T1 AT 09166406 T AT09166406 T AT 09166406T AT 09166406 T AT09166406 T AT 09166406T AT E508188 T1 ATE508188 T1 AT E508188T1
Authority
AT
Austria
Prior art keywords
compositions
oligonucleotide compositions
improved effectiveness
making
antisense oligomer
Prior art date
Application number
AT09166406T
Other languages
English (en)
Inventor
Tod M Woolf
Margaret F Taylor
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41112152&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE508188(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Application granted granted Critical
Publication of ATE508188T1 publication Critical patent/ATE508188T1/de

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11022—Cyclin-dependent kinase (2.7.11.22)
    • C—CHEMISTRY; METALLURGY
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    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
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    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised
AT09166406T 2002-02-01 2003-02-03 Oligonukleotid-zusammensetzungen mit verbesserter wirksamkeit ATE508188T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35320302P 2002-02-01 2002-02-01
US35338102P 2002-02-01 2002-02-01
US43623802P 2002-12-23 2002-12-23
US43860803P 2003-01-07 2003-01-07

Publications (1)

Publication Number Publication Date
ATE508188T1 true ATE508188T1 (de) 2011-05-15

Family

ID=41112152

Family Applications (4)

Application Number Title Priority Date Filing Date
AT03707687T ATE443133T1 (de) 2002-02-01 2003-02-03 Oligonukleotidzusammensetzungen mit verbesserter effizienz
AT09166406T ATE508188T1 (de) 2002-02-01 2003-02-03 Oligonukleotid-zusammensetzungen mit verbesserter wirksamkeit
AT10152725T ATE556714T1 (de) 2002-02-01 2003-02-03 Doppelsträngige oligonukleotide
AT10151247T ATE529512T1 (de) 2002-02-01 2003-02-03 Doppelsträngige oligonukleotide

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03707687T ATE443133T1 (de) 2002-02-01 2003-02-03 Oligonukleotidzusammensetzungen mit verbesserter effizienz

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT10152725T ATE556714T1 (de) 2002-02-01 2003-02-03 Doppelsträngige oligonukleotide
AT10151247T ATE529512T1 (de) 2002-02-01 2003-02-03 Doppelsträngige oligonukleotide

Country Status (9)

Country Link
US (9) US20040014956A1 (de)
EP (10) EP2221377B2 (de)
JP (2) JP4527984B2 (de)
AT (4) ATE443133T1 (de)
CA (2) CA2475003A1 (de)
DE (2) DE60329277D1 (de)
DK (1) DK2128248T4 (de)
HK (1) HK1147515A1 (de)
WO (2) WO2003064626A2 (de)

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US20170321219A1 (en) 2017-11-09
HK1147515A1 (en) 2011-08-12
EP2221377B1 (de) 2011-10-19
EP2924116A1 (de) 2015-09-30

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