ATE526324T1 - Substituierte imidazolverbindungen als ksp- inhibitoren - Google Patents
Substituierte imidazolverbindungen als ksp- inhibitorenInfo
- Publication number
- ATE526324T1 ATE526324T1 AT06789653T AT06789653T ATE526324T1 AT E526324 T1 ATE526324 T1 AT E526324T1 AT 06789653 T AT06789653 T AT 06789653T AT 06789653 T AT06789653 T AT 06789653T AT E526324 T1 ATE526324 T1 AT E526324T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazole compounds
- substituted imidazole
- ksp inhibitors
- ksp
- inhibitors
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70690105P | 2005-08-09 | 2005-08-09 | |
| PCT/US2006/031129 WO2007021794A1 (en) | 2005-08-09 | 2006-08-09 | Substituted imidazole compounds as ksp inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE526324T1 true ATE526324T1 (de) | 2011-10-15 |
Family
ID=37421032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06789653T ATE526324T1 (de) | 2005-08-09 | 2006-08-09 | Substituierte imidazolverbindungen als ksp- inhibitoren |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7626040B2 (de) |
| EP (1) | EP1912972B1 (de) |
| JP (1) | JP4975745B2 (de) |
| KR (1) | KR20080036611A (de) |
| CN (1) | CN101253167A (de) |
| AR (1) | AR056025A1 (de) |
| AT (1) | ATE526324T1 (de) |
| AU (1) | AU2006279991B2 (de) |
| BR (1) | BRPI0614547A2 (de) |
| CA (1) | CA2618747A1 (de) |
| ES (1) | ES2374449T3 (de) |
| GT (1) | GT200600366A (de) |
| HK (1) | HK1111995A1 (de) |
| MY (1) | MY147188A (de) |
| PE (1) | PE20070352A1 (de) |
| PL (1) | PL1912972T3 (de) |
| PT (1) | PT1912972E (de) |
| RU (1) | RU2413721C9 (de) |
| TW (1) | TW200800951A (de) |
| WO (1) | WO2007021794A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090081020A (ko) * | 2006-11-13 | 2009-07-27 | 노파르티스 아게 | Ｋｓｐ 억제제로서의 치환된 피라졸 및 트리아졸 화합물 |
| CN101622247A (zh) * | 2007-01-05 | 2010-01-06 | 诺瓦提斯公司 | 作为驱动蛋白纺锤体蛋白抑制剂的咪唑衍生物 |
| EP2220061B1 (de) | 2007-10-19 | 2016-02-17 | Merck Sharp & Dohme Corp. | Spiro-kondensierte 1,3,4-thiadiazolderivate zur inhibierung der ksp-kinesin-aktivität |
| US8252832B2 (en) * | 2007-12-14 | 2012-08-28 | Novartis Ag | Kinesin inhibitors as cancer therapeutics |
| CN102844307A (zh) | 2010-04-15 | 2012-12-26 | 诺瓦提斯公司 | 作为ksp抑制剂的***化合物 |
| US9498540B2 (en) | 2013-03-15 | 2016-11-22 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| EP2968591A1 (de) * | 2013-03-15 | 2016-01-20 | Novartis AG | Zellproliferationshemmer und konjugate davon |
| BR112016014830A2 (pt) * | 2013-12-23 | 2017-09-19 | Bayer Pharma AG | Conjugados de fármaco de anticorpo (adcs) com inibidores de ksp |
| WO2016020791A1 (en) | 2014-08-05 | 2016-02-11 | Novartis Ag | Ckit antibody drug conjugates |
| CN114917361A (zh) * | 2015-06-22 | 2022-08-19 | 拜耳医药股份有限公司 | 具有酶可裂解基团的抗体药物缀合物（adc）和抗体前药缀合物（apdc） |
| EP3919518A1 (de) | 2016-06-15 | 2021-12-08 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate mit ksp-inhibitoren und anti-cd123-antikörpern |
| EP3558387B1 (de) | 2016-12-21 | 2021-10-20 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren |
| EP3558388A1 (de) | 2016-12-21 | 2019-10-30 | Bayer Pharma Aktiengesellschaft | Binder-wirkstoff-konjugate (adcs) mit enzymatisch spaltbaren gruppen |
| CA3103327A1 (en) | 2018-06-18 | 2019-12-26 | Bayer Aktiengesellschaft | Binder/active agent conjugates directed against cxcr5, having enzymatically cleavable linkers and improved activity profile |
| CN109481436A (zh) * | 2018-08-21 | 2019-03-19 | 广东医科大学 | 血栓素a2合成酶抑制剂奥扎格雷在制备治疗吸烟所致肺癌药物中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| EP0946587A2 (de) | 1996-12-16 | 1999-10-06 | Fujisawa Pharmaceutical Co., Ltd. | Amindverbindungen und ihre verwendung als inhibitoren der bitric-oxid-synthase |
| US6117940A (en) | 1997-10-17 | 2000-09-12 | Mjalli; Adnan M. M. | Amino-ketone solid support templates |
| AU746963B2 (en) * | 1998-06-12 | 2002-05-09 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Imidazolyl derivatives |
