ATE484510T1 - Kondensierte imidazolderivate als aromataseinhibitoren - Google Patents
Kondensierte imidazolderivate als aromataseinhibitorenInfo
- Publication number
- ATE484510T1 ATE484510T1 AT07728053T AT07728053T ATE484510T1 AT E484510 T1 ATE484510 T1 AT E484510T1 AT 07728053 T AT07728053 T AT 07728053T AT 07728053 T AT07728053 T AT 07728053T AT E484510 T1 ATE484510 T1 AT E484510T1
- Authority
- AT
- Austria
- Prior art keywords
- aromates
- inhibitors
- imidazole derivatives
- condensed imidazole
- condensed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH6172006 | 2006-04-12 | ||
PCT/EP2007/053586 WO2007116100A1 (en) | 2006-04-12 | 2007-04-12 | Condensed imidazole derivatives as aromatase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE484510T1 true ATE484510T1 (de) | 2010-10-15 |
Family
ID=38171569
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07728053T ATE484510T1 (de) | 2006-04-12 | 2007-04-12 | Kondensierte imidazolderivate als aromataseinhibitoren |
AT07728050T ATE479692T1 (de) | 2006-04-12 | 2007-04-12 | Kondensierte imidazolderivate als aldosteronsynthaseinhibitoren |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07728050T ATE479692T1 (de) | 2006-04-12 | 2007-04-12 | Kondensierte imidazolderivate als aldosteronsynthaseinhibitoren |
Country Status (14)
Country | Link |
---|---|
US (3) | US7799780B2 (de) |
EP (2) | EP2004658B1 (de) |
JP (2) | JP2010523465A (de) |
CN (2) | CN101421278A (de) |
AR (1) | AR060591A1 (de) |
AT (2) | ATE484510T1 (de) |
BR (2) | BRPI0710596A2 (de) |
CA (2) | CA2649214A1 (de) |
DE (2) | DE602007008860D1 (de) |
ES (1) | ES2352092T3 (de) |
IL (2) | IL193065A0 (de) |
PL (1) | PL2004657T3 (de) |
TW (1) | TW200808812A (de) |
WO (2) | WO2007116097A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0511621A (pt) * | 2004-05-28 | 2008-01-02 | Speedel Experimenta Ag | compostos orgánicos |
CN101180344B (zh) | 2005-03-24 | 2012-01-11 | 株式会社普利司通 | 具有低挥发性有机化合物(voc)释放的配混二氧化硅补强橡胶 |
TW200804378A (en) * | 2005-12-09 | 2008-01-16 | Speedel Experimenta Ag | Organic compounds |
TW200808813A (en) * | 2006-04-12 | 2008-02-16 | Speedel Experimenta Ag | Imidazo compounds |
TW200808812A (en) * | 2006-04-12 | 2008-02-16 | Speedel Experimenta Ag | Imidazo compounds |
CA2652346A1 (en) | 2006-05-15 | 2007-11-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
US8962746B2 (en) | 2007-12-27 | 2015-02-24 | Bridgestone Corporation | Methods of making blocked-mercapto alkoxy-modified silsesquioxane compounds |
US8794282B2 (en) | 2007-12-31 | 2014-08-05 | Bridgestone Corporation | Amino alkoxy-modified silsesquioxane adhesives for improved metal adhesion and metal adhesion retention to cured rubber |
EP2435402B1 (de) | 2009-05-28 | 2016-04-13 | Novartis AG | Substituierte aminobuttersäurederivate als neprilysininhibitoren |
NZ596304A (en) | 2009-05-28 | 2014-01-31 | Novartis Ag | Substituted aminopropionic derivatives as neprilysin inhibitors |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