| CN100381428C (zh) * | 1999-10-27 | 2008-04-16 | 赛特凯恩蒂克公司 | 喹唑啉酮类化合物及应用 |
| US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US6620882B1 (en) | 2000-05-02 | 2003-09-16 | Advanced Syntech, Llc | Solid support template for preparation of highly functionalized heterocycle compounds |
| DE60128102T2 (de) * | 2000-08-01 | 2008-01-03 | Societe De Conseils De Recherches Et D`Applications Scientifiques (S.C.R.A.S.) | Imidazolderivate |
| US7026312B2 (en) * | 2002-03-14 | 2006-04-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof |
| DE10211770A1 (de) | 2002-03-14 | 2003-10-02 | Boehringer Ingelheim Pharma | Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| WO2004071448A2 (en) | 2003-02-12 | 2004-08-26 | Transtech Pharma Inc. | Substituted azole derivatives as inhibitors of protein tyrosine phosphatases |
| WO2004100873A2 (en) * | 2003-05-07 | 2004-11-25 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| JP2007500746A (ja) * | 2003-05-15 | 2007-01-18 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
| WO2005100322A1 (en) | 2004-04-14 | 2005-10-27 | Pfizer Limited | Sulphur-linked imidazole compounds for the treament of hiv |
| US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| AU2005258135B2 (en) * | 2004-06-18 | 2011-09-22 | Novartis Vaccines And Diagnostics Inc. | N- (1- (1-benzyl -4-phenyl-1H-imidazol-2-YL) -2,2-dymethylpropyl) benzamide derivatives and related compounds as kinesin spindle protein (KSP) inhibitors for the treatment of cancer |
-
2006
- 2006-08-08 MY MYPI20063824A patent/MY147188A/en unknown
- 2006-08-08 TW TW095129062A patent/TW200800951A/zh unknown
- 2006-08-09 AT AT06789653T patent/ATE526324T1/de active
- 2006-08-09 US US11/502,303 patent/US7626040B2/en not_active Expired - Fee Related
- 2006-08-09 JP JP2008526175A patent/JP4975745B2/ja not_active Expired - Fee Related
- 2006-08-09 AR ARP060103489A patent/AR056025A1/es not_active Application Discontinuation
- 2006-08-09 ES ES06789653T patent/ES2374449T3/es active Active
- 2006-08-09 PL PL06789653T patent/PL1912972T3/pl unknown
- 2006-08-09 GT GT200600366A patent/GT200600366A/es unknown
- 2006-08-09 PE PE2006000968A patent/PE20070352A1/es not_active Application Discontinuation
- 2006-08-09 RU RU2008108939/04A patent/RU2413721C9/ru not_active IP Right Cessation
- 2006-08-09 AU AU2006279991A patent/AU2006279991B2/en not_active Ceased
- 2006-08-09 EP EP06789653A patent/EP1912972B1/de active Active
- 2006-08-09 CA CA002618747A patent/CA2618747A1/en not_active Abandoned
- 2006-08-09 KR KR1020087003946A patent/KR20080036611A/ko not_active Application Discontinuation
- 2006-08-09 BR BRPI0614547-7A patent/BRPI0614547A2/pt not_active IP Right Cessation
- 2006-08-09 CN CNA2006800293472A patent/CN101253167A/zh active Pending
- 2006-08-09 PT PT06789653T patent/PT1912972E/pt unknown
- 2006-08-09 WO PCT/US2006/031129 patent/WO2007021794A1/en active Application Filing
-
2008
- 2008-06-26 HK HK08107126.4A patent/HK1111995A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20070352A1 (es) | 2007-05-30 |
| AU2006279991B2 (en) | 2011-09-29 |
| ES2374449T3 (es) | 2012-02-16 |
| RU2413721C9 (ru) | 2011-05-20 |
| JP4975745B2 (ja) | 2012-07-11 |
| EP1912972A1 (de) | 2008-04-23 |
| BRPI0614547A2 (pt) | 2011-03-29 |
| JP2009504664A (ja) | 2009-02-05 |
| EP1912972B1 (de) | 2011-09-28 |
| HK1111995A1 (en) | 2008-08-22 |
| TW200800951A (en) | 2008-01-01 |
| CA2618747A1 (en) | 2007-02-22 |
| PT1912972E (pt) | 2012-01-06 |
| WO2007021794A1 (en) | 2007-02-22 |
| KR20080036611A (ko) | 2008-04-28 |
| AR056025A1 (es) | 2007-09-12 |
| AU2006279991A1 (en) | 2007-02-22 |
| MY147188A (en) | 2012-11-14 |
| RU2413721C2 (ru) | 2011-03-10 |
| RU2008108939A (ru) | 2009-09-20 |
| GT200600366A (es) | 2007-05-10 |
| US7626040B2 (en) | 2009-12-01 |
| PL1912972T3 (pl) | 2012-02-29 |
| US20070037853A1 (en) | 2007-02-15 |
| CN101253167A (zh) | 2008-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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