TWI627167B (zh) | 2011-07-08 | 2018-06-21 | 諾華公司 | 用於高三酸甘油酯個體治療動脈粥狀硬化之方法 |
CN104093709B (zh) * | 2012-02-13 | 2017-09-22 | 霍夫曼-拉罗奇有限公司 | 作为醛固酮合酶抑制剂的咪唑基酮衍生物 |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
LT2956464T (lt) | 2013-02-14 | 2018-07-10 | Novartis Ag | Pakeisti bisfenilbutanoinės fosfonrūgšties dariniai, kaip nep (neutralios endopeptidazės) inhibitoriai |
KR20160031551A (ko) | 2013-07-25 | 2016-03-22 | 노파르티스 아게 | 심부전의 치료를 위한 시클릭 폴리펩티드 |
MX2016001021A (es) | 2013-07-25 | 2016-08-03 | Novartis Ag | Bioconjugados de polipeptidos de apelina sinteticos. |
WO2016109625A1 (en) | 2014-12-31 | 2016-07-07 | Bridgestone Corporation | Amino alkoxy-modified silsesquioxane adhesives for adhering steel alloy to rubber |
SG11201704758XA (en) | 2015-01-23 | 2017-08-30 | Novartis Ag | Synthetic apelin fatty acid conjugates with improved half-life |
JOP20190086A1 (ar) | 2016-10-21 | 2019-04-18 | Novartis Ag | مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
WO2020110008A1 (en) | 2018-11-27 | 2020-06-04 | Novartis Ag | Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder |
UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
CN113166204A (zh) | 2018-11-27 | 2021-07-23 | 诺华股份有限公司 | 作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型(PCSK9)抑制剂的环状肽 |
TW202333563A (zh) | 2021-11-12 | 2023-09-01 | 瑞士商諾華公司 | 用於治療疾病或障礙之二胺基環戊基吡啶衍生物 |
AR127698A1 (es) | 2021-11-23 | 2024-02-21 | Novartis Ag | Derivados de naftiridinona para el tratamiento de una enfermedad o un trastorno |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS579787A (en) | 1980-06-20 | 1982-01-19 | Ss Pharmaceut Co Ltd | Thiazinobenzimidazole derivative and its preparation |
JPH0670064B2 (ja) | 1986-12-08 | 1994-09-07 | 三井石油化学工業株式会社 | 二環性イミダゾ−ル誘導体 |
AU6015796A (en) * | 1995-06-14 | 1997-01-15 | Yamanouchi Pharmaceutical Co., Ltd. | Fused imidazole derivatives and medicinal composition thereof |
JPH0971586A (ja) * | 1995-09-07 | 1997-03-18 | Yamanouchi Pharmaceut Co Ltd | 新規な二環性縮合イミダゾール誘導体 |
EP1282410A2 (de) * | 2000-04-12 | 2003-02-12 | Novartis AG | Neue medizinische verwendung von aldosteron-synthase-inhibitoren, alleine oder in kombination mit at1-rezeptor-antagonisten |
ES2270143T3 (es) * | 2002-08-07 | 2007-04-01 | Novartis Ag | Compuestos organicos como agentes para el tratamiento de condiciones mediadas por aldosterona. |
BRPI0511621A (pt) | 2004-05-28 | 2008-01-02 | Speedel Experimenta Ag | compostos orgánicos |
ATE490241T1 (de) * | 2004-05-28 | 2010-12-15 | Novartis Ag | Heterocyclische verbindungen und deren verwendung als aldosteronsynthaseinhibitoren |
CA2568165A1 (en) * | 2004-05-28 | 2005-12-15 | Speedel Experimenta Ag | Heterocyclic compounds and their use as aldosterone synthase inhibitors |
TW200808813A (en) | 2006-04-12 | 2008-02-16 | Speedel Experimenta Ag | Imidazo compounds |
TW200808812A (en) | 2006-04-12 | 2008-02-16 | Speedel Experimenta Ag | Imidazo compounds |
-
2007
- 2007-04-10 TW TW096112446A patent/TW200808812A/zh unknown
- 2007-04-11 AR ARP070101537A patent/AR060591A1/es unknown
- 2007-04-12 DE DE602007008860T patent/DE602007008860D1/de active Active
- 2007-04-12 CN CNA2007800130963A patent/CN101421278A/zh active Pending
- 2007-04-12 ES ES07728050T patent/ES2352092T3/es active Active
- 2007-04-12 JP JP2009504756A patent/JP2010523465A/ja active Pending
- 2007-04-12 WO PCT/EP2007/053583 patent/WO2007116097A1/en active Application Filing
- 2007-04-12 EP EP07728053A patent/EP2004658B1/de not_active Not-in-force
- 2007-04-12 AT AT07728053T patent/ATE484510T1/de not_active IP Right Cessation
- 2007-04-12 US US12/223,789 patent/US7799780B2/en not_active Expired - Fee Related
- 2007-04-12 DE DE602007009812T patent/DE602007009812D1/de active Active
- 2007-04-12 EP EP07728050A patent/EP2004657B1/de not_active Not-in-force
- 2007-04-12 PL PL07728050T patent/PL2004657T3/pl unknown
- 2007-04-12 CA CA002649214A patent/CA2649214A1/en not_active Abandoned
- 2007-04-12 US US12/226,209 patent/US7795253B2/en not_active Expired - Fee Related
- 2007-04-12 CA CA2641473A patent/CA2641473C/en not_active Expired - Fee Related
- 2007-04-12 AT AT07728050T patent/ATE479692T1/de active
- 2007-04-12 CN CN2007800122577A patent/CN101415716B/zh not_active Expired - Fee Related
- 2007-04-12 BR BRPI0710596-7A patent/BRPI0710596A2/pt not_active IP Right Cessation
- 2007-04-12 WO PCT/EP2007/053586 patent/WO2007116100A1/en active Application Filing
- 2007-04-12 JP JP2009503598A patent/JP4980417B2/ja not_active Expired - Fee Related
- 2007-04-12 BR BRPI0709948-7A patent/BRPI0709948A2/pt not_active IP Right Cessation
-
2008
- 2008-07-24 IL IL193065A patent/IL193065A0/en unknown
- 2008-10-06 IL IL194582A patent/IL194582A0/en unknown
-
2010
- 2010-08-16 US US12/857,032 patent/US8076327B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN101421278A (zh) | 2009-04-29 |
US20100305110A1 (en) | 2010-12-02 |
EP2004658B1 (de) | 2010-10-13 |
AR060591A1 (es) | 2008-07-02 |
US7795253B2 (en) | 2010-09-14 |
WO2007116100A1 (en) | 2007-10-18 |
CN101415716B (zh) | 2012-12-12 |
BRPI0709948A2 (pt) | 2011-08-02 |
IL193065A0 (en) | 2009-02-11 |
CN101415716A (zh) | 2009-04-22 |
ES2352092T3 (es) | 2011-02-15 |
EP2004658A1 (de) | 2008-12-24 |
JP2010523465A (ja) | 2010-07-15 |
JP4980417B2 (ja) | 2012-07-18 |
JP2009532442A (ja) | 2009-09-10 |
CA2649214A1 (en) | 2007-10-18 |
TW200808812A (en) | 2008-02-16 |
US8076327B2 (en) | 2011-12-13 |
US7799780B2 (en) | 2010-09-21 |
EP2004657B1 (de) | 2010-09-01 |
BRPI0710596A2 (pt) | 2011-08-16 |
PL2004657T3 (pl) | 2011-02-28 |
US20090012068A1 (en) | 2009-01-08 |
EP2004657A1 (de) | 2008-12-24 |
CA2641473A1 (en) | 2007-10-18 |
CA2641473C (en) | 2011-11-01 |
DE602007008860D1 (de) | 2010-10-14 |
DE602007009812D1 (de) | 2010-11-25 |
ATE479692T1 (de) | 2010-09-15 |
US20090048241A1 (en) | 2009-02-19 |
IL194582A0 (en) | 2009-08-03 |
WO2007116097A1 (en) | 2007-10-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